Articles tagged with Biomedical Engineering
Researchers designed a small fluorescent protein that emits and absorbs light in the near-infrared spectrum, allowing for deeper and clearer biomedical images. The protein's ability to penetrate tissue enables the capture of detailed images of complex structures and cells.
Researchers investigated neuronal response to excessive iron accumulation associated with age-related neurodegenerative diseases. They identified two genes, CLU and HERPUD1, that responded to aging-related iron accumulation, highlighting potential preventative strategies.
Researchers from Tokyo Medical and Dental University developed a new approach to grow human intestinal mini-organs in the lab. They used cell culture plates and bioreactors to create robust and healthy intestine-like tissues that can be transplanted into mice, demonstrating the potential for regenerative medicine applications.
Researchers developed a new method to target and treat visceral adiposity using positively charged P-G3 nanomaterials, which inhibit unhealthy lipid storage in enlarged fat cells. This approach also rejuvenates healthy fat cells, promoting metabolically healthy fat cell formation.
Researchers have discovered that a specific mutation in the misfolding protein causing Parkinson's disease can also protect against multiple system atrophy (MSA), another fatal neurodegenerative disorder. The findings provide a promising lead for developing targeted treatments using personalized medicine approaches.
A new machine learning fusion model has been developed to diagnose ovarian cancer more accurately by combining ultrasound and photoacoustic tomography imaging. The model achieved an accuracy of 90% in detecting ovarian lesions, outperforming previous methods.
A new tablet-based vaccine has shown long-lasting protection against bacteria that cause urinary tract infections (UTIs) in mice. The vaccine was found to be comparable to antibiotics in efficacy, with durable antibody responses lasting for the lifetime of a mouse.
Researchers developed a wireless smart bandage that speeds up tissue repair, increases new blood flow, and enhances skin recovery by reducing scar formation. The device promotes faster closure of wounds and reduces infection risk through real-time biosensor data and electrical stimulation.
Researchers discovered that the Memo1 protein binds copper ions, blocking toxic redox reactions that damage or kill cancer cells. The protein's interaction with copper also protects against metastasis formation in breast cancer cells. This finding opens up potential new treatments for cancer.
The Wyss Center's ABILITY system, a fully implantable brain-computer interface, records neural activity in sheep with high accuracy, decoding fine movement intention from small brain areas. The device is designed to improve quality of life and independence for people with severe paralysis.
Researchers at Binghamton University discover that sodium/proton exchanger 1 (NHE1) and SWELL1 proteins regulate cancer cell migration, offering insights into metastasis. The study's findings could have wide implications for slowing down or halting the deadly disease.
Researchers at Brigham and Women's Hospital identified eutectic gallium indium (EGaIn) as a biocompatible liquid metal for biomedical applications. The team found that EGaIn can be formulated to break down in the body, providing a controllable end-of-life for devices like drug delivery systems and stents.
Researchers have developed a novel strategy to induce the effects of growth factors and cytokines with enhanced retention in brain tissues. The 'lasso-grafting' technique enables the design of protein therapeutics with desired stability and controllable pharmacokinetics.
UCR researchers find that modern ventilators overextend certain regions of the lungs, causing stress and damage, unlike natural breathing. They propose a new thick-walled model to better understand pulmonary mechanics and improve ventilation strategies.
A research team developed a smart mask integrating an ultrathin soundwave sensor that detects breathing, coughing, and speaking sounds. The mask uses machine-learning algorithms to identify respiratory diseases and improve public health by enabling prolonged monitoring.
A research group at Osaka Metropolitan University developed a nanovaccine that delivers cancer antigens to dendritic cells, inducing strong cellular immunity. The new system, using positively charged cationic lipids, increases cytokine production by approximately 100 times compared to previous designs.
A new type of pacemaker that uses precise targeting capabilities to bypass pain receptors and reduce patient discomfort is being developed. The device, which uses light and optogenetics, could improve the quality of life for millions of people affected by atrial fibrillation.
Researchers controlled magnetic bacteria to cross blood vessel walls and infiltrate tumor tissue, delivering liposomes with fluorescent dye to demonstrate their ability to carry therapeutic agents. This approach may revolutionize bacterial cancer therapy by increasing efficacy and reducing side effects.
Researchers at Duke University have developed a novel treatment that combines internal radiation and chemotherapy to eliminate tumors in 80% of mice with pancreatic cancer. The approach uses a gel-like depot implanted with radioactive iodine-131, which deposits beta radiation directly into the tumor without affecting surrounding tissue.
Researchers created a 3D electrode array that maps the locations and activity of up to 1 million potential synaptic links in living brains. The system uses recordings of millisecond-scale evolution of electrical pulses in tens of thousands of neurons, allowing for dense and accurate mapping of brain circuits.
