Researchers found that specific combinations of TP53 and CDKN2A mutations activate cGAS-STING-mediated immunity, delaying oral cancer progression. The immune activation was associated with delayed progression to invasive oral cancer.
Researchers have developed an oxidation-free approach to oligonucleotide synthesis using P(V)-fluoridates, enabling rapid coupling and automated synthesis. The new platform offers improved efficiency and stability compared to conventional methods.
A study reveals that a cellular interaction between immune cells and fibroblasts drives the progression of Sjögren's disease by promoting chronic inflammation. The CD153+ CD4+ T cell-CD30+ fibroblast axis is identified as a key trigger, and targeting this axis may provide new therapeutic opportunities.