Articles tagged with Gut Microbiota
Researchers found significant causal relationships between gut microbiome characteristics and age-related traits, including ApoM protein levels. The study suggests targeting the gut microbiota may help delay or reduce age-related inflammation and disease.
Researchers found that children with stable gut microbiomes tend to have better growth outcomes. The study created the first-ever pediatric undernutrition microbial genome catalog, which can predict and prevent malnutrition. This discovery opens the door to new diagnostics and therapeutics for addressing global child stunting issues.
A novel genome-wide association study identifies previously unrecognized connections between human genetics, gut fungi, and chronic disease. The study establishes that host genetics can influence the fungi that live in the gut and provide clues about their abundances.
A study of 344 Japanese women found that a diet rich in fermented foods, soy products, mushrooms, and seaweed was associated with improved gut microbiota and reduced depressive symptoms. Traditional Japanese cuisine may hold the key to preventing postpartum depression.
A new scientific review reveals that stress, hardship, and social challenges reshape a person's gut bacteria and brain performance, making it harder to keep weight off. Social determinants of health play a key role in obesity risk, and addressing these conditions is crucial for long-term solutions.
Researchers found 148 fungi-associated genetic variants linked to 9 fungal taxa and associated with chronic disease risk. The study sheds light on the human genetic determinants of the mycobiome, a previously understudied group of gut microorganisms.
Researchers have discovered that gut bacteria can recognize diverse chemical signals, including those from nutrients, DNA, and other metabolites. This allows them to detect and respond to nutritional values, suggesting that finding sources of nutrients is a primary function of motility in these bacteria.
Researchers discovered that smoking produces metabolites that encourage mouth bacteria to grow in the large intestines, triggering an immune response. These bacteria, specifically Streptococcus mitis, help reduce inflammation in ulcerative colitis by triggering a specific immune response.
Researchers found that a molecule produced by gut bacteria can cause inflammation, scarring and fibrosis in the kidneys, a major complication of diabetes. Corisin, a small peptide, attaches to albumin in the blood and targets the delicate kidney structures, accelerating aging and cell death.
Researchers found that patients carrying colibactin-producing Escherichia coli in their colon polyps were more than three times as likely to have a history of colorectal cancer compared to those without the bacterium. The study suggests that targeting specific microbes could help prevent cancer in high-risk groups.
Researchers at Kyushu University discovered that combining yogurt intake with hot spring bathing enhances gut microbiota diversity and improves defecation status, suggesting a potential application for preventive medicine. The study found significant improvements in gut health outcomes, particularly among healthy adults.
A new study published in Molecular Nutrition and Food Research found that red meat consumption causes an imbalance of bacteria in the intestinal microbiota, leading to exacerbated colonic inflammation. The diets resulted in a decrease in beneficial bacterial strains and an increase in pro-inflammatory cells.
Researchers discovered a multi-faceted mechanism behind ASD, revealing the gut microbiota and host immune system's influence on disease progression. Precision-selected probiotics restored metabolic balance, reduced neuroinflammation, and ameliorated behavioral abnormalities in ASD mouse models.
Researchers found that a compound produced by Lactobacillus bacteria can reverse liver and gut damage caused by aflatoxin exposure. The molecule, 10-hydroxystearic acid, activated PPARα signaling to repair liver tissue and support gut health.
Institute for Systems Biology researchers use microbial community-scale metabolic models to simulate C. diff behavior in human gut microbiome samples. They accurately predict colonization states, susceptibility, and response to probiotics, offering a path to prevent C. diff before it starts.
A new study uses Association Rule Mining to identify complex microbial relationships in the gut microbiome, revealing key beneficial microbes that contribute to gut homeostasis. The research also demonstrates how ARM can enhance disease classification accuracy for conditions like IBD, CRC, T2D, and IGT.
Researchers have identified 48 previously unknown bacterial species in the indri's microbiome, which is largely established through transmission between members of the same social group. This finding has significant implications for preserving the species' habitat and preventing extinction.
Research suggests that consuming high levels of sucralose can make cancer treatment less effective by disrupting the gut microbiome and altering T cell function. However, adding arginine or citrulline supplements to the diet may restore immunotherapy effectiveness in patients with melanoma and non-small cell lung cancer.
Researchers have mapped the microbiome of agri-food systems, revealing how diverse and balanced microbes keep our food safe, nutritious, and sustainable. The map highlights areas where targeted interventions such as probiotics and biofertilizers can improve food quality and reduce antibiotic use.
A new study has identified a common bacterial strain that produces signaling proteins influencing hormonal balance and affecting weight, bone density and blood sugar levels. The researchers discovered that RORDEP-producing bacteria can vary greatly between individuals and that people with high levels of these bacteria tend to be leaner.
