The BLING III trial found a 2% lower 90-day mortality and a 6% higher clinical cure rate for continuous β-lactam antibiotic infusions compared to intermittent infusions in critically ill patients with sepsis. Continuous infusions were also associated with improved patient outcomes.
A new report found that 90% of COVID-19 preprint data points remained unchanged after peer review, with only minor changes in estimates. This suggests that preprint studies can be reliable and trustworthy, especially for infectious-disease research.
A recent study by researchers at Stanford University School of Medicine found that p-values are being misapplied in millions of biomedical journal articles, leading to the illusion of credible research. The study suggests that this widespread misuse may not indicate an improvement in research conduct or data analysis.
The study found that the fatality rate for patients over 60 was significantly higher (43.3%) compared to those under 60 (13.2%), with an average admission to death time of 36 days. Public health measures, including hospital quarantine and contact tracing, helped slow the outbreak.