Acta Pharmaceutica Sinica B Volume 16, Issue 1 Publishes

https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/16/issue/1

Acta Pharmaceutica Sinica B ( APSB ) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue include:

Neg-entropy is the true drug target for chronic diseases by Rui Li, Tian-Le Gao, Gang Ren, Lu-Lu Wang and Jian-Dong Jiang ( https://doi.org/10.1016/j.apsb.2025.11.026 ). Chronic diseases are driven by increased biological entropy, so the authors propose targeting the body’s inherent neg-entropic mechanisms (such as homeostasis, immunity, and self-healing) rather than isolated disease pathways. They introduce “head goose molecules” (HGMs) as key regulators of neg-entropy and propose the “HGMs–neg-entropy–dCloud” axis as a new drug discovery strategy that can reprogram disease processes and treat both symptoms and root causes.

Oxygen-boosted dual-section microneedle patch for enhanced drug penetration and improved photodynamic and anti-inflammatory therapy in psoriasis by Yaqi Yuan, Peng Jiang, Chuan Xiao, Jiapeng Lei, Bo Cheng, Hankun Hu and Wei Li ( https://doi.org/10.1016/j.apsb.2025.09.037 ). A dual-section microneedle patch is designed to enhance the therapeutic efficacy of psoriasis treatment via sustained release of triamcinolone acetonide and generation of oxygen for deep penetration of drugs.

Other articles include:

Reviews

Transmitophagy in the heart: An overview of molecular mechanisms and implications for pathophysiology

Joshua Kramer, Eric Rohwer, Palaniappan Sethu, Min Xie, ... Jianhua Zhang

Targeting glial cells: Unveiling the neuroprotective mechanisms of Ginseng in the brain microenvironment

Yajun Wang, Ming Zhang, Wei Li

Unraveling the FGFR–RNA splicing axis: Mechanisms, oncogenic crosstalks and innovations for therapeutic purpose

Xuquan Xian, Ruyi Gong, Shunzi Rong, Zhihao Zhang, ... Tao Jia

Computational approaches to druggable site identification: Current status and future perspective

Anqi Lin, Zhirou Zhang, Aimin Jiang, Kexin Li, ... Peng Luo

Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design

Zhenzhen Zhou, Yanying Sun, Da Feng, Zhao Wang, ... Xinyong Liu

Omics-based large language models: A new engine for drug discovery innovation

Xia Sheng, Xiaoya Zhang, Yuxin Xing, Yuqi Shi, ... Xutong Li

The progress and perspective of nanomedicine in modulating the tumor immune microenvironment

Nan Lin, Keqin Tan, Yuhao Wei, Songtao Xie, ... Xuelei Ma

Immunocyte reprogramming empowers live-cell drug delivery: Mechanistic insights, delivery strategies, and clinical perspectives

Zheng Sun, Jun Ge, Hui Fu, Ziqiu Chen, ... Yingpeng Li

Concerns and challenges in clinics-guided nanovaccines design and applications

Yuhong Gao, Sijia Hua, Xiulin Dong, Kun Zhang, ... Jianfeng Yang

Original articles

Attenuated Salmonella secreting interleukin-21 activates T-cells and induces anti-tumor effects

Minju Han, Eunji Kim, Minchan Jeong, Solbi Kim, ... Heung Jin Jeon

Radiation-induced nuclear translocation of NPRL2 hijacks E3 ubiquitin ligases to enhance DNA repair via the AMPK/WDR24 axis, contributing to CRC radioresistance

Xuecen Wang, Yuxuan Zhao, Xingli Yang, Tingyu Liu, ... Xin Yue

Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke

Qiyuan An, Riqing Wei, Zhicheng Huang, Youyong Tang, ... Qiang Ma

DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi , targeting IMPDH2 to inhibit triple-negative breast cancer

Yu Zhu, Zhibi Zhang, Xueqin Dai, Wenjing Liu, ... Ceshi Chen

Engineered cyclic peptide targeting ITGA5 disrupts tumor–stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma

Deby Fajar Mardhian, Kunal P. Pednekar, Ahmed G. Hemdan, Praneeth Reddy Kuninty, ... Jai Prakash

USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit

Tao Yuan, Weihua Wang, Ruilin Wu, Yue Liu, ... Hong Zhu

Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis

Huanhuan Pang, Honglin Chen, Peng Chen, Xu Wei, ... Chengchao Xu

Chinese medicine and intermittent fasting integration therapy attenuate diabetic vascular calcification via miR21-5p/Tpm1-mediated osteogenic differentiation of VSMCs

