Articles tagged with Biomedical Engineering
Researchers at Washington University in St. Louis developed a new imaging tool that uses optical coherence tomography (OCT) and machine learning to detect and classify cancerous tissue samples with high accuracy. The technique, which was tested on patients in a trial, showed a 93% diagnostic accuracy rate.
PubCaseFinder, a clinical decision support system, has been updated to provide more precise phenotyping and automated differential diagnosis. The new version enables users to filter ranked lists using causative genes, modes of inheritance, and disease names, making it easier for medical professionals to diagnose rare and genetic diseases.
A new photoswitching fingerprint analysis overcomes the sub-10 nm resolution barrier in super-resolution microscopy, enabling the imaging of dynamic interactions with other molecules in cells. This breakthrough reveals molecular functions and architectures at the nanoscale, shedding light on cellular processes such as learning and memory.
A new AI-based dynamic brain imaging technology has been introduced by Carnegie Mellon University, which can map out rapidly changing electrical activity in the brain with high precision and speed. The technology uses deep learning approaches to translate scalp EEG signals back to neural circuit activity without human intervention.
The NIH announced five cash prize winners and four honorable mentions in its Maternal Health Diagnostics Challenge. The winning technologies aim to reduce maternal morbidity and mortality, with a focus on detecting and differentiating common pregnancy-related conditions.
Binghamton University researchers have developed a way to turn CDs into flexible biosensors that can monitor electrical activity in human hearts and muscles, as well as lactate, glucose, pH, and oxygen levels. The sensors are fabricated in 20-30 minutes without toxic chemicals or expensive equipment, costing around $1.50 per device.
Researchers have developed a new quantitative approach to predict and customize site-specific recombination, enabling more efficient genetic and cell therapies. The tool combines high-throughput experiments with machine learning models to control the rate of DNA editing, paving the way for personalized treatment.
The International Vaccine Institute (IVI) has launched a two-week training course for biologics development and manufacturing, targeting low- and middle-income countries. The program aims to enhance local production of vaccines and biologics in LMICs to address vaccine inequity and global pandemic preparedness.
New research by UMass Amherst professor Jinglei Ping demonstrates the use of graphene for electrokinetic biosample processing and analysis, allowing for faster and more efficient detection of biomolecules. This breakthrough enables the creation of smaller lab-on-a-chip devices with improved time and size efficiencies.
Researchers from Rice University, Duke University, Brown University and Baylor College of Medicine developed a magnetic technology to wirelessly control neural circuits in fruit flies. They used genetic engineering to express heat-sensitive ion channels in neurons that control the behavior, and iron nanoparticles to activate the channels.
A Tokyo University of Science study found that fluoride nanoparticles enhance β-sheet formation in amyloid β proteins, a common feature of Alzheimer's disease. The researchers also discovered that surrounding ions can control this process, paving the way for targeted treatments.
A low-cost device can capture 3D images of the retina, cornea, and back of the eye, revolutionizing eye screening and treatment globally. The technology has the potential to detect eye diseases like glaucoma and improve patient care.
Researchers found that cancer cells can move faster and in a specific direction when placed in an environment with optimal stiffness, which challenges previous assumptions. This discovery could lead to new treatments by understanding how cancer cells invade tissues.
Researchers found that despite a powerful brain response to sound during sleep, the level of alpha-beta waves associated with attention and expectation is significantly reduced. This means the brain can analyze auditory input but fails to focus on it, resulting in no conscious awareness.
Researchers from Tokyo University of Science developed novel complex-peptide hybrids that induce programmed cell death in apoptosis-resistant cancer cells through paraptosis. The compounds, syn-6 and anti-6, inhibit cell death by uncoupling mitochondrial calcium uptake and inducing cytoplasmic vacuolization, leading to cell death.
A new machine learning model uses network-based biomarkers to predict patient response to immunotherapy in multiple cancer types, enabling personalized treatment plans. The study improves upon conventional methods, increasing accuracy and benefiting more patients.
Rice University bioscientists have developed a novel approach to control the expression of 'silent' genes in bacteria using CRISPR technology. This strategy could lead to the discovery of new antibiotics and has potential applications in antifungal and anticancer agents, as well as agriculture.
A team of researchers has successfully created complex artificial tissue models, including a full-scale human heart model, using focused rotary jet spinning. This method enables the creation of intricate details and spatially varying alignment, rivaling biological tissues in mechanical behavior.
A team of researchers has developed a microscopic microphone that can detect sound waves by applying polymer materials to microelectro-mechanical systems. The device offers a wider auditory field than human ears and can be easily attached to the skin with a surprisingly small size, recognizing both loud and low-frequency sounds without...
