The onset of puberty is triggered by pulsatile release of the hormone GnRH from nerve cells in a region of the brain known as the hypothalamus. Exactly what signals tell these nerve cells to release GnRH in this manner has not been determined, although it has been suggested that hormones associated with good nutritional status (such as insulin and IGF-1) have a role. A team of researchers, led by Sara DiVall, at Johns Hopkins University, Baltimore, has now confirmed that in mice IGF-1 does indeed have a key role in coordinating the timing of puberty onset.
To study the issue, the team generated mice lacking either the receptor for insulin or the receptor for IGF-1 in GnRH-producing nerve cells. Male and female mice in which the receptor for insulin had been deleted displayed normal timing of puberty and fertility, but male and female mice with the receptor for IGF-1 deleted showed delayed pubertal development but normal fertility. Furthermore, administration of IGF-1 to normal female mice triggered the onset of puberty. The authors therefore conclude that IGF-1 signaling is necessary for timely triggering of pulsatile GnRH production at puberty and that it helps coordinate puberty with a specific stage of body development.
TITLE: Divergent roles of growth factors in the GnRH regulation of puberty in mice
AUTHOR CONTACT:
Sara A. DiVall
Johns Hopkins University, Baltimore, Maryland, USA.
Phone: 410.502.7573; Fax: 410.502.7580; E-mail: sdivall1@jhmi.edu .
View this article at: http://www.jci.org/articles/view/41069?key=d77a16f9916e3782bd8d
Journal of Clinical Investigation