Wenting Wang, Yanfei Liu, Yiwen Li, Qian Xu, ... Yue Liu

Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity

Tong Che, Yixiang Chen, Xinyu Cheng, Han Hu, ... Bing Xiong

Discovery of SARS-CoV-2 PLpro inhibitors and RIPK1 inhibitors with synergistic antiviral efficacy in a mouse COVID-19 model

Hengyue Shan, Yuzheng Zhou, Ying Qin, Taijie Guo, ... Li Tan

Deep learning-based discovery of tetrahydrocarbazoles as broad-spectrum antitumor agents and click-activated strategy for targeted cancer therapy

Xue Liu, Yalan Lu, Qichen Chen, Minjian Yang, ... Xiaojian Wang

Dual metabolic-inflammation modulation in MicroRNA@neutrophil-derived microvesicles achieve robust osteoarthritis therapy

Yijun Chen, Yongbin Wang, Ruonan Yan, Yichen Liu, ... Can Zhang

Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis

Fangke Zhang, Tao Ding, Jiancheng Zheng, Nan Li, ... Weisheng Guo

Construction of a localized immune niche via supramolecular hydrogel vaccine to elicit durable and enhanced immunity against infectious diseases

Qi Shang, Chenwei Jiang, Xiaolong Wang, Mingmei Guo, ... Feihu Wang

Binary pyroptosis-amplified self-assembling prodrug nanomedicine enhances immunogenicity and inhibits abdominal metastasis in ovarian cancer

Feng Fang, Min Su, Xue Liu, Jing Chen, ... Xuefeng Wang

An innovative and stable mRNA-LNP microneedle vaccine elicits humoral and multifunctional cellular immune responses

Xiaoxuan Hong, Xianfu Li, Xiaolu Han, Jinghu Lou, ... Aiping Zheng

Engineered bacterial extracellular vesicles mediate pyroptosis to counteract m ⁶ A methylation-based immunosuppression after insufficient radiofrequency ablation of hepatocellular carcinoma

Zeyu Xiao, Jiaxin Yuan, Qing Wu, Juan Qin, ... Liangping Luo

pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy

Linlin Gong, Shasha Li, Jiahui Sun, Kunhong Liu, ... Dechun Liu

Photoimmunological hydrogel vaccine creates a supportive immune niche to promote antigen cross-presentation cascade and cancer-immunity cycle progression

Hanxi Zhang, Jiazhen Lv, Wanyi Zhou, Jiangping Lei, ... Hong Yang

Endogenic transferrin-targeted cell membrane-coated biomimetic lipo-complexes for efficient targeting and enhanced antitumor efficacy in orthotopic glioblastoma

Aihua Jin, Nuoya Wang, Yanhong Liu, Shuangqing Wang, ... Mingji Jin

Inhalable songorine-integrated lipid nanomedicine for targeted ARDS therapy via repairing endothelial barrier and inactivating NLRP3 inflammasome

Haiyan Wang, Zhi-Chao Sun, Chunlei Dai, Ran Liao, ... Yuntao Liu

Regulation and Guidelines

Therapeutic drug monitoring of biologics in inflammatory bowel disease: An evidence-based multidisciplinary guideline

Chen Shi, Hong Zhou, Liangru Zhu, Liyan Miao, ... Yu Zhang

Letter to the editor

An integrated resource for ischemic heart disease defines hallmarks and heterogeneity across time and space

Tianhao Wang, Yining Hu, Wenbo Guo, Haoran Li, ... Xiaohui Fan

Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies

Liang Liao, Qiang Wang, Zhengyang Gao, Jiayao Liu, ... Jinlian Wei

Highlights

Clinical insight-driven novel drug development: Multidisciplinary integration and transformative opportunities

Baohu Li, Hui Xu, Xiaoyu Shi, Chunhua Ma, ... Peng Zhan

Commentaries

Commentary on "Neg-entropy is the true drug target for chronic diseases"

Olabisi Coker, Jun Yu

Advancing psoriasis therapy through oxygen-boosted dual-section microneedle technology

Lamyaa Albakr, Lifeng Kang

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association .

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Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

APSB is available on ScienceDirect ( https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b ).

Submissions to APSB may be made using Editorial Manager ® ( https://www.editorialmanager.com/apsb/default.aspx ).

CiteScore: 24.3

Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy)

JIF without self-citation: 13.8

ISSN 2211-3835