Articles tagged with Biomedical Engineering
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A POSTECH research team has developed a technology to select genes from animal models that accurately mimic human diseases. This allows for the prediction of success or failure of animal disease models before making them, leading to more effective new drugs.
Researchers at Karolinska Institutet have found a way to stabilize the cancer-suppressing protein p53 by adding a spider silk protein, creating a more potent variant. This discovery has potential as an approach for cancer therapy.
Researchers created a new device called the lymphangion-chip, which models a section of a lymph vessel and can recreate conditions such as lymphedema. This innovation could lead to better understanding of mechanical forces regulating lymphatic physiology and pathophysiology.
Researchers at the University of Virginia Health System have identified a potential way to treat obesity and type 2 diabetes in women by targeting a specific gene called KLF14. Increasing KLF14 abundance in fat cells may help alleviate metabolic abnormalities, including slower metabolic rates and less efficient triglyceride management.
New research from University of Utah biomedical engineer Jessica Kramer reveals that human mucus and saliva may prevent the spread of coronaviruses when dry on a surface. Mucins in mucus form a barrier around live virus, preventing infection by binding to sugars on viruses instead of cells.
Researchers have identified a protein in tick saliva that can relieve chronic pain and itching, offering a potential alternative to traditional painkillers. The findings could lead to a new medication that is more effective and safer than current options.
Researchers will study temporomandibular joint function and disorders, aiming to understand the stresses on the joint before degeneration and develop new treatments. The project is a collaboration between Clemson University, Medical University of South Carolina, and National Institute of Dental and Craniofacial Research.
Researchers developed smart contact lenses that emit far-red light to treat diabetic retinopathy. The study showed the lenses prevented retinopathy in diabetic animal models, demonstrating their safety and effectiveness.
Researchers at Rutgers University have successfully stabilized an enzyme that degrades scar tissue resulting from spinal cord injuries, promoting tissue regeneration. The study used AI-driven liquid handling robotics to synthesize and test copolymers that stabilize the enzyme, offering new hope for patients with spinal cord injuries.
Researchers developed a hair-thin patch that can measure pulse wave signals with high accuracy, creating a 2D pressure map on the wrist. This technology enables at-home diagnosis of cardiovascular diseases and pre-diagnosis of related conditions.
Researchers have discovered a genetic difference in the meniscus that makes about 50% of females more prone to developing knee osteoarthritis than males or other females. The study suggests potential for a blood test to identify high-risk individuals, allowing for early interventions and prevention strategies.
A new form of drug delivery microparticle mimics the properties of a red blood cell, enabling controlled release of drugs and targeting specific destinations. The goal is to bypass the body's filtration systems, allowing for improved efficacy and reduced negative side effects.
A team of researchers has made a breakthrough in understanding how the brain processes visual information by studying populations of neurons across multiple brain areas. The study reveals that feedforward and feedback signaling involve different neural activity patterns, shedding new light on how the brain communicates with itself.
Remote monitoring of patients with continuous pulse oximetry and heart rate devices was associated with reduced death rates. This technology advance improved patient safety, lowered mortality, and increased accuracy in care.
A new study by University of Michigan researchers found that genetics play a crucial role in how our bodies respond to vaccines and booster shots. The team identified a specific form of an antibody-related gene that predicts whether boosting will be effective for increasing innate immune responses.
Researchers at RMIT University used high-frequency sound waves to turn stem cells into bone cells, overcoming challenges in mass production and pain associated with extraction. The innovative treatment is faster, simpler, and more efficient than existing methods.
Researchers have developed a low-cost, easy-to-use focused ultrasound device that can precisely target the mouse brain. The $80 device, created using a 3D printer, has been shown to achieve sub-millimeter targeting accuracy and improve drug delivery outcome.
A recent review highlights the effects of different intestinal bacteria on colorectal cancer, exploring new therapies for disease prevention and treatment. Beneficial probiotics, such as Akkermansia muciniphila and Lactobacillus rhamnosus GG, exhibit anticancer properties and reduce CRC cell proliferation.
A new HMI system, Robotic VR, allows users to teleoperate robots with precision and feel, enabling complicated tasks such as Covid-19 swab tests and patient care. The system provides immersive feedback via Bluetooth, Wi-Fi, and the internet.
Dr. Jansen will test hypotheses on intracellular domain of pLGIC proteins, aiming to gain insights into assembly, chaperone-modulation and functional conformational transitions in various diseases. Her research focuses on neurotransmitter-gated ion channels and their interactions with RIC-3-like chaperone proteins.
