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Time to treatment with intravenous thrombolysis before thrombectomy and functional outcomes in acute ischemic stroke

Intravenous thrombolysis (IVT) plus thrombectomy demonstrates significant benefits over thrombectomy alone when administered within a short timeframe after symptom onset. This study, based on individual participant data from six randomized clinical trials, found IVT before thrombectomy to be time-dependent and statistically significant.

SourceJAMA Network·JournalJAMA·DateFeb 7, 2024

Buprenorphine, not methadone, may be safer treatment for opioid-use disorder during pregnancy

Researchers found that buprenorphine use was associated with better outcomes for the baby, including lower risk of preterm birth, small size for gestational age, and low birth weight. The study suggests increasing access to buprenorphine treatment among pregnant individuals with opioid-use disorder.

SourceRutgers University·JournalNew England Journal of Medicine·TypeData/statistical analysis·DateNov 30, 2022