Articles tagged with Regenerative Medicine
By applying analytical techniques for stirred bioreactors to orbitally shaken bioreactors, researchers reconstructed a 3D model of OSB flow and identified key features of coherent structures. The study assesses the dispersion of nutrients in OSBs using Finite-Time Lyapunov Exponent analysis.
A study by Massachusetts General Hospital researchers identified a neural circuit mechanism involved in preserving memory specificity and a genetic 'switch' that can slow down memory generalization. Targeting levels of abLIM3 protein could improve memory in aging and reduce symptoms of PTSD.
Researchers have developed novel T cell immunotherapies using custom-made receptors called synNotch that can precisely target cancer and autoimmune diseases. The technology has the potential to overcome major hurdles in T cell immunotherapies, leading to more favorable treatment outcomes for patients.
Researchers at CU Anschutz have discovered a new approach to reprogramming adult skin cells into induced pluripotent stem cells (iPSCs) with unprecedented efficiency. This breakthrough has significant implications for the development of new corrective stem cell-based therapies for currently incurable diseases like Epidermolysis Bullosa.
Researchers have developed a human intestinal lining that mirrors living tissue when placed inside microengineered Intestine-Chips. This breakthrough enables personalized testing of drug treatments for debilitating gastrointestinal diseases such as Crohn's disease and ulcerative colitis.
Researchers have developed a method for mass preparing cellular aggregates called 'hair follicle germs' that may lead to new treatment for hair loss. The therapy involves regenerating hair follicles, the tiny organs that grow and sustain hair, on a large scale.
The University of Pittsburgh's Center for Medical Innovation has awarded grants to five engineering and medicine groups to develop novel biomedical devices. The projects focus on treating conditions such as peripheral artery disease, pulmonary fibrosis, and improving auditory pathology detection.
Researchers develop optimized titanium-mesh scaffolds that promote faster and more effective bone regeneration. The study found that softer implants enhanced healing, with results applicable to various types of bone defects.
Researchers have identified genes implicated in the remarkable regenerative capacity of embryos and ESCs. COX7A1 was found to be dysregulated in various cancer types, suggesting its potential as a novel cancer therapy.
Osaka University researchers develop an enzyme-driven approach to sticking biological ink droplets together, enabling the 3D printing of highly complex biological structures with a wide variety of cell types. The method overcomes compatibility problems with sodium alginate and results in high viability rates for cells.
Researchers at Cabimer have made significant discoveries about the control of cell division, highlighting the importance of the nucleolus in ensuring accurate chromosome distribution. The study found that precise temporal control of DNA compaction is necessary for equal distribution of chromosomes during mitosis.
A new digital platform provides lay summaries of hot-topic articles from leading international academics, bridging the gap between researchers and individuals outside academia. The ultimate aim is to stimulate conversations in all sectors on the impact of regenerative medicine on society.
The new Special Focus Issue explores key perspectives on regenerative medicine innovation, including regulatory developments and challenges to international harmonization. The issue aims to facilitate discussions among stakeholders, ensuring safe, ethical, and regulated translation of research from bench to bedside.
Researchers have found that titanium dioxide nanoparticles released from metal implants can interfere with bone formation and resorption, resulting in adverse effects. The review calls for further research to characterize the biological, physical, and chemical interactions between titanium dioxide nanoparticles and bone-forming cells.
Researchers discover potential of fetal membranes in treating various medical conditions, including cardiovascular and neurological diseases, diabetes, and more. Fetal membranes contain diverse stem cells, making them a promising tool for bioengineering applications.
US stem cell clinics are successfully registering for-profit, pay-to-participate studies on ClinicalTrials.gov, often with serious ethical and scientific flaws. These studies fail to disclose that patients are charged to participate in clinical research, using inappropriate inclusion and exclusion criteria.
Researchers at the Francis Crick Institute and colleagues discover that nerve cells use two signals to measure position accurately, turning into the right type of cell. This finding could inform regenerative medicine and tissue engineering approaches.
Researchers at Northwestern University have designed a sugar-coated nanomaterial that promotes bone regeneration by binding to growth factor BMP-2, reducing its need by 100 times. The biodegradable material functions as an artificial extracellular matrix, mimicking natural cell interactions.
Macrophages, known as the Pac-Man of the immune system, promote healing by regrowing severed nerves in rats, offering a promising alternative to current treatments like autografts. The approach uses biological signals to recruit younger, undifferentiated cells destined to become pro-healing macrophages.
