Articles tagged with Systems Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
P&G is pioneering the 'Omics' revolution in beauty and grooming by applying genomics, proteomics, and metabolomics tools to map the entire biological system. This approach enables scientists to identify molecular pathways associated with common concerns in skin and hair biology.
The CHEO Research Institute has developed a secure protocol to protect patient identity while facilitating the sharing of health data for public health purposes. The new system enables providers to report diseases to authorities without fear of retribution, promoting accurate disease control and outbreak detection.
A miniature ventilation system with a simple nasal mask can help patients with chronic obstructive pulmonary disease (COPD) become more active. Advanced COPD patients improved their distance walked by an average of 38 meters, comparable to full pulmonary rehabilitation programs.
The American Institute of Physics has posted lay-language summaries of recent research presentations at the Acoustical Society meeting. These summaries cover a wide range of topics, including biomedical ultrasound, reducing underwater noise, and new car mufflers. The online collection offers easily approachable explanations of complex ...
Virginia Tech researchers aim to fuse top-down and bottom-up approaches to study cells, combining computational models with experimental analysis to understand cellular responses.
University of Cincinnati researchers have discovered the molecular system involved in weight gain linked to a class of diabetes drugs, finding it's also triggered by high-fat foods. The study may lead to modification of existing therapies and dietary recommendations.
The MarginProbe System detected positive margins in 72% of cases, compared to 22% without the device, reducing patients' need for re-excision procedures. The technology improved traditional breast cancer surgery outcomes by providing immediate feedback on excised tissues.
The Society of Interventional Radiology prioritizes patient safety through education and research on radiation dosage reduction. New articles explore techniques to optimize radiation use without compromising quality care.
A new study found that implementing a system to upload CD images of emergency transfer patients into the receiving institution's picture archiving and communication system (PACS) decreased subsequent imaging rates by 17%. This reduces unnecessary medical imaging tests, some of which expose patients to radiation.
Implementing ACOs effectively has the potential to achieve better care, population health, and lower costs. The Commission's recommendations for ACOs include strong primary care foundation, accountability for quality, informed patients, commitment to serving the community, and innovative payment methods.
A new system allows for the measurement of power that cells employ to assemble into three-dimensional tissue. The research helps engineers evaluate how quickly cell types will combine into desired structures.
A new point-of-care clinical trial approach is being tested, combining statistical validity with real-world applicability to compare treatments. The approach aims to deliver the best care to patients while learning from each experience, reducing costs and time involved in traditional clinical trials.
A collaborative quality improvement program between Blue Cross Blue Shield of Michigan and the University of Michigan Health System has improved safety and quality in several clinical areas, resulting in significant cost savings. The program achieved measurable drops in surgical complications, with a reduction of $20 million annually.
The GERONTOSHIELD project aims to understand the aging immune system and develop personalized therapies for the elderly. Researchers investigate how immune responses in young and old mice differ from each other and identify risk markers predicting increased susceptibility for infectious diseases.
A new study published in Gastroenterology found that an automated colonoscopy reminder system significantly improved adherence to endoscopic follow-up recommendations, particularly in minority populations. The system, which included a letter and telephone call, nearly doubled the rate of recommended exams.
A recent study by UCSD researchers found a significant inverse association between surgeon availability and road traffic injury-related deaths. Regions with more surgeons showed lower mortality rates, suggesting timely surgical treatment can reduce death risk.
Researchers created a computational model that describes how intestinal cells in mice respond to TNF, revealing the importance of location and protein interactions in cell fate. The study demonstrates the power of systems biology in modeling complex biological systems and predicting disease outcomes.
Trauma patients who arrive at hospitals on weekends are more likely to survive, according to new research. The study found that the unique organization and staffing of trauma systems provide a built-in protection for these critically injured patients.
Researchers at Johns Hopkins Medicine found that coupling electronic prescription drug ordering systems with computerized adverse event reporting dramatically reduced medication errors in a psychiatric unit from 27.89 to 3.43 per 1,000 patient days over four years. The system's integration of decision support and safety net tools furth...
A new motion sensor system developed by MU researchers uses sensors on a horse's head, limbs, and tail to detect lameness. This system improves early detection and treatment outcomes for horses with lameness by removing human bias and increasing frequency of motion sampling.
Researchers at Berkeley Lab are advancing systems biology research to improve understanding of cellular networks and their behavior. By integrating experimental and computational technologies, they aim to bridge the gap between correlative analysis and mechanistic insights.
