Researchers at the Catholic University of Rome found that high concentrations of NF-kB cause degeneration of intervertebral discs, leading to chronic low back pain. They developed an experimental drug, NBD peptide, to inhibit NF-kB and tested its success in mice.
Italian researchers found a DNA sequence called enhancer HS1.2 that accelerates the activity of genes involved in Lupus, an autoimmune disease affecting 60,000 people in Italy. The discovery could lead to more effective therapies against severe cases of Lupus.
Italian scientists at Catholic University of Rome discovered a molecule called CREB1 triggered by low-calorie diets, activating genes linked to longevity and brain functioning. Caloric restriction has been shown to extend life and prevent brain diseases in mice.
Researchers have developed an innovative diagnostic algorithm using a protein named HBHA in combination with IGRA, allowing for rapid identification of those infected but not yet showing symptoms. The new test has the potential to improve TB diagnosis and control strategies worldwide.
Researchers at Catholic University of Rome have developed a promising new therapy against systemic sclerosis (scleroderma), an autoimmune disease characterized by skin hardening and organ dysfunction. The treatment targets the immune system's B-cells, reducing side effects associated with traditional immunosuppressive therapies.
A study demonstrated the transfer of maternal thyroid hormones to the fetus in vivo, critical for fetal development. This finding clarifies indirect evidence of maternal thyroid hormone passage to the fetus during pregnancy, with significant implications for the development of the nervous system and overall quality of life.
Researchers from Catholic University of Rome discover that a non-pathogenic bacterium can trigger an autoimmune disease similar to multiple sclerosis in mice. The study suggests that environmental factors may play a role in the development of the disease, and could potentially lead to the development of a vaccine.
Physicians from the Catholic University of Rome assessed health conditions of 150 children living with mothers in prison. Environmental factors and early weaning are linked to premature birth, hypertension, and allergy risk. Vaccination status is also a concern, with only 14% of jail-bound children fully vaccinated.
Researchers develop novel method to identify stem cells in pancreas, showing acinar cells produce digestive enzymes and may have carcinogenic properties. The breakthrough paves the way for further study on proliferation mechanisms and potential dangers of these cells.