Developed by University of Seville researchers, the new methodology has a sensitivity of 100% and specificity of 87.5%. It can detect SARS-CoV-2 in saliva and synthetic viruses with minimal equipment and training.
Researchers found that kitchen sponges provide an optimal environment for microbial diversity by mimicking the separation and communal spaces found in healthy soil. This complex structure supports both solitary and diverse bacterial communities, leading to higher biodiversity levels.
Researchers at City University of Hong Kong have developed a novel droplet manipulation method called WRAP, which can transport micro-sized droplets using electromagnets or programmable electromagnetic fields. The method overcomes challenges in traditional magnetic actuation, such as contamination from added magnetic particles.
A new machine learning process has been developed to identify and classify hip fractures from X-rays, achieving 92% accuracy and confidence. This approach aims to improve patient outcomes, reduce care costs, and alleviate the bottleneck of unreported radiographs in the UK.
Researchers developed a fully autonomous biohybrid fish from human stem-cell derived cardiac muscle cells that recreates the muscle contractions of a pumping heart. The device has two layers of muscle cells that work together to propel the fish for over 100 days.
Researchers at UC Davis Health have developed an engineered antibody, FuG1, that can interfere with the cell-to-cell transmission ability of SARS-CoV-2. The approach targets the furin enzyme, which is critical for viral transmissibility, and could be added to existing SARS-CoV-2 antibody cocktails.
Researchers developed an optogenetic approach to control parathyroid hormone secretion and prevent secondary hyperparathyroidism-associated bone loss. The method partially attenuated SHPT-associated bone loss in animal models, suggesting its potential as a treatment for hyperparathyroidism-induced bone disease.
Markita del Carpio Landry, a young immigrant scientist, receives the Vilcek Prize for Creative Promise for her groundbreaking research on neurochemical communication and gene-editing technologies. Her work aims to address medicine's most compelling problems, including aberrations in neurotransmitter signaling.
The IEEE forum identified four major challenges to address during the pandemic: healthcare, screening, tracing, and treatment. The panel highlighted socioeconomic and education status as critical factors impacting mortality rates and hospital admission lengths.
Biomedical engineers at Duke University have developed a gene therapy that helps heart muscle cells electrically activate in live mice. The approach features engineered bacterial genes that code for sodium ion channels, which could lead to therapies to treat electrical heart diseases and disorders.
Researchers at Rosalind Franklin University have identified a new therapeutic approach for treating cystic fibrosis. The treatment uses antisense oligonucleotides to restore CFTR function by removing stop mutations. This strategy has shown promise in treating CF patients with class I mutations and similar types of mutations.
Researchers have developed a prototype insulin-loaded patch that comfortably sticks to the inside of a person's cheek, offering a less invasive way to manage blood sugar levels. The patch, activated by heat, releases insulin into the bloodstream several times faster than through skin, showing promise for diabetes treatment.
A multidisciplinary research team from the University of Pittsburgh seeks to improve vascular graft integration by developing fully biodegradable tissue-engineered vascular grafts. The goal is to keep compliance-matched as it degrades and remodels, reducing long-term graft failure rates.
Researchers at Brown University have developed a new laboratory test model to investigate fibrosis treatments without the use of animals. The model uses human cells and replicates not only the structure of human tissue but also its mechanics, enabling scientists to study the underlying mechanisms of fibrosis and test potential treatments.
UCSF cancer biologist Hani Goodarzi is recognized for his groundbreaking research on cancer metastasis and novel molecular players. His work has led to the discovery of a protein driving breast cancer metastasis and orphan noncoding RNAs in cancerous cells.
Researchers at MIT have developed a pill that can deliver RNA to the stomach, potentially making vaccines easier to tolerate and treat gastrointestinal diseases. The capsule is designed to release RNA in the stomach, where it can stimulate an immune response without being degraded by digestive enzymes.
Researchers at Northwestern University have developed a novel microfluidic device that can efficiently harvest and sort tumor-eating immune cells from tumors. This technology has shown dramatic results in shrinking tumors in mice compared to traditional methods.
A new diagnostic tool combines grayscale B-mode and strain elastography ultrasound imaging to detect breast cancer with high accuracy. The model achieved a detection rate of 90% in the study, surpassing individual models trained on either B-mode or SE imaging alone.
A research team has developed a new cancer treatment that targets lymph nodes using a prodrug that selectively reacts with glutathione to release nitric oxide. In a metastasis mouse model, the mice treated with the drug showed significantly reduced weight of metastatic cancer cells and improved survival rates.