Researchers have mapped microbial networks underpinning healthy food systems, highlighting the need for integrated approaches to address climate crisis, antibiotic overuse and pesticide reliance. This work is driving microbiome-based solutions for animal, human and environmental health.
A low FODMAP diet has been shown to improve colonic barrier function and reduce mast cell activation in patients with IBS-D. The study found that the diet reduced symptoms of diarrhea and abdominal pain, and improved intestinal permeability.
Researchers at ETH Zurich and Stanford University quantified the number of molecules produced by gut bacteria that reach the human body daily. This knowledge helps understand how the gut microbiome influences health and behavior.
Researchers discovered that indole, a key tryptophan metabolite produced by gut bacteria, can restore enteroendocrine cells in the intestines, which are diminished in obesity. The study suggests that microbial metabolites derived from dietary tryptophan may hold promise as a novel therapy for obesity-associated metabolic complications.
A study analyzing 249 individuals reveals disrupted interactions between the gut microbiome, immune system, and metabolism in ME/CFS patients. Biomarkers linked to symptoms such as sleep disturbances, headaches, and fatigue provide hope for future diagnostic tools.
Four leading Japanese corporations in the health and nutrition sectors have joined forces to advance microbiome science. The event aims to explore recent research and development achievements, engage with industry innovators, and promote practical applications of fundamental research.
Researchers at Duke University School of Medicine have identified a new system linking the microbiome to the brain, which influences behavior and appetite. The discovery was made by detecting flagellin in gut bacteria, triggering an appetite-suppressing signal to the brain.
A new study reveals that the human gut microbiota can pinpoint an individual's city of residence with high accuracy, strongly linked to each city's characteristic diet. The researchers identified unique microbial signatures and interaction networks between cities in China, shedding light on how local environments shape our inner biology.
A 21-day study found that restricting food variety triggers unique shifts in individual gut microbiomes, contradicting the assumption of uniform microbial outcomes. The results suggest personalized nutrition approaches are essential for achieving targeted microbiome modulation.
Research from North Carolina State University found that different probiotic strains have varying impacts on gut microbiome recovery. Some strains, like Lactobacillus gasseri, promoted the growth of beneficial bacteria while others increased bacterial load and delayed resistance to C. difficile infection.
The 12th World Congress on Targeting Microbiota explores the microbiome's role in diagnostics, therapeutics, and systems biology. Emerging data reveal bidirectional interactions between psychotropic medications and the microbiome, highlighting new approaches to mental health.
A study by University of California, Riverside researchers found that inhaling agricultural dust can alter the gut microbiome and impair intestinal function, leading to increased 'leaky gut' and associated chronic diseases. The study highlights the need for protective measures for agricultural workers.
Researchers created an 'encyclopedia of sugar utilization pathways' in 263 Bifidobacterium genomes. This resource helps predict which strains thrive in different conditions, enabling personalized probiotics to match children's lifestyles and dietary needs. The study suggests a potential solution to improving outcomes for preterm infants.
A new study found that consuming pistachios every night for 12 weeks altered bacteria in the gut of adults with prediabetes, increasing beneficial short-chain fatty acids like butyrate. The changes may offer long-term health benefits, potentially slowing Type 2 diabetes development or reducing inflammation.
A study found that early antibiotics exposure can impair infant immune systems, disrupting lung immunity and making them vulnerable to respiratory infections. Supplementing with a naturally occurring metabolite called inosine may help restore their ability to fight such infections.
Japan is set to host a global summit on microbiome medicine and fermentation science, featuring pioneering research and collaboration among industry leaders. The event aims to promote personalized nutrition, microbial diagnostics, and next-generation therapeutics.
Researchers analyzed over 1,400 gut microbiome samples from 292 mammalian species to find distinct gut microbiomes corresponding to different gut morphology types. These microbiomes were grouped into three enterotypes: Fusobacterium in simple-gut species, UCG-005 in foregut fermenters, and Prevotella in hindgut fermenters.
A new study from the University of Pittsburgh shows exercise improves cancer outcomes and enhances response to immunotherapy in mice by reshaping the gut microbiome. The research found that a specific compound called formate, produced by gut bacteria in exercised mice, was associated with better outcomes in patients with melanoma.
The study found that elderly patients with acute hepatitis E infection have distinct gut microbiota compositions compared to healthy controls. The relative abundance of Bacteroides fragilis was significantly associated with disease outcomes, including self-healing and non-self-healing cases. This suggests a potential role for Bacteroid...
