The Forsyth Institute receives the William J. Gies Award for outstanding achievements in oral health and education. The Institute has been a leading independent research organization since 1910, contributing significantly to dental education and scholarship.
Researchers use cryo-electron tomography to elucidate molecular architecture of Treponema pallidum, shedding light on cellular structure and movement. The study provides new understanding of how the bacterium attaches to human cells and moves with its flagella.
The Forsyth Institute has received highly competitive Challenge Grants totaling over $6 million from the NIH's American Recovery and Reinvestment Act. This funding will support innovative projects addressing various oral health challenges, including inflammation and bone resorption in oral diseases.
Researchers found significant differences in salivary bacteria populations between overweight women and non-overweight women, with a single species Selenomanas noxia linked to over 98% of cases. The study suggests oral bacteria may be related to obesity pathology.
A study of the MSX gene family over 600 million years reveals duplication and diversification of protein regions as key to understanding certain birth disorders. The research provides a molecular explanation for disease patterns associated with cleft lip and palate.
A Forsyth Institute researcher is working on a new TB diagnostic test that could save up to 625,000 lives annually. The test aims to detect the TB bacterium's molecules in patient urine, providing a non-invasive and quick diagnosis.
Researchers have identified two genes that regulate stem cell function in planarians, which could provide insights into adult tissue maintenance and regeneration. The study also reveals the role of PTEN in controlling stem cell proliferation and regeneration.
The Human Oral Microbiome Database provides detailed information on the 600 most common mouth bacteria, their role in oral health and general well-being. The database links genetic data to scientific literature and allows for analysis of microbe genomes.
Researchers at Forsyth Institute have identified a novel mechanism controlling adult stem cells, highlighting the importance of direct cell-to-cell communication. The study's findings suggest that gap junctions play a critical role in regulating stem cell behavior and tissue regeneration.
The ForsythKids program provides elementary school children with oral health education, dental exams, cleanings, and preventive care. After two rounds of treatment, there was virtually no new tooth decay among enrolled children. The program has already met and exceeded Healthy People 2010 goals in just three years.
Scientists at Forsyth Institute successfully induced frog tadpole tail regeneration using gene therapy and electric fields. This breakthrough discovery may hold key to regenerating human spinal cord tissue, providing insights into the role of bioelectricity in regeneration.
Scientists at The Forsyth Institute have discovered that programmed cell death is necessary for regeneration to occur. Apoptosis plays a critical role in development and a novel role in regeneration, allowing medically therapeutic regeneration. The study uses the Xenopus tadpole as a model organism.
Researchers found that fluoxetine stimulates new bone formation under normal conditions and reverses total bone loss triggered by inflammation. The study suggests a link between serotonin reuptake inhibitors and improved bone health.
A human study confirms that immune cells play a destructive role in periodontal disease. Researchers found that B cells and T cells produce RANKL, which induces osteoclasts and leads to bone loss.
Researchers have developed a computer-controlled system to analyze animal behavior, allowing for rapid and efficient drug screening. The Forsyth Automated Training Apparatus enables automated control of the environment, recording animal reactions to stimuli, and providing valuable insights into cognitive abilities.
Dental caries is a widespread and increasing problem globally, with 5 billion people affected. Forsyth researchers aim to develop a vaccine targeting bacterial accumulation on teeth, with initial focus on mucosal vaccines for young children.
Researchers identify a single mechanism linking ciliary, serotonergic and ion flow mechanisms to control embryonic laterality. The study challenges previous hypotheses on the role of cilia in left/right asymmetry, providing insight into human development and birth defects related to left/right asymmetry.
Research reveals a novel role of serotonin transporters in controlling left-right asymmetry, with implications for embryonic development and potential side effects of certain antidepressant medications. The study also highlights the importance of dynamic serotonin movement within cells.
Researchers at Forsyth Institute discover that gap junctions play a crucial role in planarian regeneration by facilitating long-range signaling. By closing down gap junctions, the team found that cells can adopt radically different fates, leading to the growth of complex structures.
Researchers discover bmp4 gene plays key role in regulating craniofacial diversity, with implications for understanding human craniofacial defects and preserving species biodiversity. The study provides new insights into the mechanisms underlying biodiversity and offers possibilities for exploring what genes make a head.
Researchers at Forsyth Institute have identified three bacteria associated with oral squamous cell carcinoma (OSCC), a deadly form of cancer. The study found that elevated levels of these bacteria in saliva can indicate the presence of OSCC, raising hopes for an early diagnostic marker and potentially saving lives.
Researchers found serotonin plays a crucial role in early embryonic development, providing a molecular support for the idea that it's utilized as a large-scale left-right patterning mechanism. This discovery sheds light on the evolutionary origin of a crucial neurological control system and could lead to new therapeutic applications.
Researchers discovered that blue light can rapidly kill certain oral bacteria associated with periodontitis, and may restore a healthy bacterial balance in the mouth. A handheld device using this technology is being developed to combat periodontal disease.