Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. A recent study by Xue Li and colleagues from Henan Provincial People's Hospital, China investigated the inhibitory effects of S14G-humanin on amyloid-beta protein-induced hippocampal neuronal injury, and data from this study showed that fibrillar amyloid-beta 40 disturbed cellular homeostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exhibiting a potential and effective treatment for Alzheimer's disease. These findings were published in the Neural Regeneration Research (Vol. 8, No. 27, 2013).
Article: " S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein " by Xue Li1, 2, Wencong Zhao3, Hongqi Yang1, 2, Junhong Zhang1, 2, Jianjun Ma1, 2 (1 Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China; 2 Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China; 3 Department of Pharmacology, Zhengzhou Maternal and Child Health Hospital, Zhengzhou 450012, Henan Province, China)
Li X, Zhao WC, Yang HQ, Zhang JH, Ma JJ. S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein. Neural Regen Res . 2013;8(27):2573-2580.
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Neural Regeneration Research