Articles tagged with Gut Microbiota
A new study from Texas Biomedical Research Institute found that low-dose THC significantly reduced side effects and inflammation caused by HIV and antiretroviral therapy. The treatment also increased serotonin levels, lowered cholesterol and toxic bile acids, and improved cardiovascular health.
Researchers identified 15 bacterial species linked to CAD, including strains of friendly bacteria that can turn harmful. The study suggests that microbes play a critical role in the development and progression of CAD through inflammation, metabolic imbalance, and other pathways.
A recent study published in The FEBS Journal found that specific gut bacteria can efficiently metabolize different forms of nitrogen, preventing carcinogenic nitrosamine formation. This process is critical for maintaining intestinal and systemic health, potentially decreasing the risk of certain cancers.
A comprehensive review synthesizes current insights into the intricate connections between gut microbiota and sleep regulation, highlighting the crucial role of peripheral organs in modulating brain function and behavior. Disruptions in gut microbiota composition are closely linked to sleep disturbances across multiple disorders.
The microbiota is recognized as a dynamic organ producing molecules that regulate gene expression, immunity, and mitochondrial function. Biomarkers of inflammation, metabolism, and aging can be predicted through microbiota signatures, establishing the microbiota as a pillar of predictive medicine.
A new UCLA Health study found that a child's early gut microbiome may influence their risk of developing depression, anxiety or other internalizing symptoms in middle childhood. The effect appears to be related to the way bacteria are linked to communication across emotion-related brain networks.
A study from the Champalimaud Foundation found that when fruit flies are deprived of essential amino acids, their brains upregulate two olfactory receptor genes involved in smell, leading to a refined sense of smell that guides them to protein-rich yeast and gut bacteria. This interplay between smell and taste regulates feeding behavior.
A new study reveals that a specific E. coli strain can block the gut's defense mechanism by injecting a protein called NleL, allowing it to spread more easily. This discovery could lead to new treatments that target how bacteria cause disease.
A healthy microbiome promotes overall well-being, influencing areas like cognition, mood, immunity, and disease susceptibility. By incorporating proven dietary interventions, regular exercise, stress reduction, and adequate sleep, individuals can harness their microbiome for optimal health.
Research from the University of Gothenburg has identified two bacteria that can produce bioactive serotonin, a key player in bowel movements and brain function. These findings suggest new avenues for treating functional gastrointestinal disorders like IBS.
Researchers discovered a mechanism by which certain bacteria can induce quiescence in cancer epithelial cells, making them resistant to chemotherapy. Understanding this microbe-tumor relationship may lead to the development of smarter therapies that can target treatment-resistant cancers.
Researchers discovered that non-hibernating pikas alter their gut microbiota to increase urea nitrogen salvaging, maintaining protein homeostasis during winter. This adaptation helps the animals cope with the scarcity of dietary protein during the cold season.
Researchers found that Candida albicans overgrowth increases inflammatory molecules PGE2, altering dopamine signaling and reducing desire for alcohol. Blocking PGE2 activity reverses the behavior, suggesting a potential link between gut microbiota and alcohol consumption.
A new study links gut dysbiosis to severe steatosis in MASLD, improving diagnostic accuracy when microbiota status is added to standard clinical tools. The inflammation-linked Bact2 enterotype is strongly associated with severe hepatic steatosis in MASLD.
Researchers analyzed feces samples from 11 herbivore species in Namibia's Etosha National Park to understand how environmental factors shape their gut microbiomes. The study found five types of bacteria serving as environmental indicators, which could help monitor ecosystem changes and animal adaptation.
Dr. Amin's transformative insights reshape international understanding of depression genetics, identifying novel therapeutic targets and biomarkers for diagnosis and treatment. Her systemic disease model challenges traditional views of depression as a brain disorder.
Researchers found that hosts harboring different microbial strains exhibited neurobehavioral differences. The study identified 34 significant associations between microbial single nucleotide variations and host plasma metabolites, primarily related to key physiological processes such as neuroactive regulation and oxidative stress.
Researchers from the University of South Australia explore the connection between the gut and brain to decipher their role in mental health and wellbeing. The study found that changes in the gut microbiome can directly affect brain chemistry, suggesting a potential link between gut health and mental illness.
The 2-day conference focuses on bridging the fields of mitochondrial biology, microbiome research, and extracellular vesicle science to advance translational innovation. Experts will discuss EVs as core messengers in intercellular communication and their potential therapeutic applications.
The study reveals that Christensenella tenuis significantly reduces LPS levels and improves glucose and lipid metabolism in diet-induced obesity mice. It achieves this through a distinct bile acids-LPS interaction, preventing LPS from translocating into the bloodstream.
