Articles tagged with Bioengineering
A team at Westlake University developed a high-throughput platform for engineering fast-acting covalent protein therapeutics, overcoming a fundamental limitation in the field. The platform enables rapid and irreversible target engagement with improved efficacy and safety.
A team of researchers, led by Bistra Iordanova and Liang Zhan, are developing multiscale models of brain metabolism to predict cognitive decline and dementia. They will analyze data from brain imaging, blood flow, and neural activity to identify metabolic changes that affect brain function in aging.
A five-year field study shows that small, repeated additions of biochar combined with water-saving irrigation can significantly reduce methane emissions from rice paddies over time while maintaining strong crop yields. Continuous application maintained and strengthened methane reduction, producing net negative emissions in some cases.
Researchers found that combining biochar with beneficial bacteria significantly improves phosphorus availability, reshaping plant development and increasing crop yields in greenhouse-grown cherry tomatoes. The study also showed that this approach can enhance soil fertility and crop productivity without increasing fertilizer inputs.
Aging is redefined as a systems-level failure rather than molecular defects, highlighting the need for coordinated modulation of biological networks. The International Conference on Targeting Longevity 2026 explores new translational strategies and industrial opportunities by focusing on resilience.
Researchers are developing snail-inspired soft robots to deliver targeted therapy directly to tumor sites in bowel cancer patients. The robots aim to increase drug bioavailability and reduce off-target toxicity., Transforming colorectal cancer treatment by enabling precise drug release at tumour sites.
The Hybrid Oxygenation Bioelectronics system, or HOBIT, shields cells from the immune system while providing access to oxygen and nutrients. The compact device supports higher cell densities in a smaller space, enabling the production of multiple biologic molecules simultaneously.
The latest SLAS Technology volume showcases how AI, automation, and portable technologies are transforming drug discovery and diagnostics. This advancement enables the development of innovative therapeutic solutions and improved patient care.
A new study by Beijing University of Chemical Technology proves that feeding methane to bacteria outperforms traditional soy and fish meal in both ecological savings and financial returns. The bacterial alternative eliminates the need for arable land and fresh water, effectively halting deforestation and marine depletion.
Researchers redesigned a key component of lipid nanoparticles to steer particles toward lymph nodes, reducing off-target delivery. This advancement could make mRNA vaccines more efficient, potentially achieving strong immune protection at lower doses.
Health Engineering combines engineering principles with life sciences to address pressing global health challenges, focusing on prevention, precision intervention, and long-term health maintenance. The journal publishes interdisciplinary research across various fields, including biomaterials, synthetic biology, and precision medicine.
Southwest Research Institute's new facility supports pharmaceutical development, bioengineering research, and streamlined clinical supply production. The facility enhances regulatory efficiency, quality systems, and communication between scientists.
Researchers developed a novel composite material that combines biochar, carbon nanotubes, and iron carbide, significantly accelerating the breakdown of antibiotics in water. The system achieved up to 15 times higher removal rates compared to conventional materials, while requiring substantially less energy.
Researchers developed in vitro and in vivo models to track cartilage-to-bone transition, identifying key signaling pathways and transcription factors involved. The study found that some cartilage cells can transition into bone-like cells, challenging the traditional view of bone cell origin.
Researchers developed Neuronal Type Assignment from Connectivity (NTAC) to accurately assign neuronal cell types based on synaptic wiring patterns. NTAC outperformed traditional morphology-based approaches in identifying neuron types, especially in complex brain regions.
Researchers developed a specially engineered biochar made from sewage sludge that significantly enhances plant growth when combined with beneficial bacteria. The biochar-bacteria combination improved nitrogen cycling and increased the abundance of beneficial soil microbes, leading to greater plant nutrition and growth.
A new study reveals that transforming biomass from dedicated energy crops into biochar could provide a cost-effective and scalable solution for removing carbon dioxide from the atmosphere, helping China move closer to its carbon neutrality goals. Biochar can lock carbon in soils for decades or even centuries while improving soil health.
Researchers at Rice University developed a safe bioelectronic sensor using naturally occurring polymer chitosan to effectively communicate with bacteria. The system uses a hydrogel to trap bacteria near an electrode, generating a stable electronic current when exposed to target substances.
A new study identifies a previously unknown brainstem pathway controlling hand and arm movements, revealing a multi-stage pathway integrating signals from the cortex, brainstem, and spinal networks. This finding may lead to new therapies for stroke rehabilitation, providing additional targets for neuromodulation treatments.
