Articles tagged with Antibiotics
Researchers developed a new technique to visualise the distribution of TB drugs in human macrophages at high resolution. The study found that bedaquiline accumulates in lipid droplets inside host cells, forming a reservoir that supplies the drug to Mtb over time.
A recent study found that US hospitals typically wait over a year to prescribe new antibiotics, hindering the market for needed drugs. The delay is attributed to factors such as cost, lack of clear patient guidelines, and inadequate testing for candidate patients.
Researchers have identified a combination of penicillin and clavulanic acid that can overcome resistance in some MRSA strains, making them potentially effective against the superbug. The study suggests that existing medicines could be used to treat one of the world's major strains of MRSA.
Researchers found Cannabidiol effective in killing a wide range of Gram-positive bacteria, including resistant strains, and disrupted biofilms. The compound retained its activity under extended exposure conditions that lead to resistance against other common antibiotics.
A UC Davis study found that educating physicians and patients about safe antibiotic use can reduce overuse by one-third. The study compared two approaches, including educational materials and on-site physician champions, and found significant reductions in inappropriate antibiotic treatment.
A world-first study uses 'good viruses' to eliminate targeted bacteria in green sea turtles without harming non-targeted 'good bacteria'. Researchers have identified the potential for phage therapy as an alternative treatment for bacterial infections in marine animals.
Scientists at Emory Health Sciences have found that combining certain antibiotics can effectively target and defeat bacteria with heteroresistance, a previously underappreciated form of antibiotic resistance. This approach may offer a new strategy for treating resistant infections in hospitalized patients.
Scientists at the University of Warwick have developed a new technology that can detect live bacteria in minutes using bioelectrical signals. This breakthrough could lead to faster diagnosis and treatment of infections, including antibiotic-resistant threats.
A study by Ann & Robert H. Lurie Children's Hospital of Chicago found that nearly 74% of preschool children with community-acquired pneumonia receive unnecessary antibiotics, while 43% undergo chest X-rays despite guidelines against routine use. This overuse contributes to antibiotic resistance and side effects.
Researchers discovered a new class of antibiotics produced by the microbiome that kill bacteria by disrupting their energy metabolism. Fibupeptides, such as lugdunin, have shown promise in treating multidrug-resistant infections, including those caused by MRSA.
Researchers found a compound, C10, that prevented TB bacteria from forming biofilms, making them easier to kill with antibiotics. The compound reversed drug resistance in lab-grown bacteria, potentially shortening treatment regimens for millions suffering from the deadly infection.
A recent study published in JAMA Network Open found that antibiotics prescribed by dentists as a preventive measure are unnecessary for 81% of patients. The researchers analyzed nearly 170,000 dentist-written antibiotic prescriptions from 2011 to 2015 and found that only 21% of patients had a cardiac condition that made an antibiotic p...
A recent US study found that 81% of antibiotics prescribed by dentists to prevent infections prior to dental visits are unnecessary. The study highlights the need for improved antibiotic stewardship in dental practices, particularly in Western US locations.
A new study has helped develop a treatment option for multi-drug resistant (MDR) infections, including complicated urinary tract infections. The treatment, tebipenem pivoxil hydrobromide, is an oral antibiotic agent that may facilitate earlier discharge from hospital or treat complex infections in the community.
Researchers at Swansea University have found that Manuka honey is effective in killing antimicrobial resistant bacteria by 39%, improving the activity of some antibiotics. This could provide an alternative treatment for cystic fibrosis patients struggling with deadly, antibiotic-resistant respiratory infections.
A new study has found that cranberry extract makes bacteria more sensitive to antibiotics, reducing resistance and allowing for lower doses to be effective. This breakthrough could help combat the growing threat of antibiotic resistance.
Lugdunin, a cyclic peptide with strong antimicrobial properties, works by proton transport across bacterial membranes. The researchers discovered that the thiazolidine group in lugdunin forms a critical part of its structure and is essential for its antibacterial activity.
A global study has discovered that concentrations of antibiotics in some world rivers exceed 'safe' levels by up to 300 times. The research team detected antibiotic contamination at 65% of sites monitored across six continents, with the most prevalent being trimethoprim and ciproflaxacin.
Researchers characterized Helicobacter pylori's genetic diversity in individual patients, showing adaptations to specific stomach regions and the impact of antibiotics on its population structure and resistance. The study suggests that antibiotics can select for resistant variants and shape the species' evolutionary dynamics.
Dr. Ana Rita Brochado's research focuses on gram-negative bacteria, which are difficult to treat due to their complex cellular envelope. Her work has shown that certain bacterial strains can be effectively combated using antibiotic combinations and food compounds, like vanillin.
