Monoclonal antibody (mAb) based-therapies have revolutionized treatments of cancer and autoimmune diseases because of their specificity and limited toxicity. Vectored-antibody delivery through the use of recombinant Adenovirus-Associated Virus (rAAV) is a novel therapeutic approach currently evaluated in vivo. The rAAV is used to transfer the genes encoding the mAbs (and similar molecules) directly into the cells. The transduced cells turn into "cellular factories" capable of sustainable production of therapeutic antibodies. The long-lasting therapeutic effects conferred by rAAV have considerable advantages for different applications.
More than 40 scientific papers have explored the potential of this novel therapeutic approach with the demonstration of promising pre-clinical data. In a review paper entitled "Antibody Delivery Mediated by Recombinant Adeno-associated Virus for the Treatment of Various Chronic and Infectious Diseases", researchers M.-A Robert, R. Gilbert and B. Gaillet describe the latest developments in the field. Different topics are discussed such as: advantages and limitations of vectored-antibody delivery using rAAV, vector design, antibody engineering and pre-clinical results. This excellent review was published on January 2nd, 2017 " Current Gene Therapy " (Vol 16, issue 6)
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Reference : Robert, M.; (2017). Antibody Delivery Mediated by Recombinant Adeno-associated Virus for the Treatment of Various Chronic and Infectious Diseases. Current Gene Therapy ., DOI: 10.2174/1566523217666170102111251
Current Gene Therapy