Research reveals that IL-26 is increased among chronic smokers with lung disease, mobilizing neutrophils and exacerbating bacterial infections. The study provides new insights into the pathogenic mechanisms behind COPD and chronic bronchitis, suggesting IL-26 as a promising molecular target for therapy.
The Biochemical Society has announced the winners of its annual awards, recognizing established and early-career researchers in cell biology, endocrinology, and plant sciences. The award recipients include Dr Melina Schuh, Professor Dame Caroline Dean, and Professor R. John Ellis.
Researchers found that blocking IL-17A and IL-17F significantly reduces symptoms of severe allergic asthma in mice. The study suggests a new potential treatment for people with this condition, by preventing the production of pro-inflammatory molecules triggered by T-helper cells.
Research shows carbidopa, an FDA-approved Parkinson's disease drug, has anticancer properties. The study found that carbidopa significantly inhibits cancer cell growth in both human pancreatic cancer cells and mouse models, suggesting potential as an anticancer medication.
Researchers have discovered a genetic mutation in the PLC-zeta protein that causes male infertility, but found that injecting more of this protein can restart fertilization. The study suggests that this form of infertility could be treated in the future.
Innovative ways to target antibiotic resistance include combining antibiotics with non-antibiotics, such as loperamide, which enhances effectiveness against multi-drug resistant bacteria. Rapid diagnostic tests that can quickly identify bacterial infections and their resistance to antibiotics are also crucial in reducing further develo...
Scientists have developed a new method to measure the activity of disease-causing mutations in the LRRK2 gene, a major cause of inherited Parkinson's disease. The breakthrough could help pave the way for a clinical test that could facilitate evaluation of drugs targeting this form of the condition.
A new online biochemistry course is designed to introduce students aged 15-19 to molecular bioscience and encourage further study. The Massive Open Online Course (MOOC) offers supplementary learning materials and aims to reduce barriers for entry into STEM courses.
Researchers found that exposure to cigarette smoke and flu viruses reduces the effectiveness of common COPD medication salbutamol. A new model could help identify alternative treatments for patients with these symptoms.
Researchers have uncovered how the NF-κB protein complex is activated, a pivotal step in developing cancer, viral infection and autoimmune diseases. The discovery reveals that two additional events are necessary to switch on NF-κB, paving the way for new drug targets.