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The gut microbiome’s neuroactive potential is linked to cognition and depression in Chilean older adults, per analysis of 153 Chilean older adults with cognition concerns

04.15.26 | PLOS

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The gut microbiome’s neuroactive potential is linked to cognition and depression in Chilean older adults, per analysis of 153 Chilean older adults with cognition concerns

Article URL : https://plos.io/4dTxe0z

Article title: The neuroactive potential of the elderly human gut microbiome is associated with mental health status

Author countries: Chile, Ireland, The Netherlands, U.S.

Funding: This study was supported by grants from the Geroscience Center for Brain Health and Metabolism, FONDAP-(15150012 (Chile) to CG-B), and Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia Centro Ciencia & Vida (FB210008 to FAC).

PLOS One

10.1371/journal.pone.0343493

The neuroactive potential of the elderly human gut microbiome is associated with mental health status

15-Apr-2026

I have read the journal’s policy and the authors of this manuscript have the following competing interests: J.F.C. has been an invited speaker at conferences organised by Mead Johnson, Alkermes, Janssen, Ordesa, Yakult, and has received research funding from Mead Johnson, Cremo Nutricia, Pharmavite, Dupont and 4D Pharma. G.C. has received honoraria from Janssen, Probi and Apsen as an invited speaker, is in receipt of research funding from Pharmavite, Reckitt, Tate and Lyle, Nestle Fonterra, and has received payments as a consultant from Yakult, Zentiva and Heel Pharmaceuticals. APC Microbiome Ireland has received research support from Mead Johnson, Cremo, 4D Pharma, Suntory Wellness and Nutricia. This support neither influenced nor constrained the content of this article.

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Contact Information

Hanna Abdallah
PLOS
onepress@plos.org

How to Cite This Article

APA:
PLOS. (2026, April 15). The gut microbiome’s neuroactive potential is linked to cognition and depression in Chilean older adults, per analysis of 153 Chilean older adults with cognition concerns. Brightsurf News. https://www.brightsurf.com/news/LQ4NQ958/the-gut-microbiomes-neuroactive-potential-is-linked-to-cognition-and-depression-in-chilean-older-adults-per-analysis-of-153-chilean-older-adults-with-cognition-concerns.html
MLA:
"The gut microbiome’s neuroactive potential is linked to cognition and depression in Chilean older adults, per analysis of 153 Chilean older adults with cognition concerns." Brightsurf News, Apr. 15 2026, https://www.brightsurf.com/news/LQ4NQ958/the-gut-microbiomes-neuroactive-potential-is-linked-to-cognition-and-depression-in-chilean-older-adults-per-analysis-of-153-chilean-older-adults-with-cognition-concerns.html.