Articles tagged with Systems Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Patient panels with greater proportions of underinsured, minority and non-English speaking patients were associated with lower physician quality rankings. The association suggests that inaccurate physician clinical performance rankings could lead to misallocation of resources.
A new imaging system using six different wavelengths of LED illumination is paving the way for doctors to easily screen patients for common eye diseases. The system allows doctors to distinguish between different light-absorbing characteristics of biological molecules in the eye, enabling earlier detection and diagnosis.
A team of researchers has isolated a molecule that can shut down a dysfunctional immune response, causing deadly conditions like hemorrhagic shock, delayed heart attack deaths, and rheumatoid arthritis joint destruction. The discovery marks a significant step toward clinical application, with the potential to save lives.
Researchers found that local fishermen exposed to oil clean-up efforts two years prior showed persistent airway injury, including increased prevalence rates of respiratory symptoms and biomarkers of pulmonary oxidative stress. The study suggests even short-term exposure to oil sediments may have detrimental health effects.
Using an electronic medical record (EMR) tracking system can improve follow-up after an abnormal Pap test, leading to increased diagnostic resolution and faster treatment times. The study found that physicians who used this tracking system had significantly shorter times to diagnosis compared to traditional methods.
The Virginia Bioinformatics Institute's COPASI software package has been made open source, allowing global access and use. The new license agreement enables commercial users to freely use the software, while also enhancing its compatibility with other academic programs.
A study published in Clinical Infectious Diseases found that reminder systems encouraging prompt removal of urinary catheters reduced CAUTIs by 52%. The researchers suggest that low-cost interventions like nurse-empowered catheter stop orders could be effective in reducing infections. Hospitals can implement these strategies to improve...
Researchers found that proactively disclosing medical errors decreased new legal claims and costs for health care systems. Collaboration between internists and specialists improved care for patients with chronic hepatitis C virus infection by increasing adherence to quality-of-care measures. However, administering corticosteroids to de...
Researchers developed a specialized CPOE system to alert doctors to potentially hazardous medications for older hospital inpatients. The system resulted in a significant decrease of 20% in orders for flagged medications, highlighting its potential to reduce adverse drug events and improve care for vulnerable elderly patients.
Researchers have developed an advanced search tool called QPID to assist radiologists in extracting useful data from patients' electronic medical records. The system has already been implemented at Massachusetts General Hospital and is expected to have a significant impact on various departments within the hospital and outpatient clinics.
Biologists at Tufts University have discovered a novel 'two-body' system of locomotion in the crawling tobacco hawkmoth caterpillar, where its gut moves independently of the surrounding body wall. This finding may offer valuable insights for designing soft-bodied robots and re-examining the role of soft tissues in human biomechanics.
Physicians in Northern Ontario communities can now access specialized UHN pathologists for fast and accurate diagnosis, saving time and improving patient care. The new telepathology system enables instant transmission of digital images of pathology samples, reducing travel times from hours to minutes.
Researchers at Johns Hopkins University developed a new system to detect preterm contractions with greater accuracy and sensitivity than existing tools. The device is designed to pick up electrical signals associated with uterine contractions, allowing doctors to delay preterm deliveries by six weeks or more.
Researchers found that a restricted diet reduced accumulation of senescent cells in livers and intestines, and maintained telomeres, preventing age-related disease. The study suggests that adopting a low-calorie diet later in life can still provide benefits.
A team of researchers led by Rensselaer Professor Suvranu De has won a $2.3 million federal grant to develop a touch-sensitive virtual reality simulator for training and certifying laparoscopic surgeons. The new system will employ haptic technology to realistically replicate the sensation a surgeon would feel during an actual procedure.
Researchers have developed a technique that corrects a trick of the light, enabling the use of optical microscopy to image objects or distances with resolutions as small as 0.5 nanometers, revolutionizing biology. This breakthrough allows for accurate measurements of protein structures and molecular organization in biological samples.
A survey of 2,938 US physicians found that most (64%) agree to report incompetent colleagues, but only 67% actually do. The study highlights the need for improvement in physician self-regulation and reporting systems.
Researchers found that compstatin, a drug that targets the complement system, can reduce blood clotting during dialysis for end-stage kidney disease. In severe sepsis, compstatin also blocks the activation of both complement and coagulation systems, potentially preventing multiple organ failure and death.
The collaboration aims to identify genes and novel drug targets related to the onset and progression of Huntington's disease. The team will use induced pluripotent stem cells from patients with HD to screen for drugs that might delay, prevent, or reverse the devastating condition.
