ITHACA, N.Y. - As different cells penetrate through tight, confining spaces within tissue, they often deform, causing their nuclei to rupture under the associated stress. A new study led by Cornell University engineers finds that cancer cells have a resilient ability to repair themselves, but the nuclear deformation and rupture can compromise the genomic integrity of the cancer cells, which could drive further cancer progression.
The study, "Nuclear envelope rupture and repair during cancer cell migration," will be published in the journal Science on Thursday, March 24 (please note embargo), and finds that:
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Science