Articles tagged with Bioengineering
Researchers create engineered extracellular vesicles from red blood cell lipids, evading immune cells and targeting cancer cells. The technology offers flexibility in cargo loading and packaging, enabling delivery of genetic material, proteins, and whole viruses.
WPI researchers develop new models to study uterine fibroids with NIH funding, building on student projects. The models will help researchers better understand and develop treatments for fibroids, which affect millions of women.
Researchers at Dongguk University have developed an innovative gene switch that uses electromagnetic fields to control gene expression. The switch, which targets the Lgr4 gene, demonstrates precise activation with no detectable adverse effects, making it a promising platform for non-invasive gene therapies.
Dr. Chelsea Hu's research combines device engineering, real-time feedback control and mathematical modeling to address the challenge of controlling dynamic biological systems. Her team developed LED-Embedded Microplate for Optogenetic Studies (LEMOS), a platform that makes real-time optogenetic feedback control more accessible.
A study from Institute of Science Tokyo reveals how histone variants direct DNA methylation to jumping genes, preventing accidental gene silencing in plants. This molecular framework enables plant cells to distinguish transposons from genes, ensuring precise epigenetic regulation across the genome.
Researchers are investigating whether beneficial bacteria can prevent the body from absorbing lead. The study aims to determine if probiotic supplements containing harmless bacteria can produce aptamers that trap lead for excretion, providing a potential solution for people in high-risk environments, especially children.
Researchers at MIT have created a new microscope that can image electrical activity in neurons distributed across the brain, revealing patterns of neural activity from milliseconds. The technique enabled observation of single voltage spikes and rapid bursts of spikes, shedding light on how the brain is activated following a stimulus.
Researchers at CU Anschutz and CU Boulder developed a miniature microscope that allows observing and activating individual brain cells during natural movement. This advancement could accelerate research into brain behavior and neurological diseases.
Researchers have developed a new hydrogel made from peptides that can transport ions, generate electrical signals when squeezed, or interact with cells and biological molecules. The gel has tiny water channels and is electrically polarized due to its highly organized structure made from nanofibers.
Engineers have created a bacterium that can consume all three major sugars present in corn stalks, opening up possibilities for more efficient biomanufacturing processes. The new strain of Pseudomonas putida was developed using an automated culturing platform and can potentially be used to produce valuable molecules like indigoidine.
Researchers have developed a biohybrid system that uses photosynthetic microorganisms entrapped in nanocellulose films to produce ethylene. The system remains productive for over four months with minimal water and energy requirements, making it a promising technology for sustainable chemical production.
The Cancer Dependency Map now includes nearly 150 3D cancer models, expanding its resource to include organoids and spheroids across 10 cancer types. These next-generation models reveal new genetic dependencies and disease-driving mechanisms, particularly in brain and gastrointestinal cancers.
A cross-disciplinary team developed a near-infrared fluorescent dye, SID-788, with excellent biocompatibility and superior ureter imaging performance. The dye enables clear ureter visualisation for at least four to five hours in porcine models using clinical NIR laparoscopes and robotic surgical systems.
Lehigh University researchers develop comprehensive mathematical model of the neural circuitry linking the gut and brain to regulate stomach function, opening new pathways for treating chronic digestive disorders through targeted vagus nerve stimulation. The digital twin could help accelerate therapy development and improve quality of ...
Researchers explore how engineered lanthanide carriers can tune the optical and magnetic properties of ions for improved signal contrast and reduced background signals in biomedical imaging. The study highlights opportunities for multimodal imaging, theranostics, and AI-guided probe design.
Researchers have developed a way to quickly create customizable synthetic blood vessel grafts in just minutes using additive manufacturing. The new technique, called Focused Rotary Jet Spinning, allows for precise control over diameter and wall thickness, making it ideal for acute trauma situations and complex pediatric heart surgeries.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
Researchers developed a new cell-based approach to produce several sugars naturally found in human breastmilk, including complex oligosaccharides. The method involves engineering cultured mammalian cells to express essential enzymes, allowing for the production of structurally diverse HMOs with potential applications in infant nutrition.
The University of Tennessee has received a $20 million NSF grant to establish ATHENA, a national network of AI-powered laboratories for accelerating scientific discovery. The initiative aims to revolutionize materials discovery by accelerating design, synthesis, characterization and autonomous optimization of advanced materials.
