Researchers discovered that androgen receptor signaling acts as a transcriptional repressor of liver receptor homolog-1 (LRH-1) in prostate cancer. This finding reveals a previously unknown mechanism of gene regulation and highlights the potential for targeting this axis to manage advanced prostate cancer.
A new study reveals that maternal infection during pregnancy can lead to severe heart dysfunction in offspring, primarily due to oxidative stress and lipid peroxidation. Administering antioxidants or specific lipid peroxidation inhibitors can rescue mitochondrial function and restore healthy metabolic signaling.
Researchers developed PANDORA-seq to detect sncRNAs in human sperm, revealing strong correlations between specific molecular species and clinical indicators of sperm quality. The study established novel molecular frameworks for diagnosing male infertility.
A new study links amino acid-driven oxidative stress to therapeutic vulnerability in Acute Myeloid Leukemia (AML) by targeting the UCP2-BCAA-PI3K/AKT/mTOR signaling axis. Suppressing UCP2 impairs leukemic cell proliferation and triggers apoptosis, while BCAA-induced oxidative stress activates this pathway.
Researchers explore the role of pseudogene-derived lncRNAs in governing cancer stem cell biology, highlighting their mechanisms and therapeutic targeting. These non-coding RNAs modulate CSC dynamics through various pathways, influencing tumor initiation and progression.
The review emphasizes the need for robust non-clinical safety assessment to ensure CRISPR/Cas gene therapy products' safe translation. Central risks include genotoxicity and immunogenicity, mitigated by high-fidelity Cas variants and emerging delivery strategies.
A new study identifies TIGAR as a key regulator of osteoblast redox homeostasis and bone formation under glucocorticoid stress. TIGAR mitigates oxidative damage and apoptosis by activating autophagy-dependent Nrf2 signaling.
Researchers developed a halide-perovskite metasurface strategy using dual quasi-bound states in the continuum (q-BICs) to overcome pump absorption and radiative efficiency limitations. The system achieved an external quantum efficiency of up to 98.8% and cooled materials from room temperature to -201 °C.