Articles tagged with Regenerative Medicine
Researchers at RCSI University have created a new lab-based model to test devices for heart failure with preserved ejection fraction. The model enables testing of the left atrium and ventricle, two independently controlled chambers that simulate blood flow during the resting phase.
Researchers at UCLA have developed a roadmap detailing how stem cells become sensory interneurons, which enable sensations like touch and pain. The study identifies protocols for producing all types of sensory interneurons in the laboratory, paving the way for cell therapies to restore sensation in people with spinal cord injuries.
Researchers at Indiana University School of Medicine used tissue nanotransfection (TNT) technology to edit genes in chronic wound tissue, rescuing wound healing. The study found that gene silencing due to DNA methylation was a critical barrier to wound closure.
Researchers at Texas A&M University have challenged the common belief that nerves are necessary for limb regeneration in mammals. Their studies, published in the Journal of Bone and Mineral Research and Developmental Biology, found that mechanical loading is a critical component for mammalian regeneration.
A KAUST-developed nanotechnology platform uses tiny iron wires that bend in response to magnetic fields to accelerate bone cell formation. Bone-forming stem cells grown on the moving substrate transform into mature bone much faster than usual, potentially paving the way for more efficient regeneration of bone.
Researchers identified glucocorticoids as a key factor inhibiting cardiac regenerative capacity after heart attacks. The study showed that deleting or blocking the glucocorticoid receptor increased heart muscle cell replication and regeneration.
Researchers have discovered that human urine-derived stem cells have the ability to regenerate tissue and become various cell types, making them a promising source for stem cell therapy. The study also highlights the importance of telomerase activity in maintaining regenerative potential.
A joint research group developed a robotic AI system that autonomously determines optimal conditions for growing replacement retina layers. The system achieved a 90% rate of differentiation efficiency in 185 days, compared to months of work by humans.
Izpisua Belmonte's work on cellular rejuvenation programming has the promise to improve aging and age-associated diseases, with potential therapies for new treatments. He was recognized for his innovations leading to discoveries that can reset a cell's aging clock, allowing organs to regenerate.
Researchers have developed a unique 3D printed system to harvest mesenchymal stem cells from bioreactors, which can be used for various treatments. The system combines microfluidics and 3D printing to process adult stem cells, potentially making stem cell therapies more widely available.
Researchers at Emory University treated eight patients with chronic nerve pain using a technique called interventional cryoneurolysis, which uses imaging guidance to freeze damaged nerves and promote regeneration. The study found significant improvements in pain symptoms, with six patients experiencing dramatic reductions in pain scores.
Researchers discovered that ancient retroviruses embedded in human genome can undergo retrotransposition into iPS cells, potentially posing a risk for regenerative medicine. The study found that HERV-K is expressed in SOX2-expressing cells and may cause cancer and neurological diseases by altering gene expression profiles.
Recent studies from Cedars-Sinai have shed light on the importance of a gene in embryo development and its potential link to physical abnormalities. Additionally, research has shown that getting vaccinated against Covid-19 can strengthen immune responses in patients with inflammatory bowel disease. The institution is also working on ne...
Researchers have developed a new tool to visualize leukocytes in the brain vasculature during in vivo two-photon laser scanning microscopy. The tool uses a fluorescent antibody targeting CD45, a ubiquitously expressed protein on white blood cells, allowing for tracking of circulating leukocytes over time and space.
Scientists from Tokyo Medical and Dental University uncover the reason behind titanium implants' excellent biocompatibility, allowing patients to generate less immune response. This breakthrough may lead to safer and less expensive implants for hip replacements and dental procedures.
The Edmonton Protocol team has reported that islet transplantation is an effective therapy for patients with difficult-to-control Type 1 diabetes, with a high rate of graft survival and insulin independence. The procedure has been shown to stabilize blood sugar levels and improve quality of life for patients.
A recent study published in NPJ Regenerative Medicine found that large bone injuries trigger a repair strategy recapitulating elements of skeletal formation in utero. The gene Sonic hedgehog (Shh) plays a necessary role in healing central regions, while small-scale fractures heal through a distinct program.
Researchers at Cedars-Sinai have developed an AI tool that accurately predicts pancreatic cancer patients based on CT scan images. Lowering blood cholesterol has also been shown to slow the growth of prostate cancer by enhancing immune cell action. Additionally, a new study found that an ultrasound probe plugged into a smartphone can b...
