Dana-Farber Cancer Institute scientists have developed a new biological classification of adenocarcinomas using miniaturized gene chips. The technique groups tumors by their genetic 'signatures', which can capture distinctive patterns of active and inactive genes, allowing for more accurate diagnoses and treatments.
Researchers at Dana-Farber Cancer Institute have identified a crucial protein called PGC-1 that regulates glucose production in the liver. This breakthrough could lead to new treatments for diabetes by targeting this protein with future drugs.
New study reveals how HIV subverts the immune system by mimicking other enemy invaders, rendering T cells unable to detect infection and cancer. This understanding will aid in developing new AIDS therapies targeting vulnerable points of HIV infection.
A new study by researchers at Dana-Farber Cancer Institute found that a motivational interviewing approach can reduce second-hand smoke exposure in young children. The study, known as Project KISS, showed a significant reduction in exposure to second-hand smoke among participants.
Researchers at Dana-Farber Cancer Institute uncovered how retroviruses like HIV make their escape from infected cells by using ubiquitin and a viral segment called the late domain. This study sheds light on previously unknown aspects of viral assembly and budding, potentially leading to new techniques for arresting viral spread.
A study found that earlier recognition of a child's prognosis by both parents and physicians can lead to stronger emphasis on treatment aimed at lessening suffering. The study also revealed that high-quality palliative care is more likely when both parties recognize the child's prognosis.
Early results from 19 patients treated in the Boston clinical trial show that Endostatin is safe and well-tolerated in high doses without any evidence of toxicity. Extended periods of stable disease and minor responses have been demonstrated, but further study is needed to determine its long-term effectiveness.
Researchers found that combining radiation therapy with androgen suppression therapy significantly reduced the risk of PSA failure in men with intermediate- and high-risk prostate cancer. The treatment showed efficacy even in low-risk patients, suggesting a potential benefit for all early-stage prostate cancer patients.
A new study finds that the 'cell crisis' theory explains why certain cancers become more common with age. Genetic mutations cause cells to divide uncontrollably after telomeres shorten, leading to cancer development.
Researchers at Dana-Farber Cancer Institute have charted the chain of events by which estrogen receptor-negative (ER-negative) breast cancer cells are formed. By understanding this process, scientists can identify potential targets for specific therapies to stop ER-negative tumors from growing.