Recent advances in photonic nanomaterials and healthcare devices have led to the development of wearable and implantable medical devices. These devices utilize light for precise manipulation of cells and tissues, offering new possibilities for early disease detection, light-based therapies, and personalized precision medicine.
A conductive bioglue was developed to ensure firm adhesion and stable electrical signaling within the human body. It overcomes challenges in connecting damaged tissues or attaching bioelectronic devices, promoting muscle and nerve regeneration and stable implant stability.
Researchers create living tissue at near-physiological cell density using a new bioprinting strategy called embedded 3D printing in a cell-dense suspension (EPICS). The method enables the precise fabrication of perfusable channels and dense cellular environments, mimicking real organs.
Researchers developed a new noninvasive brain stimulation technique by combining focused ultrasound with electrical stimulation, producing stronger, targeted brain responses. This approach, called transcranial electro-acoustic stimulation, clarifies conflicting results in the field and introduces a new approach to noninvasive brain sti...
Engineers at the University of Pennsylvania have developed LIBRIS, an automated microfluidic platform capable of generating lipid nanoparticle formulations at high speed and scale. This enables the creation of large, systematic datasets needed to train predictive AI models, accelerating the design of lipid nanoparticles for mRNA delivery.
A novel plant-based approach uses lettuce chloroplasts to produce functional GLP-1 peptides, paving the way for more affordable and better-tolerated oral medications. This method bypasses hurdles such as manufacturing cost, delivery system, and side effects associated with conventional approaches.
Scientists create fluorescent nanoplastics that resemble real-world plastics in morphology, enabling real-time tracking and studying chronic exposure effects. The study reveals that smaller particles retain longer in the body, highlighting the need for further research on health risks due to microplastic ingestion.
A study by MIT researchers found that nitrous oxide can hamper the growth of certain soil bacteria dependent on vitamin B12 for methionine biosynthesis. The findings suggest that N2O production in agricultural settings could influence microbial communities, potentially impacting crop health.
Engineered tissue grafts can take on the liver's function and help patients with liver failure. The injected cells remain viable in the body for at least two months, generating enzymes and proteins like normal hepatocytes.
A research team from Xi'an Jiaotong University has developed a method to align cells in muscle tissue using electric forces during electrohydrodynamic bioprinting. This breakthrough allows for the creation of living muscle tissues with tightly aligned cells, enabling the production of functional muscle constructs.
Scientists at Institute of Science Tokyo have discovered how LGP2 and MDA5 work together to recognize viral RNA. The study reveals that LGP2 binds to the ends of a dsRNA molecule, recruiting MDA5 molecules behind it and forming filament-like structures, ultimately triggering an innate immune response.
Southwest Research Institute expands manufacturing capabilities to produce safer antidotes to organophosphorus nerve agents and pesticides. The new technique avoids cancer-causing compounds during synthesis of oxime antidotes, supporting kilogram-scale manufacturing for domestic supply and reducing supply chain risks.
Researchers at UTIA and UT Knoxville create an automated sensor network to monitor compost piles, reducing labor costs and improving regulatory compliance. The new system uses battery-free sensors and machine learning algorithms to analyze temperature and moisture variations, enabling data-driven decision making.
Researchers are developing an organ-on-a-chip platform to study immune rejection in pig-to-human liver transplantation, addressing a major hurdle in xenotransplantation. The project aims to generate data supporting future preclinical studies and bring xenotransplantation closer to clinical use.
A new machine learning model interprets leg motion as expended energy, providing a more accurate measure of calories burned. The device has been shown to have double the accuracy of commercial smartwatches and activity trackers.
Researchers at Harvard's John A. Paulson School of Engineering and Applied Sciences have developed a new fabrication method for printing robotic devices with long filaments featuring precisely placed hollow channels. This allows the device to bend and deform in predetermined ways, enabling the creation of soft robots with predictable s...
Researchers at RCSI have developed an RNA-activated implant that delivers growth-promoting particles to injured nerve cells, encouraging them to regrow after spinal cord injury. The implant helps overcome molecular barriers by silencing a gene called PTEN.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
Dr. Bruce Gnade, professor emeritus at the University of Texas at Dallas, has been elected as a member of the National Academy of Engineering for his contributions to advancing electronic materials and semiconductor device technologies. He is also recognized for his leadership in education and workforce development.
