Articles tagged with Regenerative Medicine
The five-year grant will be used to mentor junior scientists, leveraging City of Hope's expertise in cancer treatment and patient care. The program will provide students with hands-on experience in cell-based therapies, regulatory approval, and commercialization.
The BRIGHTER project develops a new 3D bioprinting technology that creates complex and accurate human tissues, reducing the need for animal models. The technology uses light-sheet lithography to fabricate human skin and other tissues with high resolution and accuracy.
Scientists from Tokyo Medical and Dental University have developed a protocol to transplant 3D cellular structures called organoids into the colon to repair damaged intestinal tissue. This approach shows promise as a quick, reproducible, and minimally invasive method for treating ulcerative colitis.
Researchers developed a fully autonomous biohybrid fish from human stem-cell derived cardiac muscle cells that recreates the muscle contractions of a pumping heart. The device has two layers of muscle cells that work together to propel the fish for over 100 days.
A newly developed decoy protein has been found to be highly effective in preventing death and lung damage in humanized animal models of severe COVID-19 disease. The treatment works by competing for the spike protein of SARS-CoV-2, thereby neutralizing the virus before it can bind and enter cells.
Researchers discovered that the IL-6 family of proteins is required for maintaining and regenerating cartilage in joints and growth plates. The study found that blocking this gene could lead to severe cartilage and skeletal changes, particularly in females.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
A team from Tokyo Medical & Dental University has created a jigsaw-shaped peptide that functions as an extracellular matrix for injured tissue regeneration. The peptide's ability to incorporate and release growth factors stimulates cell growth and vascular formation, showing promise in regenerating tissues.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
Scientists from Tokyo Medical and Dental University create polyrotaxane-based biomaterials that improve epithelial cell-cell adhesion, enabling the repair of damaged tissues. The study suggests a potential application in clinical dentistry for treating periodontal disease.
Researchers at Keck School of Medicine of USC have developed a stem cell-based bio-implant to repair cartilage and delay joint degeneration. The Plurocart implant successfully integrates into damaged articular cartilage tissue and survives for up to six months.
A new study reveals that extracellular vesicles deliver genetic instructions for the longevity protein Klotho to muscle cells, which declines with age. This finding suggests that EVs could be developed into novel therapies for healing damaged muscle tissue and improving functional recovery in older individuals.
Researchers at A*STAR's Institute of Molecular and Cell Biology have discovered a novel protein therapy using Agrin to promote wound healing and repair. The study found that timely induction or exogenous supplementation of Agrin accelerates the healing process, preserving the mechanical architecture of injured skin layers.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
Researchers at RCSI University of Medicine and Health Sciences have developed a new method to enhance wound healing using 3D printing of platelet-rich plasma. The technique showed promising results in improving vascularisation and reducing fibrosis, leading to faster and more successful wound healing.
A simple change in the way donor cells are processed can maximize a single cell's production of extracellular vesicles, which are small nanoparticles naturally secreted by cells. The finding offers new avenues for research around cellular therapies, where transplanted cells are used to help the body heal or work better.
Scientists at Kobe University have successfully generated testosterone-producing Leydig cells from human iPS cells, a significant step towards developing a regenerative medicine treatment for late-onset hypogonadism. The induced cells expressed genes specific to Leydig cells and produced functional testosterone.
A recent study by James Godwin, Ph.D. has identified the liver as a primary reservoir for pro-regenerative macrophages essential to limb regeneration in axolotls. The research paves the way for regenerative medicine therapies in humans, potentially treating diseases like heart and lung disease with scar-free healing.
Researchers developed an injectable therapy that uses bioactive signals to trigger cells to repair and regenerate damaged spinal cords. The therapy, which mimics the extracellular matrix of the spinal cord, has been shown to regenerate axons, reduce scar tissue, and improve motor neuron survival.
In chronic damage, new cholesterol production determines the efficiency of repair, with nerve cells contributing to replenishing myelin-forming cells. Treatment with a cholesterol-enriched diet enhances oligodendrocyte progenitor cell proliferation.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
A recent study highlights the negative effects of misinformation on stem cell therapies for COVID-19, including exaggerated claims and unregulated sales. The researchers advocate for increased enforcement of laws and regulations to protect patients and promote responsible science communication.
