Articles tagged with Gut Microbiota
A new study from the University of Copenhagen reveals that astronauts experience changes in their gut bacteria shortly after leaving Earth and gravity behind. The researchers found increased protein fermentation, which may contribute to constipation, and suggest potential interventions for future long-duration space missions.
Researchers at Boston Children's Hospital found that fecal transplants from healthy donors reduced peanut allergy symptoms in some patients. The study suggests that the right bacteria can help restore tolerance to food through bile acid metabolites. Increased levels of immune regulatory cells also protected against allergic reactions.
Researchers discovered that newborn German cockroaches use pheromones in feces to recognize their own colony and form a kind of social bond. This behavior was found to be mediated by both innate attraction to conspecific fecal odor and learned preferences for specific odorants encountered during coprophagy soon after they hatch.
A study found that reshaping the gut microbiome with antibiotics can significantly reduce liver clearance and double chemotherapy delivery to tumors. This approach has potential as a strategy to enhance nanoparticle-based cancer drugs.
Researchers at UC Davis identified a naturally occurring metabolite, 10-hydroxystearic acid (10-HSA), that repairs gut damage caused by HIV infection. Combining 10-HSA with standard antiretroviral therapy improved viral suppression and helped rebuild gut immune defenses in animal models of AIDS.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
Researchers found that certain gut bacteria are associated with faster or slower biological aging, explaining about 15% of the differences. The study provides evidence for the importance of the gut microbiome in understanding biological aging and its potential influence on longevity.
A study led by Robert Koeth found a connection between elevated blood levels of TMAO, a gut bacteria byproduct, and an increased risk of atrial fibrillation. The research team discovered that TMAO changes the heart's electrical environment, making it more susceptible to abnormal rhythms.
Research suggests that time zone changes disrupt the synchronization between human biological clocks and gut microbiota, leading to digestive complaints, poorer sleep quality, and reduced energy levels. Gradually adjusting one's biological clock through light exposure and meal timing before departure can help reduce jet lag effects.
A randomized clinical trial found that ingesting fecal microbes from healthy donors improved sleep efficiency and reduced wake after sleep onset in participants with chronic insomnia. Sleep quality scores also showed significant improvement over two months.
Researchers discovered that fructooligosaccharide induces the selective enrichment of Anaerotruncus colihominis, a UA-degrading bacterium, via modulation of the gut microbiota. This interaction alleviates oxidative damage to the kidney and offers a new therapeutic rationale for prebiotic-based management of hyperuricemia
A study published in RMD Open found that specific oral microbiome imbalances may contribute to the development of hand osteoarthritis by influencing systemic inflammation and gut microbiome dysbiosis. The research suggests a potential role for the oral-gut microbiome axis in symptomatic hand arthritis pathogenesis.
A new study argues that the microbiome-gut-brain axis has been predominantly studied in wealthy, industrialised nations, limiting scientific discovery. The authors call for greater international collaboration and investment in research infrastructure to uncover universal biological principles that can improve mental health worldwide.
Researchers at UT MD Anderson Cancer Center have made significant progress in treating rare brain infections with a virus-specific T cell therapy, achieving an overall response rate of 56.8% in patients with progressive multifocal leukoencephalopathy (PML). The center also introduced a novel CAR T cell therapy for hard-to-treat kidney ...
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
Scientists are conducting a European clinical trial aiming to reduce antibiotic use and lower recurrent urinary tract infection rates by targeting pathogenic E. coli strains with CRISPR-enhanced phage cocktails and microbiome restoration therapies.
Researchers from the University of Nebraska-Lincoln have identified a specific gut bacterium, Bacteroides uniformis, and its metabolites that can positively impact the body's immune response to cancer. The study found that these metabolites can suppress tumor growth and boost anti-tumor immunity in mice.
A new preclinical study has identified a gut bacterium, Akkermansia muciniphila, that helps prime intestinal stem cells for faster recovery after radiation treatment. Fasting increases the population of this bacterium, which produces a small molecule that changes histone tags to allow gene expression in intestinal cells.
A systematic review found that babies born by caesarean section or exposed to antibiotics around the time of birth tend to have differences in their gut bacteria composition, with less diversity and beneficial bacterial groups less abundant. Exclusively breastfed infants appear to show a partial restoration of microbial balance.
A new study found that specific gut bacteria from children with stunted growth can be passed to their offspring, causing inflammation and damage to the intestinal lining. The researchers identified Campylobacter concisus as a key contributor to this process, which may hold promise for future treatment and prevention strategies.
