Le Saux and colleagues report on a randomized controlled trial in which 512 children aged 6 months to 5 years in whom a new episode of acute otitis media was diagnosed received either amoxicillin or placebo.
The authors report a higher rate of cure after 14 days in the group receiving amoxicillin. However, there was no statistical difference in the number of adverse events or in recurrence rates between the 2 groups.
p. 335 A randomized, double-blind, placebo-controlled noninferiority trial of amoxicillin for clinically diagnosed otitis media in children 6 months to 5 years of age
-- N. LeSaux
Canadian Medical Association Journal