A year-long study on Japanese macaques found that their gut microbiome composition and fermentative ability adjust seasonally to improve digestive efficiency. The study reveals that mature leaf consumption boosts the fermentative ability of the gut microbiome, helping monkeys handle chemically defended foods during harsh winters.
This comprehensive metagenomic survey reveals vast gut microbiome diversity, with 21,902 species-level genome bins identified. The study also uncovers a significant reservoir of previously uncharacterized microbes and identifies high-risk antibiotic resistance genes across 14 mammal species.
Researchers identified a cellular mechanism that alters the gut microbiome in a way that promotes cancer. Long-chain fatty acids serve as food for certain bacteria, such as Desulfovibrio fairfieldensis, which multiply and displace other microbes.
The University of California - Riverside is receiving a $2 million grant to investigate how gut microbes interact with their human hosts to influence health. The research aims to create next-generation probiotics that strengthen the gut microbiome, improve vaccine effectiveness, and prevent infections.
Researchers developed an engineered strain of gut-homing bacteria that induces mature tertiary lymphoid structures, associated with improved survival and stronger treatment responses. The therapy also restored healthy gut microbiota and showed excellent biocompatibility.
Research links oral bacteria to Parkinson's disease via the gut-brain axis, finding Streptococcus mutans produces metabolite imidazole propionate that contributes to disease progression. Targeting the oral-gut microbiome may offer a new therapeutic approach for Parkinson's treatment.
A study in mice found that maternal consumption of emulsifiers can alter the gut microbiota of their offspring, leading to increased risk of chronic inflammatory gut disorders and obesity. The research highlights the importance of regulating food additives, particularly in powdered baby formulas, to prevent long-term health consequences.
Researchers at DTU have discovered a way to combat antibiotic-resistant bacteria by nourishing special bifidobacteria that is naturally occurring in the gut. Special lactic acids produced by bifidobacteria play a key role in keeping antibiotic-resistant bacteria at bay.
A study published in Cell Host & Microbe found a significant link between the maternal gut microbiome and preterm birth. The researchers identified Clostridium innocuum as a key bacteria species that may contribute to preterm birth by degrading estradiol, a critical hormone during pregnancy.
Researchers found genetic peptides called alpha-defensins that shape gut bacteria, producing healthier microbiomes and reducing insulin resistance. This discovery suggests personalized treatments can be tailored to individual genes, offering new hope for addressing chronic diseases like obesity and diabetes.
Researchers found that children with stable gut microbiomes tend to have better growth outcomes. The study created the first-ever pediatric undernutrition microbial genome catalog, which can predict and prevent malnutrition. This discovery opens the door to new diagnostics and therapeutics for addressing global child stunting issues.
Researchers found significant causal relationships between gut microbiome characteristics and age-related traits, including ApoM protein levels. The study suggests targeting the gut microbiota may help delay or reduce age-related inflammation and disease.
A novel genome-wide association study identifies previously unrecognized connections between human genetics, gut fungi, and chronic disease. The study establishes that host genetics can influence the fungi that live in the gut and provide clues about their abundances.
A study of 344 Japanese women found that a diet rich in fermented foods, soy products, mushrooms, and seaweed was associated with improved gut microbiota and reduced depressive symptoms. Traditional Japanese cuisine may hold the key to preventing postpartum depression.
A new scientific review reveals that stress, hardship, and social challenges reshape a person's gut bacteria and brain performance, making it harder to keep weight off. Social determinants of health play a key role in obesity risk, and addressing these conditions is crucial for long-term solutions.
Researchers found 148 fungi-associated genetic variants linked to 9 fungal taxa and associated with chronic disease risk. The study sheds light on the human genetic determinants of the mycobiome, a previously understudied group of gut microorganisms.
Researchers have discovered that gut bacteria can recognize diverse chemical signals, including those from nutrients, DNA, and other metabolites. This allows them to detect and respond to nutritional values, suggesting that finding sources of nutrients is a primary function of motility in these bacteria.
Researchers found that a molecule produced by gut bacteria can cause inflammation, scarring and fibrosis in the kidneys, a major complication of diabetes. Corisin, a small peptide, attaches to albumin in the blood and targets the delicate kidney structures, accelerating aging and cell death.
Researchers discovered that smoking produces metabolites that encourage mouth bacteria to grow in the large intestines, triggering an immune response. These bacteria, specifically Streptococcus mitis, help reduce inflammation in ulcerative colitis by triggering a specific immune response.
Researchers found that patients carrying colibactin-producing Escherichia coli in their colon polyps were more than three times as likely to have a history of colorectal cancer compared to those without the bacterium. The study suggests that targeting specific microbes could help prevent cancer in high-risk groups.
