Articles tagged with Regenerative Medicine
A new stem cell therapy has induced regeneration of blood vessels surrounding non-healing diabetic foot ulcers, accelerating healing. The treatment uses adult stem cells harvested from fat tissue, demonstrating a novel cell injection therapy that can alleviate pain and infection.
Scientists have developed a novel technology combining 3-D bioelectronic systems with human neural cultures to study brain development and repair. The device can record electrical activity, manipulate neural activity using light pulses, and perform optogenetic experiments.
Scientists developed a tri-tube heart valve replacement that can regenerate and grow over time, addressing the need for long-term valve replacements in children with congenital heart disorders. The new design showed improved growth dynamics and reduced calcification compared to clinically used bioprosthetic valves.
Researchers at UPMC demonstrated that allogeneic adipose-derived stem cells (ASCs) can mitigate acute radiation syndrome, a condition known as total body irradiation. ASCs were found to improve survival rates and repair damage to the hematopoietic system in mice exposed to high levels of radiation.
Researchers investigate using a cell-signaling chemokine from cats to treat human kidney fibrosis and slow disease progression. The study suggests that intra-renal injection of CXCL12 may be a potential therapy for early kidney disease, offering new hope for millions with the condition.
A clinical trial revealed that bone marrow cell injections can lead to a reduction in brain injury after a stroke, with improvements seen in the corticospinal tract 12 months post-treatment. The study suggests a potential approach for regenerative therapies to improve brain health for millions of patients affected by stroke.
A phase I clinical trial reveals adipose-derived stem cells alleviate symptoms of lymphedema, improving upper extremity function and reducing treatment use. Patients experienced sustained benefits for up to four years after treatment.
Researchers at JAIST and RIKEN identify COOH-PLL as an effective cryoprotectant that prevents cellular damage during freezing. The team uses NMR spectroscopy to characterize the molecule's behavior, enabling the design of new polymeric cryoprotectants.
A new study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration, utilizing the same science used in COVID-19 vaccines. Researchers successfully induce rapid expansion of functional liver cells and recovery of liver function in injured livers.
A clinical trial evaluated the safety and effectiveness of two cell therapies for treating angiitis-induced critical limb ischemia, yielding satisfactory results. The study found that both therapies provided evidence for precise application under different conditions.
Researchers at Sungkyunkwan University found that stem cell-derived extracellular vesicles can reduce severe intraventricular hemorrhage-induced brain injuries in newborn rats. The neuroprotection is primarily mediated by BDNF transfer via EVs, providing a promising potential treatment for bleeding in the brain.
The 16th World Stem Cell Summit will be co-located with the 7th annual Regenerative Medicine Essentials Course, featuring joint single-track programming on stem cells, biomaterials, cell therapies, clinical trials, and regulatory matters. The event aims to accelerate regenerative medicine and deliver cures.
Researchers found that pre-treating early outgrowth cells with a chemical activator slows the development of atherosclerosis in mice. The study showed that this treatment reduced inflammation and plaque buildup in arteries, providing potential hope for treating cardiovascular diseases.
Researchers have developed a novel method to bioprint fibrocartilage, a crucial tissue in knee joints, using a hybrid tissue construct. The study demonstrates the potential of this regenerative medicine treatment for repairing damaged cartilage and restoring knee function.
A study in STEM CELLS Translational Medicine suggests that amniotic fluid stem cell-derived secretome can restore neuronal plasticity and improve cognition after an ischemic stroke. The findings offer a potential new avenue of treatment for ischemic stroke, which affects 87% of all strokes.
The UK Research and Innovation has partnered with the Japan Agency for Medical Research and Development to support eight new regenerative medicine research projects. The funding will focus on developing novel therapies for a range of disorders, including Parkinson's disease, blood disorders, and liver diseases.
Researchers have found a way to restore muscle regeneration and prevent scarring in Duchenne muscular dystrophy by correcting the content of extracellular vesicles. This novel approach uses pharmacologically corrected vesicles to deliver HDAC inhibitors directly to muscles, overcoming systemic adverse effects.
Researchers biofabricated human colorectal cancer organoids to understand how tumors grow in their natural microenvironment and respond to treatments. The study replicated native tumor tissue in a laboratory model and validated its effects on whole-body physiology, paving the way for new therapies targeting the extracellular matrix.
Researchers have developed a bioengineered scaffold using human mesenchymal stem cells and timolol, which significantly improved wound epithelialization and reduced inflammatory response in diabetic mice. The combination therapy resulted in more than a 70% increase in tissue repair compared to the control group.
