Articles tagged with Biomedical Engineering
Researchers developed a nanofluidic device called an 'exosome nanoporator' to load exogenous cargo into exosomes. The device efficiently loads clinically approved antitumor drugs into exosomes without damaging them, enabling the delivery of these drugs to cancer cells.
A novel method allows for the dynamic tracking and identification of tissue-specific secretory proteins in live mice, revealing distinct patterns from cell culture models. This breakthrough technique can be used to discover biomarkers and therapeutic targets with greater accuracy.
A new biomimetic system mimics the body's own receptors for anesthetics, providing prolonged nerve blockade with minimal toxicity. The system consists of nanostructures that bind to tetrodotoxin and slowly release it, allowing for long-lasting pain relief without systemic toxicity.
A novel mortality risk prediction method helps tailor treatment decisions and transplant needs for patients based on individual symptoms. The new tool uses a random survival forest algorithm to predict individual mortality risk curves, calculate mortality at any given time, and provide a 95% confidence interval.
A Penn State-led international research team developed laser-induced graphene (LIG) for wearable health devices, offering superior conductivity and heat resistance. The LIG foam exhibited electrical properties, while fibrous structures showed better performance, opening possibilities for sensing devices.
Researchers have developed a shape memory polymer that can store up to 17.9 J/g energy, allowing it to lift objects 5,000 times its own weight upon heating. The polymer's high energy density and low cost make it an ideal material for soft robotics, smart biomedical devices, and deployable space structures.
The Vilcek Foundation has awarded four prizes worth $250,000 to foreign-born scientists in the United States. The prizes recognize outstanding career contributions to biomedical science and innovative research. This year's recipients include Vishva M. Dixit, Markita del Carpio Landry, Hani Goodarzi, and Harris Wang.
Researchers at Duke University have developed an open-source software platform called ASCENT that allows non-experts to create patient-specific, 3D models of nerves being electrically stimulated. This enables more accurate predictions and potentially new therapies for diseases such as diabetes and cardiovascular disease.
Researchers at the University of Houston have developed an electrochemical actuator that utilizes organic semiconductor nanotubes, exhibiting high performance and tunable dynamics in liquid and gel-polymer electrolytes. The device demonstrates excellent stability, low power consumption, and fast response time.
During California's 2020-21 medical surge, a collaborative approach helped manage oxygen demand. The state developed a plan with backup systems to prevent pipeline freezing and shortage.
A research team has developed a cell printing technology to produce 3D cancer spheroids with varying diameters and blood vessels. This enables the reproduction of cancer metastasis properties, paving the way for personalized cancer treatments.
Silent mutations, which don't change protein sequences, hold diagnostic value in predicting cancer types and patient survival. The study analyzed over 10,000 cancer genomes and found that combining information from silent and non-silent mutations improved classification and prognostication up to 17% and 5%, respectively.
A team of scientists at McGill University has invented a smart device for personalized skin care inspired by the male diving beetle. The device collects and monitors body fluids while sticking to the skin's surface, paving the way for more accurate diagnostics and treatment for skin diseases like acne.
A team of researchers at Washington University in St. Louis has received a $3.12 million NIH grant to study neurovascular recovery after stroke. They aim to develop new neurovascular imaging technology using two-photon fluorescence microscopy and photoacoustic microscopy to visualize blood oxygen delivery in response to neuronal activity.
Researchers confirm FDA recommendation that patients keep consumer electronics, such as cell phones and smart watches, six inches away from implanted medical devices. Studies found that these devices can trigger magnet mode in pacemakers and defibrillators, posing a risk to patient safety.
A team of researchers is developing a smartphone-based device that can predict the size of aortic aneurysms and detect fluid overload in postpartum women. The device uses arterial waveforms, which can be easily recorded with a smartphone camera or smart scale, to provide a non-imaging solution for AA screening.
A portable optical sensor system could diagnose traumatic brain injury severity in the field from a single drop of blood, potentially reducing costs and improving treatment outcomes
Researchers from Carnegie Mellon University and the University of Pittsburgh conducted a study on three Rhesus monkeys, finding that their performance declined by up to 25% when offered a jackpot reward. The team also discovered a link between sensory motor processing and emotional processing in the monkeys' brains.
A team of researchers has created a bioink that can reduce toxicity and improve cell survival, enabling the fabrication of clinically relevant human-scale organs. The development paves the way for regenerative medicine applications.
A low-cost prototype breathing device designed for poorer-resourced healthcare settings has shown promising results in a pilot trial involving healthy volunteers. The device provides continuous positive airway pressure (CPAP) therapy and operates with oxygen concentrators, which are commonly used in low-pressure systems.
