Articles tagged with Bioengineering
Scientists at Institute of Science Tokyo have discovered how LGP2 and MDA5 work together to recognize viral RNA. The study reveals that LGP2 binds to the ends of a dsRNA molecule, recruiting MDA5 molecules behind it and forming filament-like structures, ultimately triggering an innate immune response.
Researchers are developing an organ-on-a-chip platform to study immune rejection in pig-to-human liver transplantation, addressing a major hurdle in xenotransplantation. The project aims to generate data supporting future preclinical studies and bring xenotransplantation closer to clinical use.
Southwest Research Institute expands manufacturing capabilities to produce safer antidotes to organophosphorus nerve agents and pesticides. The new technique avoids cancer-causing compounds during synthesis of oxime antidotes, supporting kilogram-scale manufacturing for domestic supply and reducing supply chain risks.
Researchers at UTIA and UT Knoxville create an automated sensor network to monitor compost piles, reducing labor costs and improving regulatory compliance. The new system uses battery-free sensors and machine learning algorithms to analyze temperature and moisture variations, enabling data-driven decision making.
Researchers at Harvard's John A. Paulson School of Engineering and Applied Sciences have developed a new fabrication method for printing robotic devices with long filaments featuring precisely placed hollow channels. This allows the device to bend and deform in predetermined ways, enabling the creation of soft robots with predictable s...
A new machine learning model interprets leg motion as expended energy, providing a more accurate measure of calories burned. The device has been shown to have double the accuracy of commercial smartwatches and activity trackers.
Researchers at RCSI have developed an RNA-activated implant that delivers growth-promoting particles to injured nerve cells, encouraging them to regrow after spinal cord injury. The implant helps overcome molecular barriers by silencing a gene called PTEN.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
Dr. Bruce Gnade, professor emeritus at the University of Texas at Dallas, has been elected as a member of the National Academy of Engineering for his contributions to advancing electronic materials and semiconductor device technologies. He is also recognized for his leadership in education and workforce development.
Researchers at TUM developed a coating that makes UV-A radiation visible using proteins and bacteria, opening up new possibilities for sustainable materials. The coating, which includes the protein mEosFP, reliably detects contact with UV-A light and can be integrated into paints and coatings without compromising material properties.
Researchers developed a novel CRISPR-based technology called pPro-MobV that can remove antibiotic-resistant elements from bacterial populations. The new tool uses gene-drive thinking and has the potential to combat antibiotic resistance in healthcare settings, environmental remediation, and microbiome engineering.
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
Researchers developed a light-sensitive oligonucleotide probe that selectively detects 5-formylcytosine, an epigenetically important intermediate. The probe demonstrates stable cross-linking with 5fC across various conditions, enabling its detection in target DNA and complex biological samples.
A self-regulating, implantable living technology has been developed to offer hope for millions with diabetes. The implant continuously senses blood-glucose levels, produces insulin within itself, and releases the exact amount needed, eliminating the need for daily injections.
The MIT research team has designed a new type of tissue model that accurately replicates the physiology of the liver, including blood vessels and immune cells. The model was used to study metabolic dysfunction-associated steatotic liver disease (MASLD) and showed promising results in identifying potential treatments.
The John Innes Centre has been awarded £21.5m in funding to support four precision breeding projects, aiming to reduce emissions and strengthen crop resilience. These projects will help protect two major agricultural crops from diseases, enhance the nutritional content of tomatoes, and develop sustainable sources of rubber.
Researchers at the University of Illinois have developed a novel approach to recover native lignin structure in plants, enabling higher yields of valuable materials with lower energy inputs. This breakthrough advances biofuel production by providing a key component for conversion to other valuable products.
A two-step approach to gene expression creates more resilient producers of nanostructures for advanced sensing and therapeutics. This new genetic regulatory system ensures host cells remain healthy while producing functional nanostructures.
Lipid droplets regulate diverse cellular processes in cancer, including membrane biosynthesis and metabolic homeostasis. Targeting lipid metabolism may disrupt tumor survival and counteract immune cell-mediated protumorigenic effects.
Researchers have developed a flexible, hair-like device that tracks vital signs of a fetus in real-time during surgery. This innovation provides continuous monitoring without invasive access, enabling faster interventions to prevent complications.
