Articles tagged with Biotechnology
Scientists used a gene-silencing tool and large library to understand how photosynthetic bacteria adapt to light and temperature changes. Partial suppression of genes yielded big benefits in modifying stress response in wild microbes.
Researchers have developed new seed varieties of wheat that remove harmful gluten proteins without affecting breadmaking quality. The modified wheat can reduce the risk of triggering celiac disease in people without the condition and improve flour quality.
Researchers at Karolinska Institutet have developed a technique to deliver gene editors and protein therapeutics to cells using engineered extracellular vesicles. The method shows promising results in animal studies, highlighting the potential for treating genetic diseases and neurological disorders.
Researchers at UC San Diego create a simple approach to rapidly check on human gene changes by turning everyday bacteria into living test tubes. This technique, called LEICA, uses E. coli as the host bacterium and relies on its growth rate to reflect human enzyme performance.
The RFS Awards in Science 2024 recognize outstanding peer-reviewed research by women and underrepresented minorities in STEM. The awards honor the best papers written in 2024, with winners receiving a $1,000 cash prize and free access to their publications for 90 days.
Iron-based magnetic nanomaterials have shown potential in drug delivery, magnetic hyperthermia, and iron deficiency treatment. They influence macrophage reprogramming through enzyme-like activities, modulating intracellular iron metabolism and regulating cell signaling pathways.
Researchers developed a new therapy that can be injected intravenously right after a heart attack to promote healing and prevent heart failure. The therapy both prompts the immune system to encourage tissue repair and promotes survival of heart muscle cells after a heart attack, showing effectiveness up to five weeks after injection.
A new method for DNA detection uses heterogeneous probe particles and laser light to accelerate genetic analysis. This PCR-free technique offers greater sensitivity and speed than traditional methods, making it more accessible for medical, environmental, and personal health applications.
Insilico Medicine is presenting significant achievements in cancer therapy and immunology, including AI-powered discovery of potential therapies and novel solutions for unmet needs. The company's Pharma.AI platform has received IND clearance for 10 molecules, with promising results in Phase 2a clinical studies.
Researchers at Brown University suggest that gold nanoparticles could one day be used to restore vision in people with macular degeneration and other retinal disorders. The nanoparticles, when injected into the retina, can stimulate the visual system and restore vision in mice with retinal disorders.
The University of Virginia has appointed Dr. Mark T. Esser as the inaugural head of its Manning Institute, a $350 million facility aimed at transforming healthcare and accelerating new treatments. Esser brings decades of experience in developing new medical breakthroughs and will foster an ecosystem of innovation to attract biotechnolo...
A new study found that mesenchymal stem cell-derived extracellular vesicles significantly enhance survival and facilitate substantial peripheral blood recovery in mice exposed to high-dose irradiation. The treatment promoted hematopoietic recovery, with increases in red blood cell, platelet, white blood cell, and hemoglobin levels.
The ISSCR has elected new Vice President, Treasurer, Clerk, and Directors to lead the organization. Fiona Doetsch, Lee Rubin, and Megan Munsie bring expertise in neural stem cells, iPSCs, and developmental biology to their new roles.
A study published in Science Advances has revealed promising alternative pathways to overcome photorespiration, which can reduce crop productivity by up to 36%. The researchers identified mechanisms that could improve plant productivity while adapting to climate change and growing global food demands.
Engineers at University of Bristol spin-out company Impulsonics have created a technology that can move cells using acoustic waves, enabling critical lab tasks to be carried out on a benchtop device. This innovation has the potential to accelerate drug discovery and unlock personalized medicine screening in clinics.
The ISS National Lab has launched the Orbital Edge Accelerator program, investing up to $500,000 in six startups for space-based innovation and research & development. The selected startups will receive mentorship and the opportunity to launch an ISS National Lab-sponsored investigation.
The study analyzed microbial communities on the China Space Station, revealing common characteristics of environmental microorganisms during long-term human residence. The findings provide a baseline for microbial safety measures and advance research consensus on microbial adaptation capabilities in space.
The University of Rhode Island will host the international XV Progress in Motor Control Conference from June 30 to July 2, featuring over 30 invited speakers from around the world. The conference will focus on theoretical advances in motor control, motor learning and neural plasticity, motor disorders and rehabilitation.
A new review article identifies major themes in AI application to neurosciences, including a 5-fold increase in AI-related publications. The study also notes a surge of over 13-fold in clinical neurology AI-related publications in the past decade.
Researchers at Osaka Metropolitan University developed an engineered yeast that can produce record-high yields of D-lactic acid from methanol, a key compound used in biodegradable plastics and pharmaceuticals. The optimized yeast strain achieves a 1.5-fold boost in production compared to other methanol-based methods.