Researchers at Osaka University have successfully created a 3D-bioprinted structured Wagyu beef-like meat alternative using stem cells isolated from Wagyu cows. The new technology mimics the complex texture of real Wagyu beef, allowing for customizable fat and muscle components in cultured meat.
A new spontaneous mouse model, McH-lpr-RA1, has been developed to study Sjögren's syndrome, an autoimmune disease affecting the tear system and salivary glands. The model exhibits autoimmune inflammation in the salivary gland tissue and blood vessels, destruction of the salivary gland structure, and inhibited salivary secretomotor system.
A new hydrogel platform has been developed to alleviate inflammation in rheumatoid arthritis by selectively removing nitric oxide. The hydrogel, when injected into the affected area, collects and eliminates excessive NO, reducing inflammation and alleviating symptoms.
Scientists from Osaka University create optical imaging system that can capture over a million cells in a single image, enabling simultaneous observation of centimeter-scale dynamics with micrometer resolution. This technology, termed 'trans-scale scope,' may accelerate research in fields such as neuroscience, oncology, and immunology.
Researchers have developed a new way to deliver molecular therapies to cells using a programmable system called SEND, which harnesses natural proteins in the body to encapsulate and deliver different RNA cargoes. This could lead to safer and more targeted delivery of gene editing and other molecular therapeutics.
A team of engineers and physicians developed a steerable catheter that can navigate the brain's arteries and blood vessels in any direction. The device was inspired by nature and successfully tested in pigs, with potential to treat brain aneurysms and other neurological conditions.
Researchers have developed heat-controllable CAR T cells that can target and destroy cancerous tumors, while preventing relapse. The cells are engineered to produce immunomodulators under photothermal control, increasing their effectiveness against solid tumors.
Researchers designed a 3D-bioprinted model of a blood vessel that mimics its state of health and disease, enabling more accurate cardiovascular drug advancements. The team's novel nanoengineered bioink offers high printability and ability to protect encapsulated cells.
A research team at POSTECH has developed a biocompatible nanomotor that mimics life's autonomous motility using glucose as fuel. The nanomotors exhibit directional propulsion, overcoming Brownian motion, and show potential for intracellular targeted drug delivery and precise cell manipulation.
Researchers developed nitrogen-doped fluorescent carbon dots for multi-mechanism detection of iodide ion and curcumin in complex biological and food samples. The NCDs showed remarkable sensitivity, low detection limit, and good selectivity, making them a promising prospect for biosensing and disease diagnosis.
Researchers from Terasaki Institute for Biomedical Innovation developed a method to fabricate ultrathin gold shells around silver nanowires, improving their stability and effectiveness. The gold-coated nanowires showed superior durability and performance in various tests, outperforming commercial nanowires.
A team of researchers has developed a new concept for a future brain-computer interface system that employs independent, wireless microscale neural sensors to record and stimulate brain activity. The system, dubbed 'neurograins,' successfully recorded neural signals from a rodent's cerebral cortex, demonstrating its potential to provid...
Researchers have discovered that dendrimer tentacles can avoid detection by the complement system, part of our immune system. This could lead to developing a new system for delivering drugs into the body without triggering an immune response.
Researchers identified two lectins, Clec4g and CD209c, that strongly bind to the SARS-CoV-2 Spike protein, blocking viral entry into cells. These findings hold promise for developing robust therapeutic interventions against circulating variants.
Researchers from the Hubrecht Institute have successfully corrected mutations that cause cystic fibrosis in cultured human stem cells using prime editing. The technique is safer than CRISPR/Cas9 and shows promise for application in patients, potentially leading to a cure or prevention of genetic diseases.
Researchers at Chalmers University of Technology have developed a method to prevent bacterial infections on medical implants by covering graphene with bactericidal molecules, which are released in a controlled manner. The new material has shown promising properties and paves the way for more effective antibacterial protection.
Researchers have developed a special polymer to coat blood vessels on transplanted organs, reducing rejection rates in mice by substantially diminishing immune system response. The breakthrough has the potential to eliminate the need for drugs that prevent organ rejection and improve transplant outcomes.
Researchers at Ural Federal University create enzyme-free electrocatalytic sensors using palladium and silver, increasing sensitivity and accuracy. The new method reduces storage needs and costs, making glucose measurement more reliable and accessible.
Researchers developed a sustainable source of corneal endothelial cells from pluripotent stem cells, reversing corneal transparency loss and promoting regrowth in rabbits and monkeys. The study suggests that stem cell-derived CECs may be a viable treatment option for patients with corneal endothelial dysfunction.