Researchers developed a non-invasive tracking strategy using CRISPR/Cas9 editing to insert the sodium/iodide symporter gene into iPSCs. This allows long-term monitoring of cardiomyocytes after implantation, paving the way for preclinical and clinical development of cardiac cell therapies.
The Alliance for Regenerative Rehabilitation and Training (AR3T) has received a $5 million NIH grant to continue its work in expanding scientific knowledge and expertise in regenerative medicine. The network aims to increase the efficacy of interventions designed to help people with disabilities be more independent and engaged.
A clinical trial found that breast augmentation with ASC-enriched fat grafts resulted in significantly better outcomes compared to non-enriched grafts. The study showed improved retention rates and histological appearance of the grafts, making ASCs a promising tool for increasing graft success.
Scientists have developed a method to culture human pancreatic slices for nearly two weeks, allowing them to study the regeneration of insulin-producing beta cells. The discovery has important therapeutic implications for treating diabetes.
Scientists at WFIRM have successfully engineered uterine tissue that supports fertilization, fetal development, and live birth. The study's findings suggest a regenerative medicine solution to treat uterine defects, avoiding organ rejection and the need for antirejection drugs.
Researchers have successfully used magnetic targeting to improve the efficacy of mesenchymal stem cells (MSCs) in treating silicosis. The study found that MSCs treated with magnets showed significant reductions in lung damage and improvements in pulmonary function compared to non-magnetized MSCs.
A new study shows that intranasal delivery of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) reduces inflammation in the brain, a prime factor in Alzheimer's disease. The treatment also triggers actions to guard against further degenerative effects.
A recent clinical trial has demonstrated the ability of a stem cell-based topical solution to regrow hair in individuals with androgenetic alopecia, also known as male-pattern baldness. The study found that the treatment led to significant increases in both hair count and follicle diameter.
Researchers demonstrate a potential solution to corneal scarring by using stem cells to regenerate the cornea's stroma. The study shows improved corneal transparency and vision with minimal inflammatory response.
Researchers have developed a simple method to prepare 3D keratin scaffold models that mimic the structure and biological function of native extracellular matrix. The study demonstrates the ability of cells to grow on these scaffolds without morphological changes or apoptosis, making them promising candidates for tissue engineering.
Researchers at UC San Diego Health are developing a dedicated space stem cell orbital research laboratory within the International Space Station (ISS) to study microgravity's effects on human biology. The studies aim to understand aging, degenerative diseases, and cancers in space, with potential applications for therapeutics on Earth.
Researchers successfully harnessed an evolutionarily conserved mechanism to promote tissue repair and suppress inflammation in aged tissues. This approach improved the success of stem cell-based therapies for retinal disease, restoring vision in old, blind mice.
Researchers have uncovered mechanisms of healing after a heart attack using human cardiopoietic cells, which restored cardiac muscle to its pre-attack state. The study found that these cells reversed two-thirds of the changes caused by a heart attack, with 85% of cellular functional categories responding favorably to treatment.
A collaborative project led by UCSC aims to develop innovative technology for improving wound healing, funded by up to $16 million from DARPA. The team will use bioelectronic devices, machine learning, and regenerative medicine to control physiological processes involved in wound healing.
Researchers at Wake Forest Institute for Regenerative Medicine have developed a way to accelerate functional muscle regeneration by integrating neural cells into 3D bioprinted skeletal muscle constructs. The study, published in Nature Communications, demonstrates the potential for these constructs to restore normal muscle weight and fu...
Scientists at the University of Pittsburgh School of Medicine have created a biodegradable nerve guide that can regenerate long sections of damaged nerves without stem cells or donor nerves. The technology has been tested in monkeys and shown promising results, including restored nerve conduction and replenished Schwann cells.
Susan Solomon, CEO of The New York Stem Cell Foundation (NYSCF) Research Institute, receives the 2020 ISSCR Public Service Award for her tireless efforts to support stem cell science and researchers. NYSCF has raised over $350 million for stem cell research projects.
Researchers identify Protease Activated Receptor 1 (PAR1) as a molecular switch that promotes myelin regeneration, potentially improving function in neurological disorders. The study's findings suggest new strategies for treating diseases of the central nervous system.
The Wake Forest Institute for Regenerative Medicine has been awarded a five-year, $24 million grant from the US Department of Health and Human Services to advance its lung-on-a-chip technology. The funding will be used to model the effects of chlorine gas on human lungs and develop treatments for resulting injuries.
Researchers at Istituto Italiano di Tecnologia have developed a new technique called Optoceutics, which uses visible light to specifically direct the fate of tissue cells. This breakthrough has significant potential for regenerative medicine and treating cardiovascular diseases.
The International Association for Dental Research celebrates its centennial with a special article highlighting key successes in tooth bioengineering and regenerative dentistry. Researchers discuss promising developments, including whole tooth tissue engineering and the potential for improved dental repair therapies.