The current US kidney allocation system prioritizes wait time over post-transplant survival, leading to higher repeat transplantation rates. Researchers propose ranking kidneys by potential post-transplant survival and matching them with candidates who have the longest expected survival.
Researchers tested first-generation x-ray equipment from 1896 and found significantly higher radiation doses and longer exposure times compared to modern systems. The setup produced surprisingly good images despite image blurring, highlighting the significant health risks faced by early x-ray pioneers.
The US may adopt the FHT model to manage its growing healthcare system. Developed by Queen's University professor Walter Rosser, the model combines experts from various disciplines for more efficient care. Preliminary observations suggest improved patient and doctor happiness with FHTs.
Researchers discovered that human mammary epithelial cells possess lineage-specific intrinsic abilities to self-organize into domains of lineage specificity, maintaining healthy bi-layered branching organization. The study provides insights into the coordination of stem cell differentiation and tissue architecture maintenance.
A study in Canadian Medical Association Journal highlights the need for an e-health policy to guide the implementation of health information technologies. The policy should align with major strategic priorities, such as patient safety and chronic disease management, to promote electronic health record adoption and data exchange.
Researchers at Georgia Institute of Technology have developed a computer system that accurately determines a patient's level of sedation and notifies medical staff of changes. The algorithm achieved a high level of agreement with clinical assessments, showing promise for enhancing patient safety and improving drug delivery in ICU units.
The University Hospitals system has implemented a successful approach to stroke care, increasing the use of tPA therapy for ischemic stroke patients by 13.5 times. The System Stroke Program (SSP) educated community hospital staff and ensured timely treatment, resulting in better patient outcomes.
Researchers have developed a system that recognizes hand gestures as commands to control a robotic scrub nurse or display medical images during operations. The technology aims to reduce surgery lengths and infection risks, while also having potential applications in emergency response activities.
Doctors argue that current hospital quality-improvement programs have little evidence to show improved patient outcomes, despite high administrator buy-in. A formalized 'physician management infrastructure' is proposed to encourage doctors to take leadership roles in quality improvement.
Researchers propose a new classification system for SOD based on anatomy, symptoms, endoscope tests, and radiological imaging. This four-type classification demonstrates significant advantages in guiding diagnosis and treatment in China compared to the conventional Milwaukee criteria.
Research by Dr. Sébastien Sauvé and André Lajeunesse found that antidepressants accumulate in fish tissues, affecting brain activity and potentially causing long-term harm to the Saint Lawrence River's ecosystem. The study's findings highlight the need for further research into the impact of chemical pollution on aquatic organisms.
A new program aiming to bridge the gap between body and mind has received a $3.9 million grant to create comprehensive, integrated healthcare systems in Colorado. The program, ACT, will engage local leaders to tackle fragmentation in healthcare and produce best practice models for whole-person care.
Scientists at the University of Texas Health Science Center San Antonio have discovered that sodium handling in the distal nephron is controlled by a local regulatory system. This system helps set blood pressure and its dysfunction leads to hypertension.
Implementing a computerized radiology workflow with customer service representatives leads to faster report delivery, reduced anxiety for patients, and increased productivity for radiologists. The study's findings support the cost-benefits of adding these representatives to alleviate administrative burdens.
A commentary highlights the shortcomings of Canada's current drug surveillance system, citing the off-label use of recombinant activated factor 7 (rFVIIa) as a case in point. The authors emphasize the need for improved collaboration between payers, insurers, and manufacturers to ensure safe monitoring of high-risk drugs.
Researchers developed a device using angle-resolved low coherence interferometry to detect pre-cancerous cells in the esophagus lining. The technology holds promise for earlier detection and targeted biopsies, potentially improving treatment outcomes for esophageal cancer.
A new system using electronic health records significantly improves primary care physicians' performance and the health of patients with chronic conditions. The program boosts preventive care in vaccinations and cancer and osteoporosis screenings, increasing rates by up to 10 percentage points.
A study found that trauma patients in Illinois frequently exceed the mandated 2-hour transfer window, except for those with life-threatening injuries. Despite this, the most critically ill patients typically receive care within the time frame.
Researchers are developing a robotic system that combines real-time magnetic resonance imaging (MRI) with a highly flexible robotic device to perform cardiothoracic surgeries on beating hearts. This minimally invasive approach aims to increase precision and reduce trauma, leading to faster recovery times.
A comprehensive medical education reform significantly improves failure rates of the Step 1 licensing exam and increases graduation rates among underrepresented minority medical students. The integrated curriculum shows a nearly 70% decrease in failure rates and a 94% decrease in failure rates for African American students.