A team of researchers from Osaka University and Kyoto University developed a stem cell-based biomaterial, hiPS-Cart, to treat IVD degeneration and prevent further deterioration. The biomaterial was able to survive and maintain its functionality in lab rats with NP removal, reversing IVF and vertebral bone degeneration.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
Scientists have created a new technology using colour pigments from the food industry to stimulate nerve cells with the help of implantable mini solar cells. This innovation could lead to accelerated healing and prevention of complications in severe brain injuries, as well as potential applications in pain therapy and retinal implants.
Researchers have identified the complete series of 10 factors that regulate the development of brain cell types in the visual system of fruit flies. This discovery opens new avenues of research to understand how brain development evolved in different animals and holds clues for regenerative medicine.
Researchers discovered newborn neurons and immature astroglia in patients with epilepsy, which could lead to new anti-seizure medications. The study suggests that targeting immature astroglia may be an effective approach to controlling seizures without aggressive brain surgery.
A UK team is developing personalized ‘theranostic’ dressings that speed up wound healing while providing diagnostic information. The dressings feature biomimetic macromolecules that replicate natural tissue structures, kickstarting the body’s healing processes.
Researchers developed a transgene-free method to convert human pluripotent stem cells into 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology. These cells can be used to regenerate human organs, study human embryonic development, and prevent pregnancy loss.
Researchers successfully differentiated human induced pluripotent stem cells into specific mesoderm subset for use as a novel therapy to rescue ischemic tissues and repair blood vessels. The results demonstrate significant improvement in visual acuity and electroretinograms with restoration of vascular perfusion in animal models.
The five-year grant will be used to mentor junior scientists, leveraging City of Hope's expertise in cancer treatment and patient care. The program will provide students with hands-on experience in cell-based therapies, regulatory approval, and commercialization.
The BRIGHTER project develops a new 3D bioprinting technology that creates complex and accurate human tissues, reducing the need for animal models. The technology uses light-sheet lithography to fabricate human skin and other tissues with high resolution and accuracy.
Scientists from Tokyo Medical and Dental University have developed a protocol to transplant 3D cellular structures called organoids into the colon to repair damaged intestinal tissue. This approach shows promise as a quick, reproducible, and minimally invasive method for treating ulcerative colitis.
Researchers developed a fully autonomous biohybrid fish from human stem-cell derived cardiac muscle cells that recreates the muscle contractions of a pumping heart. The device has two layers of muscle cells that work together to propel the fish for over 100 days.
A newly developed decoy protein has been found to be highly effective in preventing death and lung damage in humanized animal models of severe COVID-19 disease. The treatment works by competing for the spike protein of SARS-CoV-2, thereby neutralizing the virus before it can bind and enter cells.
Researchers discovered that the IL-6 family of proteins is required for maintaining and regenerating cartilage in joints and growth plates. The study found that blocking this gene could lead to severe cartilage and skeletal changes, particularly in females.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
A team from Tokyo Medical & Dental University has created a jigsaw-shaped peptide that functions as an extracellular matrix for injured tissue regeneration. The peptide's ability to incorporate and release growth factors stimulates cell growth and vascular formation, showing promise in regenerating tissues.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
Scientists from Tokyo Medical and Dental University create polyrotaxane-based biomaterials that improve epithelial cell-cell adhesion, enabling the repair of damaged tissues. The study suggests a potential application in clinical dentistry for treating periodontal disease.
Researchers at Keck School of Medicine of USC have developed a stem cell-based bio-implant to repair cartilage and delay joint degeneration. The Plurocart implant successfully integrates into damaged articular cartilage tissue and survives for up to six months.
A new study reveals that extracellular vesicles deliver genetic instructions for the longevity protein Klotho to muscle cells, which declines with age. This finding suggests that EVs could be developed into novel therapies for healing damaged muscle tissue and improving functional recovery in older individuals.
Researchers at A*STAR's Institute of Molecular and Cell Biology have discovered a novel protein therapy using Agrin to promote wound healing and repair. The study found that timely induction or exogenous supplementation of Agrin accelerates the healing process, preserving the mechanical architecture of injured skin layers.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
Researchers at RCSI University of Medicine and Health Sciences have developed a new method to enhance wound healing using 3D printing of platelet-rich plasma. The technique showed promising results in improving vascularisation and reducing fibrosis, leading to faster and more successful wound healing.