Wake Forest Institute for Regenerative Medicine scientists have developed a faster and more efficient gene editing tool using the CRISPR/Cas9 system. The new delivery system packages both essential components together, enabling transient Cas9 expression and avoiding unwanted results.
Researchers at USC have developed a new method for repurposing cells, which they found to be significantly more reliable than existing techniques. The approach uses enzymes to untangle DNA and has been proven to work in mice and humans with near-perfect efficiency.
The relaxation of international regenerative medicine regulations can lead to a downward spiral in standards, warns Professor Margaret Sleeboom-Faulkner from the University of Sussex. As countries compete for innovative treatments, efficacy is compromised, and risks increase, making it harder to ensure patient safety.
A recent study proposes a quality control framework for umbilical cord blood-sourced allografts, outlining future safety and potency benchmarks. The study identifies a unique liaison among the UCB-sourced allograft, host mesenchymal stem cells, and their secreted exosomes that influences tissue regeneration in vivo.
Researchers developed a method to replicate fetal bone growth, aiming to improve healing rates for large bone defects. The approach, tested in rodent models, involves delivering stem cells and adjusting mechanical forces to mimic embryonic development, showing promising results without adverse side effects.
Researchers identified messenger cells that promote bone regeneration and called into question an existing dogma in biology textbooks. The discovery may lead to better strategies for boosting bone repair in other parts of the body.
A clinical trial using mesenchymal stromal cells from patient bone marrow shows significant improvements in pain levels and quality of life for osteoarthritis patients. The study, led by Sowmya Viswanathan and Jaskarndip Chahal, found that higher doses of MSCs resulted in more effective outcomes.
A team of researchers at Massachusetts General Hospital has identified brain cells in the dorsolateral septum that regulate fearful behavior in mice. Activation of these cells predicts how an animal will behave when faced with a threatening situation, and targeting them may help treat post-traumatic stress disorder.
A new virus- and oncogene-free induced pluripotent stem cell (iPSC) technology has been developed to produce safer pluripotent stem cells from cord blood and peripheral blood. This approach aims to address safety challenges inherent with pluripotent stem cell therapies.
Researchers identified conserved genes involved in regeneration across species, including flies, mice, and zebra fish. They also discovered new types of regulatory elements that can be activated to boost organ regeneration.
Research from the University of Pittsburgh suggests that Klotho protein can rejuvenate muscle healing in old mice. By raising Klotho levels or mitigating its deficiency, researchers were able to restore functional levels of muscle regeneration in aged skeletal muscle.
Extracellular vesicles, or 'cellular dust', have shown therapeutic properties similar to stem cells without their disadvantages. These gel-like vesicles can be produced by a single donor for several patients and have demonstrated potential in repairing heart, liver, and kidney lesions.
Researchers at Stowers Institute for Medical Research have isolated a regenerative cell capable of regrowing entire organisms. By combining genomics, single-cell analysis, flow cytometry, and imaging techniques, they targeted the elusive cell, which is a subtype of adult pluripotent stem cells, to discover its secrets.
Researchers discovered that blood stem cells with a genetic mutation can be compensated by normal stem cells producing specific types of immune cells. Key findings suggest these highly productive stem cells proliferate dramatically and maintain a balanced immune system when transplanted into mice.
A team of researchers has successfully designed and produced individualized, computer-modeled regenerative heart valves grown from human cells. These bioengineered replacements can grow and regenerate themselves without causing immune reactions in patients' bodies, addressing a major limitation of current artificial implants.
The UK Regenerative Medicine Platform aims to develop novel therapies that mimic the environment where stem cells grow in the body. Researchers will use their findings to stimulate repair mechanisms in damaged tissues, funded by £4 million.
Researchers at Kessler Foundation are investigating a new treatment using micro-fragmented adipose tissue injection to alleviate chronic shoulder pain in wheelchair users with SCI. The pilot study has shown promising results, with all six participants experiencing improved range of motion and reduced pain.
Researchers at CU Anschutz are working on stem cell-created skin grafts to treat Epidermolysis Bullosa, a debilitating inherited skin disease. The $3.8M grant from the DoD will help move technology into clinical trials, bringing hope for potential cures.
Researchers have found that the human brain's tiny blood vessels can trigger the growth of spinal motor neurons, which control muscles, during early development. This discovery could provide insights into diseases such as amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders.
The National Institutes of Health (NIDCR) established the DOCTRC Program to develop resources and strategies for regenerating dental, oral, and craniofacial tissues. Two national resource centers were established: The Michigan-Pittsburgh-Wyss Resource Center and the Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration.