Articles tagged with Regenerative Medicine
The Pitt team is creating novel alloys and manufacturing processes for implantable medical devices made from dissolving metals. These devices can adapt to changes in a patient's body and dissolve once healing has occurred, reducing complications and medical expenses.
Cedars-Sinai is part of a 5-center consortium collecting and analyzing thousands of pieces of data to develop molecular signatures for motor neuron disorders. The goal is to create a 'cloud' of information that shows relationships between proteins, genes, and RNA in cells.
Researchers at USC Health Sciences have discovered how a gene mutation affects facial development, revealing the underlying mechanisms of DiGeorge syndrome. The study's findings provide new insights into the complex cellular rearrangements that shape the face during early development.
Researchers suggest progesterone as a potential treatment for spinal cord injury due to its anti-inflammatory and neuroprotective properties. Studies demonstrate that progesterone preserves white matter integrity and improves locomotor function in animal models of spinal cord lesion.
Researchers at Wake Forest Baptist Medical Center have successfully mobilized stem cells to form muscle tissue within a biomaterial scaffold. The study, published in Acta Biomaterialia, demonstrates the potential for harnessing the body's natural healing powers to regenerate damaged muscle tissue.
Researchers used CRISPR/Cas9 to correct genetic mutations leading to Duchenne muscular dystrophy in a mouse model, preventing progressive muscle weakness and degeneration. The technique may lead to permanent correction of the disease, offering hope for future therapeutic applications.
Acrolein, a highly reactive aldehyde, contributes to motor and sensory deficits following spinal cord injury. Using acrolein scavengers may attenuate neuronal damage, making it a potential novel therapeutic target.
Researchers have discovered how embryonic stem cell fate is controlled, enabling future research into artificial cell manipulation. This breakthrough aims to repair or replace damaged human cells and tissues, restoring normal function.
A Harvard-led team uses low-power laser therapy to stimulate human dental stem cells into forming dentin, a hard tissue similar to bone. The approach, led by David Mooney, could radically shift dental treatment and lead to broader clinical applications in regenerative medicine.
The Olig family is crucial for controlling differentiation and maturation of oligodendrocytes, motor neurons, and astrocytes in the central nervous system. Accumulating evidence suggests its involvement in various CNS diseases, including brain injury, multiple sclerosis, and gliomas.
Researchers used ECM from pig bladders to regenerate lost muscle tissue in human trials, improving strength and function in three out of five participants. Muscle growth was confirmed through biopsies and scans, offering hope for patients with severe leg injuries.
The Olig family is involved in regulating neural cell differentiation and affects acute and chronic central nervous system diseases. It also participates in the development of oligodendrocytes, motor neurons, and astrocytes in the central nervous system.
Tracheal bioengineering should be demonstrated as both effective and safe before further transplants. The authors report high mortality and morbidity rates among patients who received bioengineered tracheas, casting doubt on the field's current state.
Scientists have identified perivascular stem cells as a reservoir of HCMV, suggesting a potential treatment target. The discovery could lead to the development of novel targeted therapies to prevent HCMV re-activation and its associated complications.
Researchers at Cedars-Sinai Medical Center have identified gene expression regulators, microRNAs, in normal and diabetic human corneas, which may contribute to stem cell and epithelial abnormalities. The study aims to accelerate healing and repair processes in damaged corneas to reverse diabetes-induced eye complications.
Azim Surani receives the McEwen Award for Innovation for pioneering epigenetics research; Valentina Greco wins the ISSCR-BD Biosciences Outstanding Young Investigator Award for her noninvasive method to visualize skin stem cell division. Paolo Bianco, Elena Cattaneo, and Michele De Luca receive the ISSCR Public Service Award for their ...
Researchers found that hypoxic preconditioning reduced infarct volume and impaired neurological function in a mouse model of cerebral infarction. Increased vascular endothelial growth factor and CD31 expression promoted angiogenesis, leading to improved outcomes.
Researchers found that persimmon leaf flavonoid mitigates pathological injury of brain tissue following cerebral ischemia/reperfusion in rats, elevating brain ischemic tolerance. High-dose persimmon leaf flavonoid showed an identical effect to ginaton, providing a potential basis for drug development.
Researchers at Cedars-Sinai Medical Center have developed a novel procedure to prepare human amniotic membrane for use as a scaffold for specialized stem cells, which may treat corneal diseases such as blindness. The new method promises to streamline clinical applications of cell therapies and accelerate research in this area.
A team of doctors and scientists at Cedars-Sinai Medical Center used stem cell technology to create neurons from patients' skin cells and block the damaging effects of a defective gene. The study provides proof of concept for a new therapeutic strategy, suggesting a potential future therapy for Lou Gehrig's disease.