A research team at POSTECH developed a skin-attachable microphone sensor that clearly detects voices even in harsh noisy environments. This technology can be used for disaster-response communication between medical professionals wearing protective equipment and firefighters wearing gas masks.
A new project will develop a technique to quantify uncertainty in AI-based tools used for image analysis and create a questionnaire to assess patients' risk tolerance when using these tools. The goal is to ensure that AI-assisted clinical decisions are informed by the inherent uncertainty of imaging technologies.
Researchers developed a generatively designed patient-specific bone fixation device using Generative Design technology. The implants are tailored to each patient's anatomy and biomechanical needs, resulting in lighter, less prominent, and minimally invasive designs that promote faster healing and reduced revision surgery.
Researchers found that B-type procyanidins induce hormesis in hemodynamic and metabolic responses, with optimal doses triggering improved cognitive functions and stress resistance. The study suggests a link between B-type procyanidin intake and CNS neurotransmitter receptor activation.
Researchers are working on a regulatory science tool based on biomarker data to assess the efficacy of rehabilitative devices for post-stroke motor recovery. The project aims to shed light on how neurological markers can demystify complex neural communication patterns in patients.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers developed a computational platform to identify metabolic vulnerabilities in ovarian cancer genes, suggesting opportunities for targeted therapies. The study found that certain genetic alterations can create vulnerabilities in cancer cell metabolism, which can be exploited to selectively kill cancer cells.
The Leducq Foundation has awarded $7.5 million to UVA researchers, led by Mete Civelek, to investigate sex differences in atherosclerosis and $8 million to Coleen McNamara to advance immunotherapy for cardiovascular disease. These projects aim to improve understanding of heart disease and develop new treatments.
A study found that specific N-glycans on the SARS-CoV-2 spike protein regulate its development and functional maturation. This is crucial for viral entry into host cells. Researchers highlight N-linked glycans as potential drug targets for COVID-19.
Researchers develop a novel approach to increase proton transfer kinetics, enabling efficient industrial-scale water splitting. The new strategy, which integrates molecular-level proton acceptors into the catalyst, improves oxygen evolution reaction rates and achieves high current densities at low overpotential.
Researchers developed DNA nets to detect and impede COVID-19, offering a fast, sensitive, and low-cost testing platform. The technique also showed potential as an antiviral treatment, inhibiting the virus's spread in live cell cultures.
Researchers at the University of Michigan have developed a precision medicine approach to treat cancer, targeting 'backup genes' that are used by tumor cells. The algorithm successfully predicted and targeted these genes, leading to complete cancer remission in six out of six mice tested.
Researchers developed a new mathematical technique to analyze cell nucleus organization, revealing self-sustaining transcription clusters that play a key role in maintaining cell identity. This understanding may expose vulnerabilities for targeting cancer cells and reprogramming them to stop uncontrollable cell division.
Researchers at UVA will study organelles in cancer cells to identify new pathways for understanding and fighting cancer. By focusing on the interactions between genes, proteins, and organelles within cells, they hope to develop fresh clues about therapies.
Researchers at UNSW Sydney have made significant discoveries about embryonic blood stem cell creation that could one day eliminate the need for blood stem cell donors. Two studies have emerged from UNSW researchers in this area that shine new light on how precursors to blood stem cells occur in animals and humans, and how they may be i...
Researchers at Washington University in St. Louis have invented a technique to generate Airy beams in water using 3D-printed binary acoustic metasurfaces, enabling broad applications in biomedical imaging and therapy.
Researchers are exploring the use of electrical spinal cord stimulation to help people with spinal cord injuries regain some movement. The study will investigate how the central nervous system changes in response to stimulation and exercise, with the goal of developing more effective rehabilitation strategies.
A team of researchers at the University of Minnesota has developed an accessible application called MVsim that can simulate complex molecular interactions. By using this tool, scientists can design more specific drugs for diseases like cancer and COVID-19 by optimizing multivalent interactions.
The report explores diffuse optical imaging methods applicable to noninvasive human studies, including near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). It introduces state-of-the-art technologies and software, exploring their impact on neuroscience and clinical applications.
Researchers from UMass Amherst have created a tiny sensor that can simultaneously measure electrical and mechanical cellular responses in cardiac tissue. This breakthrough device has the potential to lead-edge applications in cardiac-disease experiments and improve health monitoring for cardiac disease studies.
A University of Houston engineer has developed technology to determine which patients are likely to respond to CAR T-cell therapy for lymphoma, saving time and increasing success rates. The TIMING method analyzes interactions between T cells and tumor cells, identifying a key ligand molecule that predicts patient response.
