Articles tagged with Liver Regeneration
A Michigan State University researcher has challenged a long-held belief about how the liver repairs itself after surgery. By studying mice, the team found that reducing plasminogen levels led to stronger liver regeneration and improved outcomes for patients undergoing liver surgery.
A study found that supplementing with HMB before surgery improves liver regeneration in animals by preserving energy function and improving the quality of recovery. The supplementation was shown to have a beneficial effect on mitochondrial function and metabolic performance, even after it was discontinued.
Researchers developed an optimized extended precision cut liver slice (PCLS) culture system maintaining viable human liver tissue for up to two weeks. The model captures regeneration, fibrosis, and biliary remodeling in intact human liver tissue.
A study by MedUni Vienna found that up to one-third of patients with advanced alcohol-related cirrhosis can achieve complete regression of liver-related complications through consistent abstinence from alcohol. This 're-compensation' also leads to simultaneous recovery of liver function and a significant reduction in mortality rates.
Researchers developed a vascularized liver tissueoid-on-a-chip that recapitulates key structural, functional, and immunological features of human liver tissue. The platform enabled the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system.
A new study found that MET signaling plays a critical protective role in acetaminophen-induced acute liver failure by reducing liver damage and accelerating regeneration. The findings suggest targeting MET signaling could become a game-changer for treating drug-induced ALF, potentially reducing the need for emergency liver transplants.
Researchers used single-cell transcriptomics to study liver injury and repair. They found that hepatocytes can migrate to damaged areas, and that hepatic stellate cells play a dual role in contributing to fibrosis and supporting regeneration. Endothelial cells regulate regenerative signaling, and macrophages exhibit heterogeneity durin...
Scientists at the University of Birmingham have developed a method to coat Hepatic Progenitor Cells (HPCs) with natural sugars, making them stickier and increasing their ability to repair liver tissues. The coating does not harm the cells or stop them from working properly.
This study demonstrates how Parabacteroides distasonis increases β-hydroxybutyric acid (BHB) production, which drives STAT3 signals to promote liver regeneration. Treatment with live P. distasonis significantly promotes hepatocyte proliferation and liver regeneration after partial hepatectomy.
Researchers have discovered a previously unknown mechanism of liver regeneration triggered by glutamate, which accelerates liver regeneration in minutes through changes in macrophage metabolism. Hepatocytes producing glutamine synthetase play a key role in this process.
Researchers at German Cancer Research Center found that hepatic stellate cells regulate liver metabolism, regeneration, and size. The study suggests new therapeutic approaches for liver diseases by targeting the positive functions of these cells.
Researchers found that Piezo-1 activation in vascular endothelial cells leads to the up-regulation of proteins promoting hepatocyte proliferation and partial epithelial-to-mesenchymal transition. This study provides mechanistic insights into how mechanical stimulation regulates liver regeneration.
Researchers identified distinct transcriptome and metabolome changes during different stages of hepatic ischemia-reperfusion injury. The study revealed key transcription and metabolic features of IRI, including altered glucose and lipid metabolism pathways.
A WVU biologist is studying how genes establish animal body plans and contribute to regenerative abilities. He has identified Hox genes as key players in planarian regeneration, suggesting their functions may differ in highly regenerative versus poorly regenerative organisms.
Scientists analyzed 21,000 cells from tissue samples to develop a cell atlas of regenerating liver tissue. The study reveals changes in cell composition, gene expression, and intercellular communication that facilitate liver regeneration after portal vein embolization.
The TGF-β and HIPPO pathways interact to regulate liver development, size, and regeneration. Their dysregulation contributes to liver diseases such as fibrosis, cirrhosis, and cancer.
MicroRNAs regulate liver regeneration by controlling gene expression associated with cell proliferation and liver repair. Recent studies identify new potential molecular targets for diagnosing and treating liver diseases, highlighting the therapeutic potential of miRNA-based therapies.
Fibronogen-like protein 1 (FGL1) is involved in both liver regeneration and tumor recurrence in hepatocellular carcinoma. FGL1 activates proliferative pathways that promote cancer cell growth, while its downregulation in malignant cells may contribute to HCC development.
Researchers have developed a novel patch that can help liver tissue regenerate and inhibit inflammation. The patch demonstrated restored liver function in lab tests and promoted recovery from liver fibrosis in rats, showing great potential for treating liver diseases.
