In research published in The FASEB Journal , scientists have discovered that a molecule called Yes-associated protein (YAP) plays a key role in the development of liver scarring, or fibrosis, by influencing the behavior of premature cells called liver progenitor cells.
By manipulating YAP expression in these cells, the investigators were able to improve the cells' ability to regenerate and repair liver tissue.
“Collectively, our findings indicate that liver progenitor cells’ expansion and differentiation during liver fibrosis could be modulated by YAP, further suggesting the possibility of manipulating YAP expression in these cells as a potential treatment for chronic liver diseases,” said corresponding author Xiaobo Cai, MD, PhD, of Shanghai Jiao Tong University School of Medicine, in China.
URL upon publication: https://onlinelibrary.wiley.com/doi/10.1096/fj.202201919R
Additional Information
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com .
About the Journal
The FASEB Journal publishes high quality and impactful multidisciplinary research covering biology and biomedical sciences at every level of organization: atomic, molecular, cell, tissue, organ, organismic, and population. The journal’s scope includes the spectrum of biological and biomedical sciences as well as interdisciplinary research cutting across multiple fields and extending in related areas .
About Wiley
Wiley is one of the world’s largest publishers and a global leader in scientific research and career-connected education. Founded in 1807, Wiley enables discovery, powers education, and shapes workforces. Through its industry-leading content, digital platforms, and knowledge networks, the company delivers on its timeless mission to unlock human potential. Visit us at Wiley.com . Follow us on Facebook , Twitter , LinkedIn and Instagram .
The FASEB Journal
Yes-associated protein promotes the proliferation and differentiation of liver progenitor cells during liver fibrosis
19-Apr-2023