A study published in the Journal of Cell Biology found that skin stem cell motility is crucial for wound healing and skin regeneration. The researchers discovered that a specific molecule, EGFR, drives skin stem cell movement and coordinates the production of collagen COL17A1.
A new study by University of Pennsylvania researchers uses human gingiva-derived mesenchymal stem cells to guide nerve growth and regeneration, achieving similar results as traditional autograft procedures. The approach has potential for treating larger nerve gaps, including those resulting from oral cancer surgery.
A subpopulation of mesenchymal stem cells expressing CD73 has been identified as crucial for bone regeneration, displaying enhanced proliferation and differentiation capabilities. This subgroup promotes fracture healing by forming new cartilage and bone cells, contributing to the remodeling process.
The University of California, Riverside has received a $5 million grant from the California Institute for Regenerative Medicine to train young scientists and physicians in stem cell research. The program, named TRANSCEND, will provide training in broad areas of stem cell biology and regenerative medicine.
A team of researchers has identified a cellular mechanism that enables embryonic stem cells to maintain their state as stem cells. The study, published in Cell Reports, reveals the genetic ingredients required for ESCs to decide whether to divide or differentiate.
A new ex vivo drug delivery system has been shown to keep MSCs viable longer and reprogram the peripheral immune response toward organ repair. The study's results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney.
The Lundquist Institute has received a prestigious CIRM Scholar Research Training Award to support its PhD students, postdoctoral fellows, and clinical fellows in stem cell biology and regenerative medicine. The grant will enable the institute to create a stem-cell focused program, recruit researchers, and retain talent in the field.
Researchers link repeated injury to airway stem cells with chronic lung disease, suggesting that biological aging of these cells may contribute to the development of this condition. The study found that injury caused activation of a subset of stem cells, leading to their premature aging and loss of functional capacity.
A study found that treating wounds with mesenchymal stromal cell secretions significantly reduced MRSA viability and stimulated the surrounding skin cells to build a defense. The treatment has potential as an alternative to antibiotics, reducing antibiotic resistance in both veterinary and human medicine.
Researchers developed lab-grown cochlear organoids to screen FDA-approved drugs for hair cell-inducing properties. The study identified Regorafenib as a potent stimulator of hair cell formation, even regenerating lost cells in mouse tissues.
A multi-center study found micro-fragmented adipose tissue injections to be highly effective in reducing knee pain, improving function, and enhancing quality of life. Positive effects were observed for up to 12 months, with notable differences in efficacy among demographics.
Researchers from Terasaki Institute for Biomedical Innovation develop methods to enhance mechanical properties of hydrogels, including toughness, stretchiness, and adhesive strength. By introducing dopamine and alkaline conditions, they create gel-like materials with improved biocompatibility and regenerative capabilities.
A pilot study found that a single injection of leukocyte-rich platelet-rich plasma (PRP) significantly improved functional mobility, pain, and quality of life in patients with knee osteoarthritis. The study supports the use of this combined approach to evaluate emerging biological therapies for musculoskeletal disorders.
Researchers have created brain organoids from people with 16p11.2 genomic variations, which exhibit differences in brain size seen in individuals with autism spectrum disorder. The study revealed new information about molecular mechanisms that malfunction when this region is disrupted, providing opportunities for therapeutic intervention.
A USC-led study has mapped the developmental blueprint of human kidneys, shedding light on how cells interact to form filtering units. The research provides a foundation for creating synthetic mini kidneys and could lead to new treatments for kidney diseases.
Researchers at UCLA developed brain organoids that mimic human brain structure and function, allowing for the study of neurological disorders like Rett syndrome. The organoids showed organized waves of activity similar to those found in living brains and responded to treatment with an experimental drug.
A new study from Monash University has identified RNA released from damaged cells as a signal to initiate repair in the nervous system. The research found that blocking or enhancing this recruitment of immature neurons halted or sped up neural circuit recovery, demonstrating their power in boosting neural repair.
A new clinical study reveals that treatment with mesenchymal stromal cells reduces inflammation in patients with chronic obstructive pulmonary disease (COPD). The study provides insights into the therapeutic potential of MSCs as a novel treatment for COPD, which is a leading cause of morbidity and mortality worldwide.
