Articles tagged with Biomedical Engineering
A research team has developed a new cancer treatment that targets lymph nodes using a prodrug that selectively reacts with glutathione to release nitric oxide. In a metastasis mouse model, the mice treated with the drug showed significantly reduced weight of metastatic cancer cells and improved survival rates.
Case Western Reserve University researchers create nanoparticles that generate a protein mesh to stabilize blood clots and reduce blood loss. The technology could help save lives by rapidly stabilizing clots to reduce blood loss from traumatic injuries.
Researchers at OHSU are developing a new approach to scientific imaging to study the dynamic organization of cells by examining how tiny molecules make cells work. The W. M. Keck Foundation has awarded $1 million to develop a one-of-a-kind imaging and computational system.
Researchers at Kumamoto University developed a novel 'supermolecular' material that binds to protein drugs, prolongs their effect without impairing activity, and improves overall drug performance. The material, called PEG-PRX, adds polyethylene glycol chains to proteins without compromising biological action.
Researchers at the University of Oklahoma have developed a molecular framework that solves the challenge of predicting peptide structures. The framework bridges experimental and computer sciences, enabling the use of machine learning and artificial intelligence to model peptide structures for materials engineering.
Researchers from Osaka University created patient-derived heart cells that exhibit reduced contractility and impaired desmosome assembly when carrying a mutation associated with arrhythmogenic cardiomyopathy. Replacing the mutated gene restored normal function, suggesting a potential treatment approach for this disease.
Researchers at University of Washington developed a fast, cheap test for COVID-19 that combines speed of antigen tests with accuracy of PCR tests. The Harmony COVID-19 test detects genetic material from SARS-CoV-2 virus with 97% accuracy and provides results in under 20 minutes.
A team of researchers at Harvard's Wyss Institute and ETH Zurich have developed a computational approach to identify genomic safe harbors (GSHs) with high potential for safe insertion of therapeutic genes. The study validated two GSH sites in adoptive T cell therapies and in vivo gene therapies for skin diseases.
Researchers at MIT have developed an all-in-one approach to diabetes treatment, streamlining the process of blood glucose measurement and insulin injection. The new device can automate procedures such as pricking skin, collecting blood, calculating glucose levels, and dispensing insulin, reducing the need for multiple devices and makin...
Researchers at West Virginia University have created a simple microwave catalytic process to upcycle single-use plastics into high-value benzene, toluene, and xylene. This technology aims to increase the recycling rate of plastic waste and reduce greenhouse gas emissions by providing an alternative source of petrochemical materials.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
Researchers have developed a combination of materials that can morph into various shapes before hardening, similar to the natural process of bone development in the human skeleton. The soft material can be used to create microrobots that can inject themselves into complicated bone fractures and expand to form new bone.
Researchers successfully engineered mesenchymal stromal cells to carry and deliver therapeutics specifically to targeted tissues, offering a precise and reliable approach for treating diseases. This novel cargo-carrier, dubbed 'Cargocytes,' retains most of its cellular functionality while greatly enhancing therapeutic capacity.
A team from Tokyo Medical & Dental University has created a jigsaw-shaped peptide that functions as an extracellular matrix for injured tissue regeneration. The peptide's ability to incorporate and release growth factors stimulates cell growth and vascular formation, showing promise in regenerating tissues.
Researchers develop a nanobomb that selectively targets cancer cells with heat and releases anticancer drugs, offering a promising multimodal treatment approach. The nanobomb's biodegradability and safety make it an attractive option for cancer therapy.
A team of researchers at Washington University in St. Louis used machine learning to understand how locusts can consistently recognize smells despite environmental factors, finding that combining the activity of ON and OFF neurons provides a simple yet effective solution.
Researchers developed a new class of nanomaterials that capture chemotherapy drugs before they interact with healthy tissue, reducing off-target effects. The highly efficient approach captures DOX at a capacity more than 3,200% higher than other platforms.
Researchers have developed a custom finger clip device that measures blood pressure and other vital signs like heart rate, oxygen saturation, body temperature, and respiratory rate. The device uses photoplethysmography sensors and achieves an accuracy rate of about 90% for systolic blood pressure.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
A team of researchers from Georgia Tech developed a 3D-printed tracheal replacement splint to treat Ramiah, a 4-year-old girl with tracheal agenesis. The Airway Support Device was used in her successful surgery and has improved her breathing capabilities.
Researchers have developed a new methodology combining in vitro experiments with mathematical and computational methods to understand complex regulations in intervertebral discs. This approach aims to slow down or deactivate degenerative processes, increasing understanding of lower back pain treatment options.
