Researchers have discovered a novel approach to combat hormone-resistant breast cancer, exploiting the epigenetic 'silencing' of the BCL-2 gene. This process may be detectable in blood samples, offering a diagnostic marker for resistant tumors.
Researchers found that people with Hyper IgE Syndrome have more redundancy in their immune systems than expected, allowing them to respond effectively to most viruses and cancers. This discovery highlights the differences between mouse model work and real human infectious diseases, providing valuable insights for clinical treatment.
Australian scientists discovered that up to 30% of the human genome is conserved in RNA structure, contrary to previous estimates. This finding suggests that non-coding DNA may play a crucial role in regulating gene expression and development.
Research suggests that simultaneous boosting of these hormones can reduce appetite, fat gain, and insulin-resistance in mice. The double-barreled approach stimulates complementary brain regions and nerve pathways, leading to a powerful combined effect.
Researchers mapped the genome's 3D structure, finding that selected exons are exposed and accessible to transcription machinery. This reveals a new mechanism by which the genome's folding regulates gene expression and splicing.
Researchers used nanosensors and advanced imaging techniques to track the spread of pancreatic tumors and monitor the effectiveness of drugs. The study reveals promising results for combination therapies that can enhance drug delivery and improve clinical outcomes.
Australian scientists mapped insulin action in cells with precise detail, providing a comprehensive blueprint for understanding diabetes. The breakthrough study catalogued 37,248 phosphorylation sites on 5,705 proteins, revealing 15% that changed in response to insulin.