The Wake Forest Institute for Regenerative Medicine has established a research program using organoids and artificial intelligence to study viral threats. The program aims to develop predictive algorithms for medical countermeasures and diagnostics by tracking biochemical changes in 3D organs infected with different viruses.
Researchers at UCSB develop soft, semiconducting carbon-based polymer for reconfigurable logic circuits. The conjugated polyelectrolyte enables flexible and power-efficient electronics, promising a new era in computing systems.
Researchers discovered increased cell cycle activity and proliferation in cardiomyocytes after heart surgery, allowing for remuscularization of the left ventricle. The study identified key genes involved in pathways regulating heart development and cell proliferation.
Researchers developed a bioadhesive containing allantoin and epidermal growth factor to promote wound healing. The study found that the bioadhesive effectively revived skin without sutures, resulting in minimal scarring and hair follicle loss.
A team of researchers has developed an approach to minimize off-target mutations caused by the CRISPR-Cas9 gene-editing tool. The new method, dubbed spacer-nick, uses a modified pair of molecular scissors that make nicks on opposite strands of the DNA at two different points, reducing errors and increasing precision.
University of Missouri researchers develop wearable smart bioelectronic devices, including a 'smart' face mask that can monitor physiological status and detect respiratory problems. The masks also use laser-assisted fabrication to provide breathable soft electronics for better real-time health monitoring.
Researchers found that walking enhances performance on cognitive tasks in 14 participants by increasing frontal brain function, while 12 others showed no improvement. This discovery highlights the flexibility of a healthy brain and has implications for understanding aging and neurological disorders.
Researchers at City University of Hong Kong developed a simple exfoliation method to prepare ultrathin films of small intestine tissues, which exhibit piezoelectricity. The team's findings reveal the hierarchical structure of collagen fibers as the key to generating the piezoelectric effect.
Researchers developed a new medical instrument called CAST-R-HP to diagnose and treat Helicobacter pylori infections. The tool performs rapid pathogen identification, metabolism inhibition-based antimicrobial susceptibility tests, and high-quality single-cell whole-genome sequencing.
Researchers have developed a unique 3D printed system to harvest mesenchymal stem cells from bioreactors, which can be used for various treatments. The system combines microfluidics and 3D printing to process adult stem cells, potentially making stem cell therapies more widely available.
Researchers have developed a new probe to detect Alzheimer's disease biomarkers using near-infrared fluorescence, which may help diagnose the disease early and prevent its progression. The probe binds oligomeric Aβ proteins, a hallmark of Alzheimer's disease, offering a potential alternative to existing treatments.
A NJIT-led team has created an injectable hydrogel designed to recruit dental pulp stem cells and promote tissue growth in teeth after a root canal. The therapy mimics the body's natural growth factor signaling, promoting healing and regeneration of lost tooth pulp.
Deep nerve stimulation using custom-wired electrodes and wireless implantable systems significantly lowers systolic blood pressure by up to 16% in two hours. The technology targets hypertension, a leading cause of death globally, affecting over 1 billion people.
Researchers at CMU propose a new cell delivery method using shrink-wrapped corneal endothelial cells as an alternative to cornea transplant. The technology enables rapid engraftment into intact tissues, showing promise in treating diseases such as cystic fibrosis and heart attack.
A new mathematical model has been developed to reproduce the experimental results of topological change in a partially miscible VF pattern. The researchers successfully incorporated phase separation effects and the Korteweg force into the classical miscible VF model.
Researchers from China have developed a novel bioconjugate that can suppress the growth of K-Ras mutant pancreatic tumors. The conjugate, which targets folate receptors and macropinocytosis, was found to be highly cytotoxic and effective at suppressing tumor growth.
Researchers at the University of Houston have identified blood biomarkers predicting heart disease in lupus patients and urine biomarkers for diagnosing kidney inflammation in children with lupus. These findings hold promise for early preventive measures and improved treatment outcomes.
A team of researchers at University of Zurich successfully transplanted a human liver that was treated in a machine, paving the way for a potential solution to the global organ shortage. The liver was preserved for three days outside the body using a custom-made perfusion machine.
Researchers at TU Wien develop a method to guide individual cells with laser precision, enabling reproducible production of artificial tissue and testing new drugs without animal testing. The technique involves adding special molecules to hydrogel surrounding cells, which become softer and more permeable when activated by a laser beam.
Scientists from Tokyo Medical and Dental University uncover the reason behind titanium implants' excellent biocompatibility, allowing patients to generate less immune response. This breakthrough may lead to safer and less expensive implants for hip replacements and dental procedures.
