Articles tagged with Biotechnology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a new enzyme that uses formamides as a substrate for biocatalysis, achieving equivalent or slightly better results than traditional formate-based systems. The enzyme converts formamides into NADPH, producing CO2 as a waste product and opening up new possibilities for asymmetric reductive amination.
A team of researchers from Harvard and Texas developed a soft implantable device with dozens of sensors to record single-neuron activity stably for months. The device uses fluorinated elastomers and is 10,000 times softer than conventional flexible probes.
Princeton researchers create a system to control the growth of microtubule branches, enabling precise chemical transport and potential applications in soft robotics, new medicines, and biomolecular transport. The technique harnesses cellular scaffolding to build novel materials and technologies.
Researchers at RIKEN successfully spin artificial spider silk that closely matches natural production, mimicking the complex molecular structure of silk. The eco-friendly innovation has potential benefits for environment and biomedical fields.
Researchers at Duke University developed an adaptive deep brain stimulation therapy for Parkinson's disease, targeting two key brain structures and using a novel self-adjusting device. The study found that this approach improved motor symptoms and reduced medication doses in six patients.
A team of researchers created a 3D bioprinted brain blood vessel model to investigate the impact of blood vessel curvature on metastatic cancer development. The model revealed that increased blood vessel curvature correlates with heightened cancer cell adherence and extravasation.
Researchers have enhanced microvascular sensitivity using ultrafast ultrasound, capturing the three-dimensional vascular network of renal arteries and veins without contrast agents. This technique reveals sharp decreases in renal blood flow during acute renal failure and chronic vascular degeneration in diabetic nephropathy.
Researchers from Tokyo University of Science discovered that manipulating polyamines enhances the functional profiles of monoclonal antibodies. The study found that controlling polyamine levels increases IgG galactosylation, leading to improved therapeutic efficacy.
Researchers at The University of Tokyo developed a bio-tagging method using dissolvable microneedle arrays for permanent animal identification. The approach, called 'MAPs,' uses customizable molds to tattoo unique identifiers into the skin, offering a safer and more humane alternative to traditional ear tags or RFID chips.
Researchers at Karolinska Institutet have developed a nasal spray with IgA antibodies that can protect mice from SARS-CoV-2 infection. The treatment significantly diminished virus load in infected mice and showed stronger binding to the spike protein compared to original IgG antibodies.
Researchers from Brazil have discovered two novel peptides with biotechnological potential in the venom of the pit viper Cotiara and the South American bushmaster. The peptides, including Bc-7a and Lm-10a, show promise as potential treatments for high blood pressure.
A recent study in Uganda found that asymptomatic individuals with low-level malaria infections had highly variable parasite dynamics and species present. Frequent sampling every other day or daily was sufficient to detect a proportion of infections similar to daily testing, but less frequent tests may miss up to one-third of cases.
Chicken sperm can retain fertility and viability for up to three weeks after refrigeration, making it unsuitable for traditional cryopreservation methods. The study found that removing calcium ions impacts energy metabolism dynamics, inducing a physiological dormancy-like state in the sperm cells.
Researchers have developed a mineral coating that maintains mRNA activity for up to six months at room temperature. This breakthrough enables the storage of mRNA therapeutics like COVID-19 vaccines on medical shelves, bridging the gap between rich and poor communities.
Researchers have elucidated the metabolic pathways of Halopseudomonas bacteria that break down plastic coatings. The study shows the bacteria can rapidly degrade polyester polyurethanes, making it a promising solution to global waste problems.
Letters in Applied Microbiology invites submissions on Pseudomonas biotechnology, covering applied biotechnology and metabolic engineering, as well as novel genetic tools. Early-career researchers are encouraged to share their work, fostering collaboration and inspiring future innovations.
Researchers developed a non-invasive MRI technology to measure interstitial fluid flow, crucial for tumour treatment. The new method combines phase-contrast MRI with an improved stimulation echo sequence, reducing signal loss and improving detection accuracy.
Researchers at KAIST have developed eco-friendly technologies for producing plastics and processing waste plastics using microorganisms. The team presented the latest microorganism-based technologies that can produce plastics from renewable biomass resources and decompose waste plastics, contributing to a circular economy.
The new robotic replica, called RRV, can mimic healthy and diseased states, allowing scientists to test cardiac devices and therapies. The model can also be used to study the effects of mechanical ventilation on the right ventricle and develop strategies to prevent right heart failure.