Researchers at TUM developed a coating that makes UV-A radiation visible using proteins and bacteria, opening up new possibilities for sustainable materials. The coating, which includes the protein mEosFP, reliably detects contact with UV-A light and can be integrated into paints and coatings without compromising material properties.
Researchers developed a novel CRISPR-based technology called pPro-MobV that can remove antibiotic-resistant elements from bacterial populations. The new tool uses gene-drive thinking and has the potential to combat antibiotic resistance in healthcare settings, environmental remediation, and microbiome engineering.
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
Researchers developed a light-sensitive oligonucleotide probe that selectively detects 5-formylcytosine, an epigenetically important intermediate. The probe demonstrates stable cross-linking with 5fC across various conditions, enabling its detection in target DNA and complex biological samples.
A self-regulating, implantable living technology has been developed to offer hope for millions with diabetes. The implant continuously senses blood-glucose levels, produces insulin within itself, and releases the exact amount needed, eliminating the need for daily injections.
The John Innes Centre has been awarded £21.5m in funding to support four precision breeding projects, aiming to reduce emissions and strengthen crop resilience. These projects will help protect two major agricultural crops from diseases, enhance the nutritional content of tomatoes, and develop sustainable sources of rubber.
The MIT research team has designed a new type of tissue model that accurately replicates the physiology of the liver, including blood vessels and immune cells. The model was used to study metabolic dysfunction-associated steatotic liver disease (MASLD) and showed promising results in identifying potential treatments.
Researchers at the University of Illinois have developed a novel approach to recover native lignin structure in plants, enabling higher yields of valuable materials with lower energy inputs. This breakthrough advances biofuel production by providing a key component for conversion to other valuable products.
A two-step approach to gene expression creates more resilient producers of nanostructures for advanced sensing and therapeutics. This new genetic regulatory system ensures host cells remain healthy while producing functional nanostructures.
Lipid droplets regulate diverse cellular processes in cancer, including membrane biosynthesis and metabolic homeostasis. Targeting lipid metabolism may disrupt tumor survival and counteract immune cell-mediated protumorigenic effects.
Researchers have developed a flexible, hair-like device that tracks vital signs of a fetus in real-time during surgery. This innovation provides continuous monitoring without invasive access, enabling faster interventions to prevent complications.
Protein Foundation Models (pFMs) leverage vast amounts of sequence and structural data to predict protein structures and functions, enabling novel protein design and analysis. The models have evolved into several mature technical approaches, demonstrating versatility in basic biological research, protein discovery, and biomedical appli...
Researchers at the University of Oxford have created magneto-sensitive fluorescent proteins that can interact with magnetic fields and radio waves. The breakthrough uses quantum mechanical interactions within proteins to enable practical technologies.
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
A partnership between University of Copenhagen and Danish Technical University aims to improve Europe's resilience and competitiveness by boosting innovation. The initiative seeks to develop the innovation ecosystem, drive urban development, and attract talent, companies, and investors.
Researchers developed a new technique called CLASSIC that enables large-scale testing of complex DNA circuits in human cells. The approach uses artificial intelligence and machine learning to analyze vast numbers of complete circuits at once, providing scientists with a clearer picture of the rules governing genetic part behavior.
A Japanese research team has developed a biohybrid approach that works inside the body, transforming engineered skin into a visible indicator of internal biological states. The system leverages the body's natural skin regeneration to support long-term biomarker monitoring, providing a visual readout without blood sampling.
A Carnegie Mellon-led team has secured a $28.5 million award from ARPA-H to develop a functional, 3D bioprinted liver for patients with acute liver failure. The project aims to provide a temporary liver that supports regeneration of a patient's own liver, reducing the need for full organ transplants.
A study at Kindai University has identified a single gene in eggplant that provides resistance to begomovirus infection. This finding holds promise for developing naturally protected crop varieties, reducing the need for insecticides and promoting sustainable food production.
Researchers discover giant virus that infects amoeba, providing further support for nuclear virus origin hypothesis. The new virus, ushikuvirus, has distinct features and unique caps on its surface, which may hold clues to the evolution of complex cells.
A research team led by NTU Singapore has recorded a tiny mechanical twitch in living human and rodent eyes when rod photoreceptors detect light. This breakthrough could provide a new non-invasive way to assess retinal health and diagnose blinding eye diseases earlier.
Researchers at Stanford University have created a flexible material that can change color and texture like an octopus in a matter of seconds, with patterns finer than a human hair. The material uses electron-beam patterning to control topography and visual properties at the nanoscale, opening up opportunities for dynamic camouflage, we...