Researchers developed a new photoacoustic imaging technique to visualize deep tissues using a contrast agent based on surfactant-stripped semiconducting polymer micelles. The method achieved the deepest penetration depth among PA preclinical studies, exceeding 5.8cm in tissue thickness.
Researchers at University of Rochester Medical Center found that the brain processes attended and unattended speech differently, converting attended speech into linguistic units for understanding. This study contributes to developing better wearable devices, such as hearing aids.
A new study found that a specific type of carbohydrate called ‘fodmaps’ can aggravate intestinal problems, but its impact is not as significant as previously believed. IBS symptoms were found to be influenced more by psychological factors and individual differences in metabolism and intestinal flora.
Researchers discovered that mechanical forces guide cell development, influencing gene expression and potentially leading to pathologies like heart disease. The findings could inspire advances in engineering authentic artificial tissue for medical applications.
Researchers at Washington State University discovered that combining gallic acid with stretching decreases inflammation markers and improves protein production in arthritic cartilage cells. This finding suggests a potential new procedure for treating osteoarthritis by growing healthy cartilage tissue.
Researchers have developed a gel that improves the formation of arteriovenous fistulas, a vital connection site for kidney failure patients undergoing dialysis. The gel helps reduce intimal hyperplasia and vein narrowing, leading to better blood flow and increased success rates.
A new rapid test developed by Duke University researchers can measure patient immunity against multiple COVID-19 variants like Omicron and Delta. The CoVariant-SCAN test uses a polymer brush coating to detect neutralizing antibodies, allowing for quick and accurate assessment of antibody effectiveness.
Researchers at Skoltech have created an optoacoustic endoscopic probe that can analyze atherosclerotic plaques by forcing molecules to sound their presence. The device uses laser light to make biomarkers oscillate, producing ultrasound signals that can be detected by a sensitive microphone.
Researchers at University at Buffalo successfully freeze-dried a liposome-based liquid vaccine formula, offering a thermostable solution for future COVID-19 vaccines. The freeze-dried product showed stability at elevated temperatures and induced effective antibody responses in mice.
Duke researchers developed a method to increase the depth of view of optical coherence tomography (OCT), allowing for clear images from beyond a millimeter beneath the skin's surface. The new technique, known as dual-axis OCT, tilts the light source and detector to collect more scattered light from deep tissues.
Researchers at Duke University developed a holographic system that can image and analyze tens of thousands of cells per minute to spot signs of disease. The technique distinguished between healthy samples and cancerous or pre-cancerous cells with nearly 100% accuracy, using just four basic cellular physical parameters.
Researchers used X-ray technology to study human chromosomes in their native state, discovering a fractal structure and a packing mechanism that condenses DNA into one-millionth its size. The findings could have significant implications for understanding genetics and uncovering the structures of other materials, such as viruses.
UMass Lowell researchers will focus on four projects to better protect employees in various professions, including healthcare workers and teachers. The five-year grant funding supports studies on work-life balance, engagement, burnout, and implementing programs to deal with job stressors.
Researchers create a wireless ecosystem with implantable devices and IoT infrastructure to control animal brain circuits remotely, speeding up neuroscience studies and uncovering basic brain functions.
A team of researchers led by Guy Genin and Stavros Thomopoulos found a previously unknown fibrous architecture in the shoulder joint, revealing new features of the attachment system. The discovery sheds light on how the rotator cuff functions and why repairs fail frequently.
Researchers have developed a prostate cancer organoid that can mimic the patient-specific microenvironment, opening up new avenues for targeted treatments. The study reveals that extracellular matrix regulates EZH2 activity and efficacy of inhibitors, as well as identifies potential new therapeutic targets like DRD2.
Biomedical engineers found that individual neurons fire in seconds-long, coordinated cascades during rest, triggering activity across the brain. This organized pattern of activity may be linked to arousal and memory systems, with implications for understanding cognitive decline and Alzheimer's disease.
Researchers at Durham University have developed a sugar-containing polymer coating that can repair damaged artificial joint implants by mimicking the way cartilage works to lubricate human joints. The coating uses water to create a slippery surface, protecting the surfaces from wear and tear.
The RT-CIRAM system analyzes public-domain data to determine the best times to avoid crowds and minimize COVID-19 infection risk. The mobile phone app provides personalized recommendations based on user input and factors like vaccination rates and cultural norms.
Researchers developed an AI method to correct speed of sound aberrations in photoacoustic images, resulting in improved image quality and resolution. The technique reduced streak artifacts by up to 5% and increased signal-to-noise ratio by about 25 decibels.