A team of engineers has developed a novel printing method called deep-penetrating acoustic volumetric printing (DVAP) that uses soundwaves to solidify biologically compatible structures in deep tissues. The technique involves a specialized ink that reacts to ultrasound waves, enabling the creation of intricate structures for biomedical...
Researchers have elucidated the molecular mechanism of formaldehyde poisoning in a class of efficient hydrogen-producing biocatalysts. The study suggests that modifying the enzyme to resist formaldehyde inhibition could enable its use in bio-based industrial processes and understanding metabolic pathways.
Researchers developed a flexible new platform that solves part of the daunting delivery problem in cell and gene therapies. The workhorses behind this platform are extracellular vesicles, which bind to target cells and effectively transfer drugs inside.
A new technology enables the printing of complex robots with soft, elastic, and rigid materials in one go. This allows for the creation of delicate structures and parts with cavities as desired.
A team of researchers developed synthetic enzymes that can control the behavior of the signaling protein Vg1, which plays a key role in vertebrate embryonic development. The study uses zebrafish to investigate how Vg1 is formed and found that it must undergo additional processing before it can be activated.
Researchers use 3D human breast organoids to study cellular and molecular processes of lactogenesis, milk production, and involution. The models form structures characteristic of human breast tissue, maintain various cell subtypes, and respond to hormone or drug treatments.
Researchers at Osaka University have developed a novel platform that combines nanopore technology with artificial intelligence to detect different coronavirus variants quickly. The platform was tested on 241 saliva samples and detected the Omicron variant 100% of the time.
Researchers developed 'acoustic touch' smart glasses that translate visual information into distinct sound icons, enhancing the ability of blind or low-vision individuals to navigate their surroundings. The technology significantly improved object recognition and reaching abilities, empowering independence and quality of life.
Researchers developed the DANGER analysis tool to overcome challenges in CRISPR gene editing. The tool assesses on- and off-target effects without a reference genome, quantifying phenotypic risk at the gene ontology level. This breakthrough enables safer strategies for genome editing in various organisms.
Researchers have developed soft implantable fibers that can deliver light to major nerves through the body, allowing for precise illumination of nerve pain. The fibers are flexible and stretch with the body, enabling scientists to study peripheral nerve disorders in animal models without constraining movement.
Osaka Metropolitan University scientists have developed a super-efficient laser light-induced detection method that reduces detection time from hours to minutes. The technique allows for ultrafast and ultrasensitive measurement of biological nanoparticles, including exosomes, with diameters of 50–150 nm.
A breakthrough technique has been developed by University of Oxford researchers to repair brain injuries using 3D printing. Neural cells can be printed to mimic the architecture of the cerebral cortex, showing structural and functional integration with host tissue.
Researchers at Northwestern University developed Lattice, a device that simulates human disease in multiple organs to analyze interactions and test new drugs. The technology can replicate complex disease processes, allowing scientists to study the effects of obesity on endometrial cancer, for example.
Armida Labs, a UCR-founded pharmaceutical company, has received a $400,000 NIH Small Business Innovation Research grant to develop its breakthrough pancreatic cancer therapy Targefrin. The grant will enable the company to gather industry-standard data for human clinical trials.
Scientists developed a workflow that combines CRISPR gene editing with computational models to predict necessary gene edits, reducing product development cycles from years to months. The approach showed promise in engineering strains to convert lignin into target molecules, offering an eco-friendly alternative for biomanufacturing.
A group of experts has developed a framework to research and apply brain-cell-based computer technology responsibly. The technology has significant promise for accelerating disease understanding but raises questions about the moral status of bio-computers.
Researchers highlight single cell protein as a promising alternative protein source from microorganisms, which can thrive on diverse waste materials and enhance socio-economic sustainability. The review also emphasizes the need for consumer acceptance to effectively commercialize this eco-friendly protein source.
Researchers at EPFL engineered E. coli bacteria to exhibit enhanced extracellular electron transfer, producing electricity while metabolizing organic substrates. The bioengineered E. coli surpassed previous approaches, generating three times more electrical current in various environments, including wastewater from a brewery.
Researchers at the University of Cincinnati have developed a new at-home test that uses saliva to detect early signs of gingivitis, the earliest form of gum disease. The device can identify periodontal disease caused by bacteria in saliva, providing an opportunity for consumers to protect their oral health.
Chung-Ang University researchers create an electrochemical DNA biosensor that detects HPV-16 and HPV-18 with high specificity, facilitating early diagnosis of cervical cancer. The sensor uses a graphitic nano-onion/MoS2 nanosheet composite to enhance conductivity.
