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Universitatsklinikum Bonn


Secret structure in the wiring diagram of the brain

Scientists have discovered a hidden structure in the connections between neurons in the brain, which is crucial for the stability of the neuronal network. By combining mathematical models with experimental recordings, researchers found that the relative ratios of connection strengths are more important than absolute values.

SourceUniversitatsklinikum Bonn·JournalProceedings of the National Academy of Sciences·DateOct 14, 2022

Appetite change in depression

Researchers found that appetite changes in depression are linked to specific changes in the brain's reward system, including a weaker connection between the reward system and areas processing taste stimuli. The study suggests precision medicine approaches could lead to more targeted therapies for individual symptoms of depression.

SourceUniversitatsklinikum Bonn·JournalJAMA Psychiatry·TypeCase study·DateAug 24, 2022

Comparison of two nano rulers

Scientists at University Hospital Bonn compared PELDOR and FRET spectroscopy methods to measure distances in protein molecules. While most results were comparable, inconsistencies were found in two cases, highlighting the importance of re-measurement with another nano ruler.

SourceUniversitatsklinikum Bonn·JournalNature Communications·TypeExperimental study·DateAug 1, 2022