Four UCLA researchers received significant funding to advance promising stem cell therapies for HIV/AIDS, prostate cancer, and sickle cell disease. Drs. Jerome Zack, Robert Reiter, Donald Kohn, and Gerald Lipshutz will use the grants to develop innovative treatments with potential to revolutionize disease care.
A Cedars-Sinai researcher has been awarded $5.18 million to advance stem cell technologies in segmental bone defects. The team aims to develop a novel approach to treat the condition without grafting bone, using stem cells and ultrasound to deliver a bone-forming gene.
Researchers at UC Davis have successfully generated oligodendrocytes with spiking properties, allowing them to produce myelin and mature into functional brain cells. The enhanced cells showed superior regenerative capacity and produced thicker, longer myelin sheaths than natural cells.
Researchers developed an efficient way to target and repair defective genes using a novel technique that simplifies previous methods. This breakthrough enables the potential to repair genetic defects responsible for diseases like breast cancer, Parkinson's, and others, opening doors for meaningful therapeutic applications.
A UC Davis study reveals that astrocytes can protect brain tissue and reduce disability due to stroke. The research found that a specific type of astrocyte called Olig2PC-Astros has greater antioxidant effects and improves learning and memory in rats.
Researchers discovered human kidneys discarded for transplant can serve as a natural scaffold material for manufacturing replacement organs in the lab. The study suggests that these organs could potentially be used to help solve the critical shortage of donor organs.
Researchers from USC Keck School of Medicine have uncovered unique cellular and molecular mechanisms behind tooth renewal in American alligators. The study found that alligator teeth are complex units of three components, including a functional tooth, replacement tooth, and dental lamina, which contain stem cells for regeneration.
Researchers at Massachusetts General Hospital successfully developed implantable, bioengineered rat kidneys that produced urine and functioned in living animals. The approach uses donor organs stripped of cells, repopulated with human or animal cells, and cultured to mimic native organ structure and function.
Engineered stem cells produce US2 protein to increase survival by 59%, potentially improving treatment for bowel disease, traumatic brain injury, and organ transplants. The modified cells can modulate inflammation and promote healing, offering new hope for patients in need of regenerative therapies.
Scientists at Tufts University have shown that transplanted eyes can confer vision without a direct neural connection to the brain. The study used frog models and found that ectopic eyes could 'see' and elicit responses similar to those of animals with natural eyes.
A new study on the Newt transcriptome has identified 826 proteins specific to urodeles and several newly discovered proteins that may play roles in regeneration. The data outline genes present only in regenerating tissues, which could be crucial for regenerative medicine research.
A Cedars-Sinai physician-scientist is leading a research study on Charcot-Marie-Tooth disease, the most common inherited neurological disorder, using induced pluripotent stem cells. The goal of the study is to determine if personalized stem cell lines can be generated for individual patients and potentially cure the disease.
Researchers at Wake Forest Baptist Medical Center identify a unique rat model of bladder regeneration, which may help understand regenerative processes in mammals. The study found that cells in the bladder lining proliferate and transition into stem cells to repair damaged bladders.
Researchers have discovered that embryonic endothelial precursors can differentiate into beating cardiomyocytes in the absence of Scl, a master regulator of blood development. This finding may provide new avenues for creating cardiac stem cells and treating heart conditions through regenerative medicine.
Researchers at University of Nottingham are developing new injectable materials that stimulate stem cells to form new blood vessels, heart and bone tissue. The goal is to create radical new treatments for diseases with no cure, reducing the need for invasive surgery.
Researchers at Pitt's Swanson School of Engineering and School of Medicine have developed a cell-free, biodegradable artery graft that regenerates an artery in situ within 90 days. The graft's porosity allows for immediate cell infiltration, leading to strong and compliant new arteries.
Scientists successfully created 'scaffolds' from pig kidneys to potentially build replacement kidneys for humans. The structure of the nephron was maintained, and blood vessels were able to maintain normal pressure when re-filled with blood in animal models.
Researchers employ pluripotent stem cells to model spinal muscular atrophy, revealing cell death mechanisms and identifying potential pharmaceutical treatments. The study provides an important clue for developing medicines to reverse or prevent motor neuron cell death in patients with the disease.
The review article explores how extrafollicular environments regulate hair and feather stem cell activities, as well as the role of stem cells in shaping organ forms. Researchers hope to apply this knowledge to develop regenerative medicine techniques for repairing damaged tissues, including fingers and toes.
Researchers at UC Davis Health System demonstrated the safety and efficacy of transplanting anti-HIV stem cells into mice, replicating a functioning human immune system. The technique protects and expands HIV-resistant immune cells, maintaining normal CD4 levels.
