Articles tagged with Bioengineering
Southwest Research Institute has upgraded its nuclear magnetic resonance (NMR) laboratory to provide robust chemical analysis of organic compounds used in drug discovery and development. The new facility enables rapid and cost-effective analysis using qNMR, which can be more efficient than HPLC for certain applications.
Researchers create a novel mathematical framework to control biological noise, enabling precise single-cell control. The 'Noise Robust Perfect Adaptation' technology suppresses stochastic fluctuations while maintaining stable average behavior, with promising applications in cancer therapy and synthetic biology.
Researchers outline breakthrough strategies to address poor infiltration of CAR-T cells into solid tumor microenvironments. Vascular normalization and chemokine modulation enhance T cell penetration, while combination therapies with chemotherapy and oncolytic viruses amplify results.
Researchers have developed ultrafine 3D printing nozzles inspired by mosquito feeding tubes, which can produce complex structures with high precision. This innovative technology has the potential to transform various industries, including manufacturing and biomedical engineering, by providing an environmentally friendly alternative.
Researchers at the University of Arizona developed a mesh sleeve that monitors leg movements using AI to detect early warning signs of frailty. The device sends only the analyzed results, reducing transmission and internet requirements.
Researchers at TU Wien developed a 3D bioprinting technique to create living biological tissue for studying skin diseases. The method offers a controlled and highly reproducible manner to produce tailor-made structures for different purposes, such as psoriasis and inflammatory models.
Researchers propose a new design approach for intracortical electrodes that can record from many neurons at once without damaging them. The authors outline various manufacturing approaches, including advanced silicon micromachining and thermal fiber drawing, to create flexible devices with low stiffness.
Researchers at TUM developed a new method that allows for direct analysis of urine to determine antibiotic resistance in urinary tract infections. The test reduces the time to result by up to 24 hours compared to conventional testing, enabling healthcare providers to prescribe more targeted treatments.
Researchers have created a novel synthetic enzyme that efficiently converts CO2 into formic acid, opening up new possibilities for biotechnological production of valuable chemicals and fuels. The enzyme, FAR, tolerates high concentrations of formate and is stable in both living cells and cell-free systems.
Researchers discover RFP's role in adipogenesis, a process that forms fat-storing cells. The study found that high RFP levels promote easy fat cell formation and weight gain, while low levels resist weight gain.
Researchers have developed a method to control protein levels inside different tissues of a whole, living animal for the first time. The technique uses a plant hormone called auxin to precisely regulate protein levels, allowing scientists to study the molecular underpinnings of ageing and disease.
Philip R. Troyk, director of the Pritzker Institute of Biomedical Science and Engineering at Illinois Tech, has been elected as a Fellow of the National Academy of Inventors for his groundbreaking work on neuroprosthetic devices, including an implanted cortical visual prosthesis that provides artificial vision to individuals with profo...
A new study used deep learning and large-scale computer simulations to identify structural differences in synthetic cannabinoid molecules that cause them to bind to human brain receptors differently from classical cannabinoids. Researchers found that these substances often trigger the beta arrestin pathway, leading to more severe psych...
Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.
Researchers at NYU Abu Dhabi have developed Spheromatrix, a platform that enables tumor models to be grown, frozen and stored for future use in cancer drug testing. The technology is made from specially engineered filter paper patterned to support the growth of tumor spheroids in a controlled manner.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Researchers are formulating and evaluating an intranasal oxytocin delivery system to treat post-traumatic stress disorder (PTSD). The project aims to enhance the efficacy and palatability of existing treatments, expanding on prior research that explored using oxytocin to treat alcoholism.
Researchers at Science Tokyo have developed a tunable deterministic lateral displacement (DLD) cell-sorting platform using poly(N-isopropylacrylamide) hydrogel arrays. The device sorts cancer cells of defined sizes from blood samples with high-resolution size-based sorting, offering a promising tool for biomedical applications.
Christina Tringides' CHAMELEON project aims to develop soft, sensor-laden brain implants that can monitor and treat glioblastoma with greater precision. Her lab creates hydrogel-based arrays with conductive electrodes to track neural signals in real-time.
The University of Texas at Arlington and TEES launched a new biomanufacturing training and research hub in Dallas, providing hands-on training and state-of-the-art lab space. The National Center for Therapeutics Manufacturing satellite campus strengthens North Texas' biotech workforce and expands research opportunities.
