A detailed map of the human genome will require locating at least half a million genetic markers to be useful for pharmaceutical research and development. According to Dr. Leonid Kruglyak, researchers need to locate more genetic markers to stay on track when chasing down genes that influence disease susceptibility and drug response.
Researchers developed CMA-676, an antibody-drug conjugate targeting AML cells while sparing normal blood cells. The treatment produces mild side effects and induces remission comparable to standard chemotherapy regimens.
Researchers found that vaccinated patients had a significantly lower chance of death and relapse compared to non-vaccinated patients. The THERATOPEO vaccine increased specific killing activity against cancer cells, leading to longer remission periods.
Dr. Lee Hartwell, president of the Fred Hutchinson Cancer Research Center, will join four biotechnology leaders in discussing the future of biotechnology. They will address topics such as new methods for diagnosing diseases like lupus and leukemia, and the potential impact on drug development.
Researchers at the Fred Hutchinson Cancer Research Center and the University of Washington have mapped a gene associated with prostate cancer that runs in families, also linked to primary brain cancer. The study results appear in the American Journal of Human Genetics.
Researchers found a strong relationship between reading nutrition labels and eating less fat. People who read labels tend to consume 30% or less of their daily calories from fat, compared to 35% for non-label readers.
A new experimental compound, CMA-676, demonstrates promising efficacy in treating acute myelogenous leukemia (AML) with an antibody-targeted chemotherapy approach. The treatment shows a remission rate of approximately 40% comparable to standard combination chemotherapy regimens.
A five-year study aims to define long-term issues and positive growth in bone marrow transplant survivors, while evaluating factors that impact their survival and quality of life. Researchers will assess physical and psychological health, neuropsychological changes, and menopausal symptoms in over 200 participants.
Researchers at Fred Hutchinson Cancer Center found that genetic techniques for matching patients with marrow donors can eliminate guesswork and improve survival rates. The study of 300 patients with chronic myeloid leukemia showed that even single mismatches in key genes don't affect long-term survival.
A gene-transfer system invented by Dusty Miller has been recognized as the 'Nobel Prize of Applied Research'. The Retro-X System is a retroviral gene-transfer kit used in gene-therapy research, allowing for stable gene expression and long-term therapeutic results.
Lee Hartwell, director of the Fred Hutchinson Cancer Center, is one of three scientists to share the Albert Lasker Basic Medical Research Prize. He has been honored for discovering the universal mechanism controlling cell division in eukaryotic organisms, a fundamental insight into cancer cell mutation and development.
The Seattle Gastrointestinal Program Project will investigate the role of oxidative damage in pancreatitis and chronic ulcerative colitis. Researchers aim to develop screening tests for pancreatic cancer and more sensitive early detection methods for colon cancer.
Researchers at Fred Hutchinson Cancer Center found that HLA-matched unrelated marrow transplants can be safe and effective for CML patients in chronic phase. The study showed a 57% overall survival rate, with younger patients having a higher rate of 74%, comparable to those with matched sibling donors.