Articles tagged with Regenerative Medicine
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have developed a culture method that significantly increases kidney progenitor cell proliferation while maintaining their ability to form glomeruli and tubules. This breakthrough finding has major implications for regenerative medicine, potentially aiding in the search for causes of kidney disease and new drug development.
Researchers have developed a new method to grow blood vessels in a 3D scaffold, reducing transplant rejection risks and increasing tissue integration. The technique uses human platelet lysate gel and endothelial progenitor cells, paving the way for fully vascularized tissues or organs.
Researchers found a novel neuron regeneration pathway in C. elegans that could lead to treatments for human spinal cord injury and paralysis. The discovery sheds light on the adult human nervous system's ability to regenerate, which is essential for restoring health to people with permanent neurological damage.
Scientists have successfully directed stem cell-derived neurons to regenerate lost tissue in damaged corticospinal tracts of rats. This breakthrough improves forelimb movements and upends the existing belief that corticospinal neurons lack internal mechanisms for regeneration.
The article highlights regional differences in demographics, disease prevalence, and cultural attitudes towards donated tissues and organs. Regulatory approaches vary across countries, necessitating a tailored approach to balance risk and benefit.
Researchers developed an algorithm called Mogrify that predicts the unique set of cellular factors required for converting one human cell type to another. This breakthrough has significant implications for regenerative medicine and lays the groundwork for further research into cell reprogramming.
A review article discusses novel tissue engineering approaches to repair spinal disc herniation, targeting underlying disc injury or instability. The emerging biological repair methods show promising preclinical outcomes, potentially reducing pain and restoring spine motion.
Researchers review emerging magnetic particle-based techniques to track cells in vivo, providing a promising concept for treating diseases. The techniques can be used for cell therapy, combining diagnosis and treatment.
Researchers have discovered a gene called Sox9 that enables kidney cells to switch on and repair damaged tissue after acute injury, offering new hope for treating this serious condition. The study found that the Sox9 gene promotes timely repair of the nephron's cellular lining and repairs the kidney after AKI.
A new method for testing human induced pluripotent stem cells (iPSCs) has been developed, allowing for the evaluation of their differentiation potential. This approach uses pathway activation profiling to identify impaired iPSC lines and predict in vitro differentiation capabilities.
The University of Nottingham leads a £6.5m research project to create bespoke biomaterials for specific applications in regenerative medicine, drug delivery, and medical devices. The team aims to identify new materials that can control cell response and address unmet clinical needs.
Researchers at Cedars-Sinai Medical Center identified Ets family genes as contributors to glioma brain tumors. Blocking these genes may lead to novel treatment therapies.
Scientists have developed a mouse model to study the unique marker ATRX on mom's chromosomes, which helps regulate cell divisions during early development. The findings suggest that stability of this chromosomal domain is crucial for subsequent development and health.
Researchers at Tufts University developed an algorithm that used evolutionary computation to predict the results of published laboratory experiments on planarian regeneration. The approach identified a comprehensive regulatory network that correctly predicted all 16 key experiments, shedding light on the mechanisms behind head-tail pat...
Researchers developed an algorithm to predict planarian regeneration outcomes and identified a simple regulatory network. This breakthrough applies artificial intelligence to understand complex biological processes.
A team of Massachusetts General Hospital investigators has developed a bioartificial replacement limb suitable for transplantation using an experimental approach previously used to build bioartificial organs. The researchers successfully engineered rat forelimbs with functioning vascular and muscle tissue, and provided evidence that th...
A renowned researcher has been awarded a $4.9 million grant to advance her work on retinitis pigmentosa, a degenerative retinal disease affecting 150,000 individuals nationally. The grant will support stem cell therapy aiming to delay the progression of the disease and preserve vision.
The journal Regenerative Medicine has published a special focus issue on methods to avoid immune rejection in regenerative medicine. The field is immature, but research continues to address the importance of immunity in progress and development.
Researchers have developed a new technique for islet transplantation under the skin, which shows promise in reversing diabetes in preclinical models. This approach harnesses the body's natural ability to respond to a foreign body by growing new blood vessels, offering a safer and more reliable treatment option.
A special focus issue in Nanomedicine examines the intersection of nanomedicine and regenerative medicine, showcasing advancements in nanotopography, nanofunctionalization, and stem cell research. The field of nanoregeneration has grown exponentially over the last 15 years, with potential applications in drug discovery and cell targeting.
Researchers at Keck Medicine of USC have received grants to develop a temporary liver support system for transplant patients and improve gene editing for blood diseases. They also plan to create transgenic rats for researching heart failure, diabetes, and neurodegenerative diseases.
