About The Study: This case series found that young brain donors exposed to repetitive head impacts were highly symptomatic regardless of chronic traumatic encephalopathy (CTE) status, and the causes of symptoms in this sample are likely multifactorial. Future studies that include young brain donors unexposed to repetitive head impacts are needed to clarify the association among exposure, white matter and microvascular pathologic findings, CTE, and clinical symptoms.
Authors: Ann C. McKee, M.D., of the U.S. Department of Veteran Affairs in Boston, is the corresponding author.
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(doi:10.1001/jamaneurol.2023.2907)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Neurology