The Cone Beam Computed Tomography (CBCT) scanner provides high-quality images without compressing the breast tissue, making it a promising supporting role to conventional mammography. Preliminary research shows that breast coverage and radiation dose are comparable to mammography.
The report found that employer-sponsored family health insurance premiums rose 41% across states from 2003 to 2009, outpacing median incomes. By 2020, average annual premiums would increase by 79%, reaching $23,342 for families. ACA reforms aim to slow cost growth and improve coverage.
A team of researchers has developed a novel identification system for mouse embryos by injecting silicon barcodes into their perivitelline space. The system enables the tracing of individual embryos during in vitro fertilization and embryo transfer procedures, reducing risks associated with human gamete and embryo identification.
A telephone call-in program designed to improve doctor-patient communication for heart failure patients failed to show improved patient outcomes, according to a Yale University study. The six-month study tested a telemonitoring system that allowed patients to send daily information about their condition to their doctor.
A new study found that automated remote patient monitoring did not improve outcomes for heart failure patients, despite daily interactions with healthcare clinicians. The system was compared to usual care based on national guidelines and showed no effect on hospitalization rates or mortality.
A model developed by Zhengdong Cheng simulates biochemical reactions within the human body, identifying wave patterns that can signal diseased or dead cells. This innovation may lead to better understanding of organ structure and extent of damage, enabling timely diagnosis and treatment.
Researchers are developing a manufacturing platform to produce biodegradable frames that mimic nature's fine-grained details, including vasculature. The goal is to grow replacement cardiac tissues for people who have suffered a heart attack, and create better systems for growing and studying cells in the laboratory.
A study by the University of Michigan Health System found that specialists spend over 650,000 work weeks on routine follow-up care for patients with common chronic conditions. Delegating a proportion of this care could create system-wide efficiencies and free up specialists to focus on new patients and complex cases.
Researchers used a novel imaging system to track the movement of near-infrared fluorescent nanoparticles from the lungs into the body and out again. The study found that non-positively charged nanoparticles smaller than 34nm in diameter appeared in lung-draining lymph nodes within 30 minutes.
A grant-funded program has helped increase the number of underrepresented minority surgeons in academia, with 86% of graduates acquiring fellowship training. The Diverse Surgeons Initiative addresses healthcare disparities by providing advanced minimally invasive surgery skills to qualified candidates.
A study found that complications after endoscopy are more common than previously estimated, with a 1% incidence of related hospital visits within 14 days. The average cost per hospital visit was $6,355.71, and the total cost for hospitalizations among patients undergoing screening or surveillance was $355,489.76.
A collaborative approach to sharing patient safety data among Michigan hospitals has led to a nearly 10% reduction in surgical complications. The study, which examined general and vascular surgeries between 2005 and 2007, also found improvements in reducing blood infections, septic shock, prolonged ventilator use, and cardiac arrest.
The UK faces a critical care crisis with one of the lowest numbers of intensive care unit beds, leading to concerns about its ability to cope with large-scale disasters. Increasing demand driven by ageing populations and lack of effective interventions will require huge investments for high-income and poor countries.
A UNC study found that radio frequency tags on surgical sponges can aid in preventing sponges from being left behind in patients following surgery. The researchers used a radio-frequency detection device in 1,600 operations and detected one sponge in an operation where manual counting was correct.
A new system is being developed to provide accurate patient histories, assist in treatment, and optimize remote medical diagnosis. The integrated LTM/iRevive system will guide caregivers through the observational recording process and reduce errors, allowing for greater focus on providing care.
Rapid response teams dispatched to patients' rooms may be a quick fix rather than addressing deeper issues, according to Johns Hopkins patient safety expert Peter Pronovost. Better management of patient flow and staff schedules can help improve care for sickest patients.
The UCSF Center for Systems and Synthetic Biology will investigate fundamental design principles of adaptation in cells using forward engineering and comparative genomics. The center's findings may lead to new therapeutic tools and the development of synthetic circuits that can trigger desired cellular responses.
Scientists at the University of Toronto have discovered chemicals and genes that may break Striga's stranglehold on crops in sub-Saharan Africa. By manipulating strigolactone production, they aim to reduce the parasite's ability to kill crops.
Patient panels with greater proportions of underinsured, minority and non-English speaking patients were associated with lower physician quality rankings. The association suggests that inaccurate physician clinical performance rankings could lead to misallocation of resources.