Scientists have developed a method to culture human pancreatic slices for nearly two weeks, allowing them to study the regeneration of insulin-producing beta cells. The discovery has important therapeutic implications for treating diabetes.
Researchers found near-normal glycemic profiles in five long-term islet transplant recipients, with improved time-in-range metrics and reduced glucose variability. The study demonstrates the potential of islet transplantation as a successful long-term cell therapy for select patients with type 1 diabetes.
Researchers have discovered that transplanted islets in the anterior chamber of the eye exhibit early signs of inflammation before type 1 diabetes symptoms appear, suggesting a potential biomarker for predicting disease development. Early intervention with immunosuppressive treatments may halt disease progression, and future studies ai...
Researchers have engineered a human pluripotent stem cell line containing two 'suicide genes' that induce cell death in all but the desired insulin-producing cells. This approach addresses the limitations of PSC-derived beta cells and opens the door to creating safe cell-replacement therapies for people living with type 1 diabetes.
Researchers at the Diabetes Research Institute have successfully transplanted islets into the eye of experimental recipients, achieving long-term immunosuppression-free survival. This approach also shows promise for inducing peripheral immune tolerance, allowing for reduced or eliminated anti-rejection therapy.
Scientists from the Diabetes Research Institute renewed their original theory that pancreatic progenitor cells exist and can regenerate in humans. The study's findings could potentially address a major challenge in type 1 diabetes by regrowing patients' own insulin-producing cells.
A new clinical trial will assess the impact of high-dose omega-3 fatty acids and vitamin D supplementation on halting type 1 diabetes progression. The POSEIDON Study aims to reduce inflammation, increase insulin secretion, and promote a potential cure for this autoimmune disease.
Scientists have identified progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells. These findings open the door to developing regenerative cell therapies for those living with type 1 diabetes.
Scientists at the Diabetes Research Institute have successfully transplanted tissue-engineered islet cells into a patient with type 1 diabetes, achieving long-term insulin independence. The omentum tissue site has been found to be a viable alternative for islet implantation, minimizing inflammatory reactions.
Scientists at the Diabetes Research Institute developed an oxygen-generating biomaterial to enhance insulin-producing cell survival. The material, PDMS-CaO2, generates critical oxygen for up to six weeks, mimicking the native pancreas environment.