The Human Oral Microbiome Database has been updated with a greater breadth of data, including 44 new human oral taxa and a total of 834 identified species. This expansion enables researchers to study the oral microbiome with greater precision and depth.
Researchers identified a molecule, fibromodulin, that regulates myofibroblasts at the site of tissue closure to prevent excessive scarring. A peptide drug derived from fibromodulin may help reduce scarring in cleft lip repair and other surgical procedures.
Scientists have identified new ways that bacteria interact with each other in the oral microbiome, finding that certain species bind more strongly than others. This groundbreaking discovery could lead to new insights into disease and the development of novel therapies.
The ADA Forsyth Institute has received a $6.2 million grant from the NIH to design an AI-driven amalgam replacement for dental restoratives. The new material will feature self-healing and antimicrobial properties, responding to biological signals in each individual patient's mouth.
A new narrow-spectrum antibiotic, FP 100, has been found to effectively eliminate Fusobacterium nucleatum without harming the oral or gut microbiomes. This breakthrough discovery holds significant implications for treating severe gum disease and preventing related systemic conditions such as colon cancer and Alzheimer's disease.
Scientists at ADA Forsyth Institute found that nutrient-deprived polymicrobial community conditions in hospitals favor the growth of Klebsiella, a multidrug-resistant pathogen. The bacteria can thrive for over 120 days after being deprived of nutrition.
The ADA Forsyth Institute has ranked as the top oral health research institution on the East Coast, receiving significant funding from the National Institute of Dental and Craniofacial Research. The institute's researchers have consistently demonstrated excellence in their field, with a strong track record of innovation and impact.
Researchers at ADA Forsyth Institute discovered a new phage resistance mechanism in the oral microbiome, where ultrasmall bacterial parasites, called Saccharibacteria or TM7, help their host bacteria resist lytic phages. This dynamic ecosystem promotes coexistence between antagonistic organisms.
Researchers mapped dental pulp and periodontal ligament stem cells' genomes, revealing significant differences in their differentiation potential. The study identifies the genetic composition and mechanisms of differentiation, paving the way for targeted regenerative therapies.
Researchers at ADA Forsyth have discovered the regenerative properties of Resolvins, specifically RvE1, which promotes pulp regeneration and reduces bacterial invasion in dental pulp. The technology has far-reaching potential for regenerative medicine beyond oral health, including growing bones in other parts of the body.
A study by Forsyth Institute researchers reveals a link between periodontal disease and amyloid plaque formation in the brain. Oral bacteria can travel to the brain, causing neuroinflammation and promoting cognitive decline in Alzheimer's patients.
Scientists from Forsyth Institute develop CRISPR-based diagnostic tool that can detect specific oral pathogens with high sensitivity and specificity. The test can be performed in a dental office without technical expertise, providing comprehensive information on oral health and systemic diseases like diabetes, heart disease, and cancer.
Researchers at the Forsyth Institute have discovered a molecule naturally produced by the human host that targets and inhibits Fusobacteria, an opportunistic oral pathogen linked to colorectal cancer. The findings suggest a chemically modified version of this molecule could be used as a potential therapeutic to prevent colorectal cance...
Researchers at The Forsyth Institute have made two breakthrough discoveries that could lead to new treatments for cartilage injuries and degeneration. They found that β-catenin, a multifaceted protein, plays a role in skeletal cell fate determination and ectopic chondrogenesis.
Researchers created a model system to study the ultrasmall bacteria TM7 and found that they acquired a gene cluster encoding the arginine deiminase system, which helps them survive and multiply in the human oral cavity. This discovery suggests that TM7 may play a more protective role in oral health than previously thought.
Researchers discovered that oral TM7 bacteria decreased periodontal inflammation and bone loss in a mouse model by altering the behavior of their host bacteria. They found two mechanisms by which TM7 modulate inflammation: decreasing production of a collagen binding protein and disrupting host bacterial metabolism.
