Articles tagged with Biomedical Engineering
Deep nerve stimulation using custom-wired electrodes and wireless implantable systems significantly lowers systolic blood pressure by up to 16% in two hours. The technology targets hypertension, a leading cause of death globally, affecting over 1 billion people.
Researchers from China have developed a novel bioconjugate that can suppress the growth of K-Ras mutant pancreatic tumors. The conjugate, which targets folate receptors and macropinocytosis, was found to be highly cytotoxic and effective at suppressing tumor growth.
Researchers at CMU propose a new cell delivery method using shrink-wrapped corneal endothelial cells as an alternative to cornea transplant. The technology enables rapid engraftment into intact tissues, showing promise in treating diseases such as cystic fibrosis and heart attack.
A new mathematical model has been developed to reproduce the experimental results of topological change in a partially miscible VF pattern. The researchers successfully incorporated phase separation effects and the Korteweg force into the classical miscible VF model.
Researchers at the University of Houston have identified blood biomarkers predicting heart disease in lupus patients and urine biomarkers for diagnosing kidney inflammation in children with lupus. These findings hold promise for early preventive measures and improved treatment outcomes.
A team of researchers at University of Zurich successfully transplanted a human liver that was treated in a machine, paving the way for a potential solution to the global organ shortage. The liver was preserved for three days outside the body using a custom-made perfusion machine.
Researchers at TU Wien develop a method to guide individual cells with laser precision, enabling reproducible production of artificial tissue and testing new drugs without animal testing. The technique involves adding special molecules to hydrogel surrounding cells, which become softer and more permeable when activated by a laser beam.
A Kanazawa University team has identified a DNA aptamer-based molecule that inhibits the CYP24 enzyme, leading to significant antiproliferative activity in cancer cells. This finding suggests that Apt-7 could be a promising lead candidate for anticancer therapy.
Scientists from Tokyo Medical and Dental University uncover the reason behind titanium implants' excellent biocompatibility, allowing patients to generate less immune response. This breakthrough may lead to safer and less expensive implants for hip replacements and dental procedures.
Biomedical engineers at Duke University have created a method to scan and image the blood flow and oxygen levels inside a mouse brain in real-time. The new imaging approach breaks long-standing speed and resolution barriers, enabling researchers to uncover insights into neurovascular diseases like stroke, dementia, and acute brain injury.
A new study has shown that Transcatheter Aortic Valve Implantation (TAVI) is just as effective as conventional open-heart surgery in treating severe symptomatic aortic stenosis. The procedure offers a safer and faster recovery for patients, with improved symptoms, functional capacity, and quality of life at 6 weeks.
A novel network analysis technology can pinpoint seizure originating brain regions and predict a patient's seizure outcome before surgery, using only 10 minutes of resting state recordings.
Researchers have engineered bacteria to act as data loggers, capturing gene activity and metabolic responses in the gut. This allows for non-invasive monitoring of gut health and dietary status, enabling early diagnosis of malnutrition and inflammatory responses.
A Tokyo University of Agriculture and Technology research team finds that changes in viscoelastic properties affect flow dynamics differently depending on gel elasticity, leading to a reversal of flow effects. This discovery opens new avenues for controlling flow dynamics using chemical reactions.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
Researchers at Binghamton University have developed a system that kills SARS-CoV-2 viruses using UVC light, with optimal results achieved between 260-280 nanometers. The study's findings provide a scientific basis for standardizing and regulating claims from manufacturers of UV disinfectant devices.
Researchers at Stevens Institute of Technology are developing a low-cost handheld device that can accurately diagnose skin cancers in just a few seconds. The device uses millimeter-wave imaging, which reflects differently on cancerous and healthy tissue, allowing for precise detection.
A new nanofiber-based biodegradable millirobot called Fibot can move in the intestines and release different drugs at anchored positions. Fibot's degradation capability is pH-responsive, allowing for controlled drug release.
Researchers at Lehigh University developed a new method to accurately gauge healing progress of bone fractures using 3D models. The model identifies the cutoff point between soft tissue and bone, allowing for more precise predictions of bone behavior during the healing process.
Researchers developed a 3D imaging technique that captures thin peripheral blood vessels, aiding in diagnosing and treating peripheral vascular diseases. The new modality provides functional diagnostic values for blood supply to tissues without contrast agents.