Researchers analyzed DNA samples from foraging honeybees, hive workers, and their honey to understand plant-microbe interactions in honeybee ecology. The study found that these complementary sources provide distinct insights into the complex relationships between plants, microbes, and honeybees.
A recent study published in Nature Communications has identified a clear link between the composition of gut bacteria and frailty in older women. The research found that lower gut bacterial diversity and impaired function are associated with increased vulnerability to disease, falls, functional impairment, and death.
A large Swedish study found that certain bacteria in the gut microbiota can be seen in people who develop type 2 diabetes years later. Fluctuations in metabolism and low fibre intake may also contribute to the risk. The discovery paves the way for early identification of at-risk individuals.
Researchers found that psychological stress speeds up aging-like changes in hematopoietic stem cells by altering the intestinal microbiota and reducing spermidine levels. Chronic stress impacts the balance of gut microbes, leading to immune dysfunction and bone marrow defects.
A Thai study found that shelter dogs in more crowded conditions tend to have disrupted gut microbiomes compared to those with more space. The research analyzed stress, metabolism, and fecal microbiota in dogs, providing insights into the impact of shelter conditions on animal health.
A study published in Frontiers in Cellular and Infection Microbiology found that healthy infant gut microbiomes are linked to reduced risk of malaria. Babies with beneficial microbes like Bifidobacterium were less likely to develop the disease. However, further research is needed to confirm this association.
Researchers have identified a consistent microbial signature of colorectal cancer by reanalyzing nearly 6,800 gut microbiome profiles. The study found that microbes detected in stool samples reflect microbes found directly within colorectal tumours.
Two studies found that certain fungal species in the gut play a key role in immune dysregulation and pediatric allergic diseases, positioning the infant mycobiome as a promising target for therapies. Infants' early-life antibiotic use may have a direct impact on these fungi, leading to immune dysregulation and allergic asthma.
Researchers found that over-the-counter probiotics contain only 36 unique species of bacteria, with most common species being forms of Lactobacillus. The analysis suggests a lack of consistency in the combination of species used to support gut health and vaginal health claims.
Researchers from Institute of Science Tokyo found that postbiotic foods can improve gum health in adults with mild gingivitis, reducing gum bleeding and inflammation. The study suggests a simple way to support oral health without altering oral care habits.
A study found that prebiotic xylo-oligosaccharides reduced harmful metabolites and improved liver health in overweight adults. The composition of the gut microbiota prior to supplementation influenced the benefits observed.
Researchers found that cohabiting individuals shared significantly more oral and gut strains than those living in different households. On average, cohabitors shared 19% of their gut microbiome and 26% of their oral microbiome strains with each other.
Professor Saeedi's appointment reflects ISM's commitment to advancing microbiota research toward clinical translation and precision medicine. He will contribute to identifying emerging scientific priorities and promoting the integration of microbiome science with aging biology, metabolism, cardiovascular medicine, and precision health.
Researchers found that eliminating sugar from a low-fat diet can lead to impaired glucose control, insulin resistance, and gut microbial imbalance. Balanced dietary carbohydrates are essential for supporting gut and immune homeostasis.
NUTRITION 2026 brings together thousands of researchers and health professionals to share new evidence on protein needs, infant formula regulation, microbiome mysteries, and more. The meeting features over 1,650 scientific studies and provides a platform for experts to discuss the future of nutrition science.
New research links food insecurity to altered gut microbiomes in children, with potential implications for child health and development. The study found higher levels of certain bacteria, such as Sutterella, in children from food-insecure households.
Researchers investigated the interplay between host and gut microbiota in selenium metabolism, finding that gut microbiota transform selenium into metabolites influencing utilization, detoxification, and excretion. The study also revealed that Se intake affects bacterial diversity and that gut microbes produce unique selenometabolites.
A new mathematical model developed by Arizona State University researchers estimates how much of the calories people absorb from food, considering the role of gut microbes. The model, DAMM, suggests that short-chain fatty acids produced by gut microbes contribute to an average of about 140 calories per day.
A study by Harvard T.H. Chan School of Public Health found that gut microbiome alterations persist even after adenoma removal, increasing the risk of colorectal cancer. The researchers discovered that diet and physical activity were closely tied to CRC-associated gut microbes, suggesting lifestyle habits may contribute to sustained risk.
A new screening tool tests for microbial metabolites in urine to identify children at risk for autism, with 90% sensitivity and 100% specificity. The test may guide more targeted interventions, including approaches to restore a healthy gut microbiome.