A new modeling study suggests that rapid tests for drug-resistant infections could turn the tables against bacteria, allowing doctors to target resistant strains with precision. However, the researchers found that asymptomatic carriers must also be screened and treated to reverse the spread of resistance.
Researchers have discovered that gamma/delta T cells are the specific cells mediating the mouse's defense against Staphylococcus aureus (MRSA) infection. In a study published in the Proceedings of the National Academy of Sciences, researchers identified V gamma 6/Vdelta 4+ gamma/delta T cells as the key players in this response.
A leading scientist proposes five rules to tackle antibiotic resistance, including protecting new drugs and using diverse antimicrobials. The World Health Organisation warns of a post-antibiotic era, and the study aims to provide a roadmap for integrated microbial management.
A new study found that giving all women a single dose of preventative antibiotics after childbirth involving forceps or vacuum extraction could prevent almost half of maternal infections. The trial, involving 3,420 women, suggests that this simple intervention could reduce antibiotic use by 17% and save the NHS £52.60 per woman.
A recent study from UT Southwestern Medical Center reveals that several species of bacteria can invade the bladder walls in postmenopausal women with urinary tract infections. The findings suggest that antibiotic treatment may not be effective due to high levels of bacterial resistance and a lack of targeted therapies.
Researchers developed a novel machine-learning approach to discover an additional mechanism by which some antibiotics kill bacteria. This secondary mechanism involves activating the bacterial metabolism of nucleotides necessary for DNA replication, leading to increased energy demands and toxic byproducts that contribute to cell death.
Researchers at Cornell University have identified a new stealthy, jumping gene called mcr-9, which resists the world's last-resort antibiotic colistin, threatening global health. The discovery enables early detection and isolation of resistant bacteria in hospitals and food products.
A randomized trial found that adding azithromycin to standard care reduced treatment failure rates by 49% and improved hospital stay durations. Non-smokers showed significant benefits, while current smokers experienced little improvement.
A new drug combination of gentamicin and azithromycin shows promising results in treating treatment-resistant gonorrhoea, with a cure rate of 91% compared to 98% for the current ceftriaxone treatment. The study suggests that gentamicin could be used as an alternative for patients who are allergic or intolerant to ceftriaxone.
Researchers at Thomas Jefferson University have discovered a way to target both of a bacteria's defenses with one hit, weakening its ability to develop antibiotic resistance. By interfering with a specific type of tRNA molecule, the team was able to make bacteria more susceptible to antibiotics.
Researchers at ETH Zurich develop a new technique, nanoFleming, to rapidly test for antibiotic activity in microorganisms. The method has identified 11 novel peptides with improved efficacy or resistance-bypassing properties.
Fecal transplants could block C. diff's spore from germinating and propagating disease via its toxins, repopulating the gut with diverse microbes. However, current fecal transplant products are not FDA-approved, and patients should refer to clinical trials instead.
Women who take antibiotics for two months or more are at increased risk of cardiovascular disease, especially in late adulthood and middle age. The study found that long-duration antibiotic use was associated with an increased risk of heart attack and stroke in women aged 60 or older.
Researchers at the University of Lincoln have successfully reproduced the complex 'anti-tumour antibiotic' kedarcidin, which shows promise in treating cancer and combating drug-resistant bacteria. The breakthrough could lead to new antibiotics and anticancer agents, offering hope for millions facing life-threatening infections.
For long-term acne treatment, doctors are exploring combinations of therapies instead of antibiotics. Benzoyl peroxide and topical retinoids show promise in treating the condition, which affects mainly women in their 20s to 40s.
Researchers developed a dispersion method to effectively kill biofilm bacteria by depleting pyruvate, making resident bacteria susceptible to antibiotics. The method showed improved treatment of infected wounds and enhanced efficacy of conventional antibiotic therapy.
Researchers discovered that bacteria produce a specific stress molecule when exposed to antibiotics, causing them to divide more slowly. This adaptation allows the bacteria to survive while maintaining high tolerance, enabling them to quickly regrow when the antibiotic treatment is ceased.
A new study found that a slow-growing variant form of Lyme bacteria causes severe symptoms and resists standard single-antibiotic treatment. A three-antibiotic cocktail eradicated the infection in mice, offering a potential solution for patients with persistent Lyme disease symptoms.
A KAIST research team created a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in just eight hours. This technology can aid in exploring critical pharmacological patterns of antibiotic interactions and guide clinical therapies.
Researchers developed a drug resistance index to track global trends in antibiotic therapy effectiveness. The study found that high-income countries generally have lower rates of resistance, while low- and middle-income countries face greater challenges due to limited access to newer drugs.