JMIR Publications is sponsoring the upcoming BioMedEng26 conference to promote biomedical engineering innovation. The journal JMIR Biomedical Engineering will be highlighted during the event, with Dr. Javad Sarvestan discussing its focus on cutting-edge engineering applications and peer-review process.
Researchers at Science Tokyo develop a Ramsey-based magnetometer that overcomes thermal limitations, enabling close-proximity detection of weak biomagnetic signals. The sensor achieves high sensitivity and safe operation near biological tissue.
Researchers developed an AI platform, PeptiVerse, to predict key properties of peptides, enabling early assessment of drug potential. The open-source platform allows users to evaluate ordinary and chemically modified peptides, streamlining the discovery process.
Researchers expand potential of using bacterial spores for chemical reactions, biofuel production, and pollutant breakdown. New proteins fused to spore coat enable storage under extreme conditions without refrigeration.
Researchers identified a precise gene edit that lowers cadmium in rice grains while maintaining yield and essential mineral nutrients. The OsNramp5 I441T mutation selectively limits cadmium translocation, reducing grain cadmium by 48% without compromising zinc or manganese uptake.
Researchers analyzed 49 journal articles on bacterial cellulose-derived carbon electrodes for supercapacitors, finding that preservation of the nanofiber network and mechanical properties are crucial for performance. The study highlights BCC's potential to outperform commercial activated carbon under comparable conditions.
Researchers at MIT have created a precise way to engineer artificial blood vessels by mechanically stretching and pulling a "blood vessel on a chip". The new method, reported in the Proceedings of the National Academy of Sciences, enables controlled sprouting of new vessels and programming of their growth patterns.
Reducing carbon dioxide concentration improves microbial production of biodegradable plastic, such as poly[(R)-3-hydroxybutyrate]. Lower CO2 levels trigger adaptive cellular responses that enhance carbon utilization efficiency.
Researchers developed nanoparticles that retain their protective coating in normal tissue but shed it upon reaching tumor tissue, releasing anticancer drugs. This technology reduces systemic side effects and enhances treatment efficacy.
Researchers developed an AI model to optimize water usage in agriculture and semiconductor manufacturing. The model identifies cause-and-effect relationships between water availability, crop needs, and industrial expansion, generating recommendations for each state.
The Institute for Bioengineering of Catalonia (IBEC) will participate in the ALIVE program, a six-year European grant focusing on the physics of living matter. The project aims to understand how tissues behave by measuring and modeling information flows.
Researchers developed an aerated hydrogel that allows air to pass through while maintaining its water content. This breakthrough enables longer-lasting products, such as breathable bandages, implants, and wearable sensors, with improved skin comfort and reduced sweat buildup.
Scientists have identified the genetics of caddisflies' evolutionary superpower, which involves a gene that produces a main protein in silk. The study found remarkable heterogeneity in those genes among individuals from two nearby wild populations, highlighting how nature modifies this bioadhesive material while preserving its performa...
A new study explores an FMQA-based optimization framework for RNA design, revealing that encoding matters in achieving optimal results. The approach identifies high-quality RNA sequence candidates with relatively few evaluations, outperforming competing methods.
A new study suggests that pairing iron and manganese modified biochar with carefully chosen irrigation strategies can reduce cadmium and mercury buildup in rice. FMBC helped stabilize both metals while reshaping microbial processes to control methylmercury formation.
A new gene circuit technology has enabled cells to autonomously generate programmed responses, processing multiple molecular signals at once. The RATEX platform allows cells to compute and respond to various types of molecular information.
Researchers developed a physics-informed neural network approach to predict material properties and optimize controlled-release systems. The new method requires significantly less data than traditional AI models, slashing development time for patches, bandages, and implants.
A team from Technical University of Munich developed a DNA switch that can be controlled quickly and precisely, and operates reliably over extended periods. The switch demonstrates two potential applications: controlling optical signals and chemical reactions.
The University of Pittsburgh's DPT-PhD Bioengineering Program has been awarded a five-year NIH T32 training grant. The program, co-directed by Rakié Cham and Patrick Sparto, supports students in integrating physical therapy education with bioengineering research training.
Researchers create custom-fit prosthetic hands with soft magnetic sensors that capture subtle changes in muscle shape and pressure. The system performs consistently and reliably, translating intent into control of a dexterous robotic hand with up to 90% accuracy.
A new imaging technology at UH helps scientists study exosomes, tiny particles released by human cells that may be targets for diseases. The technology uses advanced lighting at the nanoscale to analyze exosomes one at a time, measuring features to pinpoint good drug targets.
