The researchers determined the pre-fusion structure of the F protein using X-ray diffraction, providing a complete picture of how paramyxovirus F protein works to infect cells. This discovery has significant implications for developing improved protein-based vaccines and designing novel anti-viral agents.
A Northwestern University study found that self-directed walking exercise at least three times a week slows the decline of physical abilities in people with peripheral artery disease (PAD). Participants with the worst PAD at the start of the study were most likely to benefit from this type of regular exercise program.
A large-scale study found that nearly 7.5 million adolescents and 8.5 million adults have poor cardiovascular fitness, associated with increased risk of heart disease. The prevalence of poor fitness was higher in females and minority groups, highlighting the need for targeted education campaigns to promote physical activity.
A study by Northwestern University found that postmenopausal white women with a history of non-melanoma skin cancer are twice as likely to develop cutaneous melanoma. Regular skin checkups are crucial for these high-risk individuals to reduce the incidence of deadly melanoma.
A study by Northwestern University found that a major sales promotion effort by AstraZeneca and TAP Pharmaceuticals led to significant income increases for urologists. The switch to Average Sales Price-based Medicare reimbursement is expected to decrease oncologists' revenue by 8%.
Chronic major depressive episodes are associated with older age, lower education and income, medical illnesses, and lack of private insurance. African Americans and patients in primary care settings experience more chronicity.
A 12-week study found that Viagra significantly improved erectile function, self-esteem, and quality of life for men with ED and LUTS associated with benign prostatic hyperplasia (BPH). Men experienced a decrease in both irritative and obstructive BPH symptoms.
A study led by Northwestern University researchers suggests that Kawasaki disease is caused by a single respiratory viral agent, entering through the lungs and infecting bronchi. The research provides new insights into the disease's cause and course, and may lead to new treatments.
Researchers at Northwestern University discovered that human embryonic stem cells can reprogram metastatic melanoma cells to a more normal state by mimicking their natural microenvironment. The findings suggest a new approach for investigating the effects of identifying key factors in reversing tumor cell properties.
Researchers developed a model that reprograms benign skin cells to express genes associated with aggressive melanoma cells, highlighting the role of tumor cell microenvironment in transformation. The study provides potential therapeutic strategies to inhibit melanoma spread.
A study found that estrogen levels affect brain memory areas, enabling females to adapt to complex environments and enhance reproductive success. The researchers suggest this adaptation facilitates tasks such as mate selection and finding food and shelter.
A team of researchers has discovered a novel form of cancer gene regulation that inhibits the production of GLI1, a protein associated with severe birth defects and childhood cancers. This regulation mechanism involves the Quaking protein and is conserved across humans and worms.
Researchers at Northwestern University have discovered a potential target for preventing metastatic melanoma, the cancer's ability to spread and be fatal. The study identified focal adhesion kinase (FAK) as a key player in promoting aggressive melanoma behavior.
Researchers found that treating cancer cells with GLA suppressed protein levels of the oncogene Her-2/neu, leading to a 30-40 fold increased response in breast cancer cells to trastuzumab. GLA's inhibition works differently from Herceptin and may regulate breast cancer cell growth and metastasis.
A Northwestern University study using live-cell time-lapse spectroscopy clearly links the presence of mutant SOD1 protein aggregates with neuronal cell death in ALS. The research provides a new understanding of aggregate structure and composition, offering hope for developing genetic suppressors and therapeutics.
A recent study found that nearly one in five depressed African-American participants developed a disability within two years of enrolling, compared to one in twenty non-depressed peers. Chronic conditions and functional limitations also played a significant role in the excess disability incidence related to depression.
The new center aims to develop nanomaterials and nanodevices for cancer diagnostics, therapeutics, drug delivery, imaging, and monitoring applications. Researchers will focus on developing early detection tools, targeting cancer cells with chemotherapeutic agents, and creating new classes of drugs.
Researchers at Northwestern University developed the first complete micromachine that can characterize mechanical properties of nanowires and carbon nanotubes in real-time. The system uses differential capacitive sensing to measure applied forces with nano-Newton resolution.
Researchers at Northwestern University have developed uncooled infrared photon detectors using type-II superlattices, enabling high-speed operation and handheld portability. The new technology has potential in medical applications, such as detecting inflammation or cancerous tissue.
Scientists from Northwestern University and Argonne National Laboratory have created a new type of atomic force microscopy (AFM) probe made from ultra-nano-crystalline diamond, exhibiting properties similar to single-crystal diamond. The development enables improved durability and scalability for high-resolution imaging.
Researchers have discovered that microRNAs are involved in the process of oogenesis, a complex regulatory mechanism controlling protein abundance. The findings suggest that miRNA dysfunction may contribute to certain forms of infertility.
Researchers at Northwestern University have developed a tiny infrared laser that can detect explosives and chemical warfare agents, setting the stage for a portable system to warn against potential threats. The far-infrared laser's high power and efficiency make it an ideal source for sensitive chemical analysis.
Research suggests that severely mentally ill individuals are disproportionately victimized by crime, with a prevalence rate six to 23 times greater than the general population. The study's findings highlight the need for improved mental health treatment and support services to reduce revictimization.
Molecular machines can now be driven individually using an electric current, allowing for controlled operation. This breakthrough enables the use of molecular machines in applications such as computing, sensors and bioengineering.
A study found that nearly three-quarters of elderly individuals (80+ years) have hypertension, with women facing greater risks. Poor control rates were 38% among men and 23% among women, mainly due to inadequate use of combination therapy.