Researchers at Kyushu University discovered that combining yogurt intake with hot spring bathing enhances gut microbiota diversity and improves defecation status, suggesting a potential application for preventive medicine. The study found significant improvements in gut health outcomes, particularly among healthy adults.
A new study published in Molecular Nutrition and Food Research found that red meat consumption causes an imbalance of bacteria in the intestinal microbiota, leading to exacerbated colonic inflammation. The diets resulted in a decrease in beneficial bacterial strains and an increase in pro-inflammatory cells.
Researchers discovered a multi-faceted mechanism behind ASD, revealing the gut microbiota and host immune system's influence on disease progression. Precision-selected probiotics restored metabolic balance, reduced neuroinflammation, and ameliorated behavioral abnormalities in ASD mouse models.
Researchers found that a compound produced by Lactobacillus bacteria can reverse liver and gut damage caused by aflatoxin exposure. The molecule, 10-hydroxystearic acid, activated PPARα signaling to repair liver tissue and support gut health.
Institute for Systems Biology researchers use microbial community-scale metabolic models to simulate C. diff behavior in human gut microbiome samples. They accurately predict colonization states, susceptibility, and response to probiotics, offering a path to prevent C. diff before it starts.
Researchers have identified 48 previously unknown bacterial species in the indri's microbiome, which is largely established through transmission between members of the same social group. This finding has significant implications for preserving the species' habitat and preventing extinction.
A new study uses Association Rule Mining to identify complex microbial relationships in the gut microbiome, revealing key beneficial microbes that contribute to gut homeostasis. The research also demonstrates how ARM can enhance disease classification accuracy for conditions like IBD, CRC, T2D, and IGT.
Researchers have mapped the microbiome of agri-food systems, revealing how diverse and balanced microbes keep our food safe, nutritious, and sustainable. The map highlights areas where targeted interventions such as probiotics and biofertilizers can improve food quality and reduce antibiotic use.
A new study has identified a common bacterial strain that produces signaling proteins influencing hormonal balance and affecting weight, bone density and blood sugar levels. The researchers discovered that RORDEP-producing bacteria can vary greatly between individuals and that people with high levels of these bacteria tend to be leaner.
Researchers have mapped microbial networks underpinning healthy food systems, highlighting the need for integrated approaches to address climate crisis, antibiotic overuse and pesticide reliance. This work is driving microbiome-based solutions for animal, human and environmental health.
Research suggests that consuming high levels of sucralose can make cancer treatment less effective by disrupting the gut microbiome and altering T cell function. However, adding arginine or citrulline supplements to the diet may restore immunotherapy effectiveness in patients with melanoma and non-small cell lung cancer.
Researchers at ETH Zurich and Stanford University quantified the number of molecules produced by gut bacteria that reach the human body daily. This knowledge helps understand how the gut microbiome influences health and behavior.
A low FODMAP diet has been shown to improve colonic barrier function and reduce mast cell activation in patients with IBS-D. The study found that the diet reduced symptoms of diarrhea and abdominal pain, and improved intestinal permeability.
Researchers discovered that indole, a key tryptophan metabolite produced by gut bacteria, can restore enteroendocrine cells in the intestines, which are diminished in obesity. The study suggests that microbial metabolites derived from dietary tryptophan may hold promise as a novel therapy for obesity-associated metabolic complications.
Four leading Japanese corporations in the health and nutrition sectors have joined forces to advance microbiome science. The event aims to explore recent research and development achievements, engage with industry innovators, and promote practical applications of fundamental research.
A study analyzing 249 individuals reveals disrupted interactions between the gut microbiome, immune system, and metabolism in ME/CFS patients. Biomarkers linked to symptoms such as sleep disturbances, headaches, and fatigue provide hope for future diagnostic tools.
Researchers at Duke University School of Medicine have identified a new system linking the microbiome to the brain, which influences behavior and appetite. The discovery was made by detecting flagellin in gut bacteria, triggering an appetite-suppressing signal to the brain.
A new study reveals that the human gut microbiota can pinpoint an individual's city of residence with high accuracy, strongly linked to each city's characteristic diet. The researchers identified unique microbial signatures and interaction networks between cities in China, shedding light on how local environments shape our inner biology.
A 21-day study found that restricting food variety triggers unique shifts in individual gut microbiomes, contradicting the assumption of uniform microbial outcomes. The results suggest personalized nutrition approaches are essential for achieving targeted microbiome modulation.
Research from North Carolina State University found that different probiotic strains have varying impacts on gut microbiome recovery. Some strains, like Lactobacillus gasseri, promoted the growth of beneficial bacteria while others increased bacterial load and delayed resistance to C. difficile infection.