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Novel immunotherapy mechanism suppresses breast cancer development

06.03.22 | Massachusetts General Hospital

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Novel immunotherapy mechanism suppresses breast cancer development
New research from Massachusetts General Hospital describes how CD4+ T cells activated by an immune factor called thymic stromal lymphopoietin suppress breast cancer by differentiating cancer into benign cyst-like structures. Here, T cells (yellow) are inducing cyst formation in breast cancer (green), which prevents the cancer cells from proliferating (Ki67 as the marker of cell proliferation, red). Credit: Emanuela Marchese, PhD

Journal of Experimental Medicine

10.1084/jem.20201963

Experimental study

Animals

CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation

3-Jun-2022

Disclosures: M. Boieri is an employee of Zelluna Immunotherapy. S. Iyer is an employee of and has equity in Verve Therapeutics. M.N. Rivera reported grants from Advanced Cell Diagnostics and non-financial support from Merck/Serono outside the submitted work. No other disclosures were reported.

Keywords

Breast Cancer Breast Cancer Cells Cancer Immunotherapy Helper T Cells Immunotherapy

Article Information

Journal
Journal of Experimental Medicine
DOI
10.1084/jem.20201963
Method of Research
Experimental study
Subject of Research
Animals
Article Publication Date
2022-06-03
Article Title
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation
COI Statement
Disclosures: M. Boieri is an employee of Zelluna Immunotherapy. S. Iyer is an employee of and has equity in Verve Therapeutics. M.N. Rivera reported grants from Advanced Cell Diagnostics and non-financial support from Merck/Serono outside the submitted work. No other disclosures were reported.

Contact Information

Katie Marquedant
Massachusetts General Hospital
KMarquedant@partners.org

How to Cite This Article

APA:
Massachusetts General Hospital. (2022, June 3). Novel immunotherapy mechanism suppresses breast cancer development. Brightsurf News. https://www.brightsurf.com/news/LN2XRNY1/novel-immunotherapy-mechanism-suppresses-breast-cancer-development.html
MLA:
"Novel immunotherapy mechanism suppresses breast cancer development." Brightsurf News, Jun. 3 2022, https://www.brightsurf.com/news/LN2XRNY1/novel-immunotherapy-mechanism-suppresses-breast-cancer-development.html.