Genos, an open-source Human-Centric genomic foundation model, has been released to transform medicine and health research. The model achieves strong performance on ultra-long inputs, enabling the prediction of individual disease risks and the interpretation of pathogenic mutations with high accuracy.
The study provides new insights into primate speciation, genomic diversity, and phenotypic adaptability through comparative genomic analyses of 50 primate genomes. Genomic rearrangements across lineages have identified thousands of candidate genes undergoing adaptive natural selection.
A multi-institute team used BGI Stereo-seq technology to create a single-cell resolution spatiotemporal map of salamander brain development, revealing key neural stem cell subsets and dynamic changes in spatial distribution. The study provides new ideas and guidance for regenerative medicine in the mammalian nervous system.
Researchers studied ant brains using single cell technology, revealing functional specialization and complementary brain cell composition differences among individuals. The study found specialized neurons for learning and memory in worker ants and optic lobe cells in male ants.
An international team led by BGI-Research has produced the first spatiotemporal maps of cellular dynamics in mice, Drosophila, zebrafish, and Arabidopsis using Stereo-seq technology. This breakthrough enables scientists to analyze the distribution and placement of molecules and cells in situ and over time.
The study provides a single-cell transcriptome map of 45 tissues and organs from long-tailed macaque monkeys, identifying 113 major cell types. This will improve the ability to pinpoint how to develop potential treatments for human diseases with greater precision.
Researchers developed a transgene-free method to convert human pluripotent stem cells into 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology. These cells can be used to regenerate human organs, study human embryonic development, and prevent pregnancy loss.