Researchers at MDI Biological Laboratory studied various parameters of health in C. elegans to develop an empirical definition of old age and predict healthy lifespan. They found movement speed as a key marker for assessing the effect of anti-aging interventions.
A Harvard-Wyss Institute and University of Zurich team developed a nanofiber fabrication technique to create regenerative heart valves with growth potential. The technology enables rapid manufacturing of customizable, scalable, and cost-effective prostheses that can be implanted minimally invasively.
A Cedars-Sinai-led team developed a technique that cues bone to regrow its own tissue, potentially replacing bone grafts. The innovative method combines ultrasound, stem cell and gene therapies to mend severely broken bones.
Researchers at Tufts University successfully treated blind tadpoles with a serotonin receptor drug to induce nerve growth and promote visual learning, enabling the animals to process visual information from their grafted eyes. The study provides a potential road map for promoting innervation in regenerative medicine.
Researchers have developed a machine learning model that can predict the outcome of cellular interactions and design new cancer treatments. The Stampede supercomputer enabled the team to run billions of simulations, allowing them to identify patterns in the data and create a system capable of predicting laboratory results.
MDI Biological Laboratory scientists have identified a potential heart drug candidate to restore heart muscle function following a heart attack. In a breakthrough study, MSI-1436 showed significant regeneration in zebrafish and mice, with promising results in adult mice after an artificially induced heart attack.
Scientists have described a new species of fish-scale geckos (Geckolepis megalepis) that possess the largest scales of any gecko. These unique geckos can lose their skin at the slightest touch, making them challenging to study.
The 10-Year Anniversary Special Focus Issue of Regenerative Medicine explores the past decade's progress in regenerative medicine, including reviews, perspectives, and special reports. The journal has remained at the forefront of the field since its inception in 2006 and continues to showcase the latest research.
Researchers have found that axolotl salamanders can regenerate significant portions of their adult ovary after injury. This ability could lead to new treatments for pre-mature ovarian failure and reduced fertility in humans.
Researchers at UT Southwestern Medical Center have found that a low-oxygen environment can regenerate heart muscle in mice. This discovery builds on previous research that showed the ability of newborn mammals to regenerate their hearts, and demonstrates the potential for this approach to reverse heart disease.
Researchers at UT Southwestern Medical Center identified a pathway essential to heart formation, unveiling a mechanism that explains how non-coding DNA regulates neighboring genes. The discovery may have implications for understanding cardiac development and other genetic processes.
Researchers delivered human stem cells to damaged heart muscles in rats and found regional functional changes, while non-cell seeded sutures showed no effect. The study demonstrates potential for cell therapeutics to deliver cells to specific targets.
A new technique developed by Tokyo Medical and Dental University has improved bone regeneration by using double-layered cell constructs that can be transplanted onto bone defects. The technique increases the speed of bone repair and provides flexibility and durability ideal for surgical applications.
A review article explores regenerative medicine techniques in facial plastic and reconstructive surgery, including stem cells, growth factors, and synthetic scaffolds. The study suggests that these methods may improve outcomes and cost-effectiveness while minimizing risks.
The gut microbiome plays a complex role in cognitive and psychiatric disorders, including autism spectrum disorder, schizophrenia, Alzheimer's disease, and Parkinson's disease. Researchers are exploring synthetic biology to develop engineered bacteria that can remodel the gut microbiota and treat these conditions.
Researchers at Pitt School of Medicine identify mechanism by which bioscaffolds influence cellular behavior, promoting tissue repair and reconstruction. The study reveals the presence of nanovesicles in bioscaffolds, which enable cellular communication and facilitate regenerative processes.
Researchers at the University of Pittsburgh School of Medicine and McGowan Institute for Regenerative Medicine showed significant improvement in strength and range of motion, as well as evidence for skeletal muscle regeneration in patients treated with bioscaffolds. The study demonstrated the effectiveness of regenerative medicine in i...
Researchers found that a protein called b1-integrin is crucial for muscle regeneration in aged muscles. The team's study provides a promising target for therapeutic intervention to combat muscle aging or disease. By restoring the function of b1-integrin, regenerative abilities were restored to youthful levels in mice with aged muscles.
Researchers have developed a culture method that significantly increases kidney progenitor cell proliferation while maintaining their ability to form glomeruli and tubules. This breakthrough finding has major implications for regenerative medicine, potentially aiding in the search for causes of kidney disease and new drug development.
Researchers have developed a new method to grow blood vessels in a 3D scaffold, reducing transplant rejection risks and increasing tissue integration. The technique uses human platelet lysate gel and endothelial progenitor cells, paving the way for fully vascularized tissues or organs.