University at Albany researchers have pioneered new methods for designing and assembling DNA nanostructures, enhancing their potential for real-world applications. They successfully assembled these structures without the need for extreme heat and controlled cooling, using unconventional buffer substances like nickel.
Dr. Ronald Newbold has been appointed as the permanent CEO of Empire Discovery Institute (EDI), a non-profit drug discovery and development accelerator. With over 30 years of business development experience, Dr. Newbold will lead EDI's growth and expansion, including the addition of new programs and partnerships.
The TTUHSC Graduate School of Biomedical Sciences hosted the 37th Student Research Week, showcasing student researchers' work and presentations from distinguished national speakers. The event featured an increase in abstract submissions and lightning talk sessions.
Core-shell nanoparticles offer effective drug encapsulation, shielding from degradation, and controlled release. This innovation enables targeted drug delivery, improving treatment outcomes and reducing side effects. The versatility of these nanoparticles allows for tailored materials to suit different therapeutic needs.
Insilico Medicine has deployed the first bipedal humanoid AI scientist, Supervisor, to aid in data acquisition and generation for training embodied AI systems. The humanoid will assist with lab tours, telepresence, tracking, and supervision, bridging the gap between human-free fully-autonomous robotics facilities.
The collaboration combines Insilico's Pharma.AI platform with Tenacia's expertise in CNS biology and clinical development. By leveraging generative AI, the partnership seeks to expand therapeutic options and enhance outcomes for patients worldwide. Recent successes by Insilico include the nomination of ISM8969, a BBB penetrable NLRP3 i...
Researchers at Ohio State University developed an e-Taste system that uses sensors and chemical dispensers to simulate various tastes. In field testing, participants could distinguish between different sour intensities with high accuracy, paving the way for immersive virtual food experiences.
The article discusses the need for bioanalytical assays to measure immune responses to oligonucleotide therapeutic drugs, especially when they include carriers or conjugates. Highly specific antibodies may enhance the development and production of ONTs, expanding studies on their safety and efficacy.
The article presents guidelines for designing consent materials and procedures for autistic adults and people with intellectual disability, highlighting the importance of multiple modes to deliver content. These guidelines aim to improve accessibility and respectfulness in research with individuals on the autism spectrum.
Researchers developed a liquid fertilizer replacing unsustainable chemical fertilizers with organic waste, producing up to 100% of nitrogen and 77% of phosphorus. The method also increases phosphorus solubility by adjusting pH levels.
The article reviews additive manufacturing technology for biomedical metals, enabling customized implants with precise internal structures. It highlights the integration of AI and 4D printing, addressing challenges in production costs, regulatory compliance, and post-processing.
Researchers at the University of Sydney are using Zwitterions to create materials that can prevent blood clots from forming in medical devices and implants. They have successfully created a zwitterionic coating that repels water beyond the material's boundaries.
Germany's leading biotech hubs, Berlin, Munich, and Heidelberg, excel in different areas, but struggle with transforming research into market-ready solutions. The country's innovation potential is largely untapped due to the fragmentation of its biotech landscape and inadequate knowledge transfer.
A new AI-based tool can translate a person's thoughts into continuous text without requiring language comprehension, and it can be trained in under an hour. The system was developed by adapting a previous brain decoder to a new person using short, silent videos.
Researchers have developed a novel solid catalyst to efficiently reclaim materials from epoxy products, including carbon fibers and glass fibers. The process uses lower temperatures than traditional methods, reducing energy requirements and making the recovery of materials more environmentally friendly.
Researchers developed a next-generation technology, MycoBCP, using artificial intelligence to screen for antimicrobial compound candidates. This method has already vastly accelerated the team's TB research capabilities and helped identify optimal candidate compounds for drug development.
Researchers at U of T have developed a new platform called smol-seq that uses DNA sequencing to detect metabolites. This method enables the analysis of hundreds of metabolites simultaneously, making it faster and more precise than current methods.
Zebrafish have pineal gland photoreceptors that detect color using parapinopsin 1 (PP1) protein. Two genes, Sagb and Arr3a, play a crucial role in the inactivation of PP1 based on light intensity, with Sagb taking over at higher intensities.
Insilico Medicine's AI-driven platform, PandaOmics, identifies two new therapeutic targets and a repurposed FDA-approved drug for treating endometriosis. The study reveals guanylate-binding protein 2 (GBP2) and hematopoietic cell kinase (HCK) as key proteins involved in the disease mechanism.
A new study using a novel mouse strain expressing Halo-tagged SOCS1 reveals that the inhibitor needs to exceed a threshold level to suppress GM-CSF and IFN-gamma signaling. The findings emphasize SOCS1's crucial function in modulating cytokine signaling.