Scientists have developed lab-made, invisible filaments that resemble uncooked spaghetti with nanoscale dimensions, which can serve as scaffolds for tissue repair. These 'noodle gels' and 'spaghetti highways' could guide cells to specific locations for repair and deliver beneficial substances to diseased areas.
Researchers at Cedars-Sinai are exploring new treatments for Alzheimer's disease by targeting the immune system and amyloid plaques in the brain. The goal is to identify drugs that can stimulate macrophages to clean up these plaques, allowing brain regeneration.
A novel technique enhances bone growth by guiding stem cells to the bone surface, increasing bone density and preventing age-related bone loss. The study successfully tested this approach in mice with osteoporosis, paving the way for human trials.
Researchers at UC Davis have developed a new approach using stem cells to deliver gene therapy specifically targeting the genetic abnormality found in Huntington's disease. By transferring inhibitory RNA sequences from donor cells into target neurons, they significantly decreased the synthesis of the abnormal huntingtin protein.
The Cedars-Sinai Regenerative Medicine Institute has opened a new facility to produce induced pluripotent stem cells, which can be used to study human diseases and develop new treatments. Cells produced by the core will be critical for innovative research aimed at increasing our understanding of human diseases and genetic disorders.
Researchers at IRB Barcelona have identified human colon stem cells and developed a method to grow them in lab-plates. This breakthrough could lead to significant advances in regenerative medicine, potentially treating diseases such as colorectal cancer and Crohn's disease.
The Toronto XVIVO System successfully treated and improved the function of high-risk donor lungs, allowing them to be safely transplanted. This technique could significantly expand the donor organ pool and improve outcomes after transplantation.
A preclinical study found VitaKine PCT to significantly enhance cardiac function, increasing ejection fraction by 23%, compared to controls. The therapy contains white blood cells in specific ratios and concentrations, offering a precise approach to treating heart attack patients.
A pioneering study shows tissue-engineered urethras, made with the boys' own cells, are functional and viable within 3 months. The grafts have lasted at least six years and maintained adequate outflow, offering a new alternative for reconstruction.
Researchers at Wake Forest University Baptist Medical Center successfully implanted laboratory-grown urethras in five boys, showing functional results throughout a six-year follow-up period. The engineered tissue replaced damaged segments of the urinary tube, providing an alternative to traditional tissue grafts with high failure rates.
A recent study found that reprogramming stem cells leads to genomic aberrations and genetic mutations similar to those in cancer cells. This raises concerns about the safety and effectiveness of using these cells for regenerative medicine applications.
Researchers have developed bioengineered veins that can be used in life-saving vascular surgeries, offering a promising solution for patients lacking suitable veins. The technology has shown promise in reducing complications and costs associated with traditional grafts used in coronary artery bypass grafting and hemodialysis.
A Cedars-Sinai research team has received a $1.9 million grant to develop a new pharmaceutical discovery process using pluripotent stem cells, aiming to find a treatment for Spinal Muscular Atrophy. Another team will create a new imaging system to monitor stem cell treatments in real-time, providing insights into tissue regeneration.
A team of UCLA researchers has developed a chemically defined culture medium that supports the long-term quality and maintenance of human embryonic stem cells. The new medium, using a feedback system control scheme, eliminates the need for animal products and enables routine single-cell passaging.
A study by Northwestern Medicine found that CD34+ cells can stimulate new blood vessel formation in ischemic limbs, reducing the risk of amputation. The treatment also showed significant repair of cardiac and vascular tissues, providing evidence for its potential to treat previously irreversible conditions.
The Hastings Center Report has published four essays on the next generation of bioethics, exploring new areas such as pharmaceutical industry ethics, public health, and regenerative medicine. These essays propose broadening the approach to dying and creating a framework for teaching an aging population to prepare for death.
Scientists have successfully engineered miniature human livers that function like real ones in a laboratory setting. The next step is to test their function after transplantation in animal models, with the ultimate goal of providing a solution to the liver transplant shortage.
A team of researchers aims to develop a biological treatment for compression fractures, the most common type of bone fracture in osteoporosis patients. The goal is to promote healing and stimulate normal bone production.
The American Society of Hematology (ASH) has developed recommendations for advancing regenerative medicine. The key focus areas include recognizing regenerative medicine as a priority at the National Institutes of Health (NIH), re-examining clinical trial methodologies, and improving communication between basic and clinical scientists.
Researchers at MGH Center for Regenerative Medicine found that reprogrammed induced pluripotent stem cells (iPSCs) retain some characteristics of their cell of origin, which can both assist and complicate future uses. Cellular memories fade with successive generations.