Researchers developed a nanosponge-based delivery system that is three to five times more effective than direct injection in reducing tumor growth. The system uses biodegradable particles with predictable release characteristics, making it an attractive alternative for targeted cancer therapy.
A recent study published in the Annals of Thoracic Surgery found that racial disparities in heart transplant survival rates are largely due to healthcare system flaws, insurance status, and biological factors. The study analyzed over 20,000 medical records and found that African Americans had a 46% higher chance of dying within 10 year...
The Journal of General Physiology presents Perspectives on computational biology methods, including ab initio simulations and all-atom molecular dynamics. These approaches provide insights into membrane proteins and ion channels, highlighting the importance of multi-scale analysis in understanding physiological processes.
A new rule at Massachusetts General Hospital has led to a significant decrease in unnecessary imaging exams for patients. The change encourages physicians to directly log into the system, reducing low-yield exams from 5.4% to 1.9%.
A new study from Indiana University School of Medicine offers a blueprint for hospital systems, physicians, and caregivers to implement evidence-based research in patient care. The study highlights the need for healthcare providers to overcome end-zone hurdles and provides a framework for success.
The S-ICD System detected 100% of induced and spontaneous episodes of irregular heart rhythms, offering a viable alternative to traditional ICDs. The system's subcutaneous implantation eliminates the need for lead placement in or on the heart, reducing complications associated with current therapy.
A new automated 3-D mapping and labeling system has been developed to improve the accuracy, efficiency, and speed of routine freehand ultrasound exams. The system reduces scanning time by up to 16 seconds per target and accurately measures mass locations in relation to the nipple.
Researchers used electronic medical records to coordinate care for marathon participants, finding benefits include real-time patient data sharing and improved preparation for future events. The study also showed potential for identifying trends in injury patterns.
Gerald Posakony, a pioneering ultrasound expert, was honored with the John Fritz Medal for his contributions to medical diagnostic ultrasound and nondestructive evaluation technologies. His work led to modern ultrasound technology advancements, including obstetric sonography.
Operation Mend provides life-changing surgeries to military personnel severely injured in Iraq and Afghanistan. The program also offers treatment for post-traumatic stress and traumatic brain injuries, as well as patient support and family accommodations.
A leading hospitalist argues that hospital medicine can address fundamental problems in payment and delivery systems, improving access for millions of uninsured Americans. Hospitalists will be key in shaping the future of the American healthcare system, focusing on quality, safety, and efficiency.
The University of Texas Health Science Center at Houston will conduct breakthrough research to advance the adoption and meaningful use of health information technology. The NCCD will focus on patient-centered cognitive support to optimize patient outcomes.
Group Health's patient-centered IT approach results in high patient satisfaction and efficient communication with providers. Evaluations show patients value secure e-mail, phone, and online services for better care.
Researchers from Massachusetts General Hospital found that electronic health record systems have limited ability to improve measures such as patient mortality and surgical complications. The study suggests that hospitals need to pay special attention to how they implement these systems to achieve significant improvements.
The US Department of Health and Human Services has awarded $15 million to the University of Illinois at Urbana-Champaign's Information Trust Institute to improve patient outcomes while limiting access to electronic health records, health information exchange, and telemedicine. The project aims to address security and privacy barriers i...
A wireless healthcare system for diabetes management enables patients to monitor their blood glucose levels and receive timely feedback from healthcare workers. The system has been successfully tested in a pilot study with twenty patients, demonstrating its potential to reduce healthcare costs and improve patient outcomes.
A team of scientists at TUM developed an artificial sensory organ inspired by the lateral-line system found in fish and amphibians, enabling the underwater robot Snookie to orient itself in murky waters. This technology aims to enable AUVs to work autonomously in operations ranging from deep sea exploration to inspection of sewer pipes.
Experiments in China have shown that changing the incentive system for healthcare providers can lead to improved basic primary health care and reduced costs. Primary-care providers are incentivized to cover more citizens with vaccinations and health education, improving access to cost-effective care.
A new virtual biopsy probe system has shown high accuracy in detecting precancerous polyps during colonoscopy, with a success rate of 91%. The system uses Confocal Laser Endomicroscopy to magnify cells and detect changes that may indicate cancer. This technology could potentially eliminate the need for biopsies in some patients.
A large eight-year study found that Medicare patients are 5.5 times more likely to undergo routine cataract surgery than those receiving care from the Department of Veterans Affairs. The disparity may be attributed to financial incentives, physician-driven decisions, or a lack of ophthalmologists within the VA system.