Researchers use SCP-Nano to analyze distribution of extremely low doses of nanocarriers throughout the mouse body, visualizing each cell that has taken them up. The platform identifies unwanted accumulation in organs like the heart and liver, paving the way for safer mRNA therapeutics.
Researchers evaluated the noise impact of offshore wind farms on fishes and dolphins in the Pearl River Estuary. The study found that pile driving noise during construction can significantly affect marine animals, with predicted impact zones varying by species.
Critical Path Institute's Translational Therapeutics Accelerator (TRxA) is launching its 2025 global Request for Proposals to support academic researchers in bridging the 'valley of death' in drug development. The program aims to enable the transition of innovative therapeutics from lab to patients.
Scientists at the University of Stuttgart have developed a new tool for synthetic biology using DNA nanorobots that can alter artificial cells. These nanorobots enable the formation of transport channels in synthetic cell membranes, allowing large molecules to pass through and facilitating the transportation of therapeutic proteins.
The Menarini Group and Insilico Medicine have entered into an exclusive licensing agreement for a preclinical small molecule targeting solid tumor cancers. The asset has demonstrated broad anti-tumor activity in selected cancers, offering new treatment options for cancer patients with high unmet needs.
The study traces the evolutionary history of brown algae through genomic analysis, highlighting their role in sustaining coastal habitats and combating climate change. The research also identifies practical applications in aquaculture, biotechnology, and ecosystem restoration.
BGI Genomics strengthens ties with Saudi Arabian partners to advance public health development through genomics technology. The company aims to apply its expertise in precision medicine to support Saudi Arabia's Vision 2030 goals.
Researchers at Osaka Metropolitan University have discovered yeast cell wall-derived proteins that exhibit high emulsifying activity, comparable to commercial casein emulsifier. These easily released protein molecules could potentially replace emulsifiers derived from milk, eggs, and soybeans, reducing allergenic concerns.
Sage has acquired Mary Ann Liebert, Inc., expanding its portfolio of peer-reviewed journals in biotechnology and life sciences. The acquisition enhances reach and impact, ensuring high-quality science continues to make a difference.
Charles Shoemaker, a Tufts University professor, has been named Fellow of the National Academy of Inventors for his work on developing immunotherapeutics. His research focuses on creating antibody-based agents that can prevent and cure diseases, including those caused by viruses and bacteria.
Researchers have developed a biotechnological process to break down and remove the matrix from carbon fiber reinforced polymers (CFRPs), recovering valuable chemicals. Genetically modified fungi feed on benzoic acid produced during breakdown, yielding the compound OTA with potential medical applications.
The BioImage.IO Chatbot uses extensive language models and Retrieval-Augmented Generation (RAG) to provide real-time access to databases and minimize errors. It enables researchers to perform complex image analysis tasks in a simple manner, working directly with microscopes and laboratory equipment.
Scientists at the Swiss Federal Laboratories for Materials Science and Technology have successfully created luminous wood by combining fungal threads with hardwood. The process involves a two-stage enzymatic reaction that stimulates the production of luciferin, emitting green light from the treated wood.
Insilico Medicine has developed an innovative platform using generative AI to discover novel molecules. The company has nominated over 20 preclinical candidates and received IND clearance for 10 molecules.
Alex Zhavoronkov, Insilico Medicine's founder and CEO, was named Highly Cited Researchers of 2024. He has published over 40 peer-reviewed research papers, with a total H-index of 64, and led the development of Insilico's lead drug pipeline, ISM001-055.
The new effort aims to rapidly transform academic breakthroughs into life-saving therapies for a range of medical conditions. Autobahn Labs will invest up to $5 million per selected project to support the development of new pharmaceuticals.
Insilico Medicine has been selected by Fortune as one of the top AI innovators, leveraging its generative AI platform to develop novel drugs and treatments. The company's lead drug pipeline, ISM001-055, has shown promising results in Phase IIa trials, offering new hope for patients with idiopathic pulmonary fibrosis.
Researchers discovered a 10-amino-acid sequence, called the passport sequence, that facilitates efficient glycoprotein trafficking and enhances galactosylation and sialylation. This leads to improved protein stability and efficacy in biopharmaceuticals.
Researchers at Institute of Science Tokyo develop an innovative strategy to produce β- and γ-naphthocyclinones, challenging compounds that have potential for medical and biological applications. They successfully synthesize the molecules using a retrosynthetic analysis approach, achieving yields of over 70%.
Researchers developed a new AI-powered diagnostic system, FastGlioma, which reveals invisible cancerous tissue in brain tumor surgery. The technique may delay or prevent recurrence of high-grade tumors and improve patient survival.