New research reveals that asthma attacks cause overproduction of extracellular proteins and growth of blood vessels in the airways. Over time, these changes lead to constriction of breathing passages, resulting in long-term respiratory issues.
Hanyang University researchers developed AI-guided microneedle patches that actively change shape at physiological temperature to help close wounds while delivering regenerative therapy and antibacterial protection. The platform accelerates wound closure and improves tissue regeneration compared with conventional approaches.
Researchers developed a robotic system inspired by social insects to optimize mining operations. The honeybee-inspired approach outperformed others in tests, reducing travel distance by up to 80% and completing ore delivery tasks 60% faster.
A new wearable monitoring system called OMEGA aims to replace outdated fetal heart rate monitoring technology with a unified real-time assessment of fetal oxygen delivery and adaptive capacity. The system could potentially reduce C-section rates and improve maternal and fetal health outcomes, saving millions in healthcare costs.
Researchers found that the frontal cortex dynamically shifts attention between auditory and visual inputs to make sense of multilingual film scenes. The study suggests that the brain has an organized map for handling different types of information during real-world experiences.
Researchers developed an injectable hydrogel combining silk proteins and a kudzu plant compound, achieving complete wound closure within 72 hours. The material's mechanical stability and cell viability exceeded expectations.
Scientists at the University of Colorado Boulder discovered a seaweed-based ingredient that can bind earthen materials like clay and sand, making them 3D-printable. The biopolymer, sodium alginate, produces materials that are strong and printable, reducing environmental impact.
A research team has created a comprehensive map of how the anti-aging protein Klotho operates in distinct regions of the kidney, resolving long-standing scientific uncertainties. The study reveals that different kidney tubule segments carry out fundamentally different aspects of Klotho biology.
A Harvard-led team has demonstrated synthesizing 64 distinct DNA sequences on a silicon chip in parallel using a water-based enzymatic process. This breakthrough sets a new benchmark for parallel DNA synthesis and paves the way for smaller, safer, and more accessible DNA-writing instruments.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
Researchers developed a new biomaterial that forms faster and is more durable than natural blood clots, with potential applications in traumatic injuries and emergency medicine. The engineered clots can support tissue healing and reduce inflammation, offering great potential for wound healing and trauma care.
A new study published in Advanced Science shows that a programmable device can close complex wounds quickly, improving wound healing. The device uses customizable force to adapt to different wound shapes, promoting blood flow, nutrient delivery, and reduced scarring.
Researchers at RCSI University of Medicine and Health Sciences have developed an artificial model of the mitral heart valve that faithfully mimics its complex mechanical behavior. The study could help researchers better understand valve disease and develop new treatment approaches.
A new study has analyzed over 2100 samples to build a genetic dataset containing more than 500 million unique genes, revealing the immense potential of deep-sea biodiversity for developing new technologies. The research found that despite vast genetic diversity, deep-sea organisms rely on stable, core designs to survive extreme conditi...
A POSTECH research team developed a haptic device that can operate inside MRI scanners, enabling the measurement of brain activity during VR experiences. The study found that adding tactile feedback increased brain activation in areas responsible for motor control, attention, and cognitive processing.
A new study reveals that IS110 elements use two RNA-guided pathways to insert donor DNA into target sites, challenging the classical 'cut-out-paste-in' model. The researchers identified a figure-eight DNA intermediate in one pathway and a direct-transfer pathway without forming a conventional intermediate.
Researchers at NYU developed a 3-D printed stent, called the Lily stent, which can drain faster and cut costs for treating gastric leaks after weight-loss surgery. The stent's unique shape creates more effective routes for fluid to move around it, improving drainage performance.
Researchers at TUM have developed a protein-based sensor that can detect magnetic fields and be controlled by radio waves. This technology has great potential for near-term biotechnological applications, including biological quantum sensors and radio wave-controlled cell activity.
Researchers at MIT have created a pacemaker that uses ultrasound technology to stimulate the heart, offering a potential surgery-free alternative to traditional cardiac implants. The device is designed as a small sticker that sends ultrasound pulses through the chest to regulate heart contractions and correct arrhythmias.
A European research team is developing bacteria that can produce important chemical base materials from sustainable methanol, aiming to replace fossil resources in the chemical industry. The goal is to make chemical production more sustainable without jeopardizing food security.