A new study by RAND Corporation found that about one-fourth of physicians would be misclassified under cost ranking systems, raising questions about their utility for high-stakes activities like tiered health plans. Only about 40% of physicians had cost profile scores at least 70% reliable, and fewer than 10% were at least 90% reliable.
A study by Henry Ford Hospital researchers found Mechanomyography (MMG) to be extremely effective in detecting the presence of nerves during minimally invasive surgical procedures. MMG detected nerves on average 1.2 seconds earlier than Electromyography (EMG), using approximately half the amount of stimulating current.
The study found that comparing the genomes of an entire family increases accuracy, identifies rare genetic variants, and helps understand disease-linked genes. This approach has the potential to revolutionize genetic research, enabling scientists to diagnose and treat individual family members more effectively.
A study published in Intensive Care Medicine found that the AiDKlinik drug information system significantly reduces serious events resulting from drug interactions in ICU patients. The system, which includes over 64,000 drugs, helps physicians minimize adverse reactions by 43% and critical events like arrhythmia by up to 80%.
A systematic review of 28 clinical trials reveals that computer reminders improved processes of care by a median of 4.2%, with some studies showing only minor improvements.
A new study published in Medical Care found that high hospital occupancy is associated with a 5.6% increased risk of patient death, while nurse staffing levels can decrease this risk by 6%. Weekend admissions also increase the risk of death by 7.5%, while seasonal flu raises it by 11.7%.
Researchers at Charles Drew University and UC Irvine will develop a mobile app to collect daily observations on low-birth-weight babies and their parents. The system aims to improve healthcare outcomes by enabling earlier diagnoses and better quality of care.
A new federal center for Medicare and Medicaid innovation could spur significant delivery system change by implementing alternative payment structures through voluntary pilot projects. Such pilots would be particularly beneficial for health care organizations looking to reduce excess clinical spending.
A new clinical trial, PINC Trial, is testing the effectiveness of chloroquine in treating pre-invasive breast cancer. The trial aims to prevent breast cancer cells from becoming deadly by killing pre-invasive cancer cells using a novel therapy with chloroquine.
The Systems Biology Markup Language (SBML) has been widely adopted by the scientific community for sharing and evaluating models of biological processes. SBML's popularity is a validation of its usefulness, with over 500 citations in an online academic database.
Home-use IPL systems emit lower fluence rates and have physical safety features to minimize optical hazard. NPL's research confirms their safety, building on earlier work on dosimetry needs for salon-based devices.
The FiberNet Embolic Protection System had a 97.5% success rate in preventing strokes during carotid artery stenting in high-risk patients with CAD. The study found a combined major adverse event rate of 3.0% at 30 days following carotid endarterectomy.
Biophysicist Ilya Nemenman has identified parameters for several biochemical networks, simplifying the research models and potentially streamlining the development of drugs and diagnostic tools. The discovery applies to complex biological systems, such as cellular networks involving hundreds or thousands of variables.
Researchers at Johns Hopkins University have developed a noninvasive infrared scanning system to help doctors determine whether pigmented skin growths are benign moles or deadly melanoma. The system works by looking for tiny temperature differences between healthy tissue and growing tumors.
A new Penn study reveals that nearly 135 million Americans are over an hour away from primary stroke centers, where timely treatment is crucial. The study suggests using medical helicopters to transport patients faster and proposes lower-cost solutions such as inter-hospital referral networks and telemedical technology.
Researchers from Loyola University Health System found a link between premature births and cerebral palsy, with inflammation of the umbilical cord being a common complication. The study suggests that managing inflammation may reduce the risk of certain complications in these infants.
The study shows that a simple, standardized checklist can virtually eliminate central-line catheter bloodstream infections. By combining the checklist with culture change and continuous monitoring, hospitals can sustainably reduce infection rates, making them more transparent to patients.
Researchers propose national health trust to promote optimal mix of personal medical care and population health measures, reducing inefficiencies and administrative waste. The proposed system would target spending to investments with the greatest long-run returns, improving US healthcare outcomes.
Researchers found no increased mortality risk among trauma patients presenting on nights and weekends, unlike other critically ill patients. Trauma centers' 24/7 staffing ensures consistent care regardless of time of presentation.
A new online treatment system using biofeedback therapy and web technologies aims to improve patient care for individuals suffering from panic disorder. The system, developed by researchers in Taiwan, has shown promising results in reducing panic attacks and improving symptoms.
Researchers have developed a method to calculate precisely the correct type and level of noise to add, improving detection of precancerous lesions and reducing false positives by up to 36%.