Gifu University

Glucose-dependent insulinotropic polypeptide prevents diet-induced obesity in mice

Researchers found that GIPFA-085, a long-acting GIPRA, acutely inhibited feeding and lowered body weight in diet-induced obese mice. The hormone increased plasma leptin levels and activated satiety neurons, facilitating fat utilization and reducing body weight gain.

SourceGifu University·JournalDiabetes Obesity and Metabolism·TypeExperimental study·DateMar 14, 2023

Highlighting the molecular mechanism underlying pancreatic cancer development

Researchers visualized the (pro)renin receptor's protein binding site and found hand-shaped grooves allowing for multiple protein binding. The study provides new insight into disease pathogenesis and aids in exploring novel treatments.

SourceGifu University·JournalHypertension Research·DateDec 8, 2022

Development of a potential microRNA medicine against KRAS mutant cancers

A chemically modified microRNA, miR-143#12, has been developed to target KRAS mutant cancers, demonstrating potent antiproliferative activity against colon cancer cell lines and significant tumor growth inhibition in mouse models. The microRNA suppresses the expression of key genes in the KRAS signaling network, inducing cell death at ...

SourceGifu University·JournalMolecular Therapy — Nucleic Acids·DateOct 11, 2022