BioStratum's gene-attenuated virus vaccines protect macaque monkeys against HIV-1-based viruses. The study demonstrates the efficacy of two vaccines in preventing AIDS development in 11 out of 12 monkeys.
Researchers found that liver ischemia/reperfusion injury induces a caspase-dependent apoptosis in endothelial cells. The study identified the type of affected cell and the molecular pathway responsible for the damage, opening doors to develop therapies to prevent or reduce liver preservation injury.
BioNumerik Pharmaceuticals has discovered a new non-toxic platinum protecting agent, BNP7787, which substantially reduces the toxicity of platinum-type anticancer drugs. Preclinical studies show that BNP7787 increases cisplatin's antitumor activity while protecting against kidney toxicity, vomiting, and bone marrow toxicities.
The Women's Health Writers Forum will discuss the power of media on the health of menopausal women, including their knowledge of health, treatment options, and disease risk factors. The event aims to find answers to important questions about the impact of media coverage on women's health.
Researchers at the University of Hawaii report breaking ground in mammalian cloning by creating reproducible clones from adult cells, with implications for pharmaceuticals and disease research. The 'Honolulu technique' has yielded three generations of identical cloned mice, opening doors to new avenues in genetic engineering.
Researchers demonstrate intratumoral delivery of the E1A gene, downregulating HER-2/neu expression and tumor responses. The study shows promise for using E1A gene therapy to treat a broad range of cancers.
Researchers successfully delivered and expressed an E1A gene in both diseased and normal human cells using a proprietary non-viral liposomal delivery mechanism. The study showed decreased levels of surrogate tumor markers in three patients with breast and ovarian cancers, indicating potential as a treatment for various types of cancer.
BioNumerik's novel chemoprotecting agent BNP7787 appears to completely protect against major toxicities associated with widely used platinum anticancer drugs. The company's Karenitecins demonstrate potent oral antitumor activity and bypass common drug resistance mechanisms.
The Resistance Web offers health care professionals and medical researchers immediate access to 10 years of drug resistance tracking data. The site helps alert medical professionals to drug resistance patterns, over-prescribing dangers, and encourages focused surveillance activities.
The company has validated the VEGF receptor as a key target in pathological angiogenesis and expects to submit an Investigational New Drug (IND) Application for clinical trials in cancer by the end of 1998. RPI.4610 has shown activity in multiple animal models, including inhibition of tumor growth and metastasis.
Researchers describe a powerful new immunotherapeutic approach that uses heat shock protein complexes to stimulate the immune system against cancer cells, with 80% of treated mice surviving longer than control mice. The treatment has potential for treating various cancers and may be applied in conjunction with surgery and chemotherapy.
deCODE Genetics has identified the location of a gene, FET1, responsible for familial essential tremor on human chromosome 3. This discovery brings new hope for understanding and treatment of the disease, which affects an estimated 5-10 percent of the elderly population.