A longitudinal study found that the ForsythKids preventive dentistry program reduced untreated cavities from 39% to 19% over six years, highlighting the effectiveness of school-based prevention programs. The study also highlights the critical need for accessible dental care in low-income communities.
Researchers found that people with periodontitis are at higher risk of experiencing major cardiovascular events due to associated inflammation. Active gum disease was predictive of arterial inflammation, leading to heart attacks, strokes, and other cardiovascular complications.
Forsyth researchers discovered a way to reverse periodontal disease by stimulating stem cells with Maresin-1 and Resolvin-E1, two synthetic lipid mediators. This finding offers new therapeutic possibilities for treating systemic diseases associated with inflammation.
The Forsyth Institute is working with the NIH's RADx initiative to develop and deploy accurate, rapid COVID-19 point-of-care tests using saliva samples. The institute brings its expertise in salivary diagnostics and has been at the forefront of salivary research for decades.
Scientists found that ultra-small, parasitic bacteria from the TM7 phylum are present in humans, moose, dogs, cats, dolphins, and groundwater. Despite their diverse environments, these bacteria have minimally changed genomes, indicating recent acquisition by humans.
Researchers discovered that human saliva is more watery and contains distinct protein profiles compared to chimpanzees and gorillas. The differences are attributed to varying diets, with human saliva being effective at breaking down starch and fat.
A large-scale study found elevated levels of a biomarker for uranium toxicity in Kuwaiti children who developed obesity and metabolic syndrome. The study suggests that uranium exposure may contribute to the country's high rates of obesity and diabetes.
The Boston Bruins have partnered with the Forsyth Institute to provide custom mouthguards to student athletes in baseball, softball, and lacrosse, aiming to prevent oral injuries. The program will expand to fall and winter sports, offering protection for teeth, jaws, lips, tongue, and face.
A new genetic engineering approach removes a specific component of human-made DNA to make it invisible to bacterial defenses, allowing for more efficient and time-saving gene editing. This breakthrough enables researchers to engineer clinically relevant bacteria with reduced resources and increased flexibility.
Researchers found that three closely related species of bacteria outlived other oral bacteria in a 'doomsday' experiment, surviving for over 100 days without nutrients. The discovery sheds light on how certain pathogens persist in hospital environments and can cause infections.
Research reveals that HIV-infected youth have lower levels of a protective bacterium in their dental plaque, leading to higher cavities rates. The study aims to explore the role of oral microbiome in HIV-exposed youth and inform new therapies to prevent dental decay.
A new study found that salivary RNA can regulate oral bacteria growth, influencing diseases such as periodontitis. The research discovered a channel of communication between RNA messengers and bacteria in the mouth.
The expanded Human Oral Microbiome Database (eHOMD) now contains 772 species, providing a wealth of information for researchers studying oral health and overall wellness. The database's expansion will facilitate work on fighting infectious diseases and better understanding human health and disease.
A team of researchers created a three-dimensional map of the gut microbiome, revealing a surprising degree of mixing among different bacterial members. The study found that the gut microbiome lacks highly organized structure, unlike other body sites like the mouth.
A study of over 8,000 Kuwaiti adolescents found that metabolic diseases are associated with altered oral bacteria and increased risk of dental disease. The study suggests that preventive dental care is crucial for managing metabolic diseases.
Researchers at the Forsyth Institute have defined the immune-regulatory mechanisms of Sjögren's syndrome, revealing how PD-L1 and PD-1 proteins interact to suppress protective immunity. The study found that inhibiting this pathway accelerates autoimmune responses and disease development.
A recent study by Forsyth Institute researchers shows that Corynebacterium species inhibit the virulence of Staphylococcus aureus. This interaction may lead to the development of novel treatments for preventing S. aureus infections, as well as other diseases caused by pathobionts.
Researchers at Forsyth Institute use a new imaging technique to visualize bacteria in dental plaque, revealing the formation of 'hedgehog' structures that suggest functional roles within the community. This study provides critical insights into how mouth microbes interact and will help understand their role in health and disease.