A Kanazawa University team has identified a DNA aptamer-based molecule that inhibits the CYP24 enzyme, leading to significant antiproliferative activity in cancer cells. This finding suggests that Apt-7 could be a promising lead candidate for anticancer therapy.
Biomedical engineers at Duke University have created a method to scan and image the blood flow and oxygen levels inside a mouse brain in real-time. The new imaging approach breaks long-standing speed and resolution barriers, enabling researchers to uncover insights into neurovascular diseases like stroke, dementia, and acute brain injury.
A new study has shown that Transcatheter Aortic Valve Implantation (TAVI) is just as effective as conventional open-heart surgery in treating severe symptomatic aortic stenosis. The procedure offers a safer and faster recovery for patients, with improved symptoms, functional capacity, and quality of life at 6 weeks.
Researchers have engineered bacteria to act as data loggers, capturing gene activity and metabolic responses in the gut. This allows for non-invasive monitoring of gut health and dietary status, enabling early diagnosis of malnutrition and inflammatory responses.
A novel network analysis technology can pinpoint seizure originating brain regions and predict a patient's seizure outcome before surgery, using only 10 minutes of resting state recordings.
A Tokyo University of Agriculture and Technology research team finds that changes in viscoelastic properties affect flow dynamics differently depending on gel elasticity, leading to a reversal of flow effects. This discovery opens new avenues for controlling flow dynamics using chemical reactions.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
Researchers at Binghamton University have developed a system that kills SARS-CoV-2 viruses using UVC light, with optimal results achieved between 260-280 nanometers. The study's findings provide a scientific basis for standardizing and regulating claims from manufacturers of UV disinfectant devices.
Researchers at Stevens Institute of Technology are developing a low-cost handheld device that can accurately diagnose skin cancers in just a few seconds. The device uses millimeter-wave imaging, which reflects differently on cancerous and healthy tissue, allowing for precise detection.
A new nanofiber-based biodegradable millirobot called Fibot can move in the intestines and release different drugs at anchored positions. Fibot's degradation capability is pH-responsive, allowing for controlled drug release.
Researchers at Lehigh University developed a new method to accurately gauge healing progress of bone fractures using 3D models. The model identifies the cutoff point between soft tissue and bone, allowing for more precise predictions of bone behavior during the healing process.
Researchers developed a 3D imaging technique that captures thin peripheral blood vessels, aiding in diagnosing and treating peripheral vascular diseases. The new modality provides functional diagnostic values for blood supply to tissues without contrast agents.
Researchers have developed a non-invasive imaging method to examine conjunctival goblet cells (CGCs) in live rabbit eyes, which are similar to human eyes. The study found that CGC density decreased with dry eye disease (DED) and recovered over time.
Researchers at Binghamton University have discovered that human skin's unique structure allows it to maximize both durability and flexibility. The team created artificial skin membranes that mimicked the structure of mammalian skin, testing their puncture toughness and deformability.
Researchers at the University of Cincinnati are searching for the ideal exosuit design to reduce muscle load and prevent work-related musculoskeletal disorders. The study found that commercially available exosuits have limitations, with the Auxivo LiftSuit being stiff and uncomfortable during prolonged wear.
An automated nutrition app called eNutri improved participants' healthy diet scores by 6% compared to a control group. The app provides personalized nutrition advice based on evidence and uses a diet scoring system.
Researchers developed a high-performance microscopy system for non-invasive examination of conjunctival goblet cells, allowing for real-time imaging in live animal models and human patients. The system enables high-resolution images of CGCs without causing harm to the subject.
Researchers have engineered a tiny living heart chamber replica to study disease progression and test new treatments. The miniPUMP device mimics the real organ's mechanics, allowing for accurate tracking of how the heart grows in embryos and studying the impact of disease.
A new technology developed by KIT researchers uses polymer membranes coated with titanium dioxide to break down steroid hormones and other micropollutants in wastewater. The process is efficient, removing hormone concentrations close to the World Health Organization's drinking water guideline.
Researchers at Duke University discovered that SARS-CoV-2, the virus causing COVID-19, can directly infect and damage specific types of kidney cells. The virus hijacks the cell's machinery to replicate, leading to structural damage and increased production of viral particles.
Researchers at the University of Oklahoma are testing a novel therapy that combines local laser ablation and immunostimulants to treat metastatic pancreatic cancer. The treatment aims to stimulate the immune system to fight cancer cells, with promising preliminary results in pre-clinical studies and clinical trials.