New research from Northwestern University confirms that high-maintenance interactions indeed drain us. Study participants who engaged in low-maintenance interactions were more than four times as likely to elect a challenging task, while those with high-maintenance interactions struggled with self-regulation and performance anxiety.
Researchers discovered that Herceptin is effective in treating breast cancer tumors with low or undetectable HER-2 levels but high HRG expression. Continuous production of HRG activates the HER-2 receptor, promoting tumor growth and proliferation.
Researchers discovered that malignant melanoma cells secrete Nodal, a protein essential for proper embryo development, inducing abnormal skull and backbone formation in zebrafish embryos. Blocking Nodal signaling reduced melanoma cell invasiveness and promoted reversion to normal skin cells.
A Northwestern University study found that over 90% of patients support designating a proxy for health care, but less than 26% had previously been asked. The researchers advocate for routine identification of proxies to promote advance care planning and improve patient outcomes.
Researchers at Northwestern University have developed a process to create graphene-based composite materials with exceptional properties. The method involves exfoliating graphite into individual layers, which can be mixed into polymers, glasses, and ceramics.
Patients with peripheral artery disease (PAD) who are physically active have a significantly lower death rate than inactive individuals. A study published in Circulation found that higher physical activity levels are associated with a lower risk of cardiovascular disease and death in PAD patients.
Researchers from Northwestern University have developed a three-dimensional culture system to preserve immature eggs for female fertility preservation. The technology, which mimics the ovary environment, has successfully led to the live birth of healthy mice from in vitro grown follicles.
Researchers found strong association between PON2-PON3 gene cluster polymorphisms and sporadic ALS, a complex neurodegenerative disorder. Gene variations may help elucidate the cause of sporadic ALS, potentially leading to specific treatments.
A Northwestern University research team has developed a three-dimensional imaging technique that enables the study of fuel cell microstructure. This will help improve fuel cell performance and lifespan by revealing nanometer-scale features.
A team of researchers led by Ravi Allada from Northwestern University discovered that mushroom bodies play a crucial role in regulating sleep in fruitflies. The study suggests that the area may function to consolidate memories formed during the day, similar to vertebrates.
Researchers at Northwestern University have developed a new method to deliver antisense cancer drugs using gold nanoparticles, outperforming conventional agents. The nanoparticles improve stability, binding efficiency, and cellular uptake of the DNA, resulting in enhanced gene knockdown and lower toxicity.
Researchers discovered a mechanism by which misfolded SOD1 proteins form aggregates that kill motor neurons in ALS. The normal form of SOD1 is recruited to participate in disease formation through intermolecular disulfide bonds, providing potential sites for therapeutic intervention.
A study found that higher levels of education are associated with lower prevalence of coronary artery calcium, a marker of subclinical cardiovascular disease. Individuals with less than a high school degree had four times higher CAC prevalence compared to those with more than a college education.
A new study finds that PCOS is associated with elevated cholesterol levels, insulin resistance, and metabolic syndrome in mothers. The long-term health consequences of PCOS are significant, and mothers should be screened for cardiovascular disease risk factors.
Researchers have developed a new method called colorimetric screening to detect molecules that can facilitate the formation of a special form of DNA called a triple helix. This method uses gold nanoparticles and DNA to distinguish between strong, medium and weak binders to DNA.
Using a chick model, researchers demonstrated that malignant melanoma cells can respond to and be influenced by the embryonic neural-crest-rich microenvironment. This discovery may hold promise for developing new treatments for metastatic melanoma.
A Northwestern University researcher found that online communities of young people (10-16) demonstrate high levels of civic involvement, care for their communities, and exhibit unique leadership styles. These leaders prioritize synthesis, social ability, and persuasiveness over traditional traits.
A study by Northwestern University researcher David Huffaker finds that teen bloggers are vulnerable to cyberstalking due to their online presence. Blogs provide a platform for teens to share stories and feelings, but also expose them to risks such as sexual predation and bullying.
A study published in the American Journal of Public Health found that using open-ended questions to collect patient-reported data on ethnicity resulted in lower rates of missing values and unusable data compared to traditional closed-ended methods. This method also better captured the nuances of patients' self-identified ethnicities.
Researchers have developed virtual peers that can interact with children, helping them develop language and literacy skills. The virtual playmates engage in collaborative storytelling and are capable of adapting to individual children's needs.
Researchers found that polyglutamine proteins can destabilize the cell's system by interfering with other proteins having difficulty folding, leading to massive consequences. The study suggests a common mechanism may underlie various neurodegenerative diseases, including Huntington's and ALS.
Researchers found notable increases in racial differences in asthma hospitalizations and deaths since 1980, with smaller increases seen for adults. Clinicians are urged to focus on improving treatment, prevention, and education for minorities to close the unacceptable racial gap.
A recent study found that low-income minority patients are underrepresented in colon cancer screenings, with only 7% receiving correct screenings. The study highlights the need for organizational interventions to support physicians in underserved areas and promote recommended screening practices.
A recent study published in the Journal of General Internal Medicine found that nearly 10 million more adults have high LDL-C (
Researchers at Northwestern University have developed a new compound that selectively inhibits pro-inflammatory proteins called cytokines by glia, slowing or reversing neuroinflammatory cascade progression. The compound also restored normal synaptic function and attenuated Alzheimer's-like behavioral deficits in mice.
Researchers at Northwestern University have developed a gene therapy that turns off the alpha-synuclein protein, a key player in Parkinson's disease. The therapy uses RNA interference to selectively disable the gene, leaving other genes unaffected, and has shown promising results in rat models.