A team of researchers from SUTD and A*STAR Bioinformatics Institute developed a combined electric current 2D material sensor to detect breast cancer cells. The ultra-sensitive sensor can identify electrical signals from a record low number of cancer cells, offering new possibilities in the field of biosensing.
Researchers at Harvard's Wyss Institute have developed a microfluidic Organ Chip device that accurately models cystic fibrosis lung airway pathology. The model replicates key pathological hallmarks, including mucus layer changes and inflammatory responses, providing a comprehensive preclinical human model for investigating new therapies.
A new study by USC researchers uses GANs to generate synthetic neurological data that can be fed into machine-learning algorithms to improve BCI usability. This approach improved BCI training speed by up to 20 times and enabled rapid adaptation to new subjects.
A study using anonymized health data found that people with poorly managed long-term glycemic control are nearly 50% more likely to require ICU treatment if they contract COVID-19. Metformin, insulin, and corticosteroids may also reduce the risk of severe COVID-19.
Researchers develop new technique DASP, which uses spherical viscoelastic bio-ink particles to create porous 3D structures. The technology has the potential for human islet transplantation to treat type 1 diabetes.
Researchers at POSTECH demonstrate experimental demonstration of negative refraction at visible frequency for the first time, achieving high-resolution images beyond diffraction limit. The study uses a vertical hyperbolic metamaterial to exhibit negative refraction in entire visible domain, overcoming limitations of conventional materi...
A research team developed a treatment for myocardial infarction using mussel adhesive proteins, promoting cell proliferation and migration in damaged heart tissue. The MAP-based microneedle bandage alleviated fibrosis and restored the damaged myocardial wall.
A new liquid biopsy method developed by researchers at Pohang University of Science & Technology (POSTECH) demonstrates high sensitivity and specificity in detecting tumor DNA in the blood. The technique can detect even one to three specific tumor DNAs, offering a promising approach for early cancer diagnosis.
Researchers have made significant breakthroughs in understanding Parkinson's disease, revealing that affected neurons don't die but lose properties. This knowledge opens the door to new therapeutic treatments targeting the cell body, rather than just axons.
Researchers created novel frog models to replicate polycystic kidney disease, allowing for real-time observation of disease processes. AI analysis enabled rapid assessment of disease in the tiny animals.
A team of experts from Tel Aviv University has identified 5 coronavirus proteins responsible for damaging blood vessels. The researchers hope that the identification will lead to the development of targeted drugs that reduce vascular damage in COVID-19 patients.
Researchers are developing a transformative technology called Multiscale Intelligent Convergence (MusIC) to map the complexity of T cells and identify attributes essential for patient benefit. The goal is to create more reliable biomanufacturing of T cell infusion products and engineering potent immune cells.
A team of researchers developed an innovative culture system that enables intestinal epithelial cells to form a three-dimensional villi microstructure. The BASIN system reproduces the structure and function of human intestinal epithelial cells simultaneously in multiple cell culture inserts.
Researchers from Osaka City University found that non-thermal atmospheric pressure plasma (NTAPP) accelerates cell growth and promotes bone regeneration in animal models with critical bone defects. Micro-CT images showed a 1.51 times larger bone volume after 10-minute treatment, while histological analysis confirmed new bone formation ...
Researchers have demonstrated a new technique for cross-sectional medical images without the need for tomography, enabling faster and more accurate imaging. The breakthrough is made possible by ultrafast photon detectors that can precisely determine the arrival times of photons, allowing for reconstruction-free positron emission imaging.
Scientists at Harvard's Wyss Institute create eToeholds to target specific diseases, enabling more precise RNA therapy and diagnostic approaches. The technology, developed by James Collins and his team, uses internal ribosome entry sites to produce proteins only when a cell-specific or viral RNA is present.
Researchers at the University of Texas at Arlington have developed a non-invasive wearable device that can accurately measure hemoglobin levels, reducing racial disparities in blood tests. The device uses spectroscopic properties to estimate hemoglobin, showing better accuracy and consistency than current methods.
Researchers from FAU investigated G protein-coupled receptors, finding that tailor-made substances can affect receptor dimer formation and behavior. The study revealed the dopamine D3 receptor migrates into the cell interior when bound to a bivalent ligand, altering signal transmission.
A new study reveals that certain strains of Cutibacterium acnes (C. acnes) found on healthy skin can prolong the lifespan of Caenorhabditis elegans and help its innate immune system fight against Staphylococcus aureus. RNA sequencing analysis also shows these beneficial strains activate genes related to innate immunity.