The team created a specialized two-dimensional thin film dielectric designed to replace traditional heat-generating components in integrated circuit chips. This breakthrough aims to reduce the significant energy cost and heat produced by high-performance computing necessary for AI.
Researchers at Rice University have developed a way to make serum markers more sensitive by editing them inside the bloodstream, enabling clearer observation of gene-expression changes in the brain. This approach could lead to more precise diagnostic capabilities using simple blood tests.
A new study suggests that sweat can reveal information about a person's health, including hormone levels, medication doses, and early detection of diseases like diabetes and cancer. Wearable sensors using artificial intelligence can detect specific metabolites in sweat, providing personalized health insights.
MIT engineers developed artificial tendons made from hydrogel to connect lab-grown muscles with robotic skeletons. The tendons improved the robot's motion and force output by three times, enabling faster and more efficient biohybrid robots.
Researchers created a miniaturized replica of carotid arteries using 3D printing, mimicking the geometry and fluid dynamics of human blood vessels. The model revealed that platelet movement is crucial in blood clot formation, and high stress on blood vessels triggers significant platelet activity.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
Researchers at Technion-Israel Institute of Technology identify a unique mechanism in the aging of the immune system and propose a framework for improving its function in older individuals. Controlled iron supplementation has been shown to improve T-cell activation and enhance the immune response in elderly mice.
A new study could unlock the creation of brand new materials with promising biomedical applications, including smart drug delivery systems and targeted therapies. Researchers used a simple mathematical model to balance competing forces and predict the same arrangements across different materials.
Researchers have summarized recent breakthroughs in theranostic nanomaterials, engineered nanoparticles that can both diagnose and treat TBI. These materials can deliver drugs precisely where damage occurs while monitoring biological changes inside the brain.
The partnership designates JMIR Bioinformatics and Biotechnology as the official journal of MCBIOS, ensuring high-visibility publication of cutting-edge bioinformatics research. The agreement also provides benefits such as a discount on article processing fees and virtual education and training for MCBIOS members.
A nonsurgical approach has been demonstrated to quiet a specific brain circuit in an animal model by delivering engineered gene therapy only to the targeted region. The method uses low-intensity focused ultrasound to open the blood-brain barrier, allowing precise control over brain activity without impacting off-target areas.
Researchers developed a novel exoskeleton CASIA-EXO with subject-adaptive control, enabling efficient motor relearning and enhancing neural plasticity. The system uses intention-based trajectory planning and performance-based intervention adaptation to individualize training trajectories and intervention levels.
Researchers at UTA are exploring the potential of zinc to protect and regenerate muscle tissue damaged by trauma, with a focus on reducing secondary damage. The study uses a zinc-infused gel to promote muscle regeneration following blast injuries and aims to identify a safe and convenient way to apply zinc directly to muscle tissue.
Researchers uncover tandem allosteric effect enabling efficient deacetylation of proteins by Sir2, a key enzyme for biological processes. This finding reveals new target for modulating Sir2, potentially leading to novel cancer treatments and therapeutic applications.
The BioHub aims to complete over 24 pilot projects, train over 500 individuals, and create 3,000 new jobs within three years. Powered by breakthroughs in genetics, genomics, process engineering, and artificial intelligence, Central Massachusetts is poised to lead a new era of biology-based manufacturing.
A team of plant biotechnologists at Texas Tech University has developed a groundbreaking method to accelerate crop creation, bypassing the time-consuming process of tissue culture. The new technique enables plants to grow new shoots directly from wounded tissue, eliminating the need for traditional lab-based regeneration steps.
Binghamton University scientists have developed a novel bioelectronics material that combines living liquid metal with electrogens to create next-generation devices. This innovation has the potential to revolutionize fields such as biomedical sensing and device integration.
Researchers have identified iron-manganese alloys as promising candidates for temporary bone fixation. These alloys combine strength, biocompatibility, and degradation properties, allowing them to support bone healing while degrading naturally. However, challenges remain, including controlling the release of manganese, which can pose t...
A new study published in the Chinese Neurosurgical Journal explores an AI tool that identifies medulloblastoma subgroups based on magnetic resonance imaging scans. The model achieved impressive accuracy in predicting molecular subtypes and genetic risk factors, with 91% accuracy for TP53 mutations and 87% accuracy for chromosome 11 loss.