Researchers have observed that less energetic infrared flares coincide with more energetic X-ray and submillimeter flares, suggesting accelerated particles give rise to emission. The study also found that flare activity is driven by the infrared wavelength, with 40% of observations detected in this range.
A Northwestern University study found that middle-aged individuals with higher body mass indexes had significantly higher risks of hospitalizations for and deaths from heart disease and diabetes in older age. Having a normal BMI in young adulthood and middle age confers significant health benefits.
Researchers found alphaB-crystallin protein promotes uncontrolled growth in breast cancer cells, suggesting it as a molecular marker for aggressive breast cancer. The study identified a key pathway activated by alphaB-crystallin and found drug inhibitors block its effects, paving the way for new targeted therapies.
The researchers determined the pre-fusion structure of the F protein using X-ray diffraction, providing a complete picture of how paramyxovirus F protein works to infect cells. This discovery has significant implications for developing improved protein-based vaccines and designing novel anti-viral agents.
A Northwestern University study found that self-directed walking exercise at least three times a week slows the decline of physical abilities in people with peripheral artery disease (PAD). Participants with the worst PAD at the start of the study were most likely to benefit from this type of regular exercise program.
A large-scale study found that nearly 7.5 million adolescents and 8.5 million adults have poor cardiovascular fitness, associated with increased risk of heart disease. The prevalence of poor fitness was higher in females and minority groups, highlighting the need for targeted education campaigns to promote physical activity.
A study by Northwestern University found that postmenopausal white women with a history of non-melanoma skin cancer are twice as likely to develop cutaneous melanoma. Regular skin checkups are crucial for these high-risk individuals to reduce the incidence of deadly melanoma.
A study by Northwestern University found that a major sales promotion effort by AstraZeneca and TAP Pharmaceuticals led to significant income increases for urologists. The switch to Average Sales Price-based Medicare reimbursement is expected to decrease oncologists' revenue by 8%.
Chronic major depressive episodes are associated with older age, lower education and income, medical illnesses, and lack of private insurance. African Americans and patients in primary care settings experience more chronicity.
A 12-week study found that Viagra significantly improved erectile function, self-esteem, and quality of life for men with ED and LUTS associated with benign prostatic hyperplasia (BPH). Men experienced a decrease in both irritative and obstructive BPH symptoms.
A study led by Northwestern University researchers suggests that Kawasaki disease is caused by a single respiratory viral agent, entering through the lungs and infecting bronchi. The research provides new insights into the disease's cause and course, and may lead to new treatments.
Researchers at Northwestern University discovered that human embryonic stem cells can reprogram metastatic melanoma cells to a more normal state by mimicking their natural microenvironment. The findings suggest a new approach for investigating the effects of identifying key factors in reversing tumor cell properties.
Researchers developed a model that reprograms benign skin cells to express genes associated with aggressive melanoma cells, highlighting the role of tumor cell microenvironment in transformation. The study provides potential therapeutic strategies to inhibit melanoma spread.
A study found that estrogen levels affect brain memory areas, enabling females to adapt to complex environments and enhance reproductive success. The researchers suggest this adaptation facilitates tasks such as mate selection and finding food and shelter.
A team of researchers has discovered a novel form of cancer gene regulation that inhibits the production of GLI1, a protein associated with severe birth defects and childhood cancers. This regulation mechanism involves the Quaking protein and is conserved across humans and worms.
Researchers at Northwestern University have discovered a potential target for preventing metastatic melanoma, the cancer's ability to spread and be fatal. The study identified focal adhesion kinase (FAK) as a key player in promoting aggressive melanoma behavior.
Researchers found that treating cancer cells with GLA suppressed protein levels of the oncogene Her-2/neu, leading to a 30-40 fold increased response in breast cancer cells to trastuzumab. GLA's inhibition works differently from Herceptin and may regulate breast cancer cell growth and metastasis.
A Northwestern University study using live-cell time-lapse spectroscopy clearly links the presence of mutant SOD1 protein aggregates with neuronal cell death in ALS. The research provides a new understanding of aggregate structure and composition, offering hope for developing genetic suppressors and therapeutics.
A recent study found that nearly one in five depressed African-American participants developed a disability within two years of enrolling, compared to one in twenty non-depressed peers. Chronic conditions and functional limitations also played a significant role in the excess disability incidence related to depression.
The new center aims to develop nanomaterials and nanodevices for cancer diagnostics, therapeutics, drug delivery, imaging, and monitoring applications. Researchers will focus on developing early detection tools, targeting cancer cells with chemotherapeutic agents, and creating new classes of drugs.
Researchers at Northwestern University developed the first complete micromachine that can characterize mechanical properties of nanowires and carbon nanotubes in real-time. The system uses differential capacitive sensing to measure applied forces with nano-Newton resolution.
Researchers at Northwestern University have developed uncooled infrared photon detectors using type-II superlattices, enabling high-speed operation and handheld portability. The new technology has potential in medical applications, such as detecting inflammation or cancerous tissue.
Scientists from Northwestern University and Argonne National Laboratory have created a new type of atomic force microscopy (AFM) probe made from ultra-nano-crystalline diamond, exhibiting properties similar to single-crystal diamond. The development enables improved durability and scalability for high-resolution imaging.
Researchers have discovered that microRNAs are involved in the process of oogenesis, a complex regulatory mechanism controlling protein abundance. The findings suggest that miRNA dysfunction may contribute to certain forms of infertility.