Researchers have discovered a new growth factor, MYDGF, that plays a crucial role in liver regeneration. The study found that higher levels of MYDGF are present in patients' blood after partial liver removal, and that it stimulates the proliferation of human hepatocytes in tissue cultures.
A new smartphone app using the APRI+ALBI score increases the safety of liver surgery by providing an individualized risk assessment for patients prior to resection. The score offers a cheaper and less invasive option with comparable predictive power compared to standard preoperative tests.
Researchers have discovered that manipulating Yes-associated protein (YAP) expression in liver progenitor cells can improve their ability to regenerate and repair liver tissue. This could lead to new treatments for chronic liver diseases.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Researchers have discovered that leprosy parasites can reprogram liver cells to increase organ size without scarring or tumors. This natural process may be adapted to renew ageing livers and improve healthspan in humans.
A study identifies a molecule called NIK that promotes the growth of bile duct cells in the liver, leading to scarring and liver fibrosis. Removing NIK or blocking its action with inhibitors may prevent disease progression.
A recent study by Medical University of Vienna researchers has identified a crucial dual function of neutrophils in liver regeneration after partial hepatectomy. The findings suggest that these immune cells produce factors necessary for liver growth, enabling the organ to recover quickly from tissue damage.
Researchers at MIT have created a new liver tissue model that identifies one molecule playing a key role in human liver regeneration. The study also reveals several other candidates that will be explored further to discover new human-specific pathways.
A team of scientists used radiocarbon birth dating to show that human liver cells stay young throughout life, averaging less than three years old. The study found that typical liver cells renew approximately once a year, while DNA-rich cells can live up to a decade.
Researchers have found a way to partially reset liver cells to more youthful states, allowing them to heal damaged tissue at a faster rate than previously observed. The use of reprogramming molecules improves cell growth and leads to better liver tissue regeneration in mice.
Researchers discovered a key protein, c-Maf, required for naive endothelial cells to mature into liver sinusoidal blood vessels. Induced liver sinusoidal endothelial cells (iLSECs) support hepatocytes, promoting healthy function.
Researchers from Sanford Burnham Prebys have discovered a new source of stem cells that could help treat people living with Alagille syndrome. These 'outside the box' liver stem cells may offer hope for those with the rare genetic disorder, which causes severe liver damage and death.
Researchers at Skoltech have discovered structures called apical bulkheads in liver cells that are responsible for the narrow shape of bile canaliculi. The discovery reveals a key role for the Rab35 protein in regulating hepatocyte lumina formation and suggests potential avenues for medical applications in fatty liver disease and fibrosis
Researchers found a regulatory cell type, mesenchymal cells, control liver regeneration through cell-to-cell contacts. The study suggests that the wrong number of contacts between populations can lead to cancer or chronic liver diseases.
Researchers discovered a code in the liver epigenome that promotes regeneration, enabling pro-regenerative genes to activate when signaled. This finding has potential to inform regenerative medicine for non-regenerative organs like lungs and hearts.
Researchers found a large number of macrophages migrate to the liver after resection, influencing cell growth and metabolism. The study revealed essential roles of macrophages in mouse liver recovery from massive resections.
A subset of liver cells takes on a greater workload to maintain metabolic function during regeneration, while others multiply in a coordinated manner. The liver's ability to regenerate and maintain its metabolic activity is crucial for the body's overall health.
Scientists from UNIGE and HUG identified the essential role of circadian clocks in beta cell regeneration. The study found that regeneration is significantly greater at night, when mice are active, and that the BMAL1 gene plays a crucial role in this process.
Researchers found that inhibition of the MAGL enzyme impairs liver regeneration, while targeting lipid metabolism may have opposite effects on fibrosis and regeneration. The study suggests a complex relationship between MAGL and liver function.
A study published in Hepatology reveals that Annexin A6 is essential for liver regeneration after a transplant or hepatic surgery. The protein helps maintain glucose homeostasis, allowing the liver to recover and restore its functions.
A study at The University of Queensland Diamantina Institute found that growth hormone boosts liver regeneration in mice by suppressing inflammatory responses. Mice with normal growth hormone receptors survived liver surgery and experienced full liver regeneration.
Researchers have identified a molecule called TET1 that enables adult liver cells to regenerate. The discovery provides a potential target for drugs to treat chronic liver diseases, where regeneration is impaired.