Researchers at MIT developed microscopic, wireless bioelectronics that can identify and travel to specific brain regions without human guidance. These implants provide focused treatment for brain diseases like Alzheimer's and multiple sclerosis by wirelessly powering electrical stimulation in precise areas.
Research from Michigan Medicine uncovers connections between a longevity gene, behavior, and environment, suggesting that manipulating stress responses could extend life without downsides. Touch activates a circuit modulating signals to reduce the longevity effect of dietary restriction.
Advanced molecular dynamics simulations model complex RNA structures with high accuracy, enabling potential applications in RNA-based therapies and drug design. The study successfully simulated the folding of diverse RNA stem loops, revealing a distinct folding pathway for challenging motifs.
Researchers used smartphones to track patients with neuromuscular diseases, achieving results comparable to traditional movement tests. The system detected disease-specific movement patterns, allowing for early diagnosis and treatment.
Researchers developed a gel-like material that mimics the softness and microstructure of slow-twitch muscle tissue, successfully cultivating cells with genetic and metabolic traits of slow-twitch fibers. The technology has far-reaching implications for regenerative medicine, drug screening, and muscle transplantation therapies.
A UT Dallas team developed an electrochemical biosensor that accurately identifies eight volatile organic compounds linked to thoracic cancers. AI analysis enhances the accuracy of breath samples, showing promise for early lung cancer detection and improved patient outcomes.
Researchers have developed bio-hydrovoltaic technology that converts low-grade thermal energy into electricity through dynamic biological processes. This technology offers unique advantages, including self-regulation, biodegradability, and low maintenance costs.
Global experts discuss the future of additive manufacturing in various applications, including bioprinting living tissues and creating smart consumer products. Researchers showcase advancements in machine learning, real-time sensing, and multi-material 3D printing.
Researchers have developed bioelectronic hydrogels made from conducting polymer microparticles that can be injected into the body or used as injectable therapies. The material has the potential to emulate properties of the body and leverage its functions for more sophisticated ways of doing it.
The partnership creates a stable, high-impact venue for MCBIOS members to publish their research, particularly the output from the Society's annual conference. The designation of JMIR Bioinformatics and Biotechnology as the official journal provides maximum visibility for cutting-edge work in bioinformatics and computational biology.
Researchers at the University of Missouri are exploring the use of extracellular vesicles to target lung cancer. By manipulating these tiny messenger particles, scientists can deliver specific instructions to kill cancer cells while sparing healthy ones.
Researchers developed a generative AI model, BIGE, to generate optimal motions for athletes to avoid injuries and aid in rehabilitation. The model can produce realistic videos of motions that athletes can mimic during training or execute while injured.
Scientists have characterized lipid nanoparticles' internal shape and structure, which correlates with how well they deliver therapeutic cargo. The research provides a blueprint for engineering more effective RNA therapies by matching LNP designs to specific therapies and tissues.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
Researchers used a new high-resolution mapping technique to find small 3D loops connecting regulatory elements and genes that persist during cell division. These loops strengthen when chromosomes become more compact, potentially helping cells 'remember' interactions from one cell cycle to the next.
Researchers developed a method to trigger magnetic jamming in materials using wireless magnetic fields, enabling reversible and programmable clumping. This technique allows for the creation of structures that can assemble, stiffen, relax, or break apart under magnetic control.
New research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and respond to signals further away in the body. This discovery may help explain the flatworm's extraordinary ability to regenerate and offer clues for developing new ways to replace or repair tissues in humans.
A recent study published in Integrative and Comparative Biology found that bonnethead sharks' skin undergoes significant changes as they mature, with younger sharks having fewer ridges on their denticles. These changes likely improve swimming performance and protect the skin from predators or injuries.
Researchers developed a technology to detach cells from surfaces on demand, reducing waste and improving workflow in industrial processes. The system uses electrochemically generated bubbles to separate cells without damaging them, paving the way for more efficient CO2 absorption and lifesaving cell therapies.
Researchers at MIT have developed a new system that allows for precise control over the expression of synthetic genes in cells. The DIAL system uses a promoter editing mechanism to establish desired protein levels, which can be edited after delivery. This technology has the potential to improve gene therapy and cell reprogramming appli...
Researchers developed a new approach to overcome treatment resistance in aggressive cancers by activating macrophages, a type of immune cell abundant in advanced tumors. The custom anti-αvβ3 antibody triggers powerful anti-tumor responses and is highly selective, making it a potentially safer alternative.