Researchers discovered that fetal membranes can heal after injury through the action of cells called myofibroblasts and protein Cx43. This finding holds promise for reducing the risk of birth complications from preterm prelabour rupture of the membranes, a leading cause of early infant death.
Researchers used autologous adipose micrografts to treat tendon injuries in sheep, achieving similar diameter and hardness to healthy tendons within two months. The study suggests a safe, reliable, and relatively fast way to promote tendon healing, with potential for human treatment.
Scientists at University of California San Diego School of Medicine have developed a method to keep cultured hematopoietic stem cells healthy, positive news for patients seeking stem cell transplants. The findings also hint at a new way to ward off aging by super-activating the heat shock pathway.
Researchers developed gel drops from four amino acid peptides that support cell growth and induce blood vessel formation. The microgels were successfully used to grow endothelial cells on their surfaces, which then extended into tubular blood vessels.
A study confirmed the safety of a novel stem cell therapy for knee pain caused by osteoarthritis. The treatment, which involves transplanting patient's own mesenchymal stem cells into the affected knee, showed no serious side effects over five years.
The Wake Forest Institute for Regenerative Medicine and local partners receive an NSF grant to develop a regional regenerative medicine educational network. The project aims to address the workforce needs of the rapidly evolving field, focusing on skilled technician development in biomanufacturing.
Researchers from USC Stem Cell discovered a latent regenerative potential in the inner ear's sensory cells. They found that epigenetic modifications regulate hair cell development and identified a key histone decoration, H3K4me1, that keeps supporting cells primed for transdifferentiation.
A national survey reveals a pronounced lack of needed skills in the regenerative medicine biomanufacturing workforce, highlighting key findings and recommendations to address this gap. The study suggests five strategies for developing the workforce ecosystem, including faculty development opportunities, work-based learning, and policy ...
Researchers discovered a code in the liver epigenome that promotes regeneration, enabling pro-regenerative genes to activate when signaled. This finding has potential to inform regenerative medicine for non-regenerative organs like lungs and hearts.
Researchers at Cedars-Sinai are conducting a clinical trial to transplant neural progenitor cells into the brains of ALS patients to slow disease progression. The cells have been genetically reprogrammed to express GDNF, which may help keep motor neurons healthy and extend survival.
Scientists at USC have created rudimentary kidney structures, known as organoids, that resemble the collecting duct system. These organoids can be used to study kidney disease and test potential therapeutic drugs.
Experts call for global regulation to prevent unproven stem cell treatments from putting patients' lives at risk. The authors propose establishing an advisory committee on regenerative medicine and promoting harmonization among regulatory standards.
A clinical trial found that non-altered stem cells from umbilical cord connective tissue increased the survival of critically ill COVID-19 patients by 2.5 times. The treatment also showed a fourfold increase in survival for patients with chronic health conditions.
Researchers develop non-invasive tool to assess oral keratinocyte quality, correlating cell motion speed with regenerative capacity and proliferation potential. The cells/colony motion index makes a reliable quality control tool for engineered cells used in regenerative medicine.
Researchers found that autologous bone marrow stromal stem cells can lower blood glucose levels and reduce medication doses in non-obese Type 2 diabetes patients with a short disease duration. The study's results are promising for the potential treatment of this chronic disease.
Researchers discovered differences in molecular signaling that promote regeneration in axolotls, while blocking it in adult mice. This finding brings science closer to developing regenerative medicine therapies for humans.
Researchers have developed a novel strategy to treat, prevent, and possibly reverse liver damages by exploiting small extracellular vesicles derived from interferon-γ pre-conditioned MSCs. The approach has shown promising results in reducing inflammation and fibrosis in a mouse model of cirrhosis.
Researchers developed an acellular product, PEP, derived from platelets that heals ischemic wounds by delivering healing messages to cells. The study demonstrates restoration of skin integrity and function in preclinical animal models.
Researchers assessed the effectiveness of treating preterm infants with umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) directly into their tracheas. Early results showed signs of improvement for the most immature infants included in the trial, but further study is needed to solidify therapeutic benefits.
Researchers found that applying fat grafts enriched with adipose-derived stem cells improved fat retention in LoS patients. The study suggested a safe and feasible alternative to conventional treatment methods for correcting facial atrophy.