Researchers at the University of Oxford have created magneto-sensitive fluorescent proteins that can interact with magnetic fields and radio waves. The breakthrough uses quantum mechanical interactions within proteins to enable practical technologies.
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
Protein Foundation Models (pFMs) leverage vast amounts of sequence and structural data to predict protein structures and functions, enabling novel protein design and analysis. The models have evolved into several mature technical approaches, demonstrating versatility in basic biological research, protein discovery, and biomedical appli...
A partnership between University of Copenhagen and Danish Technical University aims to improve Europe's resilience and competitiveness by boosting innovation. The initiative seeks to develop the innovation ecosystem, drive urban development, and attract talent, companies, and investors.
Researchers developed a new technique called CLASSIC that enables large-scale testing of complex DNA circuits in human cells. The approach uses artificial intelligence and machine learning to analyze vast numbers of complete circuits at once, providing scientists with a clearer picture of the rules governing genetic part behavior.
A Carnegie Mellon-led team has secured a $28.5 million award from ARPA-H to develop a functional, 3D bioprinted liver for patients with acute liver failure. The project aims to provide a temporary liver that supports regeneration of a patient's own liver, reducing the need for full organ transplants.
A Japanese research team has developed a biohybrid approach that works inside the body, transforming engineered skin into a visible indicator of internal biological states. The system leverages the body's natural skin regeneration to support long-term biomarker monitoring, providing a visual readout without blood sampling.
A study at Kindai University has identified a single gene in eggplant that provides resistance to begomovirus infection. This finding holds promise for developing naturally protected crop varieties, reducing the need for insecticides and promoting sustainable food production.
Researchers at Stanford University have created a flexible material that can change color and texture like an octopus in a matter of seconds, with patterns finer than a human hair. The material uses electron-beam patterning to control topography and visual properties at the nanoscale, opening up opportunities for dynamic camouflage, we...
Researchers discover giant virus that infects amoeba, providing further support for nuclear virus origin hypothesis. The new virus, ushikuvirus, has distinct features and unique caps on its surface, which may hold clues to the evolution of complex cells.
A research team led by NTU Singapore has recorded a tiny mechanical twitch in living human and rodent eyes when rod photoreceptors detect light. This breakthrough could provide a new non-invasive way to assess retinal health and diagnose blinding eye diseases earlier.
Southwest Research Institute has upgraded its nuclear magnetic resonance (NMR) laboratory to provide robust chemical analysis of organic compounds used in drug discovery and development. The new facility enables rapid and cost-effective analysis using qNMR, which can be more efficient than HPLC for certain applications.
Researchers create a novel mathematical framework to control biological noise, enabling precise single-cell control. The 'Noise Robust Perfect Adaptation' technology suppresses stochastic fluctuations while maintaining stable average behavior, with promising applications in cancer therapy and synthetic biology.
Researchers at the University of Arizona developed a mesh sleeve that monitors leg movements using AI to detect early warning signs of frailty. The device sends only the analyzed results, reducing transmission and internet requirements.
Researchers outline breakthrough strategies to address poor infiltration of CAR-T cells into solid tumor microenvironments. Vascular normalization and chemokine modulation enhance T cell penetration, while combination therapies with chemotherapy and oncolytic viruses amplify results.
Researchers have developed ultrafine 3D printing nozzles inspired by mosquito feeding tubes, which can produce complex structures with high precision. This innovative technology has the potential to transform various industries, including manufacturing and biomedical engineering, by providing an environmentally friendly alternative.
Researchers at TU Wien developed a 3D bioprinting technique to create living biological tissue for studying skin diseases. The method offers a controlled and highly reproducible manner to produce tailor-made structures for different purposes, such as psoriasis and inflammatory models.
Researchers propose a new design approach for intracortical electrodes that can record from many neurons at once without damaging them. The authors outline various manufacturing approaches, including advanced silicon micromachining and thermal fiber drawing, to create flexible devices with low stiffness.
Researchers at TUM developed a new method that allows for direct analysis of urine to determine antibiotic resistance in urinary tract infections. The test reduces the time to result by up to 24 hours compared to conventional testing, enabling healthcare providers to prescribe more targeted treatments.