A new study found that 40% of outpatient antibiotic prescriptions were unnecessary, with urinary tract infections, bronchitis, skin structure infections, and sinusitis being common causes. Real-time alerts and patient education may help reduce misuse by targeting these factors in the outpatient setting.
Research suggests that mode of delivery influences the development of the gut microbiota in infants, with C-sections linked to delayed bacterial colonization and increased risk of respiratory infections. This may have implications for future respiratory health.
A UK study found that only one-third of patients with suspected urinary tract infections (UTIs) actually have evidence of the infection. In reality, nearly all patients receive antibiotics, which contributes to antimicrobial resistance. The study suggests implementing antimicrobial stewardship initiatives could reduce unnecessary antib...
Research reveals that over-the-counter throat medications containing topical antibiotics can contribute to antibiotic resistance in certain bacteria species. The study found that some products were not sufficiently concentrated to prevent bacterial growth, enabling resistance development.
A genetic study of an outbreak of Enterococcus faecalis revealed how the organism became resistant to new antibiotics and adapted to infect human blood. The research identified multiple mutations that enabled the bacteria to resist host immune systems and antibiotics.
A cluster of four NYC hospital patients harboring highly resistant E. coli with the MCR-1 gene were identified, highlighting the risk of spread and need for ongoing surveillance of this rare antibiotic resistance gene.
Scientists have engineered a fungus to produce a high-concentration antibiotic, which could treat African sleeping sickness. The breakthrough uses genetic modification to create a non-toxic variant of the antibiotic, offering a cost-effective solution to this neglected tropical disease.
A novel technology developed by Professor Douglas Kell uses flow cytometry to detect and count individual bacteria in urine samples. This allows doctors to determine the most effective antibiotic for treating specific bacterial infections, potentially reducing the reliance on last-resort antibiotics.
Researchers have developed a high-throughput method to produce and screen engineered antimicrobial lanthipeptides, which could lead to the creation of new antibiotics. The method involves synthesizing DNA strands coding for different ring combinations and screening them for antimicrobial potential using micro-alginate beads.
Scientists found that certain antibiotics trigger the generation of toxic molecules called reactive oxygen species (ROS), which can lead to new mutations and antibiotic resistance. ROS-reducing drugs like edaravone can prevent these mutations, suggesting a potential new strategy to combat resistance evolution
Researchers have identified bacteria with promising antibiotic activity against known pathogens in the protective mucus that coats young fish. The study found five bacterial extracts strongly inhibited methicillin-resistant S. aureus and three inhibited Candida albicans, a fungus pathogenic to humans.
University of Arizona immunobiologist Michael Johnson is using a $1.9 million grant to explore copper's potential as an antibiotic. He hopes to create therapeutics that target the copper-sensing protein CopY, which helps bacteria fight off copper stress.
An international study found that wastewater treatment plants in seven European countries have varying levels of antibiotic resistance, with southern Europe showing higher rates. The study suggests that modern treatment plants are effective in removing resistant bacteria, but older or poorly managed plants may contribute to the problem.
Researchers found that populations with high HIV/AIDS prevalence are more susceptible to antibiotic-resistant bacterial infections due to frequent antibiotic use. This increases the risk of drug-resistant diseases, posing a serious public health threat worldwide.
Researchers at Stevens Institute of Technology have developed a self-defensive surface for medical implants that releases micro-doses of antibiotics when bacteria approach. The microgels' behavior is regulated by electrical charges and can be applied to various medical devices, potentially reducing surgical infections.
The Infectious Diseases Society of America (IDSA) has released updated guidelines for asymptomatic bacteriuria (ASB), suggesting that testing should be limited to high-risk patients. This shift aims to reduce unnecessary antibiotic treatment and minimize the risk of promoting antibiotic resistance.
Researchers at Rice University suggest that fluctuating growth rates of bacteria can increase the time it takes to eradicate a bacterial infection, giving the surviving bugs a better chance to develop resistance. This approach could lead to more accurate dosing and improved treatment outcomes.
A study of 400 patients found that switching from intravenous to oral antibiotic therapy resulted in fewer deaths and complications over a median of 3.5 years. Patients who switched to oral treatment had better survival rates than those who remained on conventional intravenous therapy.
A bioabsorbable antibiotic envelope has been shown to reduce the risk of major device-related infections in cardiac devices by 40% within one year. The study involved nearly 7,000 patients across 25 countries and demonstrated the safety and effectiveness of this innovation.
A new test for identifying how single bacteria react to antibiotics could help slow down antibiotic resistance by targeting the right treatments more quickly. The test, which can analyze hundreds of bacteria at once, examines multiple properties and detects the signature of each bacterium in one hour.