Researchers have found that Topo 2, an essential enzyme for chromosome separation, needs more time to untangle long chromosomes, which can lead to mutations and cancer. The study suggests that chromosome length affects the enzyme's action and highlights the importance of understanding cell division.
A team of researchers from the Centre for Genomic Regulation in Barcelona has identified a key protein involved in stem cell reprogramming, Nanog. The study reveals how Nanog works with another protein, beta-catenin, to maintain stem cells in a pluripotent state.
A recent study has identified key sets of co-expressed genes essential for animal cells, regardless of species. The researchers used RNA-seq data from multiple tissues and developmental conditions to create a map of highly important genome regions.
Researchers confirm a mathematical theory first proposed by Alan Turing in 1952 can explain the formation of fingers, revealing how signaling molecules act as the Turing system. The study uses systems biology and computational modeling to validate the theory, with be confirming results observed in limb bud tissue experiments.
Scientists at the Centre for Genomic Regulation have made a breakthrough in understanding cell reprogramming by identifying the crucial role of the Wnt signaling pathway. By inhibiting this pathway, they increased the efficiency of the process and obtained more pluripotent cells.
The AXA Research Fund has awarded €2 million to two Spanish researchers, Professor Ben Lehner and Professor David Ríos, to study age-related diseases and adversary risk analysis. Their research aims to predict a person's health future, combine experiments with computational data analysis, and examine threats with intelligent behavior.
Researchers have sequenced the functional part of the genome of leukaemia cells and identified thousands of genes expressed differently in leukaemia cells compared to healthy B lymphocytes. The study revealed two subgroups of patients with distinct disease behaviors, one requiring minimal treatment and the other needing prompt treatment.
Researchers found that exercise increases levels of specific proteins in the mitochondria of heart cells, triggering beneficial cardiovascular effects. This study provides new insights into how physical activity improves heart function and offers potential clues for developing new treatments for cardiovascular disease.