Tokushima University

A new strategy enables oxidation-free, efficient oligonucleotide synthesis

Researchers have developed an oxidation-free approach to oligonucleotide synthesis using P(V)-fluoridates, enabling rapid coupling and automated synthesis. The new platform offers improved efficiency and stability compared to conventional methods.

SourceTokushima University·JournalJournal of the American Chemical Society·TypeExperimental study·DateJul 29, 2026

Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases

A study reveals that a cellular interaction between immune cells and fibroblasts drives the progression of Sjögren's disease by promoting chronic inflammation. The CD153+ CD4+ T cell-CD30+ fibroblast axis is identified as a key trigger, and targeting this axis may provide new therapeutic opportunities.

SourceTokushima University·JournalNature Communications·TypeExperimental study·DateJun 24, 2026