A three-year study in remote communities found a significant reduction in skin sores among Aboriginal children, with over 6000 assessments conducted on nearly 2500 children. The program's success highlights the importance of local education and treatment, but ongoing efforts are needed to address underlying causes such as poor housing ...
A new study finds that US per capita food waste has increased by about 50% since 1974 to over 1400 Calories per person per day, equivalent to 150 trillion Calories per year. This excessive energy content contributes significantly to freshwater consumption and fossil fuel emissions.
A study by John Coates and Lionel Page found that experienced traders outperform the market with a high Sharpe Ratio, indicating prudent risk-taking. The researchers also discovered that profit-sharing incentives encourage traders to lower risk variance.
Male circumcision significantly reduces HIV infection risk by 60% in rural Uganda men. The removal of foreskin tissue containing HIV target cells explains most of the protection. Circumcision also reduces genital ulcer disease by lowering rates of trauma-induced ulcers, not just those caused by herpes.
The article emphasizes the need for a more methodologically robust approach to evaluating eHealth systems. Researchers must recognize the importance of combined quantitative and qualitative work when assessing IT systems.
Genome-wide association studies are increasingly conducted in developing countries, raising ethical concerns about data release, privacy, and security. A study developed a 'managed' approach to oversee open access, define acceptable uses of data, and guide the timing of data release.
The journal PLoS Medicine is calling for international action to address the crisis of malaria drug shortages across Africa. The 'third wave' of malaria activism aims to raise awareness of the issue and find solutions.
A lack of quantity and quality of health data from poor settings threatens global research, warns Peter Byass. Alternative strategies to improve health data representativeness are discussed.
A large-scale genetic analysis of 17,296 women identified 43 genetic loci contributing to lipoprotein metabolism, providing new insights into the molecular basis of cardiovascular disease. The study also quantifies the contribution of common genetic variation to plasma lipoprotein concentrations.
The PLoS Genetics special collection presents groundbreaking research on maize genome architecture, revealing new insights into centromeres, transposons, microRNAs, and more. The studies also explore the role of copy number variation and presence/absence variation in shaping maize phenotypes.
A new treatment route for bovine spongiform encephalopathy (BSE) and its human form Creutzfeldt Jakob disease (CJD) may be closer based on new findings from the University of Leeds. Glypican-1 has been shown to cause abnormal prion proteins to rise, and reducing levels in infected cells can lower their levels.
Research published in PLoS Medicine found associations between local rainfall and temperature with cases of dengue fever, but no significant link with El Niño-Southern Oscillation. Large outbreaks occur every few years in many tropical countries, with temperature and rainfall varying strongly on an annual scale.
A study by scientists from the University of Valencia has shown that cockroaches eliminate excess nitrogen by excreting ammonia, unlike most terrestrial insects. The research suggests an evolutionary convergence between cockroaches and ants, arriving at similar metabolic solutions through their associations with endosymbionts.
Researchers identified specific genetic changes associated with an increased risk of relapse in cervical cancer patients. These changes are crucial steps in the progression of the disease towards an aggressive and treatment-resistant state.
A new study found that foreign subtitles can enhance second-language listening ability, particularly when the subtitles are in the same language as the film. English subtitling was associated with improved recognition of both familiar and unfamiliar words, while Dutch subtitling reduced this effect on new materials.
A study suggests that many dinosaurs were probably endothermic, athletic animals due to their high energy requirements during walking and running. This trait may have enabled them to thrive in various habitats, including colder regions, allowing them to cover the entire Mesozoic landscape.
A study of postmenopausal women found that the risk of hip fractures steeply rises with age, being seven times higher in 70-74 year olds than in 50-54 year olds. The study also discovered a slightly increased risk for early menopause before age 45.
Researchers found that population movement is a critical factor in dengue's spread in Rio de Janeiro. The study, published in PLOS Neglected Tropical Diseases, revealed that areas with high levels of people traffic have higher risk of transmission.
The Malawi government has introduced a national program to deliver effective pneumonia treatment, known as standard case management, to children. This initiative aims to reduce the high mortality rate of childhood pneumonia in low-income countries by providing timely and appropriate antibiotic therapy and oxygen support.
A study published in PLOS Medicine found that dementia is often associated with mixed pathological changes, including Alzheimer's and vascular dementia. The researchers estimated that drugs targeting specific pathologies may have limited impact on the overall burden of dementia.
A package of continuing care is essential for managing dementia in LMICs, comprising diagnosis, regular needs assessments, physical health checks, and carer support. The authors highlight the importance of early detection and treatment of behavioral and psychological symptoms.
A first national campaign to scale up zinc treatment of diarrhea in Bangladesh increased awareness significantly, peaking at 90% in urban areas. However, actual usage of zinc tablets was found to be low, with only 25% of children receiving the correct 10-day course of treatment.
A study found that Australian reporting standards do not require disclosure of the names of speakers, financial ties, and company roles in sponsored events. The analysis showed that medical specialists received high per-head expenditure on high-cost drugs at industry-sponsored events.
A new study published in PLOS Pathogens found that whooping cough immunity typically lasts at least 30 years and perhaps as long as 70 years after natural infection. The research suggests that repeat infections contribute relatively little to transmission and may even boost immunity in individuals with waning protection.
A study found that Laysan albatrosses nesting on Kure Atoll and Oahu ingested significantly different amounts of plastic, with those on Kure Atoll consuming almost ten times the amount. The birds' stomach contents revealed a wide range of plastic items, including Asian characters indicating their likely origin.
