Using germ-free mice colonized with normal microbiota, researchers demonstrate a link between gut microbiota and maturation of the adult enteric nervous system (ENS), which is involved in gastrointestinal functions; the authors report microbiota-induced release of serotonin and subsequent neuronal activation of serotonin receptors in the ENS, findings with potential implications for treating gastrointestinal disorders.
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Article #17-20017: "Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks," by Filipe De Vadder et al.
MEDIA CONTACT: Fredrik Bäckhed, University of Gothenburg, SWEDEN; tel: +46313427833; e-mail: < fredrik.backhed@wlab.gu.se >
Proceedings of the National Academy of Sciences