Professor Warburton's book, Stem Cells, Tissue Engineering and Regenerative Medicine, surveys current issues in stem cell biology and regenerative medicine. The book provides overviews of recent progress in stem cell research, including progenitor cell therapies for organ systems.
Scientists at Cedars-Sinai Medical Center have developed a method to re-create stem cells from stored blood samples of deceased patients. This approach enables researchers to study the biological mechanisms behind diseases and potentially design new therapies for conditions such as Crohn's disease.
The Pitt team is creating novel alloys and manufacturing processes for implantable medical devices made from dissolving metals. These devices can adapt to changes in a patient's body and dissolve once healing has occurred, reducing complications and medical expenses.
Cedars-Sinai is part of a 5-center consortium collecting and analyzing thousands of pieces of data to develop molecular signatures for motor neuron disorders. The goal is to create a 'cloud' of information that shows relationships between proteins, genes, and RNA in cells.
Researchers at USC Health Sciences have discovered how a gene mutation affects facial development, revealing the underlying mechanisms of DiGeorge syndrome. The study's findings provide new insights into the complex cellular rearrangements that shape the face during early development.
Researchers suggest progesterone as a potential treatment for spinal cord injury due to its anti-inflammatory and neuroprotective properties. Studies demonstrate that progesterone preserves white matter integrity and improves locomotor function in animal models of spinal cord lesion.
Researchers at Wake Forest Baptist Medical Center have successfully mobilized stem cells to form muscle tissue within a biomaterial scaffold. The study, published in Acta Biomaterialia, demonstrates the potential for harnessing the body's natural healing powers to regenerate damaged muscle tissue.
Researchers used CRISPR/Cas9 to correct genetic mutations leading to Duchenne muscular dystrophy in a mouse model, preventing progressive muscle weakness and degeneration. The technique may lead to permanent correction of the disease, offering hope for future therapeutic applications.
Acrolein, a highly reactive aldehyde, contributes to motor and sensory deficits following spinal cord injury. Using acrolein scavengers may attenuate neuronal damage, making it a potential novel therapeutic target.
Researchers have discovered how embryonic stem cell fate is controlled, enabling future research into artificial cell manipulation. This breakthrough aims to repair or replace damaged human cells and tissues, restoring normal function.
A Harvard-led team uses low-power laser therapy to stimulate human dental stem cells into forming dentin, a hard tissue similar to bone. The approach, led by David Mooney, could radically shift dental treatment and lead to broader clinical applications in regenerative medicine.
The Olig family is crucial for controlling differentiation and maturation of oligodendrocytes, motor neurons, and astrocytes in the central nervous system. Accumulating evidence suggests its involvement in various CNS diseases, including brain injury, multiple sclerosis, and gliomas.
Researchers used ECM from pig bladders to regenerate lost muscle tissue in human trials, improving strength and function in three out of five participants. Muscle growth was confirmed through biopsies and scans, offering hope for patients with severe leg injuries.
The Olig family is involved in regulating neural cell differentiation and affects acute and chronic central nervous system diseases. It also participates in the development of oligodendrocytes, motor neurons, and astrocytes in the central nervous system.
Tracheal bioengineering should be demonstrated as both effective and safe before further transplants. The authors report high mortality and morbidity rates among patients who received bioengineered tracheas, casting doubt on the field's current state.
Scientists have identified perivascular stem cells as a reservoir of HCMV, suggesting a potential treatment target. The discovery could lead to the development of novel targeted therapies to prevent HCMV re-activation and its associated complications.
Researchers at Cedars-Sinai Medical Center have identified gene expression regulators, microRNAs, in normal and diabetic human corneas, which may contribute to stem cell and epithelial abnormalities. The study aims to accelerate healing and repair processes in damaged corneas to reverse diabetes-induced eye complications.
Azim Surani receives the McEwen Award for Innovation for pioneering epigenetics research; Valentina Greco wins the ISSCR-BD Biosciences Outstanding Young Investigator Award for her noninvasive method to visualize skin stem cell division. Paolo Bianco, Elena Cattaneo, and Michele De Luca receive the ISSCR Public Service Award for their ...
Researchers found that hypoxic preconditioning reduced infarct volume and impaired neurological function in a mouse model of cerebral infarction. Increased vascular endothelial growth factor and CD31 expression promoted angiogenesis, leading to improved outcomes.
Researchers found that persimmon leaf flavonoid mitigates pathological injury of brain tissue following cerebral ischemia/reperfusion in rats, elevating brain ischemic tolerance. High-dose persimmon leaf flavonoid showed an identical effect to ginaton, providing a potential basis for drug development.