Researchers have developed a non-invasive imaging method to examine conjunctival goblet cells (CGCs) in live rabbit eyes, which are similar to human eyes. The study found that CGC density decreased with dry eye disease (DED) and recovered over time.
Researchers at Binghamton University have discovered that human skin's unique structure allows it to maximize both durability and flexibility. The team created artificial skin membranes that mimicked the structure of mammalian skin, testing their puncture toughness and deformability.
Researchers at the University of Cincinnati are searching for the ideal exosuit design to reduce muscle load and prevent work-related musculoskeletal disorders. The study found that commercially available exosuits have limitations, with the Auxivo LiftSuit being stiff and uncomfortable during prolonged wear.
An automated nutrition app called eNutri improved participants' healthy diet scores by 6% compared to a control group. The app provides personalized nutrition advice based on evidence and uses a diet scoring system.
Researchers developed a high-performance microscopy system for non-invasive examination of conjunctival goblet cells, allowing for real-time imaging in live animal models and human patients. The system enables high-resolution images of CGCs without causing harm to the subject.
Researchers have engineered a tiny living heart chamber replica to study disease progression and test new treatments. The miniPUMP device mimics the real organ's mechanics, allowing for accurate tracking of how the heart grows in embryos and studying the impact of disease.
A new technology developed by KIT researchers uses polymer membranes coated with titanium dioxide to break down steroid hormones and other micropollutants in wastewater. The process is efficient, removing hormone concentrations close to the World Health Organization's drinking water guideline.
Researchers at Duke University discovered that SARS-CoV-2, the virus causing COVID-19, can directly infect and damage specific types of kidney cells. The virus hijacks the cell's machinery to replicate, leading to structural damage and increased production of viral particles.
Researchers at the University of Oklahoma are testing a novel therapy that combines local laser ablation and immunostimulants to treat metastatic pancreatic cancer. The treatment aims to stimulate the immune system to fight cancer cells, with promising preliminary results in pre-clinical studies and clinical trials.
Researchers at the University of Michigan used histotripsy to destroy 50-75% of liver tumor volume in rats, allowing their immune systems to clear away the rest with no recurrence. The technique stimulated immune responses, preventing further spread and potentially improving cancer outcomes for humans.
A new data-driven approach predicts cell types within tissue, helping reduce drug costs and treat diseases. By analyzing large datasets, researchers can predict how a gene product secreted by malignant cells alters the heterocellular network in human tissues.
An international team of engineers has successfully bioprinted bone along with two growth factor encoding genes that help incorporate cells and heal defects in rats. The researchers used gene encoding PDGF-B and BMP-2, which encouraged cell multiplication and migration, resulting in a 40% increase in bone tissue creation.
A team of NYU Tandon researchers investigated the variability of mortality prediction models when applied to different hospitals and geographic regions. They found that these models exhibit a lack of generalizability due to dataset shifts in race and clinical variables, leading to disparities in performance across racial groups.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
Scientists have created a new technology using colour pigments from the food industry to stimulate nerve cells with the help of implantable mini solar cells. This innovation could lead to accelerated healing and prevention of complications in severe brain injuries, as well as potential applications in pain therapy and retinal implants.
Researchers engineered injectable microtissue containing motor and sensory neurons to provide a source of axons to muscles, preventing degeneration and loss of function while nerves regrow. The technology shows promise to improve recovery of sensory and motor function after peripheral nerve injuries.
Researchers at Columbia University have developed a way to use the body's ions to transmit data at megahertz rates for implantable bioelectronics. This technique, dubbed ionic communication, leverages electrical potential energy stored in living tissues to exchange data with external devices.
Conjunctival goblet cells play a crucial role in tear film stability, and their dysfunction is linked to various ocular surface diseases. A new microscopy system allows for non-invasive examination of CGCs in live animal models and humans, enabling precise diagnosis and treatment of ocular surface diseases.
Studies in mice show that immune cells prevent stem cell repair after volumetric muscle loss, a common type of injury such as gunshot wounds or car accidents. This understanding could lead to new treatment strategies and potentially restore function and prevent limb loss.
A new deep learning-based model called Highlights on Target Sequences (HoTS) predicts binding between drugs and target molecules, providing interpretable results. The model can predict target proteins' binding regions and interactions with drugs without a 3D complex.