The gut virome, dominated by bacteriophages, regulates gut ecology and interacts with host immunity to influence the onset and progression of gastrointestinal diseases. Harnessing the virome through novel therapies, such as phage therapy and dietary modulation, may restore health and reduce disease severity.
Scientists have discovered that certain species of gut bacteria can absorb PFAS, potentially protecting against its harmful effects. The researchers plan to develop probiotic dietary supplements to boost the levels of these helpful microbes in our gut.
Researchers found significant differences in gut microbiota composition between pregnant women with and without gestational diabetes. A diagnostic model based on genus-level markers showed high precision for early detection of the condition, offering new opportunities for prevention and personalized management.
Researchers found that alternating between standard and high-fat diets caused mice to binge eat, leading to changes in gut microbiota and brain reward system. The study suggests considering gut microbiota when patients seek medical support for weight loss efforts.
A new study reveals that women with polycystic ovary syndrome (PCOS) have a sharp reduction in the beneficial gut bacterium Parabacteroides merdae, alongside elevated levels of branched-chain amino acids. These changes may impair endometrial health and reproductive complications in women with PCOS.
A study in mice found that pesticide exposure changes specific gut bacteria growth patterns and nutrient processing, hinting at a probiotic approach to preventing health effects. The research identified certain microbes that can degrade pesticides and may lead to therapeutic strategies.
Researchers at Caltech have created a 'smart capsule' called PillTrek that can measure various biomarkers in the gastrointestinal (GI) tract, providing real-time profiling. The device is tiny, wireless, and inexpensive, and has the potential to revolutionize diagnosis and monitoring of diseases.
Researchers have discovered that supplementing with isobutyrate eases intestinal inflammation and restores gut balance in a pig model of colitis. The study shows that isobutyrate shifts the microbiome toward beneficial bacteria, reduces diarrhea and bleeding, and strengthens the intestinal barrier.
A study reveals that oral lysozyme can restore a healthy gut balance and reverse signs of vascular aging in older adults. The research identifies the PI3K–Akt signaling pathway as a key mediator, suggesting new lines of research into metabolites and microbial strains for vascular health.
A new study found that gut microbiome composition is associated with cognitive impairment in adults, and that food insecurity may jointly influence brain function. Adults with lower microbial diversity and specific imbalances in gut bacteria were more likely to experience cognitive impairment.
Researchers have discovered a gene that allows queuosine to enter cells, opening the door for potential therapies to leverage its role in cancer suppression, memory, and brain function. The identification of SLC35F2 sheds light on the vital micronutrient's importance in human health.
A new systematic review reveals a significant connection between the gut microbiome and brain function in bipolar patients, affecting treatment responses. Patients who responded to treatment had distinct gut microbiome profiles similar to healthy individuals.
Certain dietary patterns, such as high-salt foods and processed meats, create an environment conducive to GC development. Beneficial bacteria like Akkermansia muciniphila help protect against cancer by strengthening the immune response and maintaining healthy stomach conditions.
New research warns against widespread use of Fecal Microbiota Transplants (FMT) due to potential for long-lasting, unintended health consequences. Mismatches in gut ecosystems can lead to changes in metabolism, behavior, and energy balance.
A study of twins reveals that certain bacteria in the small intestine may trigger MS. Researchers identified two specific bacteria, Lachnoclostridium sp and Eisenbergiella tayi, which are associated with the disease. The findings suggest a new potential therapeutic target for MS treatment.
A new study suggests that certain microbiome compositions in babies born vaginally, specifically with a higher amount of pioneer bacteria B. longum, are less likely to be hospitalised for viral lower respiratory tract infections (vLRTI) in the first two years of life.
Researchers found that obese mice displayed more anxiety-like behaviors and showed different signaling patterns in the hypothalamus, a region involved in regulating metabolism. The study also observed distinct differences in the makeup of gut bacteria in obese mice compared to lean mice.
A recent study found that individuals with a specific type of gut bacteria (Firmicutes) had higher bone mineral density and better metabolic health. The researchers suggest that promoting the growth of butyrate-producing bacteria could be an effective strategy for maintaining bone mass and preventing osteoporosis.
A Monash University study found that rare genetic variants affecting SCFA signalling increase hypertension and cardiovascular disease risk. However, adequate dietary fibre intake mitigates this risk, highlighting the importance of SCFAs in cardio-protection.
Emerging research links microbial dysbiosis to aging, as dysbiosis accelerates DNA damage and telomere shortening. Therapeutic strategies targeting the microbiome may promote healthy longevity.
Researchers at UCSF found that certain gut bacteria can reduce chemotherapy side effects by clearing excess drugs and producing the protective vitamin K2. Patients with more beneficial bacteria had fewer side effects, suggesting that probiotics may help mitigate chemotherapy's impact.