Researchers at Cedars-Sinai Medical Center have developed a novel procedure to prepare human amniotic membrane for use as a scaffold for specialized stem cells, which may treat corneal diseases such as blindness. The new method promises to streamline clinical applications of cell therapies and accelerate research in this area.
A team of doctors and scientists at Cedars-Sinai Medical Center used stem cell technology to create neurons from patients' skin cells and block the damaging effects of a defective gene. The study provides proof of concept for a new therapeutic strategy, suggesting a potential future therapy for Lou Gehrig's disease.
Four UCLA researchers received significant funding to advance promising stem cell therapies for HIV/AIDS, prostate cancer, and sickle cell disease. Drs. Jerome Zack, Robert Reiter, Donald Kohn, and Gerald Lipshutz will use the grants to develop innovative treatments with potential to revolutionize disease care.
A Cedars-Sinai researcher has been awarded $5.18 million to advance stem cell technologies in segmental bone defects. The team aims to develop a novel approach to treat the condition without grafting bone, using stem cells and ultrasound to deliver a bone-forming gene.
Researchers at UC Davis have successfully generated oligodendrocytes with spiking properties, allowing them to produce myelin and mature into functional brain cells. The enhanced cells showed superior regenerative capacity and produced thicker, longer myelin sheaths than natural cells.
Researchers developed an efficient way to target and repair defective genes using a novel technique that simplifies previous methods. This breakthrough enables the potential to repair genetic defects responsible for diseases like breast cancer, Parkinson's, and others, opening doors for meaningful therapeutic applications.
A UC Davis study reveals that astrocytes can protect brain tissue and reduce disability due to stroke. The research found that a specific type of astrocyte called Olig2PC-Astros has greater antioxidant effects and improves learning and memory in rats.
Researchers discovered human kidneys discarded for transplant can serve as a natural scaffold material for manufacturing replacement organs in the lab. The study suggests that these organs could potentially be used to help solve the critical shortage of donor organs.
Researchers from USC Keck School of Medicine have uncovered unique cellular and molecular mechanisms behind tooth renewal in American alligators. The study found that alligator teeth are complex units of three components, including a functional tooth, replacement tooth, and dental lamina, which contain stem cells for regeneration.
Researchers at Massachusetts General Hospital successfully developed implantable, bioengineered rat kidneys that produced urine and functioned in living animals. The approach uses donor organs stripped of cells, repopulated with human or animal cells, and cultured to mimic native organ structure and function.
Engineered stem cells produce US2 protein to increase survival by 59%, potentially improving treatment for bowel disease, traumatic brain injury, and organ transplants. The modified cells can modulate inflammation and promote healing, offering new hope for patients in need of regenerative therapies.
Scientists at Tufts University have shown that transplanted eyes can confer vision without a direct neural connection to the brain. The study used frog models and found that ectopic eyes could 'see' and elicit responses similar to those of animals with natural eyes.
A new study on the Newt transcriptome has identified 826 proteins specific to urodeles and several newly discovered proteins that may play roles in regeneration. The data outline genes present only in regenerating tissues, which could be crucial for regenerative medicine research.
A Cedars-Sinai physician-scientist is leading a research study on Charcot-Marie-Tooth disease, the most common inherited neurological disorder, using induced pluripotent stem cells. The goal of the study is to determine if personalized stem cell lines can be generated for individual patients and potentially cure the disease.
Researchers at Wake Forest Baptist Medical Center identify a unique rat model of bladder regeneration, which may help understand regenerative processes in mammals. The study found that cells in the bladder lining proliferate and transition into stem cells to repair damaged bladders.
Researchers have discovered that embryonic endothelial precursors can differentiate into beating cardiomyocytes in the absence of Scl, a master regulator of blood development. This finding may provide new avenues for creating cardiac stem cells and treating heart conditions through regenerative medicine.
Researchers at University of Nottingham are developing new injectable materials that stimulate stem cells to form new blood vessels, heart and bone tissue. The goal is to create radical new treatments for diseases with no cure, reducing the need for invasive surgery.
Researchers at Pitt's Swanson School of Engineering and School of Medicine have developed a cell-free, biodegradable artery graft that regenerates an artery in situ within 90 days. The graft's porosity allows for immediate cell infiltration, leading to strong and compliant new arteries.
Scientists successfully created 'scaffolds' from pig kidneys to potentially build replacement kidneys for humans. The structure of the nephron was maintained, and blood vessels were able to maintain normal pressure when re-filled with blood in animal models.