A harmless bacterium found in the nose can inhibit a major cause of pneumonia, meningitis, and other infections. The study provides evidence that Corynebacterium accolens releases antibacterial free fatty acids from human nostrils and skin surface triacylglycerols.
A new study reveals that Mycobacterium tuberculosis hijack protective hypoxic zones in bone marrow stem cells to hide and survive. The research found that these stem cells exhibit strong binding to pimonidazole, indicating hypoxia localization, and express a key gene involved in regulating oxygen levels.
A new study from Forsyth Institute reveals that proton pump inhibitor-based antacids reduce stomach acidity, disrupting calcium absorption and increasing the risk of bone fractures. The research provides a best explanation for the side effect of these medications, which are used by 100 million Americans.
Researchers have successfully developed an oral vaccine delivery system using Streptococcus mitis to induce mucosal immune responses in the mouth and beyond. This innovative approach has potential to protect against diseases such as tuberculosis, AIDS, and intestinal infections, making it a promising tool for global health threats.
Researchers discovered a small molecule produced by benign bacteria influences the behavior of Staphylococcus aureus, causing it to form biofilms. This finding could lead to new ways to manage bacterial communities and prevent infections.
Scientists applied a new oligotyping technique to analyze the human oral microbiome, identifying over 300 oligotypes and discovering closely related species with distinct habitat distributions. This approach provides deep insight into the microbial communities in health and disease.
Researchers discovered altered salivary biomarker levels in obese children, indicating a potential non-invasive method for identifying early Type 2 diabetes risk. The study's findings provide valuable insights into childhood obesity and metabolic syndrome, paving the way for development of prevention strategies.
Researchers have developed a protocol for collecting saliva and stool samples for genomic and transcriptomic analyses, eliminating the need for specialized personnel and facilities. This method provides critical insight into the genetic makeup of the microbiome and its association with diseases such as celiac disease, oral cancer, and ...
Research finds that protein TG2 enables bacteria Porphyromonas gingivalis to adhere to cells, and blocking its associations prevents bacterial adhesion. The study provides insight into a potential target for preventing gum disease.
The Forsyth Center for Salivary Diagnostics will revolutionize disease testing using saliva-based tests, which contain virtually all medical diagnostic information as blood. The facility aims to develop and commercialize new assays that are less expensive and more convenient.
Scientists at Forsyth Institute have made a groundbreaking discovery about latent tuberculosis, finding that the bacteria can lay dormant in bone marrow stem cells. This understanding has significant clinical implications, explaining why patients with TB remain sensitive to tests and treatment is so challenging.
Researchers from Arunachal Pradesh and the Research Institute of World's Ancient Traditions Cultures and Heritage successfully isolated dormant TB bacteria from CD271+ stem cells in bone marrow. The study provides evidence that TB bacteria hide in these stem cells to escape drug treatment, making it difficult to eradicate the disease.
The Forsyth team, led by experts in oral and craniofacial microbiology, contributed to the Human Microbiome Project's definition of normal bacterial makeup. The study found that microbes contribute more genes responsible for human survival than humans themselves, with an estimated 360-times more bacterial genes.
Researchers identified four types of bacterial communities in healthy adults at 10 sites along the digestive tract. They found a core set of metabolic genes present throughout, suggesting common functions needed for bacterial communities living on mucosal surfaces.
The Forsyth Institute is developing a low-cost diagnostic tool for tuberculosis (TB), which can quickly and accurately diagnose active TB cases in developing countries. The project focuses on identifying and validating seven proteins of Mycobacterium tuberculosis as biomarkers of active disease.
Researchers at The Forsyth Institute have identified a new pathogen, Scardovia wiggsiae, connected to severe early childhood caries. This bacterium was present in the mouths of children with severe ECC when other known pathogens like Streptococcus mutans were not detected.