A recent study found that foreign-born Asian American and Pacific Island women are significantly less likely to receive breast-conserving surgery than non-Hispanic white women, despite similar demographic and tumor characteristics. Language barriers and cultural factors may contribute to these disparities.
Researchers at Northwestern University have developed a custom-built scanning tunneling microscope to image individual organic molecules on silicon, refining design constraints for molecular electronic devices. The study has also provided insight into surface chemistry, with potential applications in sensing, catalysis, and lubrication.
Researchers at Northwestern University create a new method to produce nanowires with controlled gaps, enabling the design of devices for diagnostics and drug discovery. The technique, called on-wire lithography, allows for the fabrication of nanowires with precise electrical measurements on individual molecules.
Researchers found that zebrafish embryos with human metastatic melanoma cells suppress tumor development, suggesting potential for new cancer therapies. The study provides a powerful model for investigating tumor-microenvironment interactions and reversing the aggressive phenotype of cancer cells.
Researchers found that microRNAs play a crucial role in regulating gene expression and enabling stem cells to pass from the normal stop phase to the stage of replicating their DNA for later division. The discovery suggests that microRNAs may also control cell division in cancer cells, encouraging proliferation.
Research suggests high school start times deprive teens of sleep, affecting cognitive performance and mood. Students perform better in the afternoon, but early morning classes report being wearier and less alert.
Researchers at Northwestern University discovered that brain regions involved in information integration shift depending on cognitive task. Dynamic Causal Modeling revealed that specific regions, like the lateral temporal cortex and intraparietal sulcus, act as convergence zones integrating information from other parts of the brain.
Researchers have found TRPA1 to be present in stereocilia of hair cells, crucial for both sound detection and balance. This dual role suggests that TRPA1 may play a key role in pain sensation, particularly in response to noxious stimuli.
Researchers at Northwestern University have developed a new coating that provides effective fouling resistance for over five months, outlasting existing antifouling polymers. The coating, made of two parts, sticks securely to surfaces and prevents cell and protein buildup, holding promise for use on medical implants.
The Research on Adverse Drug Events and Reports (RADAR) Project has identified serious adverse drug reactions with 14 commonly prescribed drugs and cardiac stents, affecting almost 1,700 patients. RADAR reviews have been published in leading medical journals and have helped save hundreds to thousands of patient lives.
Researchers found that successful teams in arts and sciences have diverse membership, with old and new members adding creative spark. Unsuccessful teams are isolated, whereas successful teams are interconnected like the Kevin Bacon game.
Scientists have created a Nanofountain Probe that enables sub-100 nanometer molecular writing, a capability previously unattained. The device employs a volcano-like dispensing tip and capillary-fed solutions to achieve high-resolution direct writing.
Researchers have discovered that a faulty body clock can wreak havoc on the body's metabolism, increasing the risk of obesity and diabetes. In a study published in Science, scientists found that mice with a misaligned internal timepiece gained weight and developed metabolic abnormalities when fed regular or high-fat diets.
Researchers at Northwestern University show that a magnetic field can be used to increase or decrease the flow of heat through an Andreev interferometer. The findings, published in Physical Review Letters, demonstrate the quantum mechanical nature of heat flow and its relationship with electron charge.
Researchers explain violent origins of extrasolar planetary behavior, citing planet-planet scattering as key factor. The study's findings suggest that strong instabilities led to the formation of highly eccentric orbits in multiple systems.
A Northwestern University team has designed organic molecules that self-assemble into ultra-thin layers for use in transistors. Their tailored molecular components reduce operating voltage and power consumption, making low-power consumption OTFTs a reality.
Scientists have discovered a subset of learning disabilities resulting from a dysfunction in the brainstem's encoding of basic sounds of speech. BioMAP, a simple neurophysiological test, can identify children with sound processing disorders and improve their speech discrimination skills through auditory training.
Researchers at Northwestern University have developed a new solid oxide fuel cell that converts liquid transportation fuels into hydrogen, offering a more efficient and cost-effective alternative to current technologies. The cells could lead to widespread adoption of hydrogen power in applications such as cars, trucks, and homes.
The new Local-Electrode Atom-Probe (LEAP) tomograph allows researchers to study the nanostructure and chemical composition of materials at an unprecedented level. By analyzing the structure and chemical identity of steel, scientists can design stronger materials with improved properties.
A new study suggests that breastfeeding mothers can safely resume nursing after undergoing surgery with the anesthetic propofol. The research found that less than 0.1% of the drug's dose is present in breast milk within 24 hours, minimizing infant exposure and justifying uninterrupted breastfeeding.
Researchers created tumor-specific immune cells that were insensitive to TGF-beta, a powerful substance that helps cancer cells evade the immune system. These cells were able to infiltrate and destroy tumors effectively, while preventing autoimmune disease, offering new hope for treating advanced prostate cancer.
Researchers developed a new scale to predict recovery of consciousness from coma after brain injury. The Disorders of Consciousness Scale (DOCS) accurately detected improvements, declines, and plateaus in neurobehavioral functioning.
A study of 750 women in spontaneous labor found no significant difference in C-section rates between those receiving spinal and systemic opioids. Early epidural analgesia was also associated with shorter labors and lower pain scores.
Scientists at Northwestern University have developed a new diagnostic test for Alzheimer's disease using bio-bar-code amplification technology. The test can detect miniscule amounts of a toxic protein in human cerebrospinal fluid, which may be responsible for early neurological deterioration.
Hospitalized children experience preventable adverse events at significantly lower rates than adults, with birth-related and diagnostic errors being the most common types. The study suggests that processes and systems leading to adverse events in children may differ from those in adults.