Researchers found that the gut responds to protein deficiency by activating a fast neural circuit and a slower hormonal signal, which selectively changes dietary priorities. The study reveals a previously unknown gut-brain signaling system that rapidly alters feeding behavior in animals.
A study reveals that medical exposure can rapidly change the human microbiome, with gut microbes shifting toward patterns more commonly seen in urban populations. The research found a decline in microbial diversity and a shift towards bacterial groups more common in industrialized societies.
Researchers found that gut luminal exosomes from older animals carried molecular signals associated with insulin resistance, inflammation and disruption of the gut barrier. Transferring these to young animals elicited similar effects, while transferring exosomes from young animals to older animals mitigated metabolic aging findings.
A new study reveals a correlation between body weight and gut microbiota composition, which can lead to gastrointestinal diseases. However, genetics also play a role in shaping the gut microbiome.
Researchers discovered that Akkermansia bacteria, which aid human digestion, also thrive in the ocean by breaking down seaweed sugar. This finding highlights the importance of these bacteria in both human health and marine ecosystems.
A new Northwestern University study finds metformin primarily targets the gut, driving glucose utilization inside cells lining the intestine to prevent blood sugar levels from rising. The drug slows mitochondrial energy production in gut cells, allowing the intestine to metabolize extra sugar and regulate blood sugar levels.
Researchers tracked six NCAA Division I football players over a season and found that non-concussive head impacts correlated with changes to the gut microbiome. The study suggests that even sub-symptomatic head impacts might affect the gut microbiome, both in the immediate aftermath of injury and over a longer time course.
A review from Florida Atlantic University links obesity to Alzheimer's disease through disruptions in metabolism, highlighting the importance of mitochondrial function and gut-brain axis balance. Early detection and whole-body prevention may become possible through monitoring metabolic health.
Researchers at Vanderbilt University Medical Center discovered that enterotoxigenic Bacteroides fragilis reshapes intestinal cell metabolism to support its growth, causing diseases like diarrhea and colorectal cancer. The study provides new possibilities for intervention by targeting metabolic interactions between host and microbes.
Researchers found that microbes actively adjust their behavior to minimize competition and conflict when living together, leading to more efficient coexistence. This discovery provides insights into how diverse microbial communities assemble and persist despite intense competition.
Researchers from NUS engineered bacteria to restore metabolic balance across the gut, liver and brain, reducing brain toxins and preventing neurological symptoms. The approach preserves the natural diversity of the gut microbiome and has shown promising results in long-term safety studies.
A new review found that lifestyle behaviors like physical activity and diet can positively modulate the gut microbiome of cancer patients, but these effects are often influenced by non-modifiable variables. The study also highlighted the role of intrinsic patient characteristics in shaping microbial composition.
Researchers have developed a universal toolkit for editing bacterial DNA in 15 diverse species, including human pathogens and fast-growing biotechnology organisms. The technology uses retrons, an immune system that produces DNA, to efficiently modify genes, with varying success rates across different species.
Researchers found that antibiotics disrupt gut microbiota, suppressing protective immune system pathways and increasing severity of A. baumannii pneumonia. The study highlights the gut-lung connection as a potential therapeutic target for hospital-acquired lung infections.
Researchers found that restoring a young microbiome can reverse features of aging in the liver, including inflammation and DNA damage. The study suggests that a healthy gut microbiome plays a key role in preventing liver cancer.
Researchers are close to building a 'virtual gut' capable of predicting responses to diet, drugs, and microbiome-based therapies. A new review outlines an analytical framework for host-microbiome multi-omics studies, covering preprocessing, feature selection, data integration, predictive modeling, and evaluation.
A new study found that breast milk helps maintain a balance of beneficial bacteria in babies' developing gut microbiomes, including E. coli and Bifidobacterium. This mutualistic relationship supports healthy infant development and may have implications for future synbiotics.
Researchers found distinct gut microbiome characteristics that predicted treatment response to the low FODMAP diet and rifaximin. Patients who responded to these treatments had different microbial signatures, with increases in diversity for those on the low FODMAP diet and resilience against antibiotics for those on rifaximin.
A recent study found that antibiotic-resistant bacteria are present in the gut microbiomes of American black bears in eastern North Carolina. The researchers also discovered that these pathogens can be dispersed through bear feces, making the bears a potential indicator species for environmental changes.
A new study reveals that people with Parkinson's disease have a distinct gut microbiome, as do those at genetic risk but without symptoms. This could lead to early detection and potential prevention strategies.