The discovery reveals that the nucleus deforms like a liquid drop, preserving its shape and protecting its genome. This understanding may lead to new approaches for treating cancer by aiding cell nuclei in regaining their normal shapes.
SUTD researchers leverage nanosecond electroporation to deliver cancer-related molecules into living cells with excellent viability. The platform enables pores to remain open for up to 720 minutes, paving the way for efficient drug delivery and other applications.
The University of Arizona professor is working with biomedical experts to explore the feasibility of using mmWave radar technology on falling detection and fall risk analysis. The NIH award supports a three-year study to investigate how well the technology can estimate fall risks, determine falls, and be accepted by senior citizens.
Researchers at Georgia Tech have developed a new chip that can detect cancer metastasis in blood samples with high precision and scalability. The Cluster-Well chip uses microfluidic technology to isolate circulating tumor cell clusters, allowing for earlier and more targeted treatment.
Researchers tested a core-strengthening program using the AllCore360º to improve trunk function, balance, and mobility after stroke. The study showed promising effects on functional outcomes, including improved lateral control of posture and standardized treatment dosage.
A bioengineered cornea made from collagen protein can restore vision in people with diseased corneas, offering an alternative to donated human corneas. The implant has been shown to be safe and effective in a pilot study, with patients regaining perfect vision after two years.
Researchers at the University of Minnesota have found that combining sound with electrical body stimulation activates the brain's somatosensory cortex, increasing its potential to treat chronic pain. This non-invasive technique has been tested on animals and is planned for human clinical trials in the near future.
Researchers have developed a new way to deliver vaccines through mucosal tissues in the nose, generating strong immune responses in mice and non-human primates. The technology bypasses traditional barriers to delivery by engineering antigens to bind onto albumin, allowing them to effectively target immune tissues.
Rose Faghih and her team have developed a novel inference engine to monitor brain activity in real-time using wearable devices, offering high scalability and accuracy. The algorithm can track mental states with high reliability, providing insights into autonomic nervous system activation.
Researchers at Kanazawa University create a nanoparticle called nanoHT that can both generate heat and measure temperature, allowing for controlled manipulation of cellular activity. The technology shows promise in inducing cell death in cancer cells, with HeLa cells dying after heating by 11.4°C.
Researchers at Washington University in St. Louis developed a new imaging tool that uses optical coherence tomography (OCT) and machine learning to detect and classify cancerous tissue samples with high accuracy. The technique, which was tested on patients in a trial, showed a 93% diagnostic accuracy rate.
PubCaseFinder, a clinical decision support system, has been updated to provide more precise phenotyping and automated differential diagnosis. The new version enables users to filter ranked lists using causative genes, modes of inheritance, and disease names, making it easier for medical professionals to diagnose rare and genetic diseases.
A new photoswitching fingerprint analysis overcomes the sub-10 nm resolution barrier in super-resolution microscopy, enabling the imaging of dynamic interactions with other molecules in cells. This breakthrough reveals molecular functions and architectures at the nanoscale, shedding light on cellular processes such as learning and memory.
The NIH announced five cash prize winners and four honorable mentions in its Maternal Health Diagnostics Challenge. The winning technologies aim to reduce maternal morbidity and mortality, with a focus on detecting and differentiating common pregnancy-related conditions.
A new AI-based dynamic brain imaging technology has been introduced by Carnegie Mellon University, which can map out rapidly changing electrical activity in the brain with high precision and speed. The technology uses deep learning approaches to translate scalp EEG signals back to neural circuit activity without human intervention.
Binghamton University researchers have developed a way to turn CDs into flexible biosensors that can monitor electrical activity in human hearts and muscles, as well as lactate, glucose, pH, and oxygen levels. The sensors are fabricated in 20-30 minutes without toxic chemicals or expensive equipment, costing around $1.50 per device.
Researchers have developed a new quantitative approach to predict and customize site-specific recombination, enabling more efficient genetic and cell therapies. The tool combines high-throughput experiments with machine learning models to control the rate of DNA editing, paving the way for personalized treatment.
New research by UMass Amherst professor Jinglei Ping demonstrates the use of graphene for electrokinetic biosample processing and analysis, allowing for faster and more efficient detection of biomolecules. This breakthrough enables the creation of smaller lab-on-a-chip devices with improved time and size efficiencies.
The International Vaccine Institute (IVI) has launched a two-week training course for biologics development and manufacturing, targeting low- and middle-income countries. The program aims to enhance local production of vaccines and biologics in LMICs to address vaccine inequity and global pandemic preparedness.