Researchers found a novel neuron regeneration pathway in C. elegans that could lead to treatments for human spinal cord injury and paralysis. The discovery sheds light on the adult human nervous system's ability to regenerate, which is essential for restoring health to people with permanent neurological damage.
Scientists have successfully directed stem cell-derived neurons to regenerate lost tissue in damaged corticospinal tracts of rats. This breakthrough improves forelimb movements and upends the existing belief that corticospinal neurons lack internal mechanisms for regeneration.
The article highlights regional differences in demographics, disease prevalence, and cultural attitudes towards donated tissues and organs. Regulatory approaches vary across countries, necessitating a tailored approach to balance risk and benefit.
Researchers developed an algorithm called Mogrify that predicts the unique set of cellular factors required for converting one human cell type to another. This breakthrough has significant implications for regenerative medicine and lays the groundwork for further research into cell reprogramming.
A review article discusses novel tissue engineering approaches to repair spinal disc herniation, targeting underlying disc injury or instability. The emerging biological repair methods show promising preclinical outcomes, potentially reducing pain and restoring spine motion.
Researchers review emerging magnetic particle-based techniques to track cells in vivo, providing a promising concept for treating diseases. The techniques can be used for cell therapy, combining diagnosis and treatment.
Researchers have discovered a gene called Sox9 that enables kidney cells to switch on and repair damaged tissue after acute injury, offering new hope for treating this serious condition. The study found that the Sox9 gene promotes timely repair of the nephron's cellular lining and repairs the kidney after AKI.
A new method for testing human induced pluripotent stem cells (iPSCs) has been developed, allowing for the evaluation of their differentiation potential. This approach uses pathway activation profiling to identify impaired iPSC lines and predict in vitro differentiation capabilities.
The University of Nottingham leads a £6.5m research project to create bespoke biomaterials for specific applications in regenerative medicine, drug delivery, and medical devices. The team aims to identify new materials that can control cell response and address unmet clinical needs.
Researchers at Cedars-Sinai Medical Center identified Ets family genes as contributors to glioma brain tumors. Blocking these genes may lead to novel treatment therapies.
Scientists have developed a mouse model to study the unique marker ATRX on mom's chromosomes, which helps regulate cell divisions during early development. The findings suggest that stability of this chromosomal domain is crucial for subsequent development and health.
Researchers developed an algorithm to predict planarian regeneration outcomes and identified a simple regulatory network. This breakthrough applies artificial intelligence to understand complex biological processes.
Researchers at Tufts University developed an algorithm that used evolutionary computation to predict the results of published laboratory experiments on planarian regeneration. The approach identified a comprehensive regulatory network that correctly predicted all 16 key experiments, shedding light on the mechanisms behind head-tail pat...
A team of Massachusetts General Hospital investigators has developed a bioartificial replacement limb suitable for transplantation using an experimental approach previously used to build bioartificial organs. The researchers successfully engineered rat forelimbs with functioning vascular and muscle tissue, and provided evidence that th...
A renowned researcher has been awarded a $4.9 million grant to advance her work on retinitis pigmentosa, a degenerative retinal disease affecting 150,000 individuals nationally. The grant will support stem cell therapy aiming to delay the progression of the disease and preserve vision.
The journal Regenerative Medicine has published a special focus issue on methods to avoid immune rejection in regenerative medicine. The field is immature, but research continues to address the importance of immunity in progress and development.
Researchers have developed a new technique for islet transplantation under the skin, which shows promise in reversing diabetes in preclinical models. This approach harnesses the body's natural ability to respond to a foreign body by growing new blood vessels, offering a safer and more reliable treatment option.
A special focus issue in Nanomedicine examines the intersection of nanomedicine and regenerative medicine, showcasing advancements in nanotopography, nanofunctionalization, and stem cell research. The field of nanoregeneration has grown exponentially over the last 15 years, with potential applications in drug discovery and cell targeting.
Researchers at Keck Medicine of USC have received grants to develop a temporary liver support system for transplant patients and improve gene editing for blood diseases. They also plan to create transgenic rats for researching heart failure, diabetes, and neurodegenerative diseases.
Professor Warburton's book, Stem Cells, Tissue Engineering and Regenerative Medicine, surveys current issues in stem cell biology and regenerative medicine. The book provides overviews of recent progress in stem cell research, including progenitor cell therapies for organ systems.
Scientists at Cedars-Sinai Medical Center have developed a method to re-create stem cells from stored blood samples of deceased patients. This approach enables researchers to study the biological mechanisms behind diseases and potentially design new therapies for conditions such as Crohn's disease.