Case Western Reserve University researchers create nanoparticles that generate a protein mesh to stabilize blood clots and reduce blood loss. The technology could help save lives by rapidly stabilizing clots to reduce blood loss from traumatic injuries.
Researchers at OHSU are developing a new approach to scientific imaging to study the dynamic organization of cells by examining how tiny molecules make cells work. The W. M. Keck Foundation has awarded $1 million to develop a one-of-a-kind imaging and computational system.
Researchers at Kumamoto University developed a novel 'supermolecular' material that binds to protein drugs, prolongs their effect without impairing activity, and improves overall drug performance. The material, called PEG-PRX, adds polyethylene glycol chains to proteins without compromising biological action.
Researchers at the University of Oklahoma have developed a molecular framework that solves the challenge of predicting peptide structures. The framework bridges experimental and computer sciences, enabling the use of machine learning and artificial intelligence to model peptide structures for materials engineering.
Researchers from Osaka University created patient-derived heart cells that exhibit reduced contractility and impaired desmosome assembly when carrying a mutation associated with arrhythmogenic cardiomyopathy. Replacing the mutated gene restored normal function, suggesting a potential treatment approach for this disease.
Researchers at University of Washington developed a fast, cheap test for COVID-19 that combines speed of antigen tests with accuracy of PCR tests. The Harmony COVID-19 test detects genetic material from SARS-CoV-2 virus with 97% accuracy and provides results in under 20 minutes.
A team of researchers at Harvard's Wyss Institute and ETH Zurich have developed a computational approach to identify genomic safe harbors (GSHs) with high potential for safe insertion of therapeutic genes. The study validated two GSH sites in adoptive T cell therapies and in vivo gene therapies for skin diseases.
Researchers at MIT have developed an all-in-one approach to diabetes treatment, streamlining the process of blood glucose measurement and insulin injection. The new device can automate procedures such as pricking skin, collecting blood, calculating glucose levels, and dispensing insulin, reducing the need for multiple devices and makin...
Researchers at West Virginia University have created a simple microwave catalytic process to upcycle single-use plastics into high-value benzene, toluene, and xylene. This technology aims to increase the recycling rate of plastic waste and reduce greenhouse gas emissions by providing an alternative source of petrochemical materials.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
Researchers have developed a combination of materials that can morph into various shapes before hardening, similar to the natural process of bone development in the human skeleton. The soft material can be used to create microrobots that can inject themselves into complicated bone fractures and expand to form new bone.
Researchers successfully engineered mesenchymal stromal cells to carry and deliver therapeutics specifically to targeted tissues, offering a precise and reliable approach for treating diseases. This novel cargo-carrier, dubbed 'Cargocytes,' retains most of its cellular functionality while greatly enhancing therapeutic capacity.
A team from Tokyo Medical & Dental University has created a jigsaw-shaped peptide that functions as an extracellular matrix for injured tissue regeneration. The peptide's ability to incorporate and release growth factors stimulates cell growth and vascular formation, showing promise in regenerating tissues.
Researchers develop a nanobomb that selectively targets cancer cells with heat and releases anticancer drugs, offering a promising multimodal treatment approach. The nanobomb's biodegradability and safety make it an attractive option for cancer therapy.
A team of researchers at Washington University in St. Louis used machine learning to understand how locusts can consistently recognize smells despite environmental factors, finding that combining the activity of ON and OFF neurons provides a simple yet effective solution.
Researchers developed a new class of nanomaterials that capture chemotherapy drugs before they interact with healthy tissue, reducing off-target effects. The highly efficient approach captures DOX at a capacity more than 3,200% higher than other platforms.
Researchers have developed a custom finger clip device that measures blood pressure and other vital signs like heart rate, oxygen saturation, body temperature, and respiratory rate. The device uses photoplethysmography sensors and achieves an accuracy rate of about 90% for systolic blood pressure.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
Researchers have developed a new methodology combining in vitro experiments with mathematical and computational methods to understand complex regulations in intervertebral discs. This approach aims to slow down or deactivate degenerative processes, increasing understanding of lower back pain treatment options.
A team of researchers from Georgia Tech developed a 3D-printed tracheal replacement splint to treat Ramiah, a 4-year-old girl with tracheal agenesis. The Airway Support Device was used in her successful surgery and has improved her breathing capabilities.
Researchers developed a new photoacoustic imaging technique to visualize deep tissues using a contrast agent based on surfactant-stripped semiconducting polymer micelles. The method achieved the deepest penetration depth among PA preclinical studies, exceeding 5.8cm in tissue thickness.