A recent study published in PLoS ONE found that French brown bears are at risk of extinction due to a lack of females. The researchers suggest that relocating new bears could not only boost the population size but also reverse some of the causes of the decline by introducing more females.
A new genetic method allows for precise identification of all eight tuna species from processed tissue, helping conservation efforts and trade controls. The analysis of DNA sequence variability enables full discrimination between the recognized species.
The PLOS collection explores how genomics can provide insights into emerging infectious diseases. Genomics research has the potential to track the spread of disease agents, develop vaccines, and combat pathogens more effectively. This could lead to a better preparedness for and response to biological threats.
A new study published in PLoS Medicine reexamines the development of dengue hemorrhagic fever (DHF), contradicting the long-held antibody-dependent enhancement (ADE) model. Researchers found that maternal antibodies protect infants from full-spectrum dengue disease, and a higher weight-for-age is associated with DHF risk.
A clinical trial found that adding two antiretroviral drugs to single-dose nevirapine effectively reduces drug resistance in mothers and babies. The combination regimen is safe, easy to provide, and effective in preventing subsequent nevirapine resistance.
A study published in PLoS Medicine suggests that reducing dropout rates from HIV treatment programs can lead to improved patient survival and cost-effectiveness. The researchers propose strategies such as eliminating co-payments for treatment and increasing services available to patients, which could form part of the commitment to star...
A new integrated survey protocol identified areas requiring mass treatment for schistosomiasis and intestinal worm infections in Southern Sudan. Lymphatic filariasis and loiasis were found to be extremely rare, with only four individuals testing positive or reporting symptoms.
The article discusses the need to shift focus from tertiary care services to cost-effective brief interventions for earlier stages of alcohol use disorders. Health systems in low- and middle-income countries currently prioritize treatment, but this approach is often ineffective.
A mathematical model predicts that low background levels of radiation increase the risk of cardiovascular disease. The risk is consistent with previous studies involving nuclear workers.
A recent study has discovered evidence of early human tool-making activities in a 2-million-year-old grassland-dominated ecosystem. The researchers found well-preserved faunal remains and chemical analyses of ancient soils at the Kanjera South site, which reveal that hominins were active in open settings.
Researchers from Stanford University and colleagues have discovered a gene associated with human kidney aging, revealing new insights into the aging process. The study used sequential transcriptional profiling and eQTL mapping to identify genetic variants linked to kidney aging.
A new study released in PLoS ONE explores the cumulative impacts of energy development on species in the West, with potential consequences for sage-grouse populations. The research highlights the need for scientifically credible conservation planning tools to balance natural resource development with wildlife conservation.
Researchers found that chimpanzees altruistically help conspecifics, even without direct personal gain or reciprocation, but mostly upon request. The study suggests that 'help upon request' may be a more effective strategy for altruism in animals.
A study in South Africa found that medical documentation of injuries is associated with higher conviction rates in adult rape cases, while DNA evidence has limited impact. The research highlights the importance of basic forensic medical practices in assisting courts in rape cases.
A study found that US researchers are more positive about including ethnic minorities in health research than their UK counterparts. The UK researchers were often reticent about the need, citing concerns over scientific importance and practical difficulties.
Packages of care aim to improve epilepsy recognition and management, closing the 'treatment gap' in LMICs. Epilepsy affects 65 million people worldwide, with limited access to effective treatment.
In a Rwandan pilot program, nurses safely and effectively prescribed antiretroviral therapy to patients with HIV after completing at least 50 consultations. The study found that patients who received treatment showed improved health outcomes, including increased weight gain and CD4 cell counts.
Researchers are studying naturally occurring cancers in dogs to inform the development of new cancer drugs, devices, and imaging strategies for human cancer patients. The study aims to improve care for human patients by leveraging insights gained from canine cancer biology.
A human liver fluke contributes to the development of bile duct (liver) cancer by secreting granulin, a growth hormone that causes uncontrolled cell growth. The International Agency for Research on Cancer classifies the parasite as a Group I Carcinogen.
A new series explores how to treat six major MNS disorders in settings where specialists are scarce. The series recommends 'packages of care' combining medication and psychosocial treatments for best outcomes, with non-specialist health workers playing a key role.
A new method of biocontrol using fungal biopesticides may be an effective means of reducing malaria transmission, particularly when used in combination with insecticide-treated bednets. The study suggests that this approach can substantially reduce malaria transmission rates and help manage insecticide resistance.
Masitinib targets mast cells and shows greater activity and selectivity against KIT than benchmark TKI imatinib. The study demonstrates masitinib's potential in treating KIT and PDGFR-dependent diseases, including various cancers, inflammatory diseases, and neurological indications.
Researchers discovered that Tyrannosaurus rex and its relatives had a potentially deadly infectious disease similar to trichomonosis, which causes swollen jaws and holes. The study found evidence of face-biting marks on many specimens and suggests that cannibalism or head-biting may have spread the disease.
A new study reveals that the Komodo dragon most likely evolved in Australia and dispersed westward to Indonesia. The research, published in PLOS ONE, also details fossil evidence of a new species of giant varanid found on the island of Timor.
A population-based study found that initiating cholinesterase inhibitor therapy for dementia increases the risk of hospitalization for bradycardia by over doubling. Meanwhile, a separate team led by Louisa Degenhardt examines cannabis use as a risk factor for psychosis and proposes its inclusion in global burden of disease estimates.