A GE Research-led team has demonstrated the ability to prevent or reverse diabetes in preclinical model systems using ultrasound-based bioelectronic medicine. The team's findings, published in Nature Biomedical Engineering, represent a significant milestone in this field and pave the way for future clinical translation.
Rice University engineers have developed a tiny, wireless device that can stimulate nerves and treat neurological diseases. The implant, powered by a magnetic transmitter, uses blood vessels as guides to reach targeted nerves.
A new technology called MediSCAPE has been developed by Columbia Engineers that can capture real-time cellular detail in living tissues. This allows doctors to make informed decisions about tumor removal without needing to remove tissue and wait for pathology results.
Researchers at Duke University have developed a device that manipulates particles and cells using complex sound waves, enabling selective pairing of individual cells to measure adhesion forces. This technology could lead to personalized medicine by allowing doctors to determine treatment for individual cancer patients.
Researchers will investigate the downstream effects of SARS-COV-2 on aortic valve pathology. The study aims to understand the cause-and-effect relationship between COVID-19 and heart valve damage.
In an animal study, researchers created an implantable biotechnology called MASTER that produces and releases CAR-T cells for attacking cancerous tumors. This technology reduces the manufacturing time from weeks to hours, increasing efficiency and effectiveness.
Researchers developed long-lived biological computers using RNA, which can persist inside cells. Unlike DNA-based devices, these RNA circuits are dependable and versatile, enabling continuous production in living cells.
Researchers at the University of Houston have developed a novel technology to monitor membrane protein trafficking in real-time using bioluminescence. This allows for the study of cellular processes and drug development for heart disease, metabolic disorders, cancer, infectious diseases, COVID-19, and others.
The new center aims to develop quantitative imaging markers to reduce subjectivity in medical image diagnosis and improve consistency. Researchers will explore cutting-edge imaging modalities and extract effective image features from existing clinical imaging modalities to aid in cancer detection and treatment.
Research at the University of Michigan has developed a method to quickly recognize wrong twists and chemical structures in packaged drugs using terahertz radiation. This technique could help diagnose harmful accumulations of twisted molecules in the body, including bladder stones and Alzheimer's disease.
Researchers have developed a robust and stretchable ECM hydrogel-based membrane with nanofiber scaffolds, mimicking native basement membranes. This membrane enables cyclic stretching motions and maintains stable structure over extended cell culture periods, contributing to fabricating sophisticated artificial organs.
A POSTECH research team has developed a technology to select genes from animal models that accurately mimic human diseases. This allows for the prediction of success or failure of animal disease models before making them, leading to more effective new drugs.
Researchers at Karolinska Institutet have found a way to stabilize the cancer-suppressing protein p53 by adding a spider silk protein, creating a more potent variant. This discovery has potential as an approach for cancer therapy.
Researchers at the University of Virginia Health System have identified a potential way to treat obesity and type 2 diabetes in women by targeting a specific gene called KLF14. Increasing KLF14 abundance in fat cells may help alleviate metabolic abnormalities, including slower metabolic rates and less efficient triglyceride management.
New research from University of Utah biomedical engineer Jessica Kramer reveals that human mucus and saliva may prevent the spread of coronaviruses when dry on a surface. Mucins in mucus form a barrier around live virus, preventing infection by binding to sugars on viruses instead of cells.
Researchers created a new device called the lymphangion-chip, which models a section of a lymph vessel and can recreate conditions such as lymphedema. This innovation could lead to better understanding of mechanical forces regulating lymphatic physiology and pathophysiology.
Researchers have identified a protein in tick saliva that can relieve chronic pain and itching, offering a potential alternative to traditional painkillers. The findings could lead to a new medication that is more effective and safer than current options.
Researchers developed smart contact lenses that emit far-red light to treat diabetic retinopathy. The study showed the lenses prevented retinopathy in diabetic animal models, demonstrating their safety and effectiveness.
Researchers at Rutgers University have successfully stabilized an enzyme that degrades scar tissue resulting from spinal cord injuries, promoting tissue regeneration. The study used AI-driven liquid handling robotics to synthesize and test copolymers that stabilize the enzyme, offering new hope for patients with spinal cord injuries.
Researchers will study temporomandibular joint function and disorders, aiming to understand the stresses on the joint before degeneration and develop new treatments. The project is a collaboration between Clemson University, Medical University of South Carolina, and National Institute of Dental and Craniofacial Research.