Researchers at University of Oxford have developed a miniaturized soft power source that can alter the activity of cultured human nerve cells, paving the way for miniature bio-integrated devices. The device uses internal ion gradients to generate energy, producing a current that persists for over 30 minutes.
A ferrocene-based capsule with unusual charge-transfer interactions has been synthesized, allowing for reversible encapsulation and release of guest molecules. The capsule can bind to a variety of organic and inorganic dyes and electron-accepting molecules, demonstrating its potential applications in medicine, biotechnology, and chemic...
The Texas Heart Institute has received a five-year, $2 million grant from the National Institutes of Health to advance organ bioengineering. The project aims to develop transplantable bioartificial hearts to combat end-stage heart failure.
The researcher aims to bridge completeness, efficiency, and applications in 3D graphs to solve problems in physics, fluid dynamics, and biotechnology. Geometric graphs can represent molecules, proteins, and drugs, enabling the prediction of their behavior and properties.
Researchers developed a platform that allows engineered biosensor bacteria to safely pass through the gastrointestinal tract in animal models. The platform enables real-time monitoring of gut health and can be used to diagnose and monitor various diseases, including inflammatory bowel disease. It has the potential to revolutionize pati...
LSU Health researchers found combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases effectiveness in experimental models of ER+ and TNBC. The study's findings suggest a new approach for treating treatment-resistant breast cancers.
A £1.75m project led by Professor Chenyu Du aims to develop new processes for recovering polyester and cellulose from mixed cotton and polyester fibres. The goal is to create a roadmap towards net-zero for the textiles industry, reducing plastic waste and increasing recycling rates.
A team of researchers developed a novel method that leverages temporal characteristics of blood pulse to estimate heart rates with improved accuracy, especially in scenes with ambient light fluctuations. The proposed method showed a 36.5% improvement in estimation accuracy compared to conventional methods.
A miniature human heart model, approximately half a grain of rice in size, has been developed to transform drug testing and cardiovascular research. This self-paced, multi-chambered model provides real-time measurements of essential parameters, enabling unprecedented insights into heart function and diseases.
A recent study discovered the complex circadian clock mechanisms in soil bacteria Bacillus subtilis, regulating multiple genes and behaviors. The findings have significant implications for industrial applications, human health, and plant science.
Insilico Medicine's inClinico platform uses generative AI to predict Phase II to Phase III clinical trial success with an accuracy of 79%. The tool has been validated in various studies and can provide valuable insights for investors and biotech/pharma companies.
A new study by Prof. Yossi Paltiel and colleagues reveals that nuclear spin significantly affects oxygen dynamics in chiral environments, particularly in transport. This finding challenges long-held assumptions and opens up possibilities for advancements in biotechnology and quantum biology.
Researchers developed a blood test to detect nerve injury in MS and found it works for children, even when symptom-free. The test measures neurofilament light chain levels, which reflect nerve cell injury.
Researchers found fungi can effectively degrade low-density polyethylene (LDPE) plastic without wood present. In the absence of wood, fungal biodeterioration of LDPE increased, suggesting a potential natural method for plastic waste management.
Researchers have developed a novel DNA-filtering system using α-hemolysin nanopores to reduce contamination in single-molecule DNA extraction. The technique, which uses phospholipids and the PCR clamp method, achieved a 99.98% reduction in DNA contamination.
Researchers developed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering, demonstrating potential for clinical applications. The scaffolds can reconstruct desired tissue EM through non-invasive ultrasonic stimulation, promoting cell adhesion and osteogenic differentiation.
Researchers found that young and healthy human glial progenitor cells can outcompete older and diseased cells in the adult brain, replacing them with healthier ones. This breakthrough has strong therapeutic implications for treating neurological disorders like Huntington's disease.
Research discusses challenges and future directions for porous metallic implant fabrication, focusing on microstructure, biocompatibility, and mechanical properties. The review aims to promote metabolite and nutrient exchange, bone ingrowth, and improved implant-tissue anchorage.
Researchers at MIT are developing a continuous mRNA manufacturing platform to improve vaccine development and production. The pilot-scale system aims to reduce costs, increase efficiency, and facilitate collaboration in the biopharmaceutical industry.
The project aims to develop a sustainable hemp-based supply chain in Pennsylvania, focusing on manufacturing and deployment of bio-based products. The goals include reducing greenhouse gases through carbon capture strategies and promoting diversity and inclusion.
Biotechnology holds promise for saving endangered tree species through a combination of traditional breeding approaches and innovative genetic engineering. The study emphasizes the need for public acceptance and regulators' support to harness biotech's potential.