A simple change in the way donor cells are processed can maximize a single cell's production of extracellular vesicles, which are small nanoparticles naturally secreted by cells. The finding offers new avenues for research around cellular therapies, where transplanted cells are used to help the body heal or work better.
Scientists at Kobe University have successfully generated testosterone-producing Leydig cells from human iPS cells, a significant step towards developing a regenerative medicine treatment for late-onset hypogonadism. The induced cells expressed genes specific to Leydig cells and produced functional testosterone.
A recent study by James Godwin, Ph.D. has identified the liver as a primary reservoir for pro-regenerative macrophages essential to limb regeneration in axolotls. The research paves the way for regenerative medicine therapies in humans, potentially treating diseases like heart and lung disease with scar-free healing.
Researchers developed an injectable therapy that uses bioactive signals to trigger cells to repair and regenerate damaged spinal cords. The therapy, which mimics the extracellular matrix of the spinal cord, has been shown to regenerate axons, reduce scar tissue, and improve motor neuron survival.
In chronic damage, new cholesterol production determines the efficiency of repair, with nerve cells contributing to replenishing myelin-forming cells. Treatment with a cholesterol-enriched diet enhances oligodendrocyte progenitor cell proliferation.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
A recent study highlights the negative effects of misinformation on stem cell therapies for COVID-19, including exaggerated claims and unregulated sales. The researchers advocate for increased enforcement of laws and regulations to protect patients and promote responsible science communication.
A study published in the Journal of Cell Biology found that skin stem cell motility is crucial for wound healing and skin regeneration. The researchers discovered that a specific molecule, EGFR, drives skin stem cell movement and coordinates the production of collagen COL17A1.
A new study by University of Pennsylvania researchers uses human gingiva-derived mesenchymal stem cells to guide nerve growth and regeneration, achieving similar results as traditional autograft procedures. The approach has potential for treating larger nerve gaps, including those resulting from oral cancer surgery.
A subpopulation of mesenchymal stem cells expressing CD73 has been identified as crucial for bone regeneration, displaying enhanced proliferation and differentiation capabilities. This subgroup promotes fracture healing by forming new cartilage and bone cells, contributing to the remodeling process.
The University of California, Riverside has received a $5 million grant from the California Institute for Regenerative Medicine to train young scientists and physicians in stem cell research. The program, named TRANSCEND, will provide training in broad areas of stem cell biology and regenerative medicine.
A team of researchers has identified a cellular mechanism that enables embryonic stem cells to maintain their state as stem cells. The study, published in Cell Reports, reveals the genetic ingredients required for ESCs to decide whether to divide or differentiate.
A new ex vivo drug delivery system has been shown to keep MSCs viable longer and reprogram the peripheral immune response toward organ repair. The study's results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney.
The Lundquist Institute has received a prestigious CIRM Scholar Research Training Award to support its PhD students, postdoctoral fellows, and clinical fellows in stem cell biology and regenerative medicine. The grant will enable the institute to create a stem-cell focused program, recruit researchers, and retain talent in the field.
Researchers link repeated injury to airway stem cells with chronic lung disease, suggesting that biological aging of these cells may contribute to the development of this condition. The study found that injury caused activation of a subset of stem cells, leading to their premature aging and loss of functional capacity.
A study found that treating wounds with mesenchymal stromal cell secretions significantly reduced MRSA viability and stimulated the surrounding skin cells to build a defense. The treatment has potential as an alternative to antibiotics, reducing antibiotic resistance in both veterinary and human medicine.
Researchers developed lab-grown cochlear organoids to screen FDA-approved drugs for hair cell-inducing properties. The study identified Regorafenib as a potent stimulator of hair cell formation, even regenerating lost cells in mouse tissues.
A multi-center study found micro-fragmented adipose tissue injections to be highly effective in reducing knee pain, improving function, and enhancing quality of life. Positive effects were observed for up to 12 months, with notable differences in efficacy among demographics.
Researchers from Terasaki Institute for Biomedical Innovation develop methods to enhance mechanical properties of hydrogels, including toughness, stretchiness, and adhesive strength. By introducing dopamine and alkaline conditions, they create gel-like materials with improved biocompatibility and regenerative capabilities.