Researchers at Duke University developed a robotic imaging tool that can automatically detect and scan patients' eyes for eye diseases, producing clear images in under 50 seconds. The system uses optical coherence tomography and is designed to be safe and accessible for optometrist offices, primary-care clinics, and emergency departments.
Researchers found changes in erythrocyte morphology and nanoparticles on cell surfaces during radiation therapy, which may indicate treatment effectiveness or prognosis. The study suggests that analyzing these changes could lead to the development of a diagnostic method for assessing RT efficacy.
Researchers have developed a wireless, battery-free device that can illuminate neuron activity in the brain without penetrating the skull or tissue. This breakthrough technology has the potential to revolutionize treatments for conditions like epilepsy, chronic pain, and depression by enabling less invasive optogenetics experiments.
Rice University bioengineers are developing an insulin-producing implant to regulate blood glucose levels in Type 1 diabetics. The implant uses human stem cells and 3D printing to mimic the natural behavior of the pancreas, with the goal of achieving consistent target blood glucose levels.
A new imaging technique developed by the Skala Lab can predict the efficiency of cardiomyocyte differentiation from human pluripotent stem cells, providing a non-invasive quality control method. The technique uses autofluorescence to measure metabolic activity and has been shown to be accurate in predicting outcome with high consistency.
Researchers at Carnegie Mellon University have developed a new approach to study neuronal interactions, combining spike count correlation and dimensionality reduction methods. This integration provides a more comprehensive understanding of brain function, shedding light on how neurons communicate and influence various bodily functions.
A new brain stimulation technique, sonothermogenetics, has been developed by combining ultrasound and genetics to activate specific neurons in the brain.
A new deep neural network architecture can differentiate between healthy and diseased skin images with high accuracy, offering a potential screening tool for systemic sclerosis. The proposed network reached 100% accuracy in training and validation sets, outperforming traditional CNNs.
New research from Carnegie Mellon University and the University of Pittsburgh examines how changes in internal states like engagement affect learning. The study found that fluctuations in neural activity are influenced by shifts in internal states, suggesting a key role for engagement in learning.
Researchers from Rensselaer Polytechnic Institute developed a new testing strategy that effectively reduces collusion among students taking online tests. The 'distanced online testing' approach estimates each student's competence levels and assigns questions at varying times, reducing the incentive for students to receive help.
Manu Platt, a biomedical engineer at Georgia Institute of Technology and Emory University, has received the AAAS Mentor Award for his commitment to mentoring underrepresented students. He provides opportunities for growth, encourages students to step out of their comfort zones, and advocates for diversity in STEM fields.
Researchers found that compression garments reduce immediate and delayed strength loss after strenuous exercise, allowing athletes to resume high-intensity training sooner. The study suggests wearing a below-knee compression garment during regular workouts provides mechanical support and tissue compression, reducing the risk of musculo...
Researchers at the University of Sydney have developed a new method to predict speech perception for individual recipients, enabling personalized cochlear implant configurations. This study aims to further improve the performance of cochlear implants in noisy environments.
Researchers at UC Davis have developed a new method to characterize and calibrate spectrometers using excess noise in light signals. This approach allows for faster and more accurate calibration, with results comparable to traditional methods in just a few seconds.
A new deep learning methodology called Brain-NET has been developed to accurately predict a person's level of expertise in surgical motor skills based solely on neuroimaging data. This technology has the potential to streamline the surgeon certification process, enabling real-time score feedback and remediation or training.
Researchers at UC Davis have created a device to directly measure fetal blood oxygen saturation during labor, which could lead to better information on the health of the fetus before birth. This technology has the potential to reduce the rate of C-sections and improve outcomes in difficult deliveries.
A new robot created by Rutgers University has performed as well or better than humans in blood sampling, providing quick results and reducing complications. The device includes an ultrasound-guided robot that draws blood from veins, and could be used in various medical procedures to improve patient outcomes.
Researchers at Penn State have developed a bio-inspired, liquid, sludge- and bacteria-repellent coating that can make toilets self-cleaning. The coating, called LESS, reduces the amount of water needed to flush a conventional toilet by half, making it more efficient and sustainable.
Researchers have developed a new type of fluorescent carbon dot that can effectively detect calcium levels in cells. The CDs exhibit bright blue fluorescence and have been shown to be nontoxic and biocompatible, making them a promising probe for intracellular Ca2+ detection.
The Biomedical Engineering Society has recognized Weiqiang Chen's original research on single-cell mechanical allostasis, a biological process that drives cells to reach a new equilibrium. His work employs principles of mechanical engineering and physics to identify the state of individual cells.
Researchers created a wearable, disposable respiration monitor with high-fidelity readings using inexpensive sensors from Shrinky Dinks. The device helps track breath rate and volume, aiding asthma and cystic fibrosis patients.