Researchers discover RFP's role in adipogenesis, a process that forms fat-storing cells. The study found that high RFP levels promote easy fat cell formation and weight gain, while low levels resist weight gain.
Researchers have created a novel synthetic enzyme that efficiently converts CO2 into formic acid, opening up new possibilities for biotechnological production of valuable chemicals and fuels. The enzyme, FAR, tolerates high concentrations of formate and is stable in both living cells and cell-free systems.
Researchers have developed a method to control protein levels inside different tissues of a whole, living animal for the first time. The technique uses a plant hormone called auxin to precisely regulate protein levels, allowing scientists to study the molecular underpinnings of ageing and disease.
Philip R. Troyk, director of the Pritzker Institute of Biomedical Science and Engineering at Illinois Tech, has been elected as a Fellow of the National Academy of Inventors for his groundbreaking work on neuroprosthetic devices, including an implanted cortical visual prosthesis that provides artificial vision to individuals with profo...
Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.
Researchers at NYU Abu Dhabi have developed Spheromatrix, a platform that enables tumor models to be grown, frozen and stored for future use in cancer drug testing. The technology is made from specially engineered filter paper patterned to support the growth of tumor spheroids in a controlled manner.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
A new study used deep learning and large-scale computer simulations to identify structural differences in synthetic cannabinoid molecules that cause them to bind to human brain receptors differently from classical cannabinoids. Researchers found that these substances often trigger the beta arrestin pathway, leading to more severe psych...
Researchers are formulating and evaluating an intranasal oxytocin delivery system to treat post-traumatic stress disorder (PTSD). The project aims to enhance the efficacy and palatability of existing treatments, expanding on prior research that explored using oxytocin to treat alcoholism.
Researchers at Science Tokyo have developed a tunable deterministic lateral displacement (DLD) cell-sorting platform using poly(N-isopropylacrylamide) hydrogel arrays. The device sorts cancer cells of defined sizes from blood samples with high-resolution size-based sorting, offering a promising tool for biomedical applications.
The University of Texas at Arlington and TEES launched a new biomanufacturing training and research hub in Dallas, providing hands-on training and state-of-the-art lab space. The National Center for Therapeutics Manufacturing satellite campus strengthens North Texas' biotech workforce and expands research opportunities.
Christina Tringides' CHAMELEON project aims to develop soft, sensor-laden brain implants that can monitor and treat glioblastoma with greater precision. Her lab creates hydrogel-based arrays with conductive electrodes to track neural signals in real-time.
Researchers at Rice University have developed a way to make serum markers more sensitive by editing them inside the bloodstream, enabling clearer observation of gene-expression changes in the brain. This approach could lead to more precise diagnostic capabilities using simple blood tests.
The team created a specialized two-dimensional thin film dielectric designed to replace traditional heat-generating components in integrated circuit chips. This breakthrough aims to reduce the significant energy cost and heat produced by high-performance computing necessary for AI.
MIT engineers developed artificial tendons made from hydrogel to connect lab-grown muscles with robotic skeletons. The tendons improved the robot's motion and force output by three times, enabling faster and more efficient biohybrid robots.
A new study suggests that sweat can reveal information about a person's health, including hormone levels, medication doses, and early detection of diseases like diabetes and cancer. Wearable sensors using artificial intelligence can detect specific metabolites in sweat, providing personalized health insights.
Researchers created a miniaturized replica of carotid arteries using 3D printing, mimicking the geometry and fluid dynamics of human blood vessels. The model revealed that platelet movement is crucial in blood clot formation, and high stress on blood vessels triggers significant platelet activity.
Researchers at Technion-Israel Institute of Technology identify a unique mechanism in the aging of the immune system and propose a framework for improving its function in older individuals. Controlled iron supplementation has been shown to improve T-cell activation and enhance the immune response in elderly mice.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
A new study could unlock the creation of brand new materials with promising biomedical applications, including smart drug delivery systems and targeted therapies. Researchers used a simple mathematical model to balance competing forces and predict the same arrangements across different materials.
Researchers have summarized recent breakthroughs in theranostic nanomaterials, engineered nanoparticles that can both diagnose and treat TBI. These materials can deliver drugs precisely where damage occurs while monitoring biological changes inside the brain.