Researchers at NYU Abu Dhabi have identified a new way the liver regenerates itself, involving the redistribution of epigenetic marks. By removing key epigenetic regulators, they found that genes were activated early and sustained during regeneration, providing a significant advance in understanding liver regeneration.
A Michigan State University study found that fibrinogen accumulates in the remaining liver after surgery and triggers platelet activity to aid in regeneration. Low fibrinogen levels are associated with delayed regeneration and dysfunctional livers, making it a potential predictive marker for doctors.
Researchers at UC Davis found that fibroblast growth factor 21 (FGF21) can boost the regenerative effects of human PPARα, allowing it to regenerate damaged livers in mice. The protein could offer significant therapeutic benefits for patients with liver disease or those who have had a liver transplant.
A novel complement inhibitor has been found to reduce liver cell death and stimulate post-surgery liver regrowth in mice. The treatment increased survival rates from 0% to 70% even after removing up to 90% of the liver. This breakthrough could represent a new treatment strategy for various liver injuries in humans.
Researchers have found that mature liver cells can dedifferentiate into functional progenitor cells, allowing them to regenerate a diseased liver. This discovery challenges long-held theories about the role of stem cells in liver regeneration.
A bioartificial liver machine has been scaled up and tested in a large animal model, providing temporary support for liver regeneration. The system uses encapsulated human-derived liver cells grown in a bioreactor and can be transported to a patient's bedside within 48 hours.
Researchers at the University of Southern California have identified the role of stem and progenitor cells in liver regeneration. Bone marrow-derived progenitor cells were found to be required for liver regeneration following surgical removal, shedding light on liver complications associated with suppressed bone marrow tissue.
In vivo RNAi screening reveals new key players controlling hepatocyte proliferation and regenerative capacity. The study demonstrates increased repopulation efficiency and regenerative capacity in chronically damaged mouse livers after stable knockdown of candidate genes.
Researchers from Arizona State University are studying Anolis lizards to understand their ability to regenerate tissues, with potential applications in treating human osteoarthritis and spinal cord injuries. The team is using molecular methods and the lizard's genome sequence to identify key genes involved in regeneration.
The study reveals that specialized blood vessel cells initiate and sustain liver regeneration by producing growth factors. This finding opens the door for designing new therapies to treat damaged livers. The researchers identified specific genes, such as Id1 and Wnt2, that enable endothelial cells to regulate liver regeneration.
Researchers found that the omentum increases liver size by 50% after transplantation, suggesting its role in regenerating damaged liver tissue. The study also identified oval cells as the key players in this process, which may be a promising new treatment for liver disease.
Researchers found that extensive liver resection impairs the regenerative capacity of the liver on a molecular and cellular level. Key findings include delayed activation of NF-kappa B and increased programmed cellular death in regenerating livers.
Massachusetts General Hospital researchers have developed a new method to treat liver failure by modulating the immune response. The approach uses mesenchymal stem cells to reduce inflammation and promote organ regeneration, showing promising results in animal studies.
Researchers have discovered that liver regeneration is driven by an increase in cell multiplication through regular cell divisions, rather than relying on embryonic-like processes. This finding could lead to more effective ways to stimulate liver growth and potentially improve treatment options for patients with liver diseases.
Researchers from IDIBAPS and Queensland University discovered that caveolin-1 and lipid droplets are essential for liver regeneration. The protein allows hepatocytes to accumulate energetic reserves and start the genetic machinery for division. Without it, mice are unable to regenerate their liver tissue.
Bile acids play a crucial role in signaling the liver to regenerate tissue, with research suggesting that an imbalance in these compounds can trigger the process. Understanding this mechanism could lead to new treatments for liver disease.
Researchers have discovered that the FoxM1B gene plays a crucial role in tissue healing and regeneration. The study found that the gene is essential for cells to divide and multiply, allowing tissues to repair and regenerate. Without FoxM1B, DNA duplication fails, leading to accelerated aging and age-related diseases.
Scientists at UIC found that increasing FoxM1B gene expression restored liver cell growth rates and division activity in aged mice, potentially treating aging-related diseases such as cancer and Alzheimer's. This breakthrough could lead to new therapies for the elderly using gene therapy.
A study published in the Proceedings of the National Academy of Sciences found that prostaglandins are required for efficient liver regeneration. The research used mouse models to show that blocking prostaglandin synthesis